Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrB1 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Escherichia coli +1 | - | - | U36276.1 | AAA82255.1 |
| DfrB1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | TRIMETHOPRIM, trimethoprim | Escherichia coli +7 | Global, Denmark|Taiwan|South Korea|Africa|Asia|Europe|North America|Canada|Norway|South Africa|United States, UK|Kuwait, Europe, Central Adriatic Sea | 2005, 2015, 2019, 2022, 2023, 2025 | U36276.1 | AAA82255.1 |
| dfrB1/dfrB5/dfrB6/dfrB8 | Reslit | 1 | trimethoprim | Escherichia coli +12 | India | 2014 | PRJEB6102 | - |
Molecular basis of resistance to trimethoprim, chloramphenicol and sulphonamides in Bordetella bronchiseptica.
Molecular basis of resistance to trimethoprim, chloramphenicol and sulphonamides in Bordetella bronchiseptica.
Molecular basis of resistance to trimethoprim, chloramphenicol and sulphonamides in Bordetella bronchiseptica.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Mapping the Evolution of Hypervirulent Klebsiella pneumoniae.
The study identifies antibiotic resistance genes in hypervirulent Klebsiella pneumoniae isolates, highlighting the presence of SHV beta-lactamase and additional resistance genes in one isolate, CAS813, which exhibits resistance to multiple antibiotics.
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
The study identifies DfrB1 as a trimethoprim-resistant dihydrofolate reductase and characterizes bisbenzimidazole inhibitors that target this enzyme, providing insights into the design of new antibiotics against trimethoprim-resistant bacteria.
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
The study identifies and characterizes DfrB homologues that display dihydrofolate reductase activity and confer trimethoprim resistance, highlighting the role of the SH3-like fold in providing antimicrobial resistance.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
The study identifies and characterizes DfrB homologues that display dihydrofolate reductase activity and confer trimethoprim resistance, highlighting the role of the SH3-like fold in providing antimicrobial resistance.
Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates.
The study identified multiple AMR genes and mutations in P. aeruginosa UTI isolates from the UK and Kuwait, highlighting the presence of multidrug-resistant strains, especially in Kuwaiti isolates. Key AMR genes included aac(3)-IV, aph(3')-Ib, aph(3')-IIb, aph(4)-Ia, aph(6)-Id, crpP, dfrB1, aac(6')-Ib7, aac(6')-ii, aaA61, blaPDC, and blaVIM-28. Mutations in gyrA were also found to contribute to fluoroquinolone resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Characterisation of Plasmid-Associated Antimicrobial Resistance Genes in Coastal Marine Enterobacterales from the Central Adriatic Sea: De Novo Assembly and Bioinformatic Profiling.
The study identified nine clinically relevant antimicrobial resistance genes (ARGs) in plasmid-like assemblies from marine Enterobacterales, including blaKPC, blaTEM, aacA4, folP, and tetA, highlighting the potential for horizontal gene transfer in coastal environments.
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