dfrA52

trimethoprim-resistant dihydrofolate reductase DfrA52

Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression in E. coli and functional analysis
Drug Classes: TRIMETHOPRIM, trimethoprim
Organisms: Escherichia phage vB_EcoM_BMB16, Escherichia coli, Bacillus thuringiensis
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Gene Information

Gene Name: dfrA52
Allele: DfrA52
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA52
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia phage vB_EcoM_BMB16
Sequence Accession: PV102577.1
Protein Accession: XPO54507.1

Evolutionary selection of trimethoprim-resistant dfrA genes in lytic phages affects phage and host fitness during infection.

PMID 41004581 · 2025

The study identifies dfrA genes in lytic phages that confer trimethoprim resistance to bacteria, enhancing phage reproduction and host bacterial growth during infection.

Gene Information

Gene Name: dfrA52
Allele: DfrA52
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
• Bacillus thuringiensis
Validation Method: expression in E. coli and functional analysis
Sequence Accession: QTI37399.1|CP067310|NG_242636.1|NG_070721.1|NP_414590.1|PV102577|OL964058.1

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dfrA52

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dfrA52

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