Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
d-alanine: d-alanyl carrier protein ligase
Overview
The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.
The dlt operon in Clostridium difficile confers resistance to cationic antimicrobial peptides (CAMPs) such as nisin, polymyxin B, gallidermin, and vancomycin. Disruption of the dltD gene significantly reduces resistance to these CAMPs, and complementation restores resistance.
Characterization of a regulatory network of peptide antibiotic detoxification modules in Lactobacillus casei BL23.
The study identifies dltA and mprF as genes involved in resistance to antimicrobial peptides in Lactobacillus casei BL23, with dltA playing a major role in AMP resistance.
Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics.
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
The study identified various AMR genes and mutations associated with daptomycin resistance in MRSA strains, including genes such as aac(6')-Ib, blaZ, mecA, ermC, fexB, tetM, tet38, dfrC, fosD, and vgaA, as well as mutations in mprF, rpoB, grlA, grlB, and gyrA.
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus.
The paper discusses the mechanisms of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), focusing on genes such as blaZ, mecA, and dltA, which are involved in beta-lactam and glycopeptide resistance. It highlights the importance of understanding these resistance mechanisms to develop new therapeutic strategies.
Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila.
The study identifies dltA and ffh as genes involved in resistance to host antimicrobial peptides (AMPs) in Lactiplantibacillus plantarum, demonstrating that disruptions in these genes lead to increased susceptibility to AMPs like polymyxin B and cecropin B.
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