Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(B) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 375 | QUINUPRISTIN, STREPTOGRAMIN B +16 | Staphylococcus intermedius +150 | Europe, Finland, Denmark, Italy, Germany, Latin America, Denmark|United States|Ethiopia|England|Singapore|Asia|Belgium|Kenya|New Zealand, Canada|United States|Poland|United Kingdom|France|Japan|The Netherlands, Boston, Portugal, Brazil, Ireland, United States, Texas, Europe|Belgium, Asia|Australasia, Western Greece, South Korea, USA, Switzerland, Spain, French Guiana|Senegal|Niger|France|Vietnam, Australia, France, Vietnam, North Carolina|Kansas, Global, Philadelphia, Asia, Lebanon, Global|India|Spain, United States|Brazil, Central Greece, Portugal|Germany|Italy, Chennai, south India, Bulgaria, Canada, Alaska, Thailand|Israel, Serbia, Egypt, China, Warsaw, Japan, South Africa, Nsukka agricultural zone, Nigeria, Sanandaj, Italy|Spain, USA|Flagstaff, USA, United Kingdom, England|USA|Canada, global|Europe|Belgium, France|Sweden, Tunisia, Alberta, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Northern China, Spain|Portugal|USA|China|Brazil|Tanzania|Canada|Germany|France|Italy|Japan|South Africa|Australia|UK|Hungary|Poland|Sweden|Norway|Denmark|Turkey|Egypt|Thailand|Argentina|Iran|Greece|Czech Republic|Korea|Taiwan|Mexico|Russia|India|New Zealand|Colombia|Tunisia|Europe|United States|Ethiopia, Gothenburg, Russia, Taiwan, Iran, Atlanta, GA, Pakistan|United States|USA, Israel, Alberta, Canada, Philippines, Liverpool, UK, Czech Republic|Italy|Portugal, Bangladesh, USA|Peru|Egypt|Cambodia|Kenya, GA, USA, Europe|Netherlands, Jakarta, Pacific region|Hawaii, Mongolia, Portugal|Spain|The Netherlands, Norway, Estonia|swine, Europe|Italy|United States|Switzerland|Canada|Germany|France|Spain|Netherlands|Denmark|Norway|Sweden|Portugal|Hungary|Romania|Czechia|Belgium|Ireland|Luxembourg|Austria|Finland|Estonia|Latvia|Lithuania|Slovenia|Croatia|Bulgaria|Iceland|United Kingdom|Turkey|South America|Vietnam|Poland|UK|Malta|Slovakia, Vermont, Nigeria, United Kingdom|England|Australia, Hong Kong SAR, North America, China|United States of America|United Kingdom|Canada|Spain|Netherlands|France|Germany|Denmark|Europe|North America, Alberta|Canada|Alberta, Canada, Southwest China, Poland|Ukraine, Czech Republic, Thailand, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, Kuwait, Europe|EU|China|Portugal|Germany, Austria, Peru, North America|Asia|Europe|Middle East|Africa, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Northern Ghana, UK|France, Minnesota, Hong Kong, Poland, Africa|Asia|America|Europe|Oceania|global, Khon Kaen province, Thailand, Chiang Mai province, Northern Thailand|Thailand, North of Tunisia, Barcelona, France|United States|Germany|Belgium|Poland, Tanzania, Europe|Australia|Asia|Belgium|Germany|Switzerland, New York State, Japan|Denmark|Norway|China|United States|Switzerland|India|Netherlands, Thailand|Vietnam, Shenzhen, China, Shanghai, China, Russia|Switzerland|Italy|USA|Norway|Spain|Ghana, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Qinghai province|Tibetan sheep, Thailand|China|Spain|USA|UK|Australia|Canada|Japan, West Texas, USA, central China, Rio de Janeiro, USA|Honduras|UK|Kenya, Germany|Vietnam, Ghana, Europe|Italy|Brazil|Czechia|Germany|Finland|Netherlands|Norway|Sweden, Slovak Republic, Lusaka|Ndola, UK, Malaysia, China|UK|Canada|Thailand|Netherlands|USA|Denmark|Spain|other nations, Saudi Arabia, Accra, Ghana|Ghana, Belgium|Germany|Hungary|Slovenia|Turkey, Sri Lanka, China|North America|Asia|Europe|Oceania|South America|Africa|Global|West China, Ontario, Ethiopia, Gaza Strip, Chiba prefecture, Japan, Bangladesh|India, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Northwest Ethiopia|Ethiopia, China|Denmark, Sicily, Italy, China|Netherlands|Thailand, Germany|Spain|UK|Vietnam, Mayurbhanj, Odisha, India|India, Southeast Nigeria|Nigeria, Europe|Thailand, Asia|China, Sichuan Province, China, Algeria | 1979, 1983, 1987, 1988, 1994, 1995, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF299292.1 | AAG42227.1 |
| ErmB | Card DatabaseReslit | 497 | erythromycin, clindamycin +9 | Enterococcus faecium +219 | Seattle, Wash.|Montevideo, Uruguay|DeKalb County, Ga., Toronto, Italy, Spain, Iceland, Alabama|South Carolina|Tennessee, France, Taiwan, France|Italy, human colon, Sweden, Europe|North America|Asia, New Zealand, Latin America, Poland, Hong Kong, United States, Japan, Ontario, Canada|Finland|Houston, Texas, Korea, New York|Pennsylvania, United States|Japan|Canada|Spain|New Zealand|Denmark|U.S.|U.K.|Boston, North America, Kansas|United States, Europe, Belgium|Spain|Italy|Germany, China|Vietnam, Texas|Kenya, Germany|The Netherlands|Peru|France|Austria|Monaco, Brazil, Australia, New York|Portugal|Spain|USA, Ethiopia, Turkey, South Korea, Beijing, China, Shenzhen, China, Kuwait, Chengdu, Southwestern China, Europe|Africa|Asia|Australia|Americas|global, Beijing, China, Nepal, Germany, Denmark|Europe, Eastern Cape, South Africa, Canada|United States of America|Thailand|North America, Iran, Taiwan|USA, Haiti, North America|US|Germany|Switzerland|Japan|China|Hong Kong|United Kingdom, Costa Rica, Colombia, Egypt, Spain|Canada|Brazil|Thailand, USA, Southeast Asia, Serbia, England|France|UK, UK|Latin America, Czech Republic, Switzerland, International Space Station, Germany|Danube River, The Netherlands, La Paz, Bolivia|La Paz River basin, Michigan, USA, Guangdong Province, China, Australia|Europe|Asia|North America|New Zealand, Delta State, Nigeria, Tanzania|Thailand|human|swine, northern Arizona|Northern Arizona, Namibia, Scotland|Australia|England, India, Midwestern US, Argentina, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, Accra, Ghana, California, Denmark, Maputo, Mozambique, Hungary, Canada|United Kingdom|United States, Bangladesh, wastewater treatment plants|Canada, United Kingdom, Eastern China, Italy|Far East countries, Belgium, Thailand, Switzerland|chicken, Eastern Cape Province, South Africa, Hong Kong|China, UK, Europe|Spain, South Africa, Brazilian Pampa biome|Brazil, Nigeria, Vietnam, Global|global|Turkey, Myanmar, Portugal, Lebanon, Northwestern Sicily, Indonesia, Australia|New Zealand, South Africa|Nigeria, Africa|Asia|Europe|North America|South America|global, Alberta, Canada, Kenya, South China, India|Malaysia|South China, Brasília, Brazil, Northern Xinjiang, China, Slovakia|Hungary, Northern Algeria|cattle, Philippines, Asia|Europe|North America|Australia/New Zealand, Europe|North America|Asia|Australia, Yunnan, China, Northeastern Ohio, the United States|Northeastern Ohio, India|United States, Malaysia, Europe|Netherlands, Ghana, Asia|Europe|North America, Saudi Arabia, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, South America|Asia|Europe|Africa, Mississippi State|Mississippi, Norway, Australia|Melbourne, Australia, Chile, South America, Cambodia, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Tunisia, Zambia, Northeast China, Burkina Faso, Abuja, Nigeria, Canada|United Kingdom|Alberta, Romania|Cluj County, North Western Romania, Algiers|Algeria, Pakistan, Portugal|Spain|Germany|Australia|Ireland|Italy, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Mexico, Europe|Australia|Asia|Belgium|Germany|Switzerland, Edo, Nigeria, Argentina|Australia|Brazil|China|India|United States, West Virginia, USA, Algeria, Northern Pacific Ocean|Norway Sea|Europe, Southern Germany|various, Taiyuan City, Shanxi Province, China, Northwest, China|Northwest China, South Africa|Poland|Czech Republic|Romania|China|United States|Spain|Germany|France|Canada|Japan|Brazil|India|Croatia|Hungary|Slovenia|Slovakia|Czechia|Austria|Puerto Rico|Switzerland|Nigeria|Norway|Finland|Denmark|Sweden|Italy|South Korea|USA|UK|Australia|New Zealand|Mexico|Russia|Turkey|Egypt|Kenya|Ethiopia|Uganda|Tanzania|Malawi|Zambia|Zimbabwe|Mozambique|Madagascar|Comoros|Mayotte|Réunion|Guadeloupe|Martinique|Saint Martin|Saint Barthélemy|French Guiana|Suriname|Guyana|Argentina|Chile|Peru|Bolivia|Paraguay|Uruguay|Colombia|Venezuela|Ecuador|Costa Rica|Panama|Nicaragua|Honduras|El Salvador|Guatemala|Belize|Alaska|Hawaii|Maine|Massachusetts|New York|California|Texas|Florida|Illinois|Pennsylvania|Ohio|Georgia|North Carolina|Michigan|Virginia|Washington|Arizona|Colorado|Connecticut|Delaware|District of Columbia|Idaho|Indiana|Iowa|Kansas|Kentucky|Louisiana|Maryland|Minnesota|Mississippi|Missouri|Montana|Nebraska|Nevada|New Hampshire|New Jersey|New Mexico|North Dakota|Oklahoma|Oregon|Rhode Island|South Carolina|South Dakota|Tennessee|Utah|Vermont|West Virginia|Wisconsin|Wyoming, Wenzhou, China, Thailand|China|Spain|USA|UK|Australia|Canada|Japan, Argentina|United States, Benin, Hunan Province|China, Northern Germany, South Africa|Spain|Netherlands|Switzerland|India|China|Germany|Russia|USA|Australia|Other countries, southeastern United States, Finland|Iceland|Spain, Bulgaria|cow milk|human breast milk, Southwest China, Nsukka, Nigeria, Latvia, Alexandria, Egypt, Scotland, Anhui province, China, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, Europe|Belgium|France|Germany|Netherlands|United Kingdom, England, Arctic, Europe|Russia, Davao City, Philippines, Pakistan|China|United States|United Kingdom|Canada|Australia|Spain|Denmark|UAE|Ethiopia|India|South Asia, Vancouver, Canada, Uruguay, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Africa|North America|South America|Asia|Oceania, Northwestern Transylvania, Romania, Santa Catarina, Brazil|Brazil, China|Hunan Province, Asia|Europe|America, Poland|Czech Republic|Slovakia, United Arab Emirates, Northern Italy, Europe|Northern Poland, Hubei, China, Beira, Mozambique|Mozambique, China|Europe|Americas|Asia|North Africa|Middle East, Southern India|India, Northwest China, Tianjin|Southern Karnataka, Haikou, China, Mayurbhanj, Odisha, India|India, Romania, Europe|UK, Greece, Xinjiang, China, Vietnam|Germany|South Korea, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Free State Province, South Africa|South Africa, Niger, northwest China|China, China|Shandong Province, China, Bulgaria | 1985, 1998, 1999, 2000, 2001, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF242872.1 | AAF86219.1 |
| erm B | Reslit | 27 | erythromycin, clindamycin +5 | Streptococcus pyogenes +23 | Mexico|USA, Alaska, China, Spain, India, Italy, Spain|Basque Country, United States|Virginia, Europe, Colombia, Europe|South America, Guangdong Province, Turkey, Southeast Nigeria, Brazil, Poland, Upper Oconee Watershed, Athens, GA, USA|Upper Oconee Watershed, Georgia, USA, Shandong, China, south Tunisia, Egypt, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia | 2012, 2013, 2016, 2017, 2018, 2020, 2021, 2022, 2023, 2025 | KX300038–KX300086|KY432753|KU573047–KU573052|KY924468–KY924470 | - |
| erm (B) | Reslit | 6 | erythromycin, clindamycin +3 | Streptococcus pneumoniae +2 | Arizona, Japan, Atlanta, Georgia, Europe|Asia|Belgium|Netherlands|Thailand, Europe | 2012, 2017, 2018, 2019 | DRA004833 | - |
| erm(B) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Enterococcus faecium, Plasmid pAM77, Staphylococcus intermedius, Enterococcus faecalis, Plasmid pIP1527, Clostridium perfringens, Limosilactobacillus fermentum, Streptococcus pyogenes, Clostridioides difficile 630, Mammaliicoccus lentus, Streptococcus pneumoniae, Streptococcus agalactiae, Limosilactobacillus reuteri | - | 2013 | JN899585, K00551, AF242872, AF299292, U86375, M19270, U18931, U48430, X66468, AF109075, U35228, X52632, X72021, AF080450 | - |
| erm(B)-1 | Reslit | 1 | erythromycin | Staphylococcus aureus +1 | - | 2025 | - | - |
Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
The study identifies the presence of known rRNA methylase genes (ermB, ermC, and ermF) in erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp., which confer resistance to erythromycin.
Molecular characterization of multidrug resistance in Streptococcus mitis.
The study identified the presence of mef, ermB, and tet(M) genes in multidrug-resistant Streptococcus mitis isolates, contributing to resistance against macrolides, clindamycin, and tetracycline, respectively.
Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains.
The study identifies three erythromycin resistance phenotypes in Streptococcus pyogenes: cMLS, iMLS, and M. The ermB and ermTR genes were associated with cMLS and iMLS strains, while mefA was linked to the M phenotype.
Plasmid copy number control: isolation and characterization of high-copy-number mutants of plasmid pE194.
Plasmid copy number control: isolation and characterization of high-copy-number mutants of plasmid pE194.
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.
The study identified two copies of the erm(B) gene in the macrolide-lincosamide-streptogramin B resistance determinant of Clostridium difficile 630, which are separated by a direct repeat sequence.
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.
Characterization of the Tn916-like transposon Tn3872 in a strain of abiotrophia defectiva (Streptococcus defectivus) causing sequential episodes of endocarditis in a child.
The study identifies the presence of the ermB and tet(M) genes in a strain of Abiotrophia defectiva, which confer resistance to erythromycin, clindamycin, tetracycline, and minocycline. These resistance genes are located on a chromosomally borne Tn916-like transposon, Tn3872.
Macrolide Resistance Genes in Enterococcus spp.
The study identified the presence of ermB and ermA genes in various Enterococcus species, which confer resistance to macrolides, lincosamides, and streptogramins. Additionally, a novel gene, msrC, was discovered in Enterococcus faecium, which is proposed to encode a putative ABC transporter involved in macrolide resistance.
Molecular evolution in a multidrug-resistant lineage of Streptococcus pneumoniae: emergence of strains belonging to the serotype 6B Icelandic clone that lost antibiotic resistance traits.
The study identifies the loss of tetracycline and erythromycin resistance in certain strains of the serotype 6B Icelandic clone of Streptococcus pneumoniae, indicating the potential for resistance gene inactivation or deletion.
Use of clindamycin disks To detect macrolide resistance mediated by ermB and mefE in Streptococcus pneumoniae isolates from adults and children.
The study identified ermB and mefE as major mechanisms of macrolide resistance in Streptococcus pneumoniae, with ermB causing high-level resistance to clindamycin and macrolides, while mefE conferred lower-level resistance to macrolides but susceptibility to clindamycin.
Resistance to macrolides in Streptococcus pyogenes in France in pediatric patients.
The study identified ermB, mefA, and ermTR genes as responsible for macrolide resistance in Streptococcus pyogenes isolates from French pediatric patients.
Prevalence of polyclonal mefA-containing isolates among erythromycin-resistant group A streptococci in Southern Taiwan.
The study identifies mefA, ermB, and ermTR as the primary genes responsible for erythromycin resistance in group A streptococci in southern Taiwan, with mefA being particularly prevalent in the M-phenotype isolates.
Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.
The study reports the first evidence of a direct physical linkage between the vat(E) and erm(B) genes in streptogramin-resistant Enterococcus faecium isolates from Europe, indicating a conserved genetic element mediating resistance to both streptogramins and macrolides.
Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.
Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.
Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.
In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors.
The study identified ermTR, mefA, and ermB genes as key resistance mechanisms in Streptococcus pyogenes against macrolides, lincosamides, and streptogramin B.
Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon.
The study shows extensive horizontal gene transfer of tetracycline resistance gene tetQ and erythromycin resistance genes ermF, ermG, and ermB among Bacteroides species and between Bacteroides and other genera in the human colon.
Unusual occurrence of M type 77, antibiotic-resistant group A streptococci in southern Sweden.
