dfrA38

trimethoprim-resistant dihydrofolate reductase DfrA38

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target replacement
Validation Method: cloning in E. coli + MIC assay
Drug Classes: TRIMETHOPRIM, trimethoprim
Organisms: Acinetobacter baumannii, Flavobacterium branchiophilum, E. coli
Geographic Location: Europe
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: dfrA38
Allele: DfrA38
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA38
Source Database: Reference Gene Catalog
Mechanism: antibiotic target replacement
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: MT234667.1
Protein Accession: QNL15203.1
Notes: ARO:3005349

PMID N/A

Gene Information

Gene Name: dfrA38
Allele: DfrA38
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA38
Source Database: Card Database
Mechanism: antibiotic target replacement
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: MT234667.1
Protein Accession: QNL15203.1
Notes: ARO:3005349

PMID N/A

Gene Information

Gene Name: dfrA38
Allele: DfrA38
Encodes: trimethoprim resistant dihydrofolate reductase dfr
Source Database: Card Database
Mechanism: antibiotic target replacement
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: NG_071175.1
Protein Accession: WP_197749399.1
Notes: ARO:3005349

Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim.

PMID 32969787 · 2020

The study identifies novel trimethoprim-resistance determinants in Acinetobacter clinical isolates, including dfrA38, dfrA39, dfrA40, and dfrA41, which confer resistance to trimethoprim. It also reveals that chromosomal folA genes can confer resistance to trimethoprim, indicating that resistance to trimethoprim predates clinical use.