Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim resistant dihydrofolate reductase dfr
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrD | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Listeria monocytogenes +1 | - | 1995 | U43152.1 | AAA85213.1 |
| DfrD | Card DatabaseReference Gene CatalogReslit | 14 | trimethoprim, TRIMETHOPRIM | Listeria monocytogenes BM4293 +19 | Global, Switzerland, Spain, Vietnam, global, Northern Province|Kigali District, Europe, Portugal, Belgium, Edo, Nigeria | 1995, 1997, 1999, 2014, 2015, 2019, 2020, 2022, 2023 | u0997 | CAA90487.1 |
Conjugative Mobilization of the Rolling-Circle Plasmid pIP823 from Listeria monocytogenes BM4293 among gram-positive and gram-negative bacteria.
The study characterizes the plasmid pIP823 from Listeria monocytogenes BM4293, which contains the dfrD gene that confers high-level trimethoprim resistance by encoding a trimethoprim-resistant dihydrofolate reductase type S2.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial susceptibility and antibiotic resistance gene transfer analysis of foodborne, clinical, and environmental Listeria spp. isolates including Listeria monocytogenes.
The study identified the tet(M) gene as the primary cause of tetracycline resistance in Listeria isolates, along with dfrA, dfrD, and dfrG genes responsible for trimethoprim resistance. Additionally, the transferability of these resistance genes via conjugative transposons and plasmids was demonstrated.
Antibiotic Multiresistance Analysis of Mesophilic and Psychrotrophic Pseudomonas spp. Isolated from Goat and Lamb Slaughterhouse Surfaces throughout the Meat Production Process.
The study identified multiple antibiotic resistance genes in Pseudomonas spp. isolated from slaughterhouse surfaces, including beta-lactamases (bla CTX, bla TEM), sulfonamide resistance (sulII), trimethoprim resistance (dfrD), tetracycline resistance (tetQ), erythromycin resistance (ereA), and chloramphenicol resistance (catA2).
Identification and Antimicrobial Resistance of Bacteria Isolated from Probiotic Products Used in Shrimp Culture.
The study identified several antimicrobial resistance genes in Bacillus spp. isolated from probiotic products used in shrimp culture, including ermD (macrolide resistance), tetL (tetracycline resistance), fexA (phenicol resistance), and dfrD, dfrG, dfrK (trimethoprim resistance). These genes were detected through whole genome sequencing of multiple antimicrobial-resistant Bacillus isolates.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.
The study identified several antibiotic and biocide resistance genes in Staphylococcus species associated with bovine mastitis in Rwanda, including blaZ, tet(K), erm(C), vga(A), sal(A), lnu(A), msr(A), dfrA, dfrD, dfrG, smr, qacAB, cadD, copB, and arsA. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, clindamycin, trimethoprim, and biocides like quaternary ammonium compounds.
Integrative Analysis of Whole Genome Sequencing and Phenotypic Resistance Toward Prediction of Trimethoprim-Sulfamethoxazole Resistance in Staphylococcus aureus.
The study identified dfrA, dfrG, dfrD, and dfrK genes as conferring trimethoprim resistance in Staphylococcus aureus, and mutations in the folP gene (F17L and KE257_Dup) as responsible for sulfamethoxazole resistance.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.
A novel plasmid-encoded trimethoprim-resistant dihydrofolate reductase (dfrD) was cloned and characterized from Staphylococcus haemolyticus MUR313, showing high resistance to trimethoprim.
Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.
Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
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