Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
EreA family erythromycin esterase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ere(A) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 26 | ERYTHROMYCIN, erythromycin +1 | Escherichia coli +16 | China, Pakistan, swine, Germany, Europe, Romania|France, Shenzhen, China, Germany|Australia|Taiwan|USA|Canada|Denmark, Africa|Americas|Asia|Europe|Oceania, China|North America|Asia|Europe|Africa|Other | 1985, 2001, 2003, 2010, 2012, 2015, 2018, 2019, 2021, 2022, 2023, 2024, 2025 | DQ157752.1 | AAZ91706.1 |
| ereA | Reslit | 24 | macrolides, erythromycin +6 | Escherichia coli +29 | Europe|North America|Asia, Spain, South West London, UK, Malawi, Italy, China, Bangladesh, Iran|Nepal|Jordan|China|Brazil|Egypt|Italy|France|Austria|Belgium|Serbia|global, Shandong Province|China, Japan, Zhejiang, China|China, Egypt, Saudi Arabia, India, Nepal, Iran, Poland, Argentina|Canada|Germany|United States, USA|China|Spain|Australia|Japan|Switzerland|Netherlands|Brazil|Taiwan|New Hampshire, USA|global, Europe | 2014, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | KM364994|KM365013|KM370331|KM370332 | - |
| Ere(A2) | Reference Gene CatalogReslit | 2 | MACROLIDE, macrolides | Providencia stuartii +1 | Egypt | 2003, 2013 | AY183454.1 | AAO38251.1 |
| ere(A)/ere(C) | Reslit | 1 | macrolides, lincosamides +1 | Escherichia coli +12 | India | 2014 | PRJEB6102 | - |
| ere | Reslit | 1 | erythromycin | Escherichia coli | Egypt | 2018 | - | - |
| EreA | Reslit | 1 | macrolides | Pseudomonas aeruginosa | Kenya | 2022 | PRJNA580263 | - |
| ere A | Reslit | 3 | macrolides, erythromycin | Escherichia coli +4 | North America, Egypt | 2023, 2024 | ERP146025 | - |
Novel gene cassettes and integrons.
Novel gene cassettes and integrons.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii.
An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii.
Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron.
Novel integron gene cassette arrays identified in a global collection of multi-drug resistant non-typhoidal Salmonella enterica.
Mechanism and diversity of the erythromycin esterase family of enzymes.
Mechanism and diversity of the erythromycin esterase family of enzymes.
Mechanism and diversity of the erythromycin esterase family of enzymes.
Molecular characterization of multidrug resistant hospital isolates using the antimicrobial resistance determinant microarray.
The study characterized various AMR genes in multidrug-resistant hospital isolates using the Antimicrobial Resistance Determinant Microarray (ARDM). Key findings include the detection of beta-lactamase genes (bla TEM, bla SHV, bla CTX-M, bla OXA), aminoglycoside resistance genes (aadA1, aadA2, aph3'/str(A), aph6/str(B), aac(3)-III, aac(6')-Ib), tetracycline resistance genes (tet(A), tet(B), tet(D), tet(39)), sulfonamide resistance genes (sulI, sulII), trimethoprim resistance genes (dfrA1, dfrA10, dfrA14, dfrA17), quaternary amine resistance gene (qacEΔ1), chloramphenicol resistance genes (catA1, cat4), and glycopeptide resistance genes (vanB, vanB2).
Antibiotic Multiresistance Analysis of Mesophilic and Psychrotrophic Pseudomonas spp. Isolated from Goat and Lamb Slaughterhouse Surfaces throughout the Meat Production Process.
The study identified multiple antibiotic resistance genes in Pseudomonas spp. isolated from slaughterhouse surfaces, including beta-lactamases (bla CTX, bla TEM), sulfonamide resistance (sulII), trimethoprim resistance (dfrD), tetracycline resistance (tetQ), erythromycin resistance (ereA), and chloramphenicol resistance (catA2).
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive Staphylococcus aureus and coagulase-negative staphylococcal isolates from bovine mastitis.
The study identified various MLS resistance genes, including erm(C), mph(C), erm(B), ere(A), vga(A), lnu(A), and msr(A)/msr(B), in Staphylococcus aureus and coagulase-negative staphylococci isolates from bovine mastitis, highlighting a high prevalence of inducible MLS resistance.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
Look and Outlook on Enzyme-Mediated Macrolide Resistance.
The review discusses the mechanisms of macrolide resistance, focusing on macrolide phosphotransferases (MPHs) and macrolide esterases (Eres). It highlights the role of MPHs in conferring resistance by phosphorylating macrolides, thereby reducing their efficacy.
