Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
small multidrug resistance (SMR) antibiotic efflux pump
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Ecol_emrE | Card Database | 1 | - | Escherichia coli | - | - | Z11877.1 | CAA77936.1 |
| Paer_emrE | Card Database | 1 | - | Pseudomonas aeruginosa PAO1 | - | - | AE004091.2 | AAG08375.1 |
| emrE | Reslit | 16 | acriflavine, ethidium bromide +11 | Escherichia coli W3110 +12 | China, Brazil, Quebec, Canada, United States, South Africa, Arctic | 2001, 2010, 2017, 2018, 2020, 2021, 2022, 2024 | NC_010465|NC_010466|NC_009800|NC_009801 | - |
| EmrE | Reslit | 3 | acriflavine, ethidium bromide +3 | Escherichia coli +2 | South Africa | 2012, 2022 | NP_415075|YP_289048|ZP_04040476|AAF10579|AAF10580 | - |
| emre | Reslit | 3 | aminoglycosides, phenicols +3 | Escherichia coli +2 | China | 2020, 2024, 2025 | MT820501|PRJNA668015 | - |
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
Analysis of a complete library of putative drug transporter genes in Escherichia coli.
The study identified 20 genes in Escherichia coli that confer resistance to various antimicrobial agents, including novel drug resistance determinants such as yceE, yceL, yidY, ydgFE, yegO, cusA, and ybjYZ. Additionally, several previously known genes were found to have broader resistance spectra than previously reported.
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.
The study identifies several antibiotic resistance genes in the enteroaggregative E. coli strain 042, including cat, tetA, aadA1, suI, and emrE, which contribute to resistance against chloramphenicol, tetracycline, streptomycin, spectinomycin, sulfonamide, and ethidium bromide.
New substrates on the block: clinically relevant resistances for EmrE and homologues.
The study identifies and characterizes EmrE homologues, including MrSmr, TfSmr, and Rad1005, which confer resistance to aminoglycoside antibiotics such as streptomycin and tobramycin, expanding the known substrates of the SMR family.
Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
The study identifies several AMR genes in the Nanosilver-resistant Proteus mirabilis strain SCDR1, including those conferring resistance to tetracycline, fluoroquinolones, sulfonamides, daptomycin, rifamycin, elfamycins, chloramphenicol, and amikacin.
Examination of Quaternary Ammonium Compound Resistance in Proteus mirabilis Isolated from Cooked Meat Products in China.
The study identified quaternary ammonium compound resistance genes, including mdfA, ydgE/ydgF, qacE, qacEΔ1, emrE, sugE(c), sugE(p), and qacH, in foodborne Proteus mirabilis isolates. It also discovered non-classic class 1 integrons carrying the gene structure qacH-IS440-sul3, which were located on conjugative plasmids, facilitating the co-dissemination of antimicrobial and disinfectant resistance genes.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Distribution, diversity and persistence of Listeria monocytogenes in swine slaughterhouses and their association with food and human listeriosis strains.
The study identifies the bcrABC resistance cassette and the emrE multidrug transporter gene as being associated with benzalkonium chloride resistance in persistent Listeria monocytogenes strains in swine slaughterhouses.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
Exploring antibiotic resistance in environmental integron-cassettes through intI-attC amplicons deep sequencing.
The study identified several antibiotic resistance genes (ARGs) in environmental integron-cassettes from the Velhas River, including clinically relevant genes such as blaGES-5, aacA7, dfrA21, qacH, emrE, fosB3, and novA. These genes were associated with various resistance mechanisms, primarily efflux pumps and inactivation.
The Antibiotic Dosage of Fastest Resistance Evolution: Gene Amplifications Underpinning the Inverted-U.
The study identifies gene amplifications in Escherichia coli, particularly of the acrAB, emrE, and rrlB genes, which contribute to erythromycin resistance under varying antibiotic dosages.
Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
The study presents the crystal structures of the Escherichia coli small multidrug resistance transporter EmrE in complex with various substrates, revealing insights into its substrate binding and transport mechanisms.
IncFIB-4.1 and IncFIB-4.2 Single-Replicon Plasmids: Small Backbones with Large Accessory Regions.
The study characterizes several AMR genes and mutations in IncFIB-4.1 and IncFIB-4.2 plasmids, highlighting their role in conferring resistance to various antibiotics.
Integrative Assessment of Reduced Listeria monocytogenes Susceptibility to Benzalkonium Chloride in Produce Processing Environments.
The study identifies bcrABC, qacH, and emrE as genes conferring resistance to benzalkonium chloride in Listeria monocytogenes, highlighting their prevalence in isolates from produce processing environments.
Susceptibility Tests and Predictions of Transporter Profile in Serratia Species.
The study identifies efflux pumps such as QacE, EmrE, and SmfY as responsible for disinfectant resistance in Serratia species, particularly showing that the resistant isolate Serratia sp. HRI has fewer resistance transporters compared to the susceptible strain ATCC 13880.
Identification of a Multidrug Resistant Pseudomonas aeruginosa Isolate Harboring Infrequent Red Fluorescence Plasmid from COPD Patient.
The study identifies a multidrug-resistant Pseudomonas aeruginosa isolate L1a harboring an infrequent red fluorescence plasmid. The isolate shows resistance to several antibiotics including levofloxacin, cefepime, aztreonam, and imipenem, and carries multiple drug resistance genes and efflux pump-related genes.
A novel pathogenic species of genus Stenotrophomonas: Stenotrophomonas pigmentata sp. nov.
The study identifies a novel pathogenic species, Stenotrophomonas pigmentata sp. nov., which exhibits resistance to multiple antibiotics, including β-lactams, carbapenems, and trimethoprim-sulfamethoxazole. Several multidrug resistance efflux pump and antibiotic resistance genes were found in its genome.
Detection of the epidemic Pseudomonas aeruginosa AUST-03 (ST242) strain in people with cystic fibrosis in South Africa.
The study identifies multidrug efflux pumps MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM as the primary resistance determinants in Pseudomonas aeruginosa AUST-03 isolates. Mutations in regulatory genes mexR, mexT, nalC, and nfxB contribute to the upregulation of these efflux pumps. Additionally, the study detects several antibiotic resistance genes, including crpP, blaOXA-50, blaOXA-1034, blaPDC-3, and blaPDC-374, which are associated with resistance to various antibiotics.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.
The study identified 10 antibiotic resistance genes in the Actinobacillus pleuropneumoniae strain APPFJLYC01, including genes conferring resistance to multiple antibiotic classes such as β-lactams, tetracyclines, aminoglycosides, and macrolides.
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