Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrA19 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Salmonella enterica subsp. enterica serovar Typhimurium +1 | - | 2002 | AJ310778.1 | CAC81324.1 |
| DfrA19 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 22 | TRIMETHOPRIM, trimethoprim +1 | Salmonella enterica subsp. enterica serovar Typhimurium +14 | Egypt, South West London, UK, Australia, China, Japan, Armenia|Georgia, Nigeria, Mexico, Greece, California|Europe|North America|Republic of Congo, Somali region, Ethiopia|Somali Region, Ethiopia, Europe, USA|China|Spain|Australia|Japan|Switzerland|Netherlands|Brazil|Taiwan|New Hampshire, USA|global | 2007, 2009, 2013, 2014, 2016, 2018, 2020, 2021, 2022, 2024, 2025 | AJ310778.1 | CAC81324.1 |
Composite integron array generated by insertion of an ORF341-type integron within a Tn21-like element., Mobilization of qnrB2 and ISCR1 in plasmids.
Characterisation of integrons containing the plasmid-mediated quinolone resistance gene qnrA1 in Klebsiella pneumoniae.
Characterisation of integrons containing the plasmid-mediated quinolone resistance gene qnrA1 in Klebsiella pneumoniae.
Characterisation of integrons containing the plasmid-mediated quinolone resistance gene qnrA1 in Klebsiella pneumoniae.
Mobilization of qnrB2 and ISCR1 in plasmids.
Mobilization of qnrB2 and ISCR1 in plasmids.
Molecular characterization of multidrug resistant hospital isolates using the antimicrobial resistance determinant microarray.
The study characterized various AMR genes in multidrug-resistant hospital isolates using the Antimicrobial Resistance Determinant Microarray (ARDM). Key findings include the detection of beta-lactamase genes (bla TEM, bla SHV, bla CTX-M, bla OXA), aminoglycoside resistance genes (aadA1, aadA2, aph3'/str(A), aph6/str(B), aac(3)-III, aac(6')-Ib), tetracycline resistance genes (tet(A), tet(B), tet(D), tet(39)), sulfonamide resistance genes (sulI, sulII), trimethoprim resistance genes (dfrA1, dfrA10, dfrA14, dfrA17), quaternary amine resistance gene (qacEΔ1), chloramphenicol resistance genes (catA1, cat4), and glycopeptide resistance genes (vanB, vanB2).
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats.
The study identifies the blaIMP-4 gene in Salmonella enterica Typhimurium from cats, which confers resistance to carbapenems. The gene is part of a multidrug-resistant IncHI2 plasmid carrying various resistance genes.
The Role of ISCR1-Borne P(OUT) Promoters in the Expression of Antibiotic Resistance Genes.
The study shows that IS CR1's P OUT promoters significantly enhance the expression of downstream antibiotic resistance genes, such as bla CTX-M-9 and dfrA19, contributing to antimicrobial resistance.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Molecular characterisation of extended-spectrum ß-lactamase producing Escherichia coli in wild birds and cattle, Ibadan, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli from wild birds and cattle in Nigeria, including bla CTX-M1/15, bla CTX-M9, strB, sul2, tetA, and others. These genes were associated with resistance to multiple antibiotics, highlighting the potential for inter-species transmission of AMR bacteria.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.
The study characterizes the dissemination of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones in Enterobacter species, highlighting their co-occurrence with other resistance genes and their global distribution.
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