Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrB4
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| DfrB4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | TRIMETHOPRIM, trimethoprim | Aeromonas sobria +2 | Abuja, Nigeria, Australia, Ethiopia, China | 2009, 2017, 2022, 2023, 2024, 2025 | FM877484.1 | CAT00052.1 |
| dfrB4 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Escherichia coli +1 | - | 2005 | EU339233.1 | ABY55281.1 |
| dfr B4 | Reslit | 1 | trimethoprim | Escherichia coli | Southeast Nigeria | 2022 | PRJEB43719 | - |
Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria., Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey.
Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey.
Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey.
Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey.
Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance.
The study identifies dfrB4 as a novel gene associated with trimethoprim resistance in Escherichia coli, demonstrating that overexpression of DfrB4 significantly increases trimethoprim resistance.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Molecular insights into the persistence and co-occurrence of two different carbapenem-resistant Pseudomonas aeruginosa lineages within a hospital setting.
The study identifies several carbapenem-resistant Pseudomonas aeruginosa lineages with specific resistance genes, including blaOXA-10, blaVIM-2, and others, highlighting the role of plasmids in the spread of resistance.
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