Antimicrobial resistance genes in pathogenic Escherichia coli isolated from diseased broiler chickens in Egypt and their relationship with the phenotypic resistance characteristics.
The study identified multiple antimicrobial resistance genes in pathogenic E. coli isolates from broiler chickens in Egypt, including CITM, ere, aac(3)-(IV), tet(A), tet(B), dfr(A1), and aad(A1). These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant E. coli in poultry.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Genomic comparison of diverse Salmonella serovars isolated from swine.
The study identified various AMR genes in Salmonella serovars isolated from swine, including beta-lactamases (bla TEM-1, bla CMY-2, bla CARB-2), tetracycline resistance genes (tetA, tetB, tetC, tetG), aminoglycoside resistance genes (aadA2, strA, strB), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and dihydrofolate reductase genes (dfrA1, dfrA7, dfrA12, dfrA16), as well as erythromycin esterase (ereA).
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Biological Characteristics and Genetic Analysis of a Highly Pathogenic Proteus Mirabilis Strain Isolated From Dogs in China.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.
Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat.
The study identified multiple antibiotic resistance genes in multidrug-resistant E. coli isolates from chicken meat, including tetA, sul1, aadA1, ereA, aac-3-IV, cmlA, catA1, SHV, and CITM, highlighting the prevalence of resistance to various antibiotics such as tetracycline, sulfonamide, streptomycin, erythromycin, gentamicin, chloramphenicol, and beta-lactams.
Structural and functional insights into esterase-mediated macrolide resistance.
Structural and functional insights into esterase-mediated macrolide resistance.
Molecular Detection of Antibiotic Resistance Genes in Shiga Toxin-Producing E. coli Isolated from Different Sources.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.
Mechanisms of Resistance to Macrolide Antibiotics among Staphylococcus aureus.
The paper discusses the mechanisms of resistance to macrolide antibiotics among Staphylococcus aureus, focusing on the roles of ermA, ermB, ermC, and msrA genes in mediating resistance through modifications of the ribosomal target site and efflux mechanisms.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
The study identified multiple AMR genes and mutations in P. aeruginosa isolates from Kenya, including carbapenemases (blaNDM-1, blaVIM-6), fluoroquinolone resistance genes (qnrVC1, crpP), aminoglycoside resistance genes (aac(3)-IId, aph(3')-Ib, ant(3'')-Ia), tetracycline resistance genes (tetA, tetG), phenicol resistance genes (floR, cmlA), sulfonamide resistance gene (sul), trimethoprim resistance gene (dfrB), glycopeptide resistance gene (ble), and macrolide resistance gene (EreA). Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Epidemiological investigation on drug resistance of Salmonella isolates from duck breeding farms in Shandong Province and surrounding areas, China.
The study identified 12 types of antibiotic resistance genes in 110 Salmonella isolates from duck farms in Shandong Province, China, including beta-lactam, aminoglycoside, tetracycline, macrolide, and quinolone resistance genes. The most prevalent resistance genes were blaTEM, aac(6')-Ib-cr, and tetA. The study also found that class I integrons and plasmids play a significant role in the dissemination of these resistance genes.
Hitherto-Unnoticed Self-Transmissible Plasmids Widely Distributed among Different Environments in Japan.
The study identified new subgroups of IncP/P-1 and PromA plasmids, including antibiotic resistance genes such as blaIMP-1, blaKPC-2, mcr-1, and various tetracycline and aminoglycoside resistance genes.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Isolation, Identification, and Genetic Characterization of Antibiotic Resistance of Salmonella Species Isolated from Chicken Farms.
The study identified several AMR genes in Salmonella isolates from chicken farms in Egypt, including blaTEM, blaSHV, ermB, ereA, and mphA, which conferred resistance to ampicillin, erythromycin, and lincomycin.
Genetic characteristics, antimicrobial resistance, and prevalence of Arcobacter spp. isolated from various sources in Shenzhen, China.
The study identified several AMR genes in Arcobacter spp., including beta-lactamase genes (blaOXA464, blaOXA491), tetracycline resistance genes (tet(L), tet(H), tet(M)), a macrolide resistance gene (ere(A)), and aminoglycoside resistance genes (APH(3')-IIIa, ant(6)-Ia, SAT-4). Additionally, a mutation in the gyrA gene (C254T) was found to confer fluoroquinolone resistance.
Isolation, Identification and Genetic Characterization of Antibiotic Resistant Escherichia coli from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.
The study identified several antimicrobial resistance genes in E. coli isolates from frozen chicken meat, including tet(A), tet(B), aadA1, aac(3)-IV, ereA, blaCITM, blaSHV, sulI, catA1, and cmlA, which confer resistance to tetracycline, streptomycin, gentamicin, erythromycin, ampicillin, sulfonamide, and chloramphenicol.