The study identifies tetM, ermB, and mefA as the primary resistance genes in multidrug-resistant group A streptococci in southern Sweden, highlighting the emergence of novel MLS resistance subphenotypes.
In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species.
The study found that telithromycin is effective against erythromycin-resistant Streptococcus species, except for S. pyogenes strains with a constitutive erm(B) gene, which showed high MICs. S. pneumoniae strains with a constitutive erm(B) gene had low MICs to telithromycin.
Efficacies of ABT-773, a new ketolide, against experimental bacterial infections.
The study characterizes the resistance mechanisms mediated by ermB and mefE genes in Streptococcus pneumoniae, demonstrating the efficacy of ABT-773 against strains harboring these resistance determinants.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Indication of transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium.
The study identifies the transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium, demonstrating their co-transfer and physical linkage.
Indication of transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium.
High prevalence of inducible erythromycin resistance among Streptococcus bovis isolates in Taiwan.
The study reports the high prevalence of inducible erythromycin resistance among Streptococcus bovis isolates in Taiwan, with the majority of resistant strains carrying the ermT or ermB gene.
Emergence of group A streptococcus strains with different mechanisms of macrolide resistance.
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.
The study identifies essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens, showing that mutations in conserved motifs impair erythromycin resistance.
Resistance determinants and clonal diversity in group A streptococci collected during a period of increasing macrolide resistance.
The study identified erm(B), erm(TR), and mef(A) as key resistance determinants in group A streptococci, with erm(B) being the most prevalent contributor to increased macrolide resistance.
Antistreptococcal activity of telithromycin compared with seven other drugs in relation to macrolide resistance mechanisms in Russia.
Bactericidal Effect and Pharmacodynamics of Cethromycin (ABT-773) in a Murine Pneumococcal Pneumonia Model.
The study identified the presence of mef(A) and erm(B) genes in Streptococcus pneumoniae isolates, which confer resistance to macrolides, lincosamides, and streptogramin B. Cethromycin demonstrated effective bactericidal activity against both macrolide-susceptible and -resistant isolates.
A clonal lineage of VanA-type Enterococcus faecalis predominates in vancomycin-resistant Enterococci isolated in New Zealand.
The study identifies the VanA-type Enterococcus faecalis as the predominant clonal lineage in vancomycin-resistant Enterococci (VRE) isolated in New Zealand, highlighting the presence of vanA, ermB, and tet(M) genes associated with glycopeptide, macrolide, and tetracycline resistance, respectively.
Macrolide-Resistant Streptococcus pneumoniae and Streptococcus pyogenes in the Pediatric Population in Germany during 2000-2001.
The study identified erm(A), erm(B), and mef(A) as the primary resistance mechanisms in macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes. A new mutation in the 23S rRNA (T2166C) was associated with telithromycin resistance.
Antimicrobial resistance of invasive pneumococci in Finland in 1999-2000.
The study identified mef(A) and erm(B) as the primary mechanisms of macrolide resistance in invasive pneumococci in Finland, along with specific ribosomal mutations contributing to resistance.
Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Latin America: results from the PROTEKT surveillance study (1999-2000).
The study identified various macrolide resistance genes, including mef(A), erm(B), mefA, ermTR, and ermB, in Streptococcus pneumoniae and Streptococcus pyogenes isolates from Latin America.
Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Latin America: results from the PROTEKT surveillance study (1999-2000).
The study identified various macrolide resistance genes, including mef(A), erm(B), mefA, ermTR, and ermB, in Streptococcus pneumoniae and Streptococcus pyogenes isolates from Latin America.
Telithromycin and quinupristin-dalfopristin resistance in clinical isolates of Streptococcus pyogenes: SMART Program 2001 Data.
The study identified the mefA gene associated with erythromycin resistance and the ermB gene linked to resistance against erythromycin and clindamycin in Streptococcus pyogenes isolates.
Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.
The study identified tet(M), erm(B), mef(A), and mef(E) as the primary genes responsible for tetracycline and erythromycin resistance in Streptococcus pneumoniae strains.
Recent emergence of an epidemic clindamycin-resistant clone of Clostridium difficile among Polish patients with C. difficile-associated diarrhea.
The study identifies the ermB gene as a key determinant of clindamycin and erythromycin resistance in a widespread epidemic clone of Clostridium difficile isolated from Polish patients with C. difficile-associated diarrhea.
A new Bacteroides conjugative transposon that carries an ermB gene.
The study identifies a new conjugative transposon, CTnBST, carrying the ermB gene, which confers erythromycin resistance in Bacteroides species. The ermB gene was found to be integrated into the chromosome and is part of a 100-kb element.
Clinical and molecular epidemiology of erythromycin-resistant beta-hemolytic lancefield group G streptococci causing bacteremia.
The study identifies ermTR, ermB, and mef genes as mediators of erythromycin resistance in beta-hemolytic group G streptococci, highlighting the role of horizontal gene transfer in the spread of resistance.
Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987.
The study identified the presence of acquired macrolide resistance genes erm(B), erm(C), erm(F), and mef(A) in Neisseria gonorrhoeae and Neisseria meningitidis isolates from 1940 to 1987. These genes were found in isolates dating back to 1955 and 1963, demonstrating the long-standing presence of these resistance mechanisms.
A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.
The study identifies a novel tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes, which confers resistance to tylosin.
Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping.
The study identified the erm(B) gene as a mediator of clindamycin resistance in toxin A-negative, toxin B-positive Clostridium difficile isolates.
Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area.
The study identified multiple mechanisms of resistance to macrolide and lincosamide antibiotics in Streptococcus pyogenes, including erm(A), erm(B), and mef(A) genes.
Effects of Tylosin Use on Erythromycin Resistance in Enterococci Isolated from Swine
The study found that ermB was the primary gene responsible for erythromycin resistance in enterococci isolated from swine, with 95% of resistant isolates carrying this gene.
The mef(A) Gene Predominates among Seven Macrolide Resistance Genes Identified in Gram-Negative Strains Representing 13 Genera, Isolated from Healthy Portuguese Children.
The study identified seven macrolide resistance genes in gram-negative bacteria from healthy Portuguese children, with mef(A) being the most predominant. The genes included mef(A), erm(B), ere(A), ere(B), mph(A), mph(B), and mph(D).
Phenotypic and molecular characteristics of Streptococcus agalactiae isolates recovered from milk of dairy cows in Brazil.
The study identified erm(B), tet(O), and tet(M) as the primary genes responsible for erythromycin and tetracycline resistance in Streptococcus agalactiae isolates from dairy cows in Brazil.
Antibiotic Resistance and Virulence Traits of Enterococci Isolated from Baylough, an Irish Artisanal Cheese
The study identified tetracycline resistance genes (tet(M) and tet(L)) and an erythromycin resistance gene (erm(B)) in Enterococcus strains isolated from an Irish artisanal cheese.
Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.
Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.
The study identified mef(A) and erm(B) as the predominant macrolide resistance genes in Streptococcus pneumoniae isolates, and multiple mutations in gyrA, parC, and parE as the main mechanisms of fluoroquinolone resistance.
Characterization of ermB gene transposition by Tn1545 and Tn917 in macrolide-resistant Streptococcus pneumoniae isolates.
The study characterizes the ermB gene's role in macrolide resistance in Streptococcus pneumoniae, highlighting its presence on transposons Tn1545 and Tn917, with distinct resistance profiles depending on the transposon type.
Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin.
The study identifies several AMR genes and mutations in Streptococcus pneumoniae, including erm(B) and mef(E) for macrolide resistance, and gyrA and parC mutations for fluoroquinolone resistance. It also reports 23S rRNA mutations linked to resistance against macrolides, telithromycin, and streptogramins.
Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas.
The study identified erm(B), erm(C), and erm(A) genes as mediators of inducible clindamycin resistance in pediatric community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains. The prevalence of inducible resistance decreased from 1999 to 2002.
Hidden epidemic of macrolide-resistant pneumococci.
The paper discusses the mechanisms of macrolide resistance in Streptococcus pneumoniae, highlighting the roles of mef(A) and erm(B) genes. These genes confer resistance to macrolides, lincosamides, and streptogramin B.
Macrolide- and telithromycin-resistant Streptococcus pyogenes, Belgium, 1999-2003.
The study identifies erm(B) and mef(A) as the primary mechanisms of macrolide resistance in Streptococcus pyogenes, with a specific H118R mutation in erm(B) linked to telithromycin resistance.
Genetic diversity among type emm28 group A Streptococcus strains causing invasive infections and pharyngitis.
The study identified the presence of macrolide resistance genes mefA, ermB, and ermTR in less than 2% of the emm28 group A Streptococcus strains analyzed.
Prevalence and molecular genetics of macrolide resistance among Streptococcus pneumoniae isolates collected in Finland in 2002.
The study identified mef(E), mef(A), and erm(B) as the primary macrolide resistance mechanisms in Streptococcus pneumoniae isolates from Finland in 2002, with mef(E) being the most prevalent subtype.
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins.
The study identified several AMR genes including erm(A), erm(C), erm(B), vat(D), vgb(A), and vga(A) that confer resistance to streptogramins. Mutations in the rplV gene, encoding ribosomal protein L22, also contributed to resistance against streptogramin B.
Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis.
The study identified mef(A), erm(A), and erm(B) genes as major contributors to erythromycin resistance in S. pyogenes isolates, with erm(B) also linked to telithromycin resistance. Additionally, two novel mutations in the 23S rRNA gene (T2136C and T2166C) were associated with resistance to macrolides.
Vancomycin-resistant Enterococcus faecium clone in swine, Europe.
The study identified a vancomycin-resistant Enterococcus faecium clone carrying the vanA gene, which confers resistance to glycopeptides, and the erm(B) gene, which confers resistance to erythromycin. Additionally, two Spanish isolates carried the aph(3')-IIIa gene, which provides resistance to kanamycin and streptomycin.
Ecology of antibiotic resistance genes: characterization of enterococci from houseflies collected in food settings.
The study identified tet(M) and erm(B) as the primary tetracycline and erythromycin resistance genes in enterococci from houseflies in food settings.
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.
The study identifies vancomycin resistance plasmids pSL1 and pSL2 in Enterococcus faecalis isolates from humans and chicken feces, which carry multiple resistance genes including vanA, ermB, aph(3')-IIIa, ant(6')-Ia, and aac(6')-aph(2').
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
The study identifies vanA, tet(S), and tet(U) as key genes contributing to vancomycin and tetracycline resistance in VRSA isolates, highlighting the role of plasmid-mediated gene transfer in the emergence of multidrug-resistant Staphylococcus aureus.
Antibiotic resistances of starter and probiotic strains of lactic acid bacteria.
The study identified the ermB gene in Lactobacillus salivarius BFE 7441, which confers resistance to erythromycin. Additionally, it found that many lactic acid bacteria strains exhibited intrinsic resistance to aminoglycosides, quinolones, and glycopeptides.
Modes and modulations of antibiotic resistance gene expression.
The paper discusses the regulation of antibiotic resistance genes, focusing on glycopeptide resistance in enterococci, efflux pumps in Gram-negative and Gram-positive bacteria, and the role of two-component systems in modulating resistance gene expression.
Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene.
The study identifies and characterizes genetic elements carrying the erm(B) gene, which confers resistance to macrolides, lincosamides, and streptogramin B, and its association with the tet(M) gene, which confers tetracycline resistance in Streptococcus pyogenes.
Genotypes and related factors reflecting macrolide resistance in pneumococcal pneumonia infections in Japan.
The study identified ermB and mefA genes as major contributors to macrolide resistance in Streptococcus pneumoniae isolates from Japanese patients with community-acquired pneumonia.
Isolation and molecular characterization of antibiotic-resistant lactic acid bacteria from poultry and swine meat products.
The study identified tetracycline resistance genes (tet(M)), erythromycin resistance genes (erm(B)), and penicillin resistance gene (blaZ) in lactic acid bacteria isolated from poultry and swine meat products.
Nasal carriage of a single clone of community-acquired methicillin-resistant Staphylococcus aureus among kindergarten attendees in northern Taiwan.
The study identified the ermB gene as a key contributor to macrolide-lincosamide-streptogramin B resistance in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates from a kindergarten in northern Taiwan.
Genetic diversity among Enterococcus faecalis.
The study identifies various AMR genes in Enterococcus faecalis, including blaZ, ermB, tetM, and vanA, which confer resistance to beta-lactams, macrolides, tetracyclines, and glycopeptides, respectively.
Molecular epidemiology and distribution of serotypes, surface proteins, and antibiotic resistance among group B streptococci in Italy.
The study identified erythromycin resistance genes erm(B), erm(A), and mef(A), and tetracycline resistance gene tet(M) in group B streptococci (GBS) in Italy. Erythromycin resistance was predominantly associated with serotype V and the PFGE type 1/CC1 group.
Rapid determination of macrolide and lincosamide resistance in group B streptococcus isolated from vaginal-rectal swabs.
The study developed real-time PCR assays to detect ermB, ermTR, and mefA genes in Group B Streptococcus (GBS) isolates, showing that the presence of erm genes predicts clindamycin resistance with high sensitivity and specificity.
Antimicrobial susceptibility patterns and macrolide resistance genes of beta-hemolytic viridans group streptococci in a tertiary Korean hospital.
The study identified erm(B) and mef(A) as the primary macrolide resistance genes in beta-hemolytic viridans group streptococci, with erm(B) being dominant in cMLS B phenotypes and mef(A) in M phenotypes.
Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.
A deletion in the leader sequence of erm(B) in Streptococcus pneumoniae leads to constitutive expression of the gene, increasing rRNA methylation and conferring telithromycin resistance.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1-4.
The study identified mef(A) and erm(B) as the primary mechanisms of macrolide resistance in Streptococcus pneumoniae, with a significant increase in the prevalence of isolates carrying both genes, leading to multidrug resistance.
Antibiotic resistance of enterococci in American bison (Bison bison) from a nature preserve compared to that of Enterococci in pastured cattle.
The study identified ermB and tetO as the primary erythromycin and tetracycline resistance genes in enterococci from both bison and cattle, with tetM also found in some bison isolates. Ciprofloxacin resistance was noted but not linked to specific mutations.
erm(B)-Carrying Elements in Tetracycline-Resistant Pneumococci and Correspondence between Tn1545 and Tn6003.
The study identified and characterized erm(B)-carrying transposons in tetracycline-resistant pneumococci, showing that Tn1545 and Tn6003 have similar resistance gene combinations, including erm(B), tet(M), and aphA-3. It also revealed that Tn6002 was the most common transposon among the isolates.
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors.
The mlr operon, consisting of erm(B) and cfr, confers resistance to multiple classes of protein synthesis inhibitors by modifying specific residues in 23S rRNA. The cfr gene is under the control of the erm(B) promoter, and both genes are expressed constitutively.
Translational Attenuation and mRNA Stabilization as Mechanisms of erm(B) Induction by Erythromycin
The study identifies erm(B) as a gene involved in macrolide-lincosamide-streptogramin B resistance through translational attenuation and mRNA stabilization mechanisms.
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
The study characterizes new SCCmec elements and mutations in topoisomerase genes associated with fluoroquinolone and methicillin resistance in Staphylococcus pseudintermedius.
Phenotypic and molecular assessment of antimicrobial resistance in Lactobacillus paracasei strains of food origin.
Three L. paracasei strains from cheese showed acquired resistance to tetracycline and/or erythromycin, linked to the presence of tet(M), tet(W), and erm(B) genes.
Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B).
The study identifies the presence of mef(E) and erm(B) genes in Streptococcus pneumoniae isolates in Spain, contributing to macrolide resistance. The combination of these genes leads to a constitutive MLS(B) phenotype.
Longitudinal study of antimicrobial resistance among Escherichia coli isolates from integrated multisite cohorts of humans and swine.
The study identified various AMR genes in E. coli isolates from humans and swine, highlighting differences in resistance profiles between the two hosts. Key genes included beta-lactamases (blaCTX-M, blaTEM, blaSHV), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance (tet(A)), quinolone resistance (qnrS1), macrolide resistance (erm(B)), and efflux pumps (mexAB-OprM).
Genotypic diversity, antimicrobial resistance, and virulence factors of human isolates and probiotic cultures constituting two intraspecific groups of Enterococcus faecium isolates.
The study identified erm(B) as a gene conferring erythromycin resistance in Enterococcus faecium isolates, with one probiotic isolate carrying this gene that was not transferable to enterococcal recipients.
Clindamycin-resistant clone of Clostridium difficile PCR Ribotype 027, Europe.
The study identifies the ermB gene as a genetic marker for clindamycin resistance in Clostridium difficile PCR ribotype 027.
Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European artificial groundwater recharge systems.
The study identified the presence of antibiotic resistance genes including tetO, ermB, mecA, blaSHV-5, ampC, and vanA in reclaimed water from three European artificial groundwater recharge systems. These genes were detected using real-time qPCR, indicating their potential impact on the environment.
Transfer of antibiotic resistance marker genes between lactic acid bacteria in model rumen and plant environments.
