dltC

View on PubMed

d-alanyl carrier protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dltC

AMR Rules

Browse AMR rules for dltC

Validation StatusCandidate

Overview

Mechanism: D-alanine--poly(phosphoribitol) ligase subunit DltC
Validation Method: MIC determination and growth assays
Drug Classes: polymyxin b, vancomycin, daptomycin
Organisms: Clostridium difficile, Enterococcus faecium
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S63C	-	D-alanine--poly(phosphoribitol) ligase subunit DltC	Enterococcus faecium	daptomycin	Reference Gene Catalog	Candidate

Papers2

The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.

PMID 21330441 · 2011

The dlt operon in Clostridium difficile confers resistance to cationic antimicrobial peptides (CAMPs) such as nisin, polymyxin B, gallidermin, and vancomycin. Disruption of the dltD gene significantly reduces resistance to these CAMPs, and complementation restores resistance.

Gene Information

Gene Name: dltC
Allele: dltC
Encodes: d-alanyl carrier protein
Source Database: Reslit
Confers Resistance To: polymyxin bvancomycin
Organisms Tested In: • Clostridium difficile
Validation Method: MIC determination and growth assays
Sequence Accession: AM180355

Comments (0)

No comments yet. Be the first to comment!

dltC

Mutations

Gene Information

Browse AMR Genes

dltC

Mutations

Gene Information