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins.
The study identified various AMR genes associated with resistance to macrolides, lincosamides, and streptogramins in Enterococci, including ermB, ermA, ermC, ereA, lnuA, mphC, mefA, and mefE. These genes were found to be highly prevalent and contribute to the resistance mechanisms observed in the isolates.
Impact of immigration on antibiotic resistance genes in activated sludge: A study using digital droplet PCR and amplicon sequencing
The study reveals that immigration of influent wastewater into activated sludge leads to an increase in the abundance of over 70% of the quantified antibiotic resistance genes (ARGs). Specific ARGs such as blaTEM, blaMOX, qnrS, qnrB, mphE, dfrA, tetO, tetQ, tetE, marR, msrD, robA, qacL, blaOXA, and ereA were found to increase in abundance with immigration, indicating the impact of influent immigration on the persistence of AMR in wastewater treatment plants.
Resistance profiles, virulence and antimicrobial resistance genes of XDR S. Enteritidis and S. Typhimurium.
The study identified multiple antimicrobial resistance genes including blaTEM, blaCTX-M, blaNDM, sul1, tetA, aadA1, and ereA in XDR S. Enteritidis and S. Typhimurium isolates from diseased broilers. These genes conferred resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and aminoglycosides.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Isolation and molecular characterization of multidrug‑resistant Escherichia coli from chicken meat.
The study identified multidrug-resistant Escherichia coli from chicken meat, highlighting the presence of resistance genes such as blaTEM, tetA, ereA, CITM, and cmlA.
Antimicrobial resistance of avian pathogenic Escherichia coli isolated from broiler, layer, and breeder chickens.
The study identified multiple antibiotic resistance genes in avian pathogenic Escherichia coli (APEC) isolates from commercial chickens in Nepal, including blaTEM, sul1, qnrA, tetB, cat1, ereA, mcr1, and aac(3)-IV, which confer resistance to various antimicrobial agents.
Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli., An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii., Novel gene cassettes and integrons., Occurrence of antibiotic resistance gene cassettes aac(6')-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India.
Inducible clindamycin-resistant and biofilm formation in the Staphylococcus aureus isolated from healthcare worker's anterior nasal carriage.
The study identified the presence of ermC, ermA, ermB, and ereA genes in Staphylococcus aureus isolates from healthcare workers, contributing to macrolide-lincosamide-streptogramin B resistance and clindamycin resistance.
Role of migratory birds as a risk factor for the transmission of multidrug resistant Salmonella enterica and Escherichia coli to broiler poultry farms and its surrounding environment.
The study identified several AMR genes, including Sul1, Tet A (A), bla TEM, ere A, and qnrA, in multidrug-resistant Salmonella enterica and Escherichia coli isolated from migratory birds and broiler poultry farms.
Global genomic epidemiology of bla (GES-5) carbapenemase-associated integrons.
The study characterizes the global genomic epidemiology of blaGES-5, a carbapenemase-associated integron, highlighting its prevalence in Pseudomonas aeruginosa and its association with various gene cassettes.
Impact of the Technical Snow Production Process on Bacterial Community Composition, Antibacterial Resistance Genes, and Antibiotic Input-A Dual Effect of the Inevitable.
The study identified several antibiotic resistance genes (ARGs) in water and snow samples from ski resorts, including blaTEM, blaCTX-M, mecA, ereA, ermB, strA, tetK, and sulIII. These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and sulfonamides. The presence of these ARGs highlights the potential environmental impact of technical snow production on antimicrobial resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Phenotypic and genotypic characteristics of macrolide, lacosamide, and streptogramin resistance in clinically resistant Streptococci and their correlation with reduced biocide susceptibility.
The study identifies ermB, ereA, msrA, mefA, and mefE as key genes associated with MLS resistance in Streptococci, highlighting the role of efflux mechanisms and ribosomal methylation in conferring resistance to macrolides, lincosamides, and streptogramins.
Comparative genomics of Pseudomonas paraeruginosa.
The study identifies various AMR genes and mutations in Pseudomonas paraeruginosa, including carbapenemases like blaVIM-2, blaVIM-6, blaVIM-28, and blaKPC-2, as well as efflux pump genes (mexAB-oprM, mexCD-oprJ, etc.), and mutations in oprD, mexS, mexR, mexZ, lasR, mvfR, and vqsM that contribute to antibiotic resistance.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.
The study characterizes the dissemination of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones in Enterobacter species, highlighting their co-occurrence with other resistance genes and their global distribution.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
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