The study demonstrates the transfer of antibiotic resistance marker genes, specifically erm(B) and tet(M), between lactic acid bacteria in both in vitro and in vivo models, highlighting the potential for horizontal gene transfer in natural environments.
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
The study identifies various genes in Streptococcus suis strains that are associated with virulence and potential drug resistance, highlighting the genomic diversity and evolution of this pathogen.
Antibiotic resistance genes in the vaginal microbiota of primates not normally exposed to antibiotics.
The study identified tetracycline resistance genes (tet(M), tet(W), tet(Q)) and erythromycin resistance genes (ermB, ermF) in the vaginal microbiota of primates not typically exposed to antibiotics, indicating the presence of antibiotic resistance genes in these animals despite limited antibiotic exposure.
Escherichia coli as reservoir for macrolide resistance genes.
The study identified the plasmid-borne mph(A) gene as the most common macrolide resistance gene in Escherichia coli isolates from five countries on four continents, along with the rare erm(B) and mph(B) genes.
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms.
The study evaluated the in vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms, identifying erm(B) and mef(A) as key genes responsible for macrolide resistance.
Molecular characterization of pneumococcal isolates from pets and laboratory animals.
The study identified macrolide-resistant Streptococcus pneumoniae isolates from pet cats and rats, carrying either the ermB gene (conferring iMLS B phenotype) or the mef(A) gene (conferring M phenotype).
Human group A streptococci virulence genes in bovine group C streptococci.
The study identified antimicrobial resistance genes erm(B), erm(A), linB, tet(M), and tet(O) in bovine group C streptococci, indicating their potential role in multidrug resistance and horizontal gene transfer.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates.
The study identified erm(B), mef(E), mef(A), mel, and msr(D) as key genes responsible for macrolide resistance in Streptococcus pneumoniae isolates, highlighting the role of Tn 916 family transposons in the dissemination of these resistance determinants.
Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome.
The study identified the long-term persistence of the macrolide resistance gene erm(B) in the gut microbiome following antibiotic treatment, highlighting the potential for prolonged antibiotic resistance development.
Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
The study identified various AMR genes including erm(B), linB, lnuD, tet(M), tet(S), and tet(O) associated with resistance to macrolides, lincosamides, and tetracyclines in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis.
Identification of a novel keyhole phenotype in double-disk diffusion assays of clindamycin-resistant erythromycin-sensitive strains of Streptococcus agalactiae.
The study identifies a novel keyhole phenotype in clindamycin-resistant erythromycin-sensitive Streptococcus agalactiae strains, characterized by mutations in the erm(B) gene leading to erythromycin sensitivity despite the presence of the gene, and the presence of the lnu(B) gene associated with clindamycin resistance.
The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008.
The study reports the presence and expression of tet(L) in Streptococcus suis strains and highlights the co-expression of multiple tetracycline resistance genes contributing to high MIC levels against tetracycline.
Insects in confined swine operations carry a large antibiotic resistant and potentially virulent enterococcal community.
The study identifies tet(M) and erm(B) as the most common resistance genes in enterococci from insects and swine feces, highlighting their role in multidrug resistance.
Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates.
The study identified the distribution of erm genes (ermA, ermB, and ermC) among staphylococci isolates and found that constitutive MLS B resistance was the most prevalent phenotype, with ermA being the most common gene in S. aureus and ermC in CNS isolates.
Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam.
The study identified tetracycline resistance genes tet(M), tet(O), and tet(L), and erythromycin resistance gene erm(B) in Streptococcus suis serotype 2 strains isolated from slaughterhouse pigs in southern Vietnam.
Antibiotic resistance determinants in the interplay between food and gut microbiota.
The study identifies tetracycline resistance genes tet(M) and tet(W), and erythromycin resistance gene erm(B) in Lactobacillus paracasei strains isolated from Italian dairy and meat products.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Acquired antibiotic resistance: are we born with it?
The study identified the presence of tetracycline resistance gene tet (M), erythromycin resistance gene ermB, sulfonamide resistance gene sul2, and beta-lactam resistance gene bla TEM in the gut microbiota of infants, indicating that antibiotic resistance genes are present in the human gut microbiota from an early age.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Serotype emergence and genotype distribution among macrolide-resistant invasive Streptococcus pneumoniae isolates in the postconjugate vaccine (PCV-7) era.
The study identifies the prevalence of macrolide resistance genes mef(A) and erm(B) in Streptococcus pneumoniae isolates, highlighting shifts in resistance mechanisms over time.
Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.
The study identified genic differences in the blp bacteriocin locus and erythromycin resistance genes among PMEN1 strains, contributing to variations in virulence and antibiotic resistance.
Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains isolated from invasive and non-invasive infections from Mexico and the USA during 1999-2010.
The study identified mef A, erm B, and erm TR as the primary genes responsible for erythromycin resistance in Streptococcus pyogenes isolates from Mexico and the USA. The M phenotype was linked to mef A, while the cMLS and iMLS phenotypes were associated with erm B and erm TR, respectively.
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study.
The study identified high levels of erythromycin resistance in Streptococcus pneumoniae isolates from Asian countries, primarily mediated by the erm(B) and mef(A) genes. It also noted a significant increase in the prevalence of serotype 19A, which was associated with multidrug resistance.
Genotypes and serotype distribution of macrolide resistant invasive and non-invasive Streptococcus pneumoniae isolates from Lebanon.
Macrolide resistance in S. pneumoniae in Lebanon is mainly through target site modification (erm(B)) but is also mediated through efflux pumps (mef), with serotype 19F having dual resistance and being the most prevalent and invasive.
Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona.
The study identifies mef (E) and erm (B) genes as the primary drivers of macrolide resistance in Streptococcus pneumoniae isolates in Arizona, with dual-positive isolates being multidrug-resistant and predominantly belonging to clonal complex CC271.
The fitness cost of antibiotic resistance in Streptococcus pneumoniae: insight from the field.
The study identified mefA/E and ermB as the primary mechanisms of azithromycin resistance in Streptococcus pneumoniae and estimated their relative fitness costs.
Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.
The paper discusses the mechanisms of resistance to β-lactams, glycopeptides, and fluoroquinolones, highlighting the role of β-lactamases such as TEM, SHV, CTX-M, KPC, VIM, and NDM, glycopeptide resistance operons like vanA and vanB, and other resistance genes such as ermB, mecA, qnrA, and aac(6')-Ib.
The application of multiplex PCR to detect seven different DNA targets in group B streptococci.
The study developed a multiplex PCR method to detect seven DNA targets in Group B Streptococcus (GBS), including the macrolide resistance genes ermB and mefA/E.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
Clinical and microbiologic characteristics of tcdA-negative variant Clostridium difficile infections.
The study identified the ermB gene as a significant contributor to clindamycin resistance in tcdA-negative variant Clostridium difficile strains.
Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens.
The study identifies a novel mobile genetic element, 15K, carrying multiple antibiotic resistance genes including tet(O/W/32/O), erm(B), aadE, aphA, and tet(40), which can be transferred between major streptococcal pathogens.
Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes.
The study identified the pbp5-R allele, which confers ampicillin resistance in Enterococcus faecium strain TX16. This resistance determinant was found in most HA-clade isolates but not in CA-clade isolates.
Comparative genomics of the Staphylococcus intermedius group of animal pathogens.
The study identifies several antibiotic resistance genes in S. pseudintermedius ED99, including bla operon, aad6-sat4-aphA-3, ermB, and tetM, which confer resistance to beta-lactams, aminoglycosides, macrolides, lincosamides, streptogramins, and tetracyclines.
Evaluation of methods for identification and determination of the taxonomic status of strains belonging to the Streptococcus porcinus-Streptococcus pseudoporcinus complex isolated from animal, human, and dairy sources.
The study identified and characterized the presence of erm(A) and erm(B) genes in Streptococcus pseudoporcinus and Streptococcus porcinus, respectively, which confer resistance to erythromycin and clindamycin.
ICESp1116, the genetic element responsible for erm(B)-mediated, inducible resistance to erythromycin in Streptococcus pyogenes.
The study characterizes ICE Sp1116, a genetic element responsible for erm(B)-mediated inducible resistance to erythromycin in Streptococcus pyogenes.
Molecular characteristics of erythromycin-resistant Streptococcus pneumoniae from pediatric patients younger than five years in Beijing, 2010.
The study identified the ermB and tetM genes as the primary factors contributing to erythromycin and tetracycline resistance in Streptococcus pneumoniae isolates from pediatric patients in Beijing. Additionally, the mec gene was found to be associated with erythromycin resistance.
Macrolide resistance determinants among Streptococcus pneumoniae isolates from carriers in Central Greece.
The study identified erm(B), mef(E), and mef(A) as the primary macrolide resistance determinants in Streptococcus pneumoniae isolates from Central Greece. erm(B) conferred high-level resistance to macrolides, lincosamides, and streptogramin B, while mef(E) and mef(A) were associated with efflux-mediated resistance.
Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis.
The study identified tetracycline resistance genes tet(M) and tet(O), the erythromycin resistance gene erm(B), and the streptomycin resistance gene aadA in Streptococcus canis isolates, highlighting the presence of antimicrobial resistance mechanisms in this species.
Changes in enterococcal populations and related antibiotic resistance along a medical center-wastewater treatment plant-river continuum.
The study identified the presence of erm(B), mef(A), and tet(M) genes in Enterococcus faecium isolates from hospital and retirement home effluents, contributing to macrolide and tetracycline resistance.
Characterization of Enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese hospital: detection of extensive diversity in erm(B)-regulator regions.
Characterization of Enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese hospital: detection of extensive diversity in erm(B)-regulator regions.
Characterization of Enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese hospital: detection of extensive diversity in erm(B)-regulator regions., A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis., Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe., Molecular epidemiology and genetic linkage of macrolide and aminoglycoside resistance in Staphylococcus intermedius of canine origin., Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics., Evidence for natural gene transfer from gram-positive cocci to Escherichia coli., The closely related ermB-ermAM genes from Clostridium perfringens, Enterococcus faecalis (pAM beta 1), and Streptococcus agalactiae (pIP501) are flanked by variants of a directly repeated sequence., Isolation and characterization of a plasmid from Lactobacillus fermentum conferring erythromycin resistance., Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence analysis of the orf eta-copS region., The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes., Macrolide-lincosamide-streptogramin B resistance in Staphylococcus lentus results from the integration of part of a transposon into a small plasmid., Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545., Complete nucleotide sequence of plasmid pGB3631, a derivative of the Streptococcus agalactiae plasmid pIP501.
Genotyping of erythromycin resistant group C & G streptococci isolated in Chennai, south India.
The study identified erythromycin resistance in 12.2% of group C and G streptococci isolates in Chennai, India, with erm(B) being the most common genotype among clinical isolates and mef(A) prevalent among carriers.
PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan.
The study identified the presence of mefA and ermB genes in Streptococcus pneumoniae isolates, which confer resistance to macrolides. These genes were found to be prevalent among certain serotypes, particularly 19F and 23F.
Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines.
The study identified macrolide resistance genes erm(B) and mef(E) in Streptococcus pneumoniae and amino acid substitutions in the ftsI gene of Haemophilus influenzae contributing to ampicillin resistance.
Antimicrobial susceptibility and molecular subtypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China.
The study identified mecA, ermC, and ermB genes associated with methicillin and erythromycin resistance in Staphylococcus aureus isolates from pig tonsils and cow's milk in China.
Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078.
The study identified tet(M) and erm(B) as key resistance genes in C. difficile PCR-ribotype 078 isolates, along with gyrA mutations contributing to fluoroquinolone resistance.
Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle.
The study found that erythromycin resistance in Staphylococcus spp. was primarily mediated by the erm(C) gene, which was detected in isolates from beef cattle. The use of macrolides in cattle led to an increase in erythromycin-resistant enterococci, mainly Enterococcus hirae.
Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing invasive diseases from Shenzhen Children's Hospital.
The study identified ermB and mefA genes as the primary mechanisms of macrolide resistance in Streptococcus pneumoniae isolates from Shenzhen, China.
Nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among children from Brazil before the introduction of the 10-valent conjugate vaccine.
The study identified erythromycin resistance genes mef(A/E) and erm(B) in Streptococcus pneumoniae isolates, with the former being associated with the M phenotype. Penicillin non-susceptibility was linked to specific serotypes such as 14 and 23F.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
Molecular resistance mechanisms of macrolide-resistant invasive Streptococcus pneumoniae isolates from Alaska, 1986 to 2010.
The study identifies mef and erm(B) genes as the primary mechanisms of macrolide resistance in invasive Streptococcus pneumoniae isolates from Alaska, with mef being the most prevalent.
Seven-year surveillance of emm types of pediatric Group A streptococcal pharyngitis isolates in Western Greece.
The study identified specific emm types associated with macrolide resistance and susceptibility in Group A streptococcal isolates, including the presence of erm(A), erm(B), and mef(A) resistance genes.
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
The study identifies a novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45, along with various AMR genes such as mecA, blaZ, aac(6')-Ie–aph(2')-Ia, aph(3')-III, ant(6)-Ia, sat4, erm(B), tet(M), dfr(G), and cat pC221. Additionally, fluoroquinolone resistance was linked to specific mutations in gyrA and grlA.
Molecular epidemiology of serotype 19A Streptococcus pneumoniae among invasive isolates from Alaska, 1986-2010.
The study identified the presence of mef E and erm B genes in serotype 19A Streptococcus pneumoniae isolates, which contribute to macrolide resistance. The mef E gene was detected in 62% of erythromycin-resistant isolates, while the erm B gene was found in all CC320 isolates.
Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains.
The study identifies the erm(B) gene within the novel transposon Tn6215, which confers erythromycin resistance in Clostridium difficile through phage-mediated transduction.
Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paraná, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants.
The study identified resistance to erythromycin and clindamycin in Streptococcus agalactiae isolates, primarily mediated by the ermA, ermB, and mefA/E genes.
In vitro activity of solithromycin against erythromycin-resistant Streptococcus agalactiae.
Solithromycin showed potent activity against erythromycin-resistant Streptococcus agalactiae, with MIC 50 and MIC 90 values of 0.03 μg/ml and 0.125 μg/ml, respectively. The study identified erm(B) and mef(A/E) as the primary resistance mechanisms.
Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia.
The study identified the prevalence of inducible clindamycin resistance in staphylococcal isolates, with erm(C) being the most prevalent gene among S. aureus isolates.
Application of microarray and functional-based screening methods for the detection of antimicrobial resistance genes in the microbiomes of healthy humans.
The study identified various antimicrobial resistance genes in the microbiomes of healthy humans, including erm(B), bla TEM, sul2, acrRAB, and folP, which confer resistance to macrolides, beta-lactams, sulphonamides, and other antibiotics.
Notes from the field: Shigella with decreased susceptibility to azithromycin among men who have sex with men - United States, 2002-2013.
The study identifies Shigella isolates with decreased susceptibility to azithromycin, primarily due to the presence of mphA and ermB macrolide resistance genes.
Extensively drug-resistant Streptococcus pneumoniae, South Korea, 2011-2012.
The study identified five extensively drug-resistant Streptococcus pneumoniae isolates carrying the erm(B) gene, which confers resistance to macrolides such as erythromycin and clarithromycin.
Evaluation of Curetis Unyvero, a multiplex PCR-based testing system, for rapid detection of bacteria and antibiotic resistance and impact of the assay on management of severe nosocomial pneumonia.
The study evaluated the Curetis Unyvero assay for rapid detection of bacteria and antibiotic resistance markers in patients with severe nosocomial pneumonia. It identified several AMR genes, including ermB, bla OXA-51-like, sul1, int1, mecA, and bla CTX-M, which conferred resistance to various antibiotics.
Multilocus sequence types of invasive and colonizing neonatal group B streptococci in Poland.
The study identified ermB as a gene conferring resistance to erythromycin and clindamycin in Streptococcus agalactiae isolates from neonates in Poland.
Antibiotic resistance in lactic acid bacteria isolated from some pharmaceutical and dairy products.
The study identified the presence of tet(M) and erm(B) genes in lactic acid bacteria (LAB) isolated from pharmaceutical and dairy products, indicating tetracycline and erythromycin resistance, respectively.
Emergence of multidrug-resistant Campylobacter species isolates with a horizontally acquired rRNA methylase.
The study identifies the emergence of multidrug-resistant Campylobacter isolates carrying the horizontally acquired rRNA methylase gene erm(B), which confers high-level resistance to macrolides, lincosamides, and streptogramin B.
Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements.
The study identified the vanA gene as the primary determinant of vancomycin and teicoplanin resistance in Enterococcus faecium outbreaks. Additional resistance genes such as erm(B), tet(M), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, and aad6 were also characterized, contributing to multidrug resistance.
Erythromycin-resistant genes in group A β-haemolytic Streptococci in Chengdu, Southwestern China.
The study identified ermB and mefA as the primary erythromycin resistance genes in group A β-haemolytic Streptococci in Chengdu, with ermB being the most prevalent.
Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study.
