Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrB5 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Pseudomonas aeruginosa | - | 2005 | AY943084.1 | AAX46054.1 |
| DfrB5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | TRIMETHOPRIM, trimethoprim | Pseudomonas aeruginosa +1 | India, Russia|Moscow, Singapore, Greece, Argentina|Canada|Germany|United States, Egypt, Europe | 2005, 2015, 2021, 2023, 2025 | AY943084.1 | AAX46054.1 |
| dfrB-5 | Reslit | 1 | trimethoprim | Pseudomonas aeruginosa | Saudi Arabia | 2021 | PRJNA751257 | - |
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.
The study reports the draft genome sequence of MDR Pseudomonas aeruginosa strain VRFPA09, identifying several AMR genes including blaVeb-1, blaOXA-10, aadA1, aph(3')Iib, Sul1, CatB7, TetG, dfrB5, and fosA, which contribute to resistance against various antibiotics.
CRISPR Element Patterns vs. Pathoadaptability of Clinical Pseudomonas aeruginosa Isolates from a Medical Center in Moscow, Russia.
The study identified multiple antibiotic resistance genes in clinical Pseudomonas aeruginosa isolates, including blaVIM-2, blaOXA-396, blaOXA-488, floR, tetG, sul1, dfrA5, dfrB2, dfrB5, aph(3)-Ib, blaPAO, catB7, and fosA, which confer resistance to various antibiotics such as beta-lactams, chloramphenicol, tetracycline, sulfonamides, trimethoprim, aminoglycosides, and fosfomycin.
Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages.
The study identified GES-5-producing ST235 and VIM-2-producing ST233 sub-lineages of Pseudomonas aeruginosa in Saudi Arabia, highlighting their global dissemination and the presence of various resistance genes including blaGES-5, blaVIM-2, and others.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Comparative genomics of Pseudomonas paraeruginosa.
The study identifies various AMR genes and mutations in Pseudomonas paraeruginosa, including carbapenemases like blaVIM-2, blaVIM-6, blaVIM-28, and blaKPC-2, as well as efflux pump genes (mexAB-oprM, mexCD-oprJ, etc.), and mutations in oprD, mexS, mexR, mexZ, lasR, mvfR, and vqsM that contribute to antibiotic resistance.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model.
The study identified 15 AMR genes significantly more frequent in high-risk P. aeruginosa clones, including aminoglycoside, beta-lactam, phenicol, fluoroquinolone, trimethoprim, sulfonamide, and tetracycline resistance genes. These genes are often associated with mobile genetic elements, indicating a mobility-linked resistome in high-risk clones.
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