Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(50)

rRNA adenine N-6-methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(50)

Browse AMR rules for erm(50)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: whole-genome sequencing and transconjugation experiments
Drug Classes: macrolides, clindamycin, QUINUPRISTIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, ERYTHROMYCIN, CLARITHROMYCIN, VIRGINIAMYCIN S
Organisms: Cutibacterium acnes, Cutibacterium granulosum
Geographic Location: Japan
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(50)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	macrolides, clindamycin +7	Cutibacterium acnes +1	Japan	2020, 2023	AP019664\|LC473083	BBJ25230.1
erm(50)	ResFinder Database	1	QUINUPRISTIN, PRISTINAMYCIN IA +4	Cutibacterium acnes	-	2020	LC473083	-

Papers2

1

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

PMID 31844016 · 2020

The study identified a novel macrolide-clindamycin resistance gene, erm(50), and a tetracycline resistance gene, tet(W), on a transferable multidrug-resistant plasmid pTZC1 in Cutibacterium acnes.

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: rRNA adenine N-6-methyltransferase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
Geographic Location: Japan
Validation Method: whole-genome sequencing and transconjugation experiments
Sequence Accession: AP019664|LC473083

2

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

3

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

4

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50), Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: Target modification, antibiotic target alteration
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

5

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083

6

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface.

PMID 36847559 · 2023

The study identifies the multidrug resistance plasmid pTZC1, which contains the macrolide-clindamycin resistance gene erm(50) and the tetracycline resistance gene tet(W), and demonstrates its transfer between Cutibacterium acnes and Cutibacterium granulosum strains.

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
• Cutibacterium granulosum
Validation Method: PCR and sequencing
Sequence Accession: AP026712|AP026713|AP026710|AP026711

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