The study identified mutations in gyrA and gyrB genes associated with ciprofloxacin resistance, and the presence of tetM and ermB genes conferring resistance to tetracycline and clindamycin, respectively, in Clostridium difficile isolates.
Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant Clone, Spain.
The study identifies the emergence of a multidrug-resistant Streptococcus pneumoniae serotype 8-ST63 clone in Spain, characterized by the presence of ermB and tetM genes, and mutations in parC and gyrA that confer resistance to fluoroquinolones.
Genomic Analysis of Antimicrobial Resistance in Clinical Isolates of Escherichia coli
The study identified various AMR genes in ExPEC E. coli strains, including beta-lactamases (blaCTX-M, blaSHV, blaTEM), quinolone resistance genes (qnrS1), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance genes (tet(A)), macrolide resistance genes (mph(A), erm(B), mef(A)), and others. These genes were associated with resistance to multiple antibiotics.
Global phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineages.
The study identifies tetM, ermB, and mefE as genes responsible for tetracycline and macrolide resistance in nonencapsulated Streptococcus pneumoniae isolates, highlighting the antibiotic resistance profile of the classic lineage ST344 and ST448.
Antimicrobial Resistance Mechanisms in Salmonella and Other Bacteria
The paper discusses multidrug efflux pumps from various bacterial food pathogens including Enterobacteriaceae, Vibrio cholerae, and Staphylococcus aureus, highlighting their role in multidrug resistance.
Unraveling antimicrobial resistance genes and phenotype patterns among Enterococcus faecalis isolated from retail chicken products in Japan.
The study identified several antimicrobial resistance genes in Enterococcus faecalis isolated from retail chicken products in Japan, including aac(6')-Ie-aph(2")-Ia, aph(3')-IIIa, ant(6)-Ia, tet(L), tet(M), tet(O), and erm(B). These genes were associated with resistance to various antibiotics such as kanamycin, gentamicin, streptomycin, dihydrostreptomycin, oxytetracycline, and erythromycin.
Serotypes, antibiotic susceptibilities, and multi-locus sequence type profiles of Streptococcus agalactiae isolates circulating in Beijing, China.
The study identified ermB as a macrolide resistance gene in Streptococcus agalactiae isolates, with high resistance rates to erythromycin, azithromycin, clarithromycin, and clindamycin. The ermB gene was found in 72.7% of erythromycin-resistant isolates.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Antibiotic susceptibilities of enterococcus species isolated from hospital and domestic wastewater effluents in alice, eastern cape province of South Africa.
The study identified the presence of vancomycin resistance genes (vanB, vanC1, vanC2/3) and the macrolide resistance gene erm(B) in Enterococcus isolates from hospital wastewater and final effluent of a wastewater treatment plant in South Africa.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Effect of in-feed administration and withdrawal of tylosin phosphate on antibiotic resistance in enterococci isolated from feedlot steers.
The study found that tylosin phosphate administration increased the proportion of erythromycin and tylosin resistant enterococci, but withdrawal reduced their prevalence. The resistance was primarily mediated by the erm(B) gene and msrC gene.
Sampling and Pooling Methods for Capturing Herd Level Antibiotic Resistance in Swine Feces using qPCR and CFU Approaches.
The study identified several antibiotic resistance genes in swine fecal samples using qPCR, including tetracycline resistance genes (tet(A), tet(B), tet(C), tet(M), tet(O), tet(W)), erythromycin resistance genes (ermB, ermF), sulfonamide resistance genes (sulI, sulII), beta-lactam resistance genes (blaCTX-M-1 group, blaCMY-2, blaSHV family), and glycopeptide resistance gene (vanA).
Virulence and antimicrobial resistance factors of Enterococcusspp. isolated from fecal samples from piggery farms in Eastern Cape, South Africa.
The study identified vancomycin resistance genes (vanB, vanC1, vanC2/3), erythromycin resistance gene (ermB), and streptomycin resistance gene (strA) in Enterococcus spp. isolated from pig fecal samples. High levels of multidrug resistance were observed, with resistance to vancomycin, erythromycin, and streptomycin being particularly prevalent.
Dynamics of serotype 14 Streptococcus pneumoniae population causing acute respiratory infections among children in China (1997-2012).
Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive Staphylococcus aureus and coagulase-negative staphylococcal isolates from bovine mastitis.
The study identified various MLS resistance genes, including erm(C), mph(C), erm(B), ere(A), vga(A), lnu(A), and msr(A)/msr(B), in Staphylococcus aureus and coagulase-negative staphylococci isolates from bovine mastitis, highlighting a high prevalence of inducible MLS resistance.
Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.
The study identified erm(C), erm(B), erm(A), msr(A), and lnu(A) as the primary genes responsible for resistance to macrolides, lincosamides, and streptogramin B in Staphylococcus hominis isolates.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Epidemiological and Inducible Resistance in Coagulase Negative Staphylococci.
The study identified erm(A), erm(B), erm(C), and erm(TR) genes in erythromycin-resistant Coagulase Negative Staphylococci (CNS) isolates, indicating inducible clindamycin resistance. The majority of the isolates exhibited unique genomic patterns, suggesting limited transmission of resistant strains.
A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy.
The study identifies multiple AMR genes in CC97 MRSA isolates from Italian dairy cattle and pigs, including erm(B), erm(C), vga(A), tet(K), tet(M), blaZ, and aacA-aphD, which confer resistance to various antibiotics such as erythromycin, clindamycin, tiamulin, tetracycline, penicillin, and aminoglycosides.
Antibiotic Susceptibility Profiles of Dairy Leuconostoc, Analysis of the Genetic Basis of Atypical Resistances and Transfer of Genes In Vitro and in a Food Matrix.
The study identified several AMR genes in Leuconostoc strains, including erm(B) for erythromycin resistance, tet(S) for tetracycline resistance, and others like aadE, aphA-3, sat4, and vat(E) for aminoglycoside and virginiamycin resistance.
Genome sequence and virulence factors of a group G Streptococcus dysgalactiae subsp. equisimilis strain with a new element carrying erm(B).
The study identifies a new transposable element carrying the macrolide-resistant gene erm(B) in a Streptococcus dysgalactiae subsp. equisimilis strain, which confers resistance to macrolides, clindamycin, and streptogramins B.
Comparative Genomic Analysis of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine Isolates in China.
The study identifies and characterizes the ICESa2603 family of integrative and conjugative elements (ICEs) carrying the macrolide resistance gene erm(B) and tetracycline resistance gene tet(O). These ICEs are widespread in swine and bovine isolates in China and contribute to the spread of antibiotic resistance.
Population Structure and Antimicrobial Resistance Profiles of Streptococcus suis Serotype 2 Sequence Type 25 Strains.
The study identifies tetracycline resistance gene tetO and macrolide resistance gene ermB in ST25 S. suis strains, which are carried on integrative and conjugative elements (ICEs).
Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats.
The study found that high levels of tulathromycin (10 and 100 μg/mL) disturbed colonization resistance and selected for antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried the ermB gene, which confers resistance to macrolides and tulathromycin.
Distribution of Genes Encoding Resistance to Macrolides Among Staphylococci Isolated From the Nasal Cavity of Hospital Employees in Khorramabad, Iran.
The study identified the presence of ermA, ermB, ermC, and msrA genes in Staphylococcus isolates from hospital employees, highlighting the prevalence of macrolide resistance mechanisms in both S. aureus and coagulase-negative staphylococci.
Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.
The study identifies several macrolone compounds with potent antibacterial activity against key respiratory pathogens, including those with macrolide resistance mechanisms. These compounds demonstrate superiority over existing macrolide antibiotics in vitro and in vivo, with minimal induction of resistance genes.
Metagenome and Metatranscriptome Analyses Using Protein Family Profiles.
The study demonstrates the utility of HMM-GRASPx for profiling antimicrobial resistance (AMR) gene families in metagenomic data sets, highlighting the distinct resistome profiles across different body sites and the importance of AMR gene abundance in understanding bacterial communities.
Molecular Epidemiology of Streptococcus pneumoniae Isolates from Children with Recurrent Upper Respiratory Tract Infections.
The study identified multiple AMR genes in Streptococcus pneumoniae isolates from children with recurrent upper respiratory tract infections, including erm(B), mef(E), tet(M), and cat pC194, which confer resistance to macrolides, tetracyclines, and chloramphenicol.
Characterisation of Phenotypic and Genotypic Antibiotic Resistance Profile of Enterococci from Cheeses in Turkey.
The study identified several antibiotic resistance genes in enterococci from Turkish cheeses, including ermB, tetM, aph(3')-IIIa, cat, and aac(6')-Ieaph(2")-Ia, which confer resistance to macrolides, lincosamides, streptogramin B, tetracycline, kanamycin, gentamicin, and chloramphenicol.
Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA.
The study identifies distinct antibiotic resistance gene profiles in Staphylococcus aureus ST59 isolates from the USA and East Asia, with the East Asia clade exhibiting higher resistance to beta-lactams, chloramphenicol, tetracyclines, and macrolides.
Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus.
The study identifies the ermB gene as the most prevalent erythromycin resistance determinant in methicillin-susceptible Staphylococcus aureus (MSSA) isolates, highlighting its presence in a novel Tn1546-like element originating from Enterococcus faecium.
Drug Resistance Characteristics and Macrolide-Resistant Mechanisms of Streptococcus pneumoniae in Wenzhou City, China.
The study identified the erm B and mef A genes as the primary mechanisms of macrolide resistance in Streptococcus pneumoniae in Wenzhou City, China. The erm B gene was detected in 98.5% of isolates, while the mef A gene was detected in 91.2% of isolates.
Elevated Risk for Antimicrobial Drug-Resistant Shigella Infection among Men Who Have Sex with Men, United States, 2011-2015.
The study found that Shigella isolates from clusters associated with men who have sex with men (MSM) showed significantly higher rates of resistance to azithromycin, ciprofloxacin, and ceftriaxone compared to other clusters. Azithromycin resistance was primarily due to the presence of macrolide resistance genes mphA and ermB.
Genomic Analysis Reveals Multi-Drug Resistance Clusters in Group B Streptococcus CC17 Hypervirulent Isolates Causing Neonatal Invasive Disease in Southern Mainland China.
The study identifies multiple antibiotic resistance genes, including tetO, ermB, ant6, aphA, ant9, and lnuB, in Group B Streptococcus CC17 isolates from China, highlighting the emergence of multi-drug resistance in these hypervirulent strains.
The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.
Nonsense mutations in the ErmBL leader peptide of Staphylococcus aureus lead to high basal and induced expression of ErmB, resulting in increased resistance to macrolides. Erythromycin enhances the stability of ermB mRNA, contributing to resistance.
Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China.
The study identifies that the inducible expression of both ermB and ermT genes confers high macrolide resistance in S. gallolyticus subsp. pasteurianus isolates from China.
Macrolide Resistance in Streptococcus pneumoniae.
The study identifies erm(B), mef(E), and mel as key genes involved in macrolide resistance in Streptococcus pneumoniae, highlighting their roles in ribosomal modification and efflux mechanisms.
More than 50% of Clostridium difficile Isolates from Pet Dogs in Flagstaff, USA, Carry Toxigenic Genotypes.
The study identified toxigenic Clostridium difficile isolates from pet dogs in Flagstaff, USA, highlighting their potential role as a source of community-acquired infections in humans.
The First Report of a Fully Sequenced Resistance Plasmid from Shigella boydii.
The study reports the first fully sequenced resistance plasmid from Shigella boydii, p2246-CTXM, which carries bla CTX-M-14, erm(B), and mph(A) genes, conferring resistance to ceftriaxone, erythromycin, and azithromycin.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Antimicrobial Susceptibility of Autochthonous Aquatic Vibrio cholerae in Haiti.
The study identified several AMR genes in environmental isolates of Vibrio cholerae non-O1/non-O139 in Haiti, including strA, strB, sul1, sul2, ermA, ermB, and mefA, which confer resistance to streptomycin, sulfonamide, and erythromycin.
Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells.
The study demonstrates that prophages in Staphylococcus aureus can facilitate the transfer of antibiotic resistance genes from neighboring cells through a process called 'autotransduction.' Resistance genes such as ermB, cat, and tetM were successfully transferred.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Antimicrobial usage and resistance in beef production.
The review discusses the impact of antimicrobial usage in beef production on the emergence and spread of antimicrobial resistance (AMR) in bovine pathogens. It highlights the role of antimicrobial use in promoting AMR, particularly in respiratory and liver abscess pathogens, and emphasizes the need for judicious use to mitigate risks to both animal and human health.
Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014.
The study identifies the emergence of multidrug-resistant serotype 15A Streptococcus pneumoniae in the UK, highlighting the presence of resistance genes erm(B) and tet(M) associated with macrolide and tetracycline resistance, respectively.
Determination of Characteristics of Erythromycin Resistant Streptococcus pneumoniae with Preferred PCV Usage in Iran.
The study identified ermB and mef genes as the primary mechanisms of erythromycin resistance in Streptococcus pneumoniae isolates in Iran, with ermB being the most common.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Interspecies transfer of vancomycin, erythromycin and tetracycline resistance among Enterococcus species recovered from agrarian sources.
The study identified the transfer of vancomycin, erythromycin, and tetracycline resistance genes among Enterococcus species, highlighting the potential for horizontal gene transfer in agrarian environments.
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.
The study identifies multiple AMR genes and mutations contributing to multidrug resistance in a Clostridium difficile lineage endemic to Costa Rican hospitals, including ermB, tetM, catD, aacA-aphD, and ant6-sat4-aphA-3, as well as gyrA and rpoB mutations.
Comparative genomics of Enterococcus spp. isolated from bovine feces.
The study identified several antibiotic resistance genes in Enterococcus spp. isolated from bovine feces, including erm(B) for macrolide-lincosamide-streptogramin B resistance, tet(L), tet(M), and tet(O) for tetracycline resistance, and the vanC operon for glycopeptide resistance.
Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting.
The study found that copper addition affected the abundance of copper resistance genes (CRGs) and antibiotic resistance genes (ARGs) during swine manure composting. Specifically, the absolute abundances of pcoA, tcrB, erm(A), erm(B), and intI1 decreased, while those of copA and cusA increased. The high concentration of copper slowed down the dissipation of CRGs, ARGs, and intI1 during composting.
Evidence for natural gene transfer from gram-positive cocci to Escherichia coli.
Evidence for natural gene transfer from gram-positive cocci to Escherichia coli.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.
The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms.
Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.
The paper discusses the role of bacteria from animals as a reservoir of antimicrobial resistance genes, highlighting the presence of various AMR genes such as erm(B), tet(M), cfr, and others in different bacterial species, emphasizing their contribution to the spread of resistance.
Campylobacter coli in Organic and Conventional Pig Production in France and Sweden: Prevalence and Antimicrobial Resistance.
The study found that erythromycin resistance in Campylobacter coli isolates from France was prevalent, but the erm(B) gene was not detected in these isolates. Tetracycline resistance was common in France but rare in Sweden.
High Prevalence of Macrolide-resistance and Molecular Characterization of Streptococcus pyogenes Isolates Circulating in China from 2009 to 2016.
The study identified high prevalence of macrolide resistance in Streptococcus pyogenes isolates in China, with erm(B) and mef(A/E) genes being the primary mechanisms. Tet(M) was the main determinant of tetracycline resistance, and mutations in gyrA and parC were associated with fluoroquinolone resistance.
Occurrence of the mcr-1 Colistin Resistance Gene and other Clinically Relevant Antibiotic Resistance Genes in Microbial Populations at Different Municipal Wastewater Treatment Plants in Germany.
The study identified the mcr-1 colistin resistance gene and several other clinically relevant antibiotic resistance genes, including ermB, tetM, CTX-M, CTX-M-32, blaTEM, and CMY-2, in wastewater treatment plant samples in Germany.
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
Antibiotic resistance, ability to form biofilm and susceptibility to copper alloys of selected staphylococcal strains isolated from touch surfaces in Polish hospital wards.
The study identified methicillin-resistant staphylococcal strains carrying the mecA gene, erythromycin resistance genes ermB and msrA/B, and mupirocin resistance gene mup. These genes conferred resistance to methicillin, erythromycin, clindamycin, and mupirocin.
Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital.
The study identifies several AMR genes and mutations in Corynebacterium striatum, including bla, erm(X), erm(B), aph(3')-Ic, aac(3)-XI, aph(3'')-Ib, and aph(6)-Id, along with gyrA mutations contributing to fluoroquinolone resistance.
Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms.
The study identified several antimicrobial resistance (AMR) genes, including ermB, ermF, sulI, sulII, tet(M), tet(O), and tet(W), and examined their association with antimicrobial exposure in Danish pig farms. The results showed complex relationships between antimicrobial exposure and AMR gene levels, with varying correlations depending on the specific gene and antimicrobial class.
Molecular characterization of vancomycin-resistant Staphylococcus aureus strains isolated from clinical samples: A three year study in Tehran, Iran.
