Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosome methylase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(38) | Card DatabaseReference Gene CatalogReslit | 6 | macrolides, lincosamides +3 | Mycobacterium smegmatis +3 | Philadelphia | 2003, 2005, 2006, 2020 | AY154656|AY154657 | AAN86837.2 |
| erm(38) | ResFinder Database | 1 | TELITHROMYCIN, LINCOMYCIN +2 | Mycolicibacterium smegmatis | - | 2003 | AY154657 | - |
| erm38 | Reslit | 1 | macrolides, lincosamides | Mycobacterium smegmatis | - | 2022 | WP_063844518|Q79N53 | - |
Intrinsic Macrolide Resistance in Mycobacterium smegmatis Is Conferred by a Novel erm Gene, erm(38).
The study identifies a novel erm gene, erm(38), which confers intrinsic macrolide and lincosamide resistance in Mycobacterium smegmatis. The gene was experimentally validated through expression in trans and knockout mutant analysis.
Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).
Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).
Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38)., Intrinsic macrolide resistance in rapidly growing mycobacteria.
Mycobacterium smegmatis Erm(38) Is a Reluctant Dimethyltransferase.
The study identifies Erm(38) as a dimethyltransferase that confers resistance to lincosamides and macrolides by methylating nucleotide A2058 in 23S rRNA, though its activity is less efficient compared to other Erm dimethyltransferases.
Intrinsic macrolide resistance in rapidly growing mycobacteria.
This study identifies erm genes in various rapidly growing mycobacteria species, demonstrating their role in intrinsic macrolide resistance.
Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly.
The study identified potential antimicrobial resistance genes in Mycobacterium chelonae isolates, including LRA-3, erm(38), and mtrA, which may contribute to resistance against imipenem, macrolides, and lincosamides. However, the presence of these genes did not consistently correlate with the observed drug susceptibility profiles.
Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase Erm38 reveals its RNA-binding site.
The study characterizes Erm38, a mycobacterial erythromycin resistance methyltransferase, revealing its RNA-binding site through structural analysis and mutagenesis. Erm38 confers resistance to macrolides and lincosamides.
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