dfrA51

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dihydrofolate reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA51

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: functional studies in E. coli
Drug Classes: trimethoprim
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

PMID 40503927 · 2025

The study identified two novel trimethoprim resistance genes, dfrA50 and dfrA51, in phage-plasmids, which confer resistance to trimethoprim in Escherichia coli.

Gene Information

Gene Name: dfrA51
Allele: dfrA51
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: functional studies in E. coli
Sequence Accession: NG_242637.1|NG_242639.1|NG_242636.1|WP_038694170.1|QYR06304.1|WP_040203768.1|QBP27508.1|WP_000781812.1|AFL47010.1

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dfrA51

Gene Information

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dfrA51

Gene Information