The study identified vancomycin-resistant Staphylococcus aureus (VRSA) strains carrying the vanA gene, along with multiple resistance genes such as mecA, ermA, ermB, ermC, msrA, msrB, tetM, ant(4')-Ia, aac(6')-Ie/aph(2'')-Ia, and aph(3')-IIIa. These strains exhibited high-level resistance to vancomycin and other antibiotics.
Characterization of Enterococcus Isolates Colonizing the Intestinal Tract of Intensive Care Unit Patients Receiving Selective Digestive Decontamination.
The study identified the erm(B) gene as a major contributor to macrolide resistance in Enterococcus isolates from ICU patients receiving SDD therapy.
A Population-Based Assessment of the Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines on Macrolide-Resistant Invasive Pneumococcal Disease: Emergence and Decline of Streptococcus pneumoniae Serotype 19A (CC320) With Dual Macrolide Resistance Mechanisms.
The study identifies the dual macrolide resistance mechanisms in Streptococcus pneumoniae serotype 19A (CC320), involving the genes mef (E)/ mel and erm (B). These genes confer resistance to macrolides, lincosamides, and streptogramin B. The introduction of PCV13 led to a significant decline in dual macrolide-resistant invasive pneumococcal disease.
Population and Whole Genome Sequence Based Characterization of Invasive Group A Streptococci Recovered in the United States during 2015.
The study identified several AMR genes and mutations in invasive group A streptococci, including ermT, ermB, ermTR, tetM, lsaC, mef, msrD, and mutations in ParC and GyrA that confer resistance to macrolides, tetracycline, and fluoroquinolones.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
Dissemination of macrolides, fusidic acid and mupirocin resistance among Staphylococcus aureus clinical isolates.
The study characterizes mupA and mupB genes involved in mupirocin resistance in methicillin-resistant Staphylococcus aureus.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
ICESag37, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in Streptococcus agalactiae.
The study characterizes ICE Sag37, a novel integrative and conjugative element carrying multiple antimicrobial resistance genes, including erm(B), tet(O), aadE, aphA, and ant(6), in Streptococcus agalactiae.
Characterization of Streptococcus pneumoniae isolates from Austrian companion animals and horses.
The study identified multidrug-resistant Streptococcus pneumoniae isolates from rats, which exhibited resistance to tetracycline, erythromycin, clindamycin, chloramphenicol, and trimethoprim-sulfamethoxazole. Resistance genes tet(M), erm(B), and cat pC194 were detected, along with mutations in the dfr gene associated with trimethoprim resistance.
Detection of Antibiotic Resistance and Resistance Genes in Enterococci Isolated from Sucuk, a Traditional Turkish Dry-Fermented Sausage.
The study identified several AMR genes including ermB, ermC, gyrA, tetM, tetL, and vanA in Enterococcus isolates from Sucuk, highlighting the potential for these bacteria to serve as reservoirs of antibiotic resistance genes.
Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain.
The study characterizes 15 Streptococcus pyogenes isolates from animals in Spain, identifying macrolide resistance genes mef A and erm B, and tetracycline resistance genes tet M and tet O. Most isolates exhibited the M phenotype for macrolide resistance, while some showed cMLS B or iMLS B phenotypes.
Community-acquired infection with hypervirulent Clostridium difficile isolates that carry different toxin and antibiotic resistance loci: a case report.
The study identified the presence of ermB and tetM genes in hypervirulent Clostridium difficile isolates, indicating resistance to erythromycin/clindamycin and tetracycline, respectively.
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
The study identified various AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including bla TEM-1B, mtrR, ponA, penB, gyrA, parC, rpsJ, and 23S rRNA mutations, contributing to resistance against penicillin, ciprofloxacin, tetracycline, and azithromycin.
Polymerase chain reaction detection of genes responsible for multiple antibiotic resistance Staphylococcus aureus isolated from food of animal origin in Egypt.
The study identified several antibiotic resistance genes in multiple drug-resistant Staphylococcus aureus isolates from food of animal origin in Egypt, including blaZ, tetK, ermB, msrA, ermC, and aac(6')-aph(2").
Characterization of multiple antibiotic resistance of culturable microorganisms and metagenomic analysis of total microbial diversity of marine fish sold in retail shops in Mumbai, India.
The study identified multiple antibiotic resistance genes in marine fish isolates, including blaTEM, Class I integron, tetA, aph(3')-IIIa, ermB, aadA, and sul1, indicating a potential risk of antibiotic resistance transmission to humans through the food chain.
Antibiotic Resistance-Susceptibility Profiles of Streptococcus thermophilus Isolated from Raw Milk and Genome Analysis of the Genetic Basis of Acquired Resistances.
The study identified tet(S) and ermB as the genes responsible for tetracycline and erythromycin/clindamycin resistance in Streptococcus thermophilus isolates from raw milk. No aminoglycoside resistance genes were found in the streptomycin/neomycin-resistant strain.
Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.
The study identified multiple tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in Streptococcus suis serotype 9 strains, highlighting the widespread presence of antibiotic resistance mechanisms in these isolates.
Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.
The study identifies the emergence of multidrug resistance (MDR) in Clostridium difficile strain DH/NAP11/106 through genomic changes, including the acquisition of a 46,000 bp genomic element containing ermB, which confers clindamycin resistance, and mutations in rpoB, gyrB, and pbp genes that contribute to resistance to rifaximin, moxifloxacin, and ampicillin, respectively.
Azithromycin Resistance in Shigella spp. in Southeast Asia.
The study identified mphA and ermB as the primary genes responsible for azithromycin resistance in Shigella spp. in Southeast Asia.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance among Listeria monocytogenes Isolated from Australian Food Production Chains.
The study identified ermB as a gene conferring erythromycin resistance in L. monocytogenes isolate Lm16-001 and two ciprofloxacin-resistant isolates (2948 and Lm16-001) with mutations in the fepR gene, which regulates the fluoroquinolone efflux pump.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Changes in Macrolide Resistance Among Group A Streptococci in Serbia and Clonal Evolution of Resistant Isolates.
The study identified the genes mefA, ermB, ermTR, and tetM as responsible for macrolide and tetracycline resistance in Group A Streptococci in Serbia.
Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species.
The study identifies the azithromycin resistance plasmid pKSR100 and its associated genes mphA and ermB as critical drivers of epidemics among multiple Shigella species, highlighting the role of horizontal gene transfer in the spread of antimicrobial resistance.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015.
The study identifies a significant increase in macrolide resistance among Streptococcus agalactiae isolates causing invasive disease in non-pregnant adults in Portugal, primarily linked to the expansion of a specific capsular-transformed lineage (CC1) harboring resistance genes such as erm(B), erm(TR), erm(T), mef(E), tet(M), tet(O), and tet(L).
Molecular characterization of serogroup 19 Streptococcus pneumoniae in the Czech Republic in the post-vaccine era.
The study identified the presence of the ermB and tetM genes in serogroup 19 Streptococcus pneumoniae isolates, which conferred resistance to erythromycin and tetracycline, respectively. Additionally, mutations in penicillin-binding protein (PBP) genes were associated with penicillin resistance in 19F isolates.
Combination Therapy Strategies Against Multiple-Resistant Streptococcus Suis.
The study identifies several AMR genes in multidrug-resistant Streptococcus suis isolates, including tetM, lnuB, erm(B), tetO, tetL, and aph3′, which confer resistance to tetracycline, clindamycin, erythromycin, and aminoglycosides.
Molecular epidemiology and antimicrobial susceptibility of human Clostridium difficile isolates from a single institution in Northern China.
The study identified mutations in GyrA (F86Y) and GyrB (D426N, D426V, S416A) that confer quinolone resistance, and mutations in RpoB (H502N, R505K, E573A, G603D) that confer rifampin resistance. Additionally, the erm(B) and erm(G) genes were found to mediate resistance to macrolide-lincosamide-streptogramin B antibiotics.
The draft genomes and investigation of serotype distribution, antimicrobial resistance of group B Streptococcus strains isolated from urine in Suzhou, China.
The study identified several AMR genes in GBS isolates from urine in Suzhou, including tetM, ermB, mefE, lnuB, and others, associated with resistance to tetracycline, erythromycin, clindamycin, and fluoroquinolones.
Antimicrobial Resistance in Enterococcus spp. of animal origin.
The paper reviews the prevalence and mechanisms of antimicrobial resistance in Enterococcus species of animal origin, focusing on glycopeptide resistance genes such as vanA, vanB, and vanC1, as well as linezolid resistance genes like cfr and optrA.
Molecular characterization of fluoroquinolones, macrolides, and imipenem resistance in Haemophilus influenzae: analysis of the mutations in QRDRs and assessment of the extent of the AcrAB-TolC-mediated resistance.
The study identified specific amino acid substitutions in GyrA, ParC, and ParE that are associated with fluoroquinolone resistance in Haemophilus influenzae. Additionally, the ermB gene was found to be present in all six fluoroquinolone-resistant isolates, contributing to macrolide resistance.
Understanding the impact of antibiotic therapies on the respiratory tract resistome: a novel pooled-template metagenomic sequencing strategy.
The study identifies changes in the prevalence of specific macrolide resistance genes, such as ermB, in response to erythromycin therapy, highlighting the utility of pooled-template metagenomic sequencing for tracking resistance gene carriage in respiratory microbiomes.
Novel linezolid resistance plasmids in Enterococcus from food animals in the USA.
The study identifies novel linezolid resistance plasmids containing optrA and cfr genes in Enterococcus isolates from food animals in the USA, highlighting the potential for horizontal transfer of resistance genes.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Safety and Growth Optimization of Lactic Acid Bacteria Isolated From Feedlot Cattle for Probiotic Formula Design.
The study identified several AMR genes in feedlot lactobacilli, including ermB, tet(S), aadA, ant(6), bla, and aph(3''-III), which confer resistance to erythromycin, tetracycline, streptomycin, kanamycin, and ampicillin. These genes were detected through PCR analysis and correlate with phenotypic resistance in some strains.
Antimicrobial Resistance in Lactobacillus Species: A Genomic and Phenotypic Analysis
The study identifies various tetracycline, erythromycin, chloramphenicol, and aminoglycoside resistance genes in Lactobacillus species, highlighting their potential role in antimicrobial resistance and horizontal gene transfer.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces.
The study identified the presence of antimicrobial resistance genes such as bla and vanA in the microbial communities associated with International Space Station environmental surfaces, indicating the persistence of these resistance mechanisms in a closed-system environment.
Reduction of Antibiotic Resistant Bacteria During Conventional and Advanced Wastewater Treatment, and the Disseminated Loads Released to the Environment.
The study identifies several antibiotic resistance genes (ARGs) in wastewater, including mecA, ctx-M32, ermB, blaTEM, sul1, vanA, and intI1, and evaluates the effectiveness of advanced wastewater treatment technologies in reducing their abundance.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
Molecular characteristics and comparative genomics analysis of a clinical Enterococcus casseliflavus with a resistance plasmid.
The study identified six resistance genes (aph3', ant6, bla, sat4, and two ermB) on the plasmid pEC369, along with a vanC-2 gene cluster on the chromosome, contributing to resistance against erythromycin, kanamycin, streptomycin, and vancomycin in Enterococcus casseliflavus EC369.
Distribution of Transferable Antibiotic Resistance Genes in Laboratory-Reared Edible Mealworms (Tenebrio molitor L.).
The study identified tetracycline resistance genes (tet(M), tet(K), tet(S)), the MLS B resistance gene erm(B), and the aac-aph gene in laboratory-reared mealworms, indicating the presence of transferable antibiotic resistance genes in edible insects.
A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the U.S. During 2015-2016.
The study identifies multiple AMR genes and mutations in Streptococcus pneumoniae isolates, including ermB, mef, folA, and folP, which confer resistance to macrolides, trimethoprim, and penicillin. Mutations in pbp2x and pbp1a are associated with penicillin resistance.
Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains.
The study identified erythromycin resistance genes erm(B) and erm(C) and tetracycline resistance genes tet(K) and tet(M) in Lactobacillus fermentum strains. None of the strains were able to transfer these resistance genes to other bacteria via conjugation.
Nosocomial outbreak of multi-resistant Streptococcus pneumoniae serotype 15A in a centre for chronic pulmonary diseases.
The study identifies the presence of tetM and ermB genes in multi-resistant Streptococcus pneumoniae serotype 15A, contributing to resistance against tetracycline, macrolides, and lincosamides.
Investigation of the Dominant Microbiota in Ready-to-Eat Grasshoppers and Mealworms and Quantification of Carbapenem Resistance Genes by qPCR.
The study quantified the presence of carbapenem resistance genes (bla OXA-48, bla NDM-1, and bla VIM) in ready-to-eat mealworms and grasshoppers from various countries, revealing varying frequencies of these genes in different samples.
The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.
The study identified mcr-1 and mcr-3 genes as the primary colistin resistance genes in the Funan River, along with other resistance genes such as sul1, sul2, aac(6')-Ib-cr, bla CTX-M, tetM, ermB, qnrS, and aph(3')-IIIa. These genes were found in various bacterial species, highlighting the presence of multidrug-resistant strains in the river.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium.
Vascular access infection by Staphylococcus aureus from removed dialysis accesses.
The study identified erythromycin resistance genes erm(A), erm(B), erm(C), and msr(A) in Staphylococcus aureus isolates, highlighting their role in resistance mechanisms.
Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin.
The study identifies that the erm(B) gene mediates a constitutive macrolide-lincosamide-streptogramin B (cMLSB) resistance phenotype in Staphylococcus aureus, leading to reduced susceptibility to solithromycin.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China.
The study identified several AMR genes and mutations in MRSA isolates from Guangdong, China, including aac(6')-aph(2"), ermA, ermB, ermC, lnuA, dfrG, rpoB, fexA, and mutations in gyrA, gyrB, grlA, and grlB associated with resistance to various antibiotics.
Genetic Diversity Analysis of Methicillin-resistant Staphylococcus aureus Strains Isolated from Intensive Care Unit in Iran.
The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Global Population Structure and Evolution of Clostridioides difficile ST11 and ST258 Lineages
The study identifies tetracycline resistance genes tetM and tet-44, along with the erythromycin resistance gene ermB, in C. difficile ST11 and ST258 lineages, highlighting their role in antimicrobial resistance.
Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand.
The study identifies the ST108 lineage of vancomycin-resistant Enterococcus faecalis as having an agricultural origin, with multiple resistance genes including vanA, ermB, tetL, tetM, and bcr operon components contributing to its persistence in New Zealand.
Sequence of the adenine methylase gene of the Streptococcus faecalis plasmid pAM beta 1.
Sequence of the adenine methylase gene of the Streptococcus faecalis plasmid pAM beta 1.
Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species From Ready-to-Eat Seafood.
The study identified various antimicrobial resistance genes including ermA, ermB, ermC, mphC, vanA, vanB, tetA, and tetM in Enterococcus species isolated from ready-to-eat seafood, indicating the presence of multidrug-resistant strains.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Emerging erm(B)-Mediated Macrolide Resistance Associated with Novel Multidrug Resistance Genomic Islands in Campylobacter.
The study identified the emergence of erm(B)-mediated macrolide resistance in Campylobacter, associated with novel multidrug resistance genomic islands (MDRGIs). Three novel MDRGI types were identified, and erm(B) was found to be linked with resistance to multiple antibiotics, including aminoglycosides, tetracyclines, and fluoroquinolones.
High-Level Macrolide Resistance Due to the Mega Element [mef(E)/mel] in Streptococcus pneumoniae.
The study identifies the Mega element [mef(E)/mel] as a cause of high-level macrolide resistance in Streptococcus pneumoniae. Deletion of mef(E)/mel eliminated macrolide resistance, demonstrating its role in resistance.
A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.
The study identified several AMR genes and mutations in C. difficile ST1 isolates from northern Arizona, including cdeA, tetM, ermB, dfrF, and vanG, along with the gyrA Thr82Ile mutation associated with fluoroquinolone resistance.
FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences.
FLASH-NGS was developed for the detection of antimicrobial resistance genes and mutations in clinical samples, demonstrating high sensitivity and specificity for various pathogens including Staphylococcus aureus, Enterococcus faecium, and Plasmodium falciparum.
Emergence of multidrug resistance and extensive drug resistance among enterococcal clinical isolates in Egypt.
The study identified several AMR genes in enterococcal isolates, including aac(6')-Ie-aph(2'')-Ia, ant(6')-Ia, ermB, msrA/B, tetK, tetL, tetM, vanB, vanC1, and optrA, which confer resistance to various antibiotics such as gentamicin, streptomycin, macrolides, lincosamides, tetracyclines, vancomycin, and linezolid.
Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system.
The study generated a fully erythromycin-sensitive strain of Clostridioides difficile by removing both ermB genes using CRISPR-Cas9 genome editing.
Eukaryotic cell culture media affect macrolide minimum inhibitory concentrations but not resistance interpretation for foodborne pathogens.
The study shows that the growth medium affects macrolide MICs but not resistance interpretation for foodborne pathogens. It highlights the role of mphA and ermB genes in macrolide resistance.
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland.
