Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrA21 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Salmonella enterica subsp. enterica serovar Bredeney +1 | - | 2005 | AM932669.1 | CAP69659.1 |
| DfrA21 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | trimethoprim, TRIMETHOPRIM +1 | Salmonella enterica serotype Livingstone +6 | Tunisia, China, United Kingdom, Brazil, Brazil|Europe|United Kingdom|United States | 2005, 2019, 2021, 2023, 2024 | AY552589 | AAS66087.1 |
| dfr A21 | Reslit | 1 | trimethoprim | Escherichia coli | Southeast Nigeria | 2022 | PRJEB43719 | - |
Nosocomial outbreak caused by Salmonella enterica serotype Livingstone producing CTX-M-27 extended-spectrum beta-lactamase in a neonatal unit in Sousse, Tunisia.
The study identifies the CTX-M-27 extended-spectrum beta-lactamase and the dfrA21 gene, which confer resistance to ceftazidime, ceftriaxone, and trimethoprim in Salmonella enterica serotype Livingstone.
Nosocomial outbreak caused by Salmonella enterica serotype Livingstone producing CTX-M-27 extended-spectrum beta-lactamase in a neonatal unit in Sousse, Tunisia.
Nosocomial outbreak caused by Salmonella enterica serotype Livingstone producing CTX-M-27 extended-spectrum beta-lactamase in a neonatal unit in Sousse, Tunisia.
Nosocomial outbreak caused by Salmonella enterica serotype Livingstone producing CTX-M-27 extended-spectrum beta-lactamase in a neonatal unit in Sousse, Tunisia.
Nosocomial outbreak caused by Salmonella enterica serotype Livingstone producing CTX-M-27 extended-spectrum beta-lactamase in a neonatal unit in Sousse, Tunisia.
Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Bla(ndm-1) from Hospital Sewage.
The study characterizes a carbapenem-resistant Kluyvera cryocrescens isolate carrying blaNDM-1 on a self-transmissible IncX3 plasmid, along with other resistance genes such as blaSHV-12, blaCTX-M-3, qnrS1, sul1, fosA, dfrA21, and dfrA14.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Exploring antibiotic resistance in environmental integron-cassettes through intI-attC amplicons deep sequencing.
The study identified several antibiotic resistance genes (ARGs) in environmental integron-cassettes from the Velhas River, including clinically relevant genes such as blaGES-5, aacA7, dfrA21, qacH, emrE, fosB3, and novA. These genes were associated with various resistance mechanisms, primarily efflux pumps and inactivation.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant Salmonella Mbandaka ST413 Strains.
The study identified nine resistance genes, including aac(6')-Iaa, sul1, qacE, blaOXA-129, tet(B), and aadA1, as well as a point mutation in ParC (T57S) associated with quinolone resistance in Salmonella Mbandaka ST413 strains.
The expression of integron arrays is shaped by the translation rate of cassettes.
The study demonstrates that the identity of the first cassette in an integron array significantly influences the expression of downstream cassettes, thereby affecting the resistance phenotype. Specifically, aacA54, aacA61, and aacA8 were shown to reduce resistance to β-lactams and aminoglycosides, while blaVIM-1 and catB3 conferred resistance to carbapenems and chloramphenicol, respectively.
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