Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrA23 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Salmonella enterica subsp. enterica serovar Typhimurium | - | 2005 | AJ746361.2 | CAG34233.2 |
| DfrA23 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | trimethoprim, TRIMETHOPRIM | Salmonella enterica serovar Typhimurium +4 | Italy, South Africa, Greece, Europe | 2005, 2019, 2020, 2021, 2023 | AJ746361 | CAG34233.2 |
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
The study identifies a novel trimethoprim resistance gene, dfrA23, on a Salmonella enterica serovar Typhimurium virulence plasmid, along with other resistance genes such as aadB, blaOXA-30, and aadA1.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
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