The study identifies multiple AMR genes in Scottish vancomycin-resistant Enterococcus faecium (VREfm) isolates, including aac(6')-Ii, aac(6')-aph(2''), ermB, pbp5-R, vanA, ant(9)-Ia, tetL, and dfrG. These genes confer resistance to various antibiotics, highlighting the multidrug-resistant nature of the isolates.
Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries.
The study identified several antimicrobial resistance genes associated with antimicrobial use on broiler farms, including bla TEM, erm (B), tet (W), aadA cluster, cmx, and dfrA1.
Establishing Antimicrobial Resistance Surveillance & Research Network in India: Journey so far.
The study characterizes various AMR genes and mutations in different bacterial pathogens, highlighting the prevalence of resistance to multiple antibiotics, including beta-lactams, fluoroquinolones, and aminoglycosides. Key findings include the widespread presence of bla OXA-48, bla TEM, and qnrS1 in Enterobacteriaceae, and mecA, mupA, cfr, and ermC in Staphylococcus aureus.
Heterogeneity of macrolide-lincosamide-streptogramin phenotype & conjugal transfer of erm(B) in Pediococcus pentosaceus.
The study identified the erm(B) and msr(C) genes in Pediococcus pentosaceus isolates, which confer resistance to macrolide-lincosamide-streptogramin B antibiotics. The erm(B) gene was successfully transferred to Enterococcus faecalis via conjugation.
Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan.
The study identified the presence of ermB, mefE, and tetM genes in meropenem-resistant Streptococcus pneumoniae serotype 19A-CC3111 strains in Japan, contributing to erythromycin and tetracycline resistance.
Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets.
Early life antimicrobial interventions, specifically procaine penicillin G (PPG) and tulathromycin (TUL), significantly increased the relative abundance of ermB and tetW in piglets, suggesting a promotion of antimicrobial resistance genes in the gut microbiota.
Detection of Antibiotic Resistance and Classical Enterotoxin Genes in Coagulase-negative Staphylococci Isolated from Poultry in Poland.
The study identified several AMR genes in coagulase-negative Staphylococcus (CNS) isolates from poultry in Poland, including blaZ, mecA, tetK, tetL, ermA, ermB, aac(6')-Ie-aph(2'')-Ia, msrA/B, and cfr. These genes conferred resistance to various antibiotics such as beta-lactams, methicillin, tetracyclines, macrolides, lincosamides, streptogramin B, aminoglycosides, phenicols, oxazolidinones, pleuromutilins, and streptogramin A.
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina.
The study identified various AMR genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates from Argentina, including mecA, blaZ, ermB, dfrG, aph(3')-III, ant(6)-Ia, tetM, and aac(6')-Ie-aph(2')-Ia. Mutations in gyrA (S84L) and grlA (S80I) were associated with ciprofloxacin resistance.
Erythromycin-resistant lactic acid bacteria in the healthy gut of vegans, ovo-lacto vegetarians and omnivores.
The study identified the erm(B) gene as a key determinant of erythromycin resistance in lactic acid bacteria isolated from the guts of vegans, ovo-lacto vegetarians, and omnivores.
Characteristics of methicillin-resistant Staphylococcus aureus from broiler farms in Germany are rather lineage- than source-specific.
The study identified multiple AMR genes in MRSA isolates from German broiler farms, including tet(K), tet(L), tet(M), erm(B), vga(A), dfrK, spc, and cat(pC221), which confer resistance to tetracycline, MLS B antibiotics, tiamulin, trimethoprim, spectinomycin, and chloramphenicol, respectively.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
Pneumococcal carriage among children under five in Accra, Ghana, five years after the introduction of pneumococcal conjugate vaccine.
The study identified the presence of the tet(M) and ermB genes in Streptococcus pneumoniae isolates, which confer resistance to tetracycline and erythromycin, respectively.
Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant.
The study analyzed the effectiveness of ultrafiltration and ozone treatment in reducing antibiotic resistance genes (ARGs) and facultative pathogenic bacteria in wastewater. It identified several ARGs, including sul1, blaTEM, tetM, CTX-M, CTX-M-32, blaOXA-48, blaVIM, CMY-2, vanA, mcr-1, blaNDM, ermB, and intl1, which were found to be prevalent in the wastewater. Both ultrafiltration units showed significant reduction in these ARGs and pathogenic bacteria, whereas ozone treatment was less effective.
Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.
The study characterizes the AMR genes and mutations in Streptococcus gallolyticus subsp. pasteurianus isolates from China, identifying erm(B), erm(A), erm(T), mef(A/E), tet(L), tet(O), and tet(M) as major contributors to erythromycin, clindamycin, and tetracycline resistance.
Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci.
The study demonstrates the use of CRISPR-Cas9 delivered via conjugative plasmids to selectively deplete antibiotic resistance genes, specifically ermB and tetM, from Enterococcus faecalis populations in vitro and in vivo.
Prevalence of Various Vaccine Candidate Proteins in Clinical Isolates of Streptococcus pneumoniae: Characterization of the Novel Pht Fusion Proteins PhtA/B and PhtA/D.
The study identified the prevalence of various vaccine candidate proteins in clinical isolates of Streptococcus pneumoniae, including the novel Pht fusion proteins PhtA/B and PhtA/D. It also characterized resistance mechanisms such as erm(B), mef(A/E), tet(M), and mutations in pbp1a, pbp2x, and pbp2b contributing to macrolide, tetracycline, and penicillin resistance.
The fecal resistome of dairy cattle is associated with diet during nursing.
The study identified various antimicrobial resistance genes (ARGs) in the fecal microbiota of dairy calves, highlighting the association between diet and the resistome. Key genes include ermB, lnuC, mefA, tet32, tet40, tetO, tetQ, tetW, and optrA, which confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines, as well as oxazolidinones and phenicols.
Spatiotemporal dynamics of multidrug resistant bacteria on intensive care unit surfaces.
The study identified various AMR genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, erm(B), vanA, msr(C), fosA, oqxA, aph(3')-lb, bla PAO, bla OXA-50, catB7, and bla GES-5, in multidrug-resistant bacteria isolated from ICU surfaces in Pakistan and the USA.
Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains.
The study identified multiple antimicrobial resistance genes in Elizabethkingia meningoseptica strains, including beta-lactamases, tetracycline resistance genes, and efflux pumps, indicating a multidrug-resistant profile.
Azithromycin non-susceptible Shigella circulating in Israel, 2014-2016.
The study identified the presence of macrolide resistance genes mph(A) and erm(B) in azithromycin non-susceptible Shigella strains in Israel, highlighting the need for establishing clinical breakpoints for azithromycin susceptibility testing.
Evolution of Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated from Healthy Turkeys in Egypt: First Report of Linezolid Resistance.
This study identified the first report of linezolid resistance in coagulase-negative staphylococci (CoNS) isolated from healthy turkeys in Egypt. The study found that 79.5% of the isolates were resistant to linezolid, and the resistance was associated with the presence of the cfr, optrA, and valS genes. The study also found high levels of resistance to other antibiotics, including erythromycin, chloramphenicol, oxacillin, daptomycin, and tigecycline.
Prevalence of Multidrug-Resistant Enterococcus faecalis in Hospital-Acquired Surgical Wound Infections and Bacteremia: Concomitant Analysis of Antimicrobial Resistance Genes.
The study identified ere(B) and erm(B) genes as primary mediators of erythromycin resistance, and vanA as the main determinant of vancomycin resistance in multidrug-resistant Enterococcus faecalis isolates from hospital-acquired infections.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Genotypic diversity of Streptococcus suis and the S. suis -like bacterium Streptococcus ruminantium in ruminants.
The study identified several antibiotic resistance genes in Streptococcus ruminantium isolates, including genes conferring resistance to tetracycline, streptomycin, erythromycin, kanamycin, and chloramphenicol. These genes were located in genomic islands and showed similarities to integrative conjugative elements.
Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus.
The study identifies specific AMR genes such as tet(M), erm(B), mef(A), msr(D), tet(O), erm(A), ant(6)-Ia, aph(3')-III, and erm(T) associated with resistance to tetracycline, erythromycin, clindamycin, and aminoglycosides in group A Streptococcus (GAS) strains. These genes are linked to high-frequency resistance in certain emm types, particularly emm11, emm75, emm77, and emm92, which are overrepresented in invasive GAS infections.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Cigarette smoke exposure induces expression of the pneumococcal erm(B) macrolide resistance gene.
Exposure to cigarette smoke condensate (CSC) increases expression of the erm(B) macrolide resistance gene in Streptococcus pneumoniae, suggesting a potential mechanism by which smoking could impair the efficacy of macrolide-based antimicrobial therapy.
High prevalence of group B streptococcus ST17 hypervirulent clone among non-pregnant patients from a Hungarian venereology clinic.
The study identified high levels of macrolide and clindamycin resistance in Streptococcus agalactiae isolates from non-pregnant patients in Hungary, with the presence of ermB, ermTR, mef, and linB genes contributing to resistance. The ST-17 hypervirulent clone was prevalent among the isolates.
Emerging Variants of the Integrative and Conjugant Element ICEMh1 in Livestock Pathogens: Structural Insights, Potential Host Range, and Implications for Bacterial Fitness and Antimicrobial Therapy.
The study identified multiple antimicrobial resistance genes within the ICE Mh1 PM22, including aminoglycoside, sulfonamide, macrolide, and tetracycline resistance genes. These genes contribute to multidrug resistance in livestock pathogens.
Novel Multidrug-Resistant Enterococcal Mobile Linear Plasmid pELF1 Encoding vanA and vanM Gene Clusters From a Japanese Vancomycin-Resistant Enterococci Isolate.
The study identifies a novel multidrug-resistant enterococcal mobile linear plasmid pELF1 that encodes vanA and vanM gene clusters, conferring resistance to vancomycin, as well as other antibiotics such as streptomycin, streptothricin, kanamycin, and erythromycin.
Identification and characterization of Shigella with decreased susceptibility to azithromycin in the United States, 2005 to 2014.
The study identified Shigella isolates with decreased susceptibility to azithromycin, primarily due to the presence of mphA and ermB genes on plasmids, and also noted mutations in rrlH, rplD, and rplV genes in one isolate.
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Genomic Diversity and Antimicrobial Resistance of Escherichia coli Isolated from Soils and Feces in Rural Bangladesh
The study identified the presence of antimicrobial resistance genes such as mph(A) and ermB in E. coli isolates from soils and feces in rural Bangladesh, contributing to azithromycin resistance.
Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain.
The study identifies a clindamycin-resistant Clostridioides difficile strain (DQ/RT591) that is closely related to the fluoroquinolone-resistant epidemic BI/RT027 strain. The strain was found to harbor a variant ermB gene, which is known to confer clindamycin resistance.
Safety profiles of beneficial lactic acid bacteria isolated from dairy systems.
The study identified several AMR genes in lactic acid bacteria isolated from dairy systems, including vanC2, vanA, ermB, aac(6′)-Ie-aph(2″)-Ia, tet(S), ant(4′)-Ia, tdc, cpd, int, mur-2ed, asa1, ccf, and hyl. These genes conferred resistance to various antibiotics such as vancomycin, gentamicin, tetracycline, and chloramphenicol.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Resistance to change: AMR gene dynamics on a commercial pig farm with high antimicrobial usage.
The study identified multiple AMR genes, including tetB, tetQ, ermA, ermB, and dfrA1, which were associated with tetracycline, macrolide, and trimethoprim resistance in porcine fecal samples. These genes were found to be prevalent and diverse, with no significant changes in their abundance despite antimicrobial treatments.
High-Level Resistance of Toxigenic Clostridioides difficile Genotype to Macrolide-Lincosamide-Streptogramin B in Community Acquired Patients in Eastern China.
The study identifies the ermB gene as a key determinant of high-level resistance to erythromycin and clindamycin in toxigenic Clostridioides difficile isolates from community-acquired infections in Eastern China.
Characterization of the First mecA-Positive Multidrug-Resistant Staphylococcus pseudintermedius Isolated from an Argentinian Patient.
The study characterizes the first mecA-positive multidrug-resistant Staphylococcus pseudintermedius isolate from an Argentinean patient, identifying several AMR genes and mutations associated with resistance to multiple antibiotics.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt.
The study identified multiple drug-resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt, highlighting the prevalence of various antimicrobial resistance genes such as TEM-220, NDM-11, aph(6)-Id, sul2, and others, indicating a significant threat to immunocompromised patients.
Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico.
Investigation of a Reduction in Tylosin on the Prevalence of Liver Abscesses and Antimicrobial Resistance in Enterococci in Feedlot Cattle.
The study identified several AMR genes in enterococci isolated from feedlot cattle, including erm(B), msr(C), tet(L), tet(M), and tet(O), which confer resistance to macrolides and tetracyclines.
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain(23F)-ST81, Taiwan.
The study identifies pbp2b, pbp2x, and pbp1a as key genes contributing to meropenem resistance in Streptococcus pneumoniae, along with ermB, tetM, and cat as resistance genes. Mutations in PBP2b, PBP2x, and PBP1a were linked to increased meropenem resistance.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Point Deletion or Insertion in CmeR-Box, A2075G Substitution in 23S rRNA, and Presence of erm(B) Are Key Factors of Erythromycin Resistance in Campylobacter jejuni and Campylobacter coli Isolated From Central China.
Next-Generation Sequencing and MALDI Mass Spectrometry in the Study of Multiresistant Processed Meat Vancomycin-Resistant Enterococci (VRE).
The study identified multiple AMR genes in vancomycin-resistant enterococci (VRE) isolated from processed meat, including vanA, vanC1, erm(B), aac(6')-Ii, aadE, ant(9)-Ia, lsa(E), msr(C), lnu(B), tet(M)+tet(L), dfrG, dfrK, adeC, and efmA, which confer resistance to various antibiotics such as vancomycin, erythromycin, tetracycline, aminoglycosides, and trimethoprim.
Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile.
The study identified ermB, tetM, and tetW genes as the primary determinants of clindamycin, tetracycline, and moxifloxacin resistance in C. difficile isolates. Mutations in GyrA (Thr82→Ile) and GyrB (Asp426→Asn) were linked to moxifloxacin resistance.
emm Types and clusters and macrolide resistance of pediatric group A streptococcal isolates in Central Greece during 2011-2017.
The study identified macrolide resistance genes erm(B), erm(TR), and mef(A) in Streptococcus pyogenes isolates from Central Greece, with erm(B) and erm(TR) being the primary drivers of resistance.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
The study identified several AMR genes in Staphylococcus aureus isolates from goat mastitis, including blaZ, ermA, ermB, mecA, tetK, tetM, norA, norC, and lmrS. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, methicillin, tetracycline, and fluoroquinolones.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Antibiotic Resistance Is Associated with Integrative and Conjugative Elements and Genomic Islands in Naturally Circulating Streptococcus pneumoniae Isolates from Adults in Liverpool, UK.
The study identifies tetracycline and macrolide resistance genes, including tet(M), erm(B), tet(32), mef(A), and msr(D), located on mobile genetic elements in naturally circulating Streptococcus pneumoniae isolates.
Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran.
The study identified the presence of ermB, mefA/E, and tetM genes in invasive Streptococcus pneumoniae isolates, which contribute to resistance against erythromycin and tetracycline.
Antibiotic Susceptibility Patterns and Prevalence of Streptococcus Agalactiae Rectovaginal Colonization Among Pregnant Women in Iran.
The study identified the ermB gene in 35.29% of erythromycin-nonsusceptible Streptococcus agalactiae isolates, while the mefA gene was not detected in any isolates.
Plausible Minimal Substrate for Erm Protein.
The study identifies the minimal RNA substrate required for methylation by Erm proteins, highlighting the importance of specific nucleotide sequences and structural motifs in the 23S rRNA for resistance to macrolides, lincosamides, and streptogramin B.
Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among Enterococcus species From Yaks in Aba Tibetan Autonomous Prefecture, China.
The study identified multiple antimicrobial resistance (AMR) genes in Enterococcus species isolated from yaks, including ermA, ermB, tetA, tetB, tetM, tetL, cat, optrA, and poxtA. These genes conferred resistance to various antibiotics such as erythromycin, tetracycline, chloramphenicol, and linezolid. Additionally, a high prevalence of multidrug-resistant (MDR) Enterococcus strains was observed.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
Molecular epidemiology and antimicrobial resistance of group a streptococcus recovered from patients in Beijing, China.
The study identified ermB and mefA as the primary genes responsible for erythromycin resistance in GAS isolates from Beijing, China.
Isolation and Comparative Genomic Analysis of Reuterin-Producing Lactobacillus reuteri From the Chicken Gastrointestinal Tract.
The study identified ermB and tetW genes in L. reuteri strains from chicken GIT, which confer resistance to erythromycin and tetracycline, respectively. These genes were validated through PCR and sequencing.
Occurrence, Virulence and Antimicrobial Resistance-Associated Markers in Campylobacter Species Isolated from Retail Fresh Milk and Water Samples in Two District Municipalities in the Eastern Cape Province, South Africa.
