dltB

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d-alanyl transfer protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dltB

AMR Rules

Browse AMR rules for dltB

Validation StatusCandidate

Overview

Validation Method: MIC determination and growth assays
Drug Classes: polymyxin b, vancomycin, polymyxins
Organisms: Clostridium difficile, Dickeya dadantii
Papers: 2
Databases: Reslit

Papers2

The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.

PMID 21330441 · 2011

The dlt operon in Clostridium difficile confers resistance to cationic antimicrobial peptides (CAMPs) such as nisin, polymyxin B, gallidermin, and vancomycin. Disruption of the dltD gene significantly reduces resistance to these CAMPs, and complementation restores resistance.

Gene Information

Gene Name: dltB
Allele: dltB
Encodes: d-alanyl transfer protein
Source Database: Reslit
Confers Resistance To: polymyxin bvancomycin
Organisms Tested In: • Clostridium difficile
Validation Method: MIC determination and growth assays
Sequence Accession: AM180355

Transcriptome of Dickeya dadantii infecting Acyrthosiphon pisum reveals a strong defense against antimicrobial peptides.

PMID 23342088 · 2013

The study identifies genes involved in resistance to antimicrobial peptides (AMPs) in Dickeya dadantii during infection of the pea aphid, including pmrC, arnB, and dltB, which contribute to resistance against polymyxin.