dfrB21

trimethoprim-resistant dihydrofolate reductase DfrB21

Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression in E. coli and characterization of MIC and Dfr activity
Drug Classes: TRIMETHOPRIM, trimethoprim
Organisms: Pseudomonadota bacterium, Escherichia coli
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Gene Information

Gene Name: dfrB21
Allele: DfrB21
Encodes: trimethoprim-resistant dihydrofolate reductase DfrB21
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Pseudomonadota bacterium
Sequence Accession: JAPLQT010000137.1
Protein Accession: MCX7177162.1

Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.

PMID 36551425 · 2022

The study identifies 10 new DfrB family members (DfrB12-DfrB21) that confer high trimethoprim resistance in E. coli. These genes were discovered in diverse environmental settings not associated with antibiotic use, suggesting an evolutionary advantage unrelated to antibiotic resistance.

Gene Information

Gene Name: dfrB21
Allele: DfrB21
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: expression in E. coli and characterization of MIC and Dfr activity

Comments (0)

No comments yet. Be the first to comment!

dfrB21

Gene Information

Gene Information

Browse AMR Genes

dfrB21

Gene Information

Gene Information