Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrE
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| DfrE | Reference Gene Catalog | 1 | TRIMETHOPRIM | Mammaliicoccus sciuri | - | - | KF129410.1 | AGR88949.1 |
| dfrE | Card DatabaseResFinder DatabaseReslit | 18 | trimethoprim, TRIMETHOPRIM | Enterococcus faecalis EnGen0074 +12 | China, China|Russia|Mongolia, wastewater treatment plants|Canada, Alberta, Canada, Atlantic Southwest Shelves Province|Antarctic Province|Indian South Subtropical Gyre, Pacific region|Hawaii, Europe|Christmas Island, Nigeria, Antarctica, USA, South Africa | 1999, 2017, 2018, 2020, 2021, 2023, 2024 | AIIS01000002.1 | EOD99669.1 |
| dfr(E) | Reslit | 1 | trimethoprim | Enterococcus faecalis | Bangladesh | 2023 | - | - |
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
Comparative genomic analysis of Enterococcus faecalis: insights into their environmental adaptations.
The study identified 293 environment-specific genes and found that blood-originating strains had the highest number of antibiotic resistance genes, including vanA and vanB-type vancomycin resistance clusters.
Epidemiological characteristics and genetic structure of linezolid-resistant Enterococcus faecalis.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples.
The study identified 313 ARGs in the global ocean, including mcr-1, which confers resistance to colistin. The most frequent ARGs were Qac and TETB(60), associated with multidrug efflux pumps and tetracycline resistance, respectively.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Genomic Insights Into the Pathogenicity of a Novel Biofilm-Forming Enterococcus sp. Bacteria (Enterococcus lacertideformus) Identified in Reptiles.
The study identified several antimicrobial resistance and virulence genes in Enterococcus lacertideformus, including DfrE, EfrB, ClpP, Fss3, and various metal resistance genes such as mgtA, copB, and ziaA. These genes suggest resistance to trimethoprim, macrolides, rifamycins, fluoroquinolones, and heavy metals.
Genomic Insights Into the Pathogenicity of a Novel Biofilm-Forming Enterococcus sp. Bacteria (Enterococcus lacertideformus) Identified in Reptiles.
The study identified several antimicrobial resistance and virulence genes in Enterococcus lacertideformus, including DfrE, EfrB, ClpP, Fss3, and various metal resistance genes such as mgtA, copB, and ziaA. These genes suggest resistance to trimethoprim, macrolides, rifamycins, fluoroquinolones, and heavy metals.
The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated dfrE, Spread Unnoticed.
The study identifies and characterizes the transferable trimethoprim resistance gene dfrE in Staphylococcus sciuri C2865, which confers high-level resistance in Staphylococcus aureus and Escherichia coli.
The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated dfrE, Spread Unnoticed.
Metagenomic strategies identify diverse integron-integrase and antibiotic resistance genes in the Antarctic environment.
The study identified various antibiotic resistance genes in Antarctic metagenomes, including aminoglycoside-modifying enzymes, beta-lactamases, and multidrug resistance transporters.
Taxonomic Assignment-Based Genome Reconstruction from Apical Periodontal Metagenomes to Identify Antibiotic Resistance and Virulence Factors.
The study identified several antibiotic resistance genes (ARGs) in metagenomic assemblies from apical periodontal infections, highlighting the presence of multidrug resistance mechanisms in Enterobacter and Pseudomonas species.
Virulence and antibiotic-resistance genes in Enterococcus faecalis associated with streptococcosis disease in fish.
The study identified various antibiotic-resistance genes in three strains of Enterococcus faecalis associated with streptococcosis in fish, including genes conferring resistance to tetracycline, macrolide-lincosamide-streptogramin, and vancomycin.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.
The study identifies several antibiotic resistance genes in South African Enterococcus faecalis and Enterococcus lactis isolates, including dfrE, vanW, vanT, efrA, tet(M), AAC(6')-Ii, msrC, and vanY, which confer resistance to trimethoprim, glycopeptides, tetracycline, macrolides, and aminoglycosides.
Characterization of Dihydrofolate Reductase Genes from Trimethoprim-Susceptible and Trimethoprim-Resistant Strains of Enterococcus faecalis.
The study identifies two dihydrofolate reductase genes, dfrE and dfrF, responsible for high-level trimethoprim resistance in Enterococcus faecalis. dfrE is an intrinsic gene, while dfrF is an acquired gene that confers resistance when expressed in E. coli.
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