Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydrofolate reductase
Overview
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.
The study identifies 10 new DfrB family members (DfrB12-DfrB21) that confer high trimethoprim resistance in E. coli. These genes were discovered in diverse environmental settings not associated with antibiotic use, suggesting an evolutionary advantage unrelated to antibiotic resistance.
Bacteria of the order Burkholderiales are original environmental hosts of type II trimethoprim resistance genes (dfrB).
The study identifies bacteria of the order Burkholderiales, particularly the family Comamonadaceae, as the original environmental hosts of dfrB genes, which confer resistance to trimethoprim. These genes are prevalent in both freshwater and soil microbiomes.
No comments yet. Be the first to comment!