dltD

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d-alanine transfer protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dltD

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: MIC determination and growth assays
Drug Classes: polymyxin b, vancomycin, daptomycin
Organisms: Clostridium difficile, Staphylococcus capitis
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G122D	-	-	Staphylococcus capitis	daptomycin	Reslit	Candidate

Papers2

The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.

PMID 21330441 · 2011

The dlt operon in Clostridium difficile confers resistance to cationic antimicrobial peptides (CAMPs) such as nisin, polymyxin B, gallidermin, and vancomycin. Disruption of the dltD gene significantly reduces resistance to these CAMPs, and complementation restores resistance.

Gene Information

Gene Name: dltD
Allele: dltD
Encodes: d-alanine transfer protein
Source Database: Reslit
Confers Resistance To: polymyxin bvancomycin
Organisms Tested In: • Clostridium difficile
Validation Method: MIC determination and growth assays
Sequence Accession: AM180355

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dltD

Mutations

Gene Information

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dltD

Mutations

Gene Information