The study identified several antimicrobial resistance genes in Campylobacter species isolated from retail fresh milk and water samples, including catII, tetA, tetB, tetM, ermB, gyrA, ampC, and aac(3)-IIa-(aacC2). These genes were associated with resistance to chloramphenicol, tetracycline, erythromycin, gentamicin, and ampicillin.
Multidrug-Resistant Streptococcus agalactiae Strains Found in Human and Fish with High Penicillin and Cefotaxime Non-Susceptibilities.
The study identifies multidrug-resistant Streptococcus agalactiae strains with high penicillin and cefotaxime non-susceptibilities, highlighting the emergence of MDR and PEN-NS GBS in both human and aquatic environments.
Whole genome sequencing of macrolide resistant Streptococcus pneumoniae serotype 19A sequence type 416.
The study identified the presence of erm(B) and tet(M) genes in macrolide-resistant Streptococcus pneumoniae serotype 19A sequence type 416 isolates, contributing to resistance against erythromycin, clindamycin, and tetracycline.
Molecular subtyping and antimicrobial susceptibility of Streptococcus dysgalactiae subspecies equisimilis isolates from clinically diseased pigs.
The study identified macrolide resistance genes erm(B) and mef(A/E), tetracycline resistance genes tet(M) and tet(O), and two mutations in parC associated with fluoroquinolone resistance in SDSE isolates from pigs.
Drug Resistance Determinants in Clinical Isolates of Enterococcus faecalis in Bangladesh: Identification of Oxazolidinone Resistance Gene optrA in ST59 and ST902 Lineages.
The study identified the oxazolidinone resistance gene optrA in Enterococcus faecalis isolates from Bangladesh, along with other resistance genes such as erm(B), aac(6')-Ie-aph(2'')-Ia, tet(M), and tet(L). Mutations in gyrA and parC were associated with levofloxacin resistance.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration.
The study identifies ermF, intI1, and mphA as genes that show positive selection under specific antibiotic concentrations, highlighting their role in antibiotic resistance development at low concentrations.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Outbreak of multi-drug-resistant (MDR) Shigella flexneri in northern Australia due to an endemic regional clone acquiring an IncFII plasmid.
The study identifies several AMR genes in a multi-drug-resistant Shigella flexneri strain, including bla DHA, bla OXA-1, tet(B), catA1, dfrA1, mph(A), ermB, qnrB, aadA, and qacEΔ1, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, trimethoprim, macrolides, quinolones, aminoglycosides, and quaternary ammonium compounds.
Farming Practices Influence Antibiotic Resistance and Biogenic Amine Capacity of Staphylococci from Bulk Tank Ewe's Milk.
The study identified tetracycline resistance gene tetM, erythromycin resistance genes ermB and ermC, and ciprofloxacin resistance gene grlA in staphylococci from bulk tank ewe's milk. These genes were experimentally validated through PCR and phenotypic assays.
Genotyping and molecular characterization of antimicrobial resistance in thermophilic Campylobacter isolated from poultry breeders and their progeny in Eastern Spain.
The study identified qnrS, blaTEM, tetC, and ermB genes associated with resistance to quinolones, beta-lactams, tetracyclines, and macrolides in Campylobacter isolates from poultry breeders and their progeny.
Streptococcus agalactiae: Identification methods, antimicrobial susceptibility, and resistance genes in pregnant women.
The study identified resistance genes ermB, mefA, and ermTR in erythromycin and/or clindamycin-resistant Streptococcus agalactiae strains from pregnant women in Brazil.
The Role of Urban Wastewater in the Environmental Transmission of Antimicrobial Resistance: The Current Situation in Italy (2010-2019).
The study identified several AMR genes in urban wastewater treatment plants in Italy, including bla TEM-1, bla AmpC, bla CTX-M-15, bla KPC-3, bla SHV-1, tet A, sul II, erm B, qnr S, int I1, aad A2, dfr 17, aadA 5, aadA 10, sat 1, bla TEM, bla OXA, bla CTX, bla KPC, and tet W. These genes confer resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, macrolides, fluoroquinolones, and aminoglycosides.
Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes.
The study shows that early inoculation of microbial suspensions affects the transmission of maternal microbiota and the associated antibiotic resistance genes (ARGs) in piglets. Specific ARGs such as aadE_2, aphA3, ermB, lnuB, vanTG, tetQ, tnpA, mpmB, lnuC, and tetW were found to be influenced by the inoculation of microbial suspensions S1 and S2.
Characterization of Pneumococcal Colonization Dynamics and Antimicrobial Resistance Using Shotgun Metagenomic Sequencing in Intensively Sampled South African Infants.
The study identified AMR genes such as msrD, mefA, ermB, and tetM, along with mutations in pbp1a (S351A), pbp2x (H394L), folA (I100L), and folP (6-bp insertion) associated with resistance to erythromycin, penicillin, and cotrimoxazole in Streptococcus pneumoniae.
Clinical characteristics and molecular epidemiology of invasive Streptococcus agalactiae infections between 2007 and 2016 in Nara, Japan.
The study identified macrolide resistance genes ermA, ermB, and mefA, as well as quinolone resistance mutations in gyrA and parC in Streptococcus agalactiae isolates.
Antimicrobial Resistance of Coagulase-Positive Staphylococcus Isolates Recovered in a Veterinary University Hospital.
The study identified various antimicrobial resistance genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates, including blaZ, erm(B), erm(C), aph(3'), ant(6), aad(6), SAT-4, cat(pc221), dfr(G), tet(K), and tet(M). These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, trimethoprim, and tetracycline.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Antibiotic Resistance Profiles and Molecular Mechanisms of Campylobacter From Chicken and Pig in China.
The study identified the gyrA C257T mutation, tetO gene, and ermB gene as key contributors to fluoroquinolone, tetracycline, and macrolide resistance in Campylobacter isolates from chickens and pigs in China.
Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.
The study identified tetracycline resistance genes tetM, tetL, and tetO, macrolide/lincosamide resistance genes ermTR, ermB, and lnu, and aminoglycoside resistance gene aac(6')-Ib in Streptococcus agalactiae isolates. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
A Possible Role of Insertion Sequence IS1216V in Dissemination of Multidrug-Resistant Elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus.
The study identifies the role of insertion sequence IS1216V in the dissemination of multidrug-resistant elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus, highlighting the contribution of IS1216V in mediating the transfer of resistance genes such as ermB, aph(3')-IIIa, aadE, aacA-aphD, and cat.
Multidrug-resistant Escherichia coli and Salmonella spp. isolated from pigeons.
The study identified multidrug-resistant Escherichia coli and Salmonella spp. from pigeons, highlighting resistance to several antibiotics including ampicillin, amoxicillin, gentamicin, tetracycline, erythromycin, and azithromycin.
Prevalence of antimicrobial-resistant staphylococci in nares and affected sites of pet dogs with superficial pyoderma.
The study identified several antimicrobial resistance genes including aacA-aphD, tetM, ermB, and lnuA in Staphylococcus pseudintermedius, Staphylococcus schleiferi, and Staphylococcus aureus isolated from pet dogs with superficial pyoderma. These genes conferred resistance to gentamicin, tetracycline, erythromycin, and lincomycin.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Multidrug Resistance in Enterococci Isolated From Wild Pampas Foxes (Lycalopex gymnocercus) and Geoffroy's Cats (Leopardus geoffroyi) in the Brazilian Pampa Biome.
The study identified multidrug-resistant Enterococcus strains in wild Pampas foxes and Geoffroy's cats, with resistance genes ermB, msrC, tetL, and tetM detected in erythromycin and tetracycline-resistant isolates.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Molecular characterisation of extended-spectrum ß-lactamase producing Escherichia coli in wild birds and cattle, Ibadan, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli from wild birds and cattle in Nigeria, including bla CTX-M1/15, bla CTX-M9, strB, sul2, tetA, and others. These genes were associated with resistance to multiple antibiotics, highlighting the potential for inter-species transmission of AMR bacteria.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
Research Note: Antimicrobial resistance of Campylobacter species isolated from chickens near Ulaanbaatar city, Mongolia.
The study identified tetracycline resistance mediated by the tet(O) gene and erythromycin resistance via the erm(B) gene and a nucleotide substitution at nt 2,075 of 23S rDNA in Campylobacter isolates from Mongolian chickens. Fluoroquinolone resistance was linked to a single-nucleotide substitution at codon 86 of the gyrA gene.
Occurrence of Antibiotic Resistance Genes in Hermetia illucens Larvae Fed Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae.
The study identified several tetracycline resistance genes (tet(M), tet(S), tet(K)), erythromycin resistance genes (erm(B), erm(C)), a methicillin resistance gene (mecA), and an aminoglycoside resistance gene (aac(6')-Ib) in Hermetia illucens larvae and frass. The presence of these genes suggests potential safety concerns regarding the reuse of frass in agriculture.
Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.
The paper discusses the major determinants of virulence and antibiotic resistance in ESKAPE pathogens, focusing on genes such as vanA, poxtA, blaZ, mecA, blaKPC-2, blaKPC-3, armA, aacA4, aadA1, acrAB, blaCTX-M, blaGES, blaPER, blaSHV, blaTEM, blaVEB, aac(3')-Ia, ant(2’)-Ia, tetA, tetB, gyrA, parC, pmrC, pmrA, and pmrB, which are associated with resistance to various antibiotics.
Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
The study identified multiple AMR genes and mutations in pneumococcal strains from Myanmar, including genes conferring resistance to azithromycin, tetracycline, chloramphenicol, and quinolones, as well as mutations in penicillin-binding proteins and DNA gyrase. These findings highlight the spread of AMR in pneumococcal strains in Myanmar.
Predominance of III/ST19 and Ib/ST10 Lineages With High Multidrug Resistance in Fluoroquinolone-Resistant Group B Streptococci Isolates in Which a New Integrative and Conjugative Element Was Identified.
The study identifies mutations in gyrA and parC genes contributing to fluoroquinolone resistance in Group B Streptococcus (GBS) isolates, along with the presence of resistance genes tetM, ermB, and lnuB. A new integrative and conjugative element (ICE) carrying tetM and gyrA was also identified.
SWINE VIRULENCE ASSESSMENT
This study analyzed the virulence and genomic characteristics of nine United States Streptococcus suis isolates, identifying genomic attributes associated with swine-virulent phenotypes. However, no specific AMR genes or mutations were experimentally validated in this paper.
Implanted Port Catheter System Infection Caused by Methicillin-resistant Staphylococcus pseudintermedius ST71-SCCmec type III.
The study reports a case of implanted port catheter system infection caused by methicillin-resistant Staphylococcus pseudintermedius ST71-SCC mec III, identifying several AMR genes and mutations including aac(6')-aph(2''), ant(6')-Ia, aph(3')-III, sat4A, mecA, blaZ, erm(B), dfrG, GyrA Ser84Leu, and GrlA Ser80Ile.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Antimicrobial Resistance in Porcine Enterococci in Australia and the Ramifications for Human Health.
The study identified antimicrobial resistance genes such as aac(6')-li, ermB, msrC, and vanC in porcine Enterococcus faecium isolates, highlighting the presence of resistance to aminoglycosides, macrolides, streptogramins, and glycopeptides.
The Emergence of Invasive Streptococcus pneumoniae Serotype 24F in Lebanon: Complete Genome Sequencing Reveals High Virulence and Antimicrobial Resistance Characteristics.
The study identified the presence of ermB and tet(M) genes in Streptococcus pneumoniae serotype 24F isolates, which confer resistance to erythromycin, clindamycin, and tetracycline.
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
The study identifies several antimicrobial resistance genes in old Enterococcus faecalis isolates, including tet(L), cat, erm(B), aac(6')-aph(2''), aadD, drfC, and ble, demonstrating the early emergence of antimicrobial resistance traits in this species.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks.
The study identified AMR genes such as tet(W), erm(B), and mph(A) in probiotic isolates, highlighting potential health risks associated with these products.
Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci.
The study identified Tn916-Tn1545 family elements in oral streptococci, including novel variants Tn6815 and Tn6816, which carry the tetracycline resistance gene tet(M).
A Comparative Analysis of Aquatic and Polyethylene-Associated Antibiotic-Resistant Microbiota in the Mediterranean Sea.
The study found that polyethylene (PE) waste samples from both seawater and freshwater contained a higher number of antibiotic resistance genes (ARGs) compared to the corresponding water samples, highlighting the role of PE as a carrier of ARGs in the marine environment.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Molecular Characterization of Enterococcus Isolates From Different Sources in Estonia Reveals Potential Transmission of Resistance Genes Among Different Reservoirs.
The study identified vanB genes in two vancomycin-resistant E. faecalis isolates and characterized various tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in E. faecalis and E. faecium isolates from different sources in Estonia.
Molecular Identification of Invasive Non-typeable Group B Streptococcus Isolates From Denmark (2015 to 2017).
The study identified several AMR genes associated with erythromycin and clindamycin resistance in invasive non-typeable Group B Streptococcus isolates from Denmark, including mre(A), erm(B), erm(A), mef(A), msr(D), and Isa(C).
Isolation and detection of antibiotics resistance genes of Escherichia coli from broiler farms in Sukabumi, Indonesia.
The study identified four antibiotic resistance genes in Escherichia coli isolates from broiler farms in Sukabumi, Indonesia: tetA, blaTEM, gyrA, and ermB. These genes conferred resistance to tetracycline, oxytetracycline, ampicillin, nalidixic acid, ciprofloxacin, enrofloxacin, and erythromycin.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2018/2019.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, including high resistance levels to ampicillin, tetracyclines, and fluoroquinolones in Salmonella and Campylobacter isolates. It also notes the emergence of resistance to third-generation cephalosporins and carbapenems, along with the detection of linezolid-resistant strains harboring the cfr gene in fattening pigs.
Do Long-Term Conservation Pasture Management Practices Influence Microbial Diversity and Antimicrobial Resistant Genes in Runoff?
The study investigated the impact of long-term conservation pasture management on microbial diversity and antimicrobial resistant genes (AMR) in runoff. It found that while certain AMR genes (ermB, sulI, intlI) were present in agricultural samples, there was no significant impact of pasture management on their abundance. The blaCTX-M gene was not detected in any surface water samples.
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains.
The study characterizes two XDR Acinetobacter baumannii isolates, NFAb-1 and NFAb-2, obtained from a fatal necrotizing fasciitis case. These isolates exhibit resistance to multiple antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and others, indicating the presence of various AMR genes such as blaOXA-51-like, blaOXA-23-like, blaOXA-58-like, blaADC, blaNDM, blaKPC, aac(6')-Ib, aadA, ant(3'')-Ia, mph(A), erm(B), tet(A), tet(G), qnrS1, mexAB-oprM, acrAB-tolC, oqxAB, cat, cfr, and optrA.
From the Farms to the Dining Table: The Distribution and Molecular Characteristics of Antibiotic-Resistant Enterococcus spp. in Intensive Pig Farming in South Africa.
The study identified tetracycline, erythromycin, streptomycin, and gentamicin resistance genes in Enterococcus spp. isolated from intensive pig farming in South Africa, highlighting the presence of multidrug-resistant strains and the potential for transmission to humans.
Characterization of methicillin-resistant Staphylococcus pseudintermedius isolates from Australian animals: discovery of novel sequence types
The study identified several AMR genes in MRSP isolates, including blaZ, mecA, cat-pC221, ermB, ermC, tetM, dfrG, aac6-aph2, ant6-Ia, aph3-III, and aadD, which confer resistance to various antibiotics such as oxacillin, penicillin, chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim, and gentamicin.
Azithromycin and Ciprofloxacin Treatment Outcomes During an Outbreak of Multidrug-Resistant Shigella sonnei Infections in a Retirement Community-Vermont, 2018.
The study identified macrolide resistance genes mph(A) and erm(B) in multidrug-resistant Shigella sonnei isolates, which conferred resistance to azithromycin. Additionally, a gyrA S83L mutation was found, contributing to decreased susceptibility to ciprofloxacin despite being classified as susceptible by CLSI criteria.
Antimicrobial Resistance Genes in Bacteria Isolated From Japanese Honey, and Their Potential for Conferring Macrolide and Lincosamide Resistance in the American Foulbrood Pathogen Paenibacillus larvae.
The study identified the ermC gene on the plasmid pJ18TS1mac and the lsaB and oleC genes on an integrative conjugative element (ICE) in honey-derived bacteria, which conferred resistance to tylosin and lincomycin in Paenibacillus larvae. Additionally, the ermL and ermB genes on plasmid pJ45TS6 were found to contribute to macrolide resistance.
Multidrug Resistance and Molecular Characterization of Streptococcus agalactiae Isolates From Dairy Cattle With Mastitis.
The study identified several AMR genes in S. agalactiae isolates from dairy cattle with mastitis, including tet(O), ermB, lnu(B), and aphA3, which confer resistance to tetracycline, erythromycin, clindamycin, pirlimycin, and kanamycin.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Evaluation of Metagenomic-Enabled Antibiotic Resistance Surveillance at a Conventional Wastewater Treatment Plant.
The study evaluated the resistome in a conventional wastewater treatment plant, identifying several antibiotic resistance genes (ARGs) such as bla OXA-210, bla OXA-212, bla OXA-309, bla OXA-333, qnr S2, sul 1, sul 2, erm B, aac (6′)-Ib7, aac (6′)-Ib8, mph D, msr E, ade J, ade K, mex K, mtr A, sme R, oqx B, qac H, and others. These genes were found to confer resistance to various antibiotics, highlighting the importance of monitoring ARGs in wastewater treatment processes.
Emergence of Invasive Serotype Ib Sequence Type 10 Group B Streptococcus Disease in Chinese Infants Is Driven by a Tetracycline-Sensitive Clone.
The study identifies the emergence of invasive serotype Ib sequence type 10 Group B Streptococcus (GBS) disease in Chinese infants, highlighting the presence of multiple resistance mechanisms including ermB, mefA, lnuB, tetM, and tetO genes, along with fluoroquinolone resistance mediated by mutations in gyrA and parC.
A Peek into the Plasmidome of Global Sewage
The study identifies several antimicrobial resistance (AMR) genes in plasmidomes from global sewage samples, highlighting the prevalence of macrolide, lincosamide, streptogramin B, and quinolone resistance genes on plasmids.
Phenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal.
The study identifies the presence of blaZ, mecA, and erm(B) genes in Staphylococcus coagulans isolates, along with various mutations in grlA and gyrA that contribute to fluoroquinolone resistance.
Mitigating Antibiotic Resistance Genes in Wastewater by Sequential Treatment with Novel Nanomaterials.
The study demonstrates the effectiveness of novel nanomaterials in reducing antibiotic resistance genes (ARGs) in wastewater, including bla CTXM, erm B, qnr S, sul 1, tet O, mec A, van A, and intI 1.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.
The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.
Predicting Antimicrobial Resistance Using Partial Genome Alignments.
The study identifies chromosomal regions and genes associated with antimicrobial resistance using machine learning models trained on partial genome alignments.
Whole-Genome Analysis of Streptococcus pneumoniae Serotype 4 Causing Outbreak of Invasive Pneumococcal Disease, Alberta, Canada.
The study identified antimicrobial resistance determinants in 7 out of 190 S. pneumoniae serotype 4 isolates, including a single ParC D83 aa substitution, ermB and tetM determinants, folA I100L, and folP amino acid insertion.
Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow's Milk in Kenya.
The study identified several antimicrobial resistance genes in staphylococci isolated from mastitic cow's milk in Kenya, including blaZ, strB, msrA, ermB, tetM, and tetK, which confer resistance to beta-lactams, streptomycin, erythromycin, and tetracycline.
Highly Prevalent Multidrug-Resistant Campylobacter spp. Isolated From a Yellow-Feathered Broiler Slaughterhouse in South China.
The study identified multiple AMR genes and mutations in Campylobacter spp. isolated from a yellow-feathered broiler slaughterhouse, highlighting high levels of multidrug resistance.
Antimicrobial Resistance Profiles of Coagulase-Negative Staphylococci in Community-Based Healthy Individuals in Germany.
The study identified several AMR genes in commensal CoNS from healthy individuals in Germany, including mecA, tetK/L, tetM, ermA, ermC, ermB, fusB, fusC, aac(6')/aph(2"), cat194, fexB, and spc. These genes were associated with resistance to methicillin, tetracycline, erythromycin, fusidic acid, gentamicin, chloramphenicol, florfenicol, and spectinomycin.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Antimicrobial Susceptibility of Lactic Acid Bacteria Strains of Potential Use as Feed Additives - The Basic Safety and Usefulness Criterion.
The study identified several AMR genes in LAB strains, including aph(3")-IIIa, erm(B), lnu(A), msr(C), tet(K), and tet(M), which confer resistance to aminoglycosides, macrolides, lincomycins, and tetracyclines. These findings highlight the potential of LAB as reservoirs of AMR genes.
Role of CRISPR-Cas system on antibiotic resistance patterns of Enterococcus faecalis.
The study identified several AMR genes, including tetM, ermB, aac6'-aph(2"), aadE, ant(6), and vanA, which are associated with resistance to tetracycline, erythromycin, gentamicin, and vancomycin in Enterococcus faecalis isolates.
Directed Recovery and Molecular Characterization of Antibiotic Resistance Plasmids from Cheese Bacteria.
The study identified tet(S) and ermB as the primary genes responsible for tetracycline and erythromycin resistance in plasmids from cheese bacteria, highlighting the role of plasmids in the spread of antibiotic resistance.
Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes.
The study identified multiple AMR genes in three multi-drug resistant L. innocua isolates, including tet(M), optrA, fexA, dfrG, lnu(B), lsa(E), ant(6)-Ia, erm(B), aph(3')-IIIa, catA8, lnu(A), msr(D), and mef(A). These genes confer resistance to various antibiotics such as tetracycline, oxazolidinones, fluoroquinolones, trimethoprim, lincomycin, macrolides, aminoglycosides, and chloramphenicol.
Emergence of Erythromycin Resistance Methyltransferases in Campylobacter coli Strains in France.
The study identified two methyltransferases, erm(B) and a novel erm(N), associated with erythromycin resistance in Campylobacter coli strains in France.
The Resistome and Mobilome of Multidrug-Resistant Staphylococcus sciuri C2865 Unveil a Transferable Trimethoprim Resistance Gene, Designated dfrE, Spread Unnoticed.
The study identifies and characterizes the transferable trimethoprim resistance gene dfrE in Staphylococcus sciuri C2865, which confers high-level resistance in Staphylococcus aureus and Escherichia coli.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Resistance and virulence distribution in enterococci isolated from broilers reared in two farming systems.
The study identified tetracycline, erythromycin, gentamicin, and penicillin resistance genes in enterococci from broilers, with no vancomycin-resistant isolates found.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
The study identified various beta-lactamase genes, including blaSHV-11, blaKPC-2, and blaNDM-1, along with qnrS1, aadA1, dfrA1, and sul1, which contribute to multidrug resistance in extensively drug-resistant Klebsiella pneumoniae isolates.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Prevalence and Characteristics of Staphylococcus aureus Isolated From Retail Raw Milk in Northern Xinjiang, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail raw milk in northern Xinjiang, China, including blaZ, mecA, ermA, ermB, ermC, aacA-aphD, tetK, tetM, vanA, rpoB, linA, optrA, and cfr, which confer resistance to penicillin, methicillin, oxacillin, erythromycin, gentamicin, tetracycline, vancomycin, rifampin, clindamycin, linezolid, chloramphenicol, and florfenicol.
Antimicrobial Resistance of Enterococcus sp. Isolated from Sheep and Goat Cheeses.
The study identified the presence of vanA, ermB, ermA, ermC, and msrC genes in Enterococcus isolates from sheep and goat cheeses, contributing to resistance against vancomycin and erythromycin.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
A Conjugative IncI1 Plasmid Carrying erm(B) and bla(CTX-M-104) That Mediates Resistance to Azithromycin and Cephalosporins.
The study identifies a conjugative IncI1 plasmid carrying the erm(B) gene, which mediates resistance to azithromycin in Klebsiella pneumoniae, Escherichia coli, and Salmonella Typhimurium. The plasmid also carries bla(CTX-M-104), conferring resistance to cephalosporins.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Epidemiology of Staphylococcus pseudintermedius in cats in Poland.
The study characterized the antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from cats in Poland, identifying several resistance genes including blaZ, mecA, aac(6')Ie-aph(2")Ia, ermB, tet(L), and tet(M).
Population genetic structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in children in Argentina.
The study identified several AMR genes in Streptococcus pneumoniae isolates from Argentina, including ermB, mefA, tet(M), cat, folA, and folP, which confer resistance to erythromycin, tetracycline, chloramphenicol, and cotrimoxazole. These genes were validated through molecular characterization and WGS.
Population Genomics Reveals Distinct Temporal Association with the Emergence of ST1 Serotype V Group B Streptococcus and Macrolide Resistance in North America.
The study identifies macrolide resistance genes erm(A), erm(B), and lsa(C) in ST1 serotype V Group B Streptococcus, highlighting their association with increased macrolide resistance in adult invasive disease.
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs.
The study identified several AMR genes in Streptococcus suis serotype 7 strains, including tetracycline resistance genes (tet(O), tet(M), tet(W)), macrolide/lincosamide/streptogramin resistance gene (erm(B)), aminoglycoside resistance genes (ant(6)-Ia, aph(3')-IIIa, aac(6')-Ie-aph(2'')-Ia), trimethoprim resistance gene (dfrF), and chloramphenicol resistance gene (cat-TC).
Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.
The study identified several AMR genes including ermB, mphA, blaTEM, blaCTX-M1, blaDHA, blaOXA-1, dfrA, and sul in Shigella isolates. Mutations in gyrA (83L) and parC (80I) were associated with ciprofloxacin resistance.
Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies.
The study identified tet K, tet M, erm B, and erm C as the primary genes responsible for tetracycline and erythromycin resistance in meat-associated bacteria, highlighting the impact of livestock management strategies on the spread of antibiotic resistance.
Molecular Characterization of Staphylococcus aureus Isolated from Human and Food Samples in Northern Algeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from human and food samples in northern Algeria, including blaZ, ermB, ermC, aphA3, sat, tetK, and tetM.
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions.
The study reports the case of a patient with a polymicrobial biofilm infection involving Staphylococcus aureus with an inducible macrolides-lincosamides-streptogramin B (iMLSB) resistance phenotype, mediated by the ermB gene. Phage therapy in combination with antibiotics showed variable success, highlighting the importance of assessing phage-antibiotic interactions on a case-by-case basis.
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
Optimization of five qPCR protocols toward the detection and the quantification of antimicrobial resistance genes in environmental samples.
The study presents optimized qPCR protocols for detecting and quantifying five antimicrobial resistance genes (ermB, bla CTXM1-like, bla CMY-2, qnrA, and qnrS) in environmental samples, demonstrating their accuracy and reliability.
Determination of Capsular Serotypes, Antibiotic Susceptibility Pattern, and Molecular Mechanism of Erythromycin Resistance among Clinical Isolates of Group B Streptococcus in Isfahan, Iran.
The study identified ermB, ermTR, and mefA genes as the primary mechanisms of erythromycin resistance in Group B Streptococcus isolates, with ermB being the most prevalent.
Bacteriological and histopathological findings in cetaceans that stranded in the Philippines from 2017 to 2018.
The study identified multiple antibiotic-resistant bacteria from cetaceans stranded in the Philippines, highlighting the presence of resistance genes such as ermB, aadA, aac(6')-Ib, blaTEM, blaCTX-M, blaSHV, blaOXA, qnrS1, tet(A), and mph(A).
Antimicrobial resistance, virulence genes and biofilm formation in Enterococcus species isolated from milk of sheep and goat with subclinical mastitis.
The study identified several antimicrobial resistance genes, including blaZ, vanA, ermB, tetM, and optrA, in Enterococcus species isolated from subclinical mastitic milk. High rates of multidrug resistance were observed, particularly against oxacillin, vancomycin, and linezolid.
Antimicrobial Resistance in Enterococcus Spp. Isolated from a Beef Processing Plant and Retail Ground Beef.
The study identified several AMR genes, including tet(M), erm(B), msrC, aac(6')-Ii, and optrA, in Enterococcus faecalis and Enterococcus faecium isolates from a beef processing plant and retail ground beef.
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.
This study identifies multiple AMR genes and mutations in Clostridioides difficile, including ermB, tetM, mefH, and various mutations in gyrA, gyrB, rpoB, pbp1, and pbp3. These findings highlight the widespread nature of AMR in C. difficile and its potential role in the spread of the bacterium.
Molecular Characterization Based on Whole-Genome Sequencing of Streptococcus pneumoniae in Children Living in Southwest China During 2017-2019.
The study identified the presence of erythromycin resistance gene erm(B) and tetracycline resistance gene tet(M) in Streptococcus pneumoniae isolates from children in Southwest China, highlighting the prevalence of resistance to these antibiotics.
Antimicrobial susceptibility, multilocus sequence typing, and virulence of listeria isolated from a slaughterhouse in Jiangsu, China.
The study identified tetracycline resistance genes tetA and tetM, erythromycin resistance genes ermA, ermB, and ermC, and the aminoglycoside resistance gene aac(6')-Ib in Listeria isolates from a slaughterhouse in Jiangsu, China.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study.
The study identifies various carbapenem resistance genes such as blaOXA232, blaNDM1, blaNDM5, blaOXA181, and others in Klebsiella pneumoniae isolates from India. It also characterizes mutations in ompK35 and ompK36 contributing to carbapenem resistance.
Resistance to Antibiotics in Thermophilic Campylobacters.
The study characterizes multiple AMR genes and mutations in thermophilic Campylobacter species, including gyrA mutations for fluoroquinolone resistance, 23S rRNA mutations for macrolide resistance, tet(O) for tetracycline resistance, aacA4 and aadA2 for aminoglycoside resistance, and blaOXA-61 for beta-lactam resistance.
Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine-review.
The review highlights the presence of antibiotic-resistant bacteria and resistance genes in the environments of animal farms in Poland and Ukraine, emphasizing the spread of multidrug-resistant strains such as MRSA and Salmonella. Key resistance genes identified include blaTEM, blaPSE, floR, tetA, tetB, tetC, tetG, cat1, dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3, ermB, tetL, tetW, tetM, blaZ, mecA, qnrS1, qnrS3, qnrB10, qnrB19, blaCTX-M-25, and blaOXA-21.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.
The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015-2019.
The study identified the presence of ermB, tetO, and tetM genes in Streptococcus agalactiae strains, which conferred resistance to erythromycin, clindamycin, and tetracycline, respectively. The MDR CC-17 sub-clone was associated with increased resistance rates.
Prevalence of Vancomycin-Resistant Enterococci and Antimicrobial Residues in Wastewater and Surface Water.
The study identified vanA and vanB genes in vancomycin-resistant Enterococcus faecium isolates, along with tet(M) and erm(B) genes associated with tetracycline and macrolide resistance, respectively. Aminoglycoside resistance was mediated by aac(6′)-Ie-aph(2′)-Ia and aph(3′)-IIIa genes.
Molecular Characteristics of Streptococcus pyogenes Isolated From Chinese Children With Different Diseases.
The study identified ermB and tetM as the primary genes responsible for macrolide and tetracycline resistance in Streptococcus pyogenes isolates from Chinese children.
Emerging Fatal Ib/CC12 Hypervirulent Multiresistant Streptococcus agalactiae in Young Infants With Bloodstream Infection in China.
The study identifies multiple antibiotic resistance genes in Ib/CC12 Streptococcus agalactiae strains, including genes conferring resistance to macrolides, clindamycin, aminoglycosides, tetracycline, and other antibiotics.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Characterization of Carbapenem-Resistant Enterobacteriaceae Cultured From Retail Meat Products, Patients, and Porcine Excrement in China.
The study identified bla NDM-5, bla KPC-2, and mcr-1 as key resistance genes in carbapenem-resistant Enterobacteriaceae isolated from retail meat products, patients, and porcine excrement in China.
Genomic Characterization of Streptococcus suis Serotype 24 Clonal Complex 221/234 From Human Patients.
The study identified tet(O) and erm(B) genes in three Streptococcus suis serotype 24 CC221/234 strains, which confer resistance to tetracycline, erythromycin, and clindamycin.
Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study.
The study identified several AMR genes and mutations in Clostridioides difficile isolates, including ermB conferring resistance to MLSB antibiotics, catP conferring resistance to chloramphenicol, and mutations in gyrA, gyrB, and rpoB that confer resistance to fluoroquinolones and rifamycins.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
The study identifies multiple AMR genes and mutations in the pandrug-resistant K. pneumoniae strain DJ, including carbapenemases (bla NDM-5, bla OXA-181, bla CTX-M-15), aminoglycoside resistance genes (rmtB, rmtF, aac(6')-Ib, aadA2, strAB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase (dfrA12), polymyxin resistance gene (mgrB), tetracycline resistance gene (ramR), chloramphenicol resistance genes (catA2, catB), fosfomycin resistance gene (fosA), and macrolide resistance genes (mphA, ermB). Mutations in gyrA, parC, ompK35, ompK36, and ramR contribute to resistance to fluoroquinolones, polymyxins, tetracyclines, and other antibiotics.
Antibiotic resistance genes in gut of breast-fed neonates born by caesarean section originate from breast milk and hospital ward air.
The study identifies multiple antibiotic resistance genes (ARGs) in the gut of breast-fed neonates born via cesarean section, primarily originating from breast milk and hospital ward air. Key ARGs include mecA, blaTEM, ampC, tetM, ermB, sul2, and aac(6)-Ib, which were detected in S. epidermidis isolates from neonatal faeces, colostrum, and ward air.
Occurrence and Antimicrobial Resistance of Enterococci Isolated from Goat's Milk.
The study identified several AMR genes in enterococci isolated from goat's milk, including ermB, vgaA, and tet(M