Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
deoxyxylulose phosphate reductoisomerase
Overview
Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).
AMR mechanisms in L. interrogans serovars: a comprehensive study.
The study identified 32 AMR genes in Leptospira interrogans serovars, with 20 key genes consistently present across most strains. Unique efflux pump systems were found in serovar Pomona, suggesting distinct resistance mechanisms.
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry.
The study introduces the iSPP method to assess target-engagement of anti-infectives in bacterial cell lysates, identifying key drug targets such as DXR, DHFR, RpoB, and PBPs in various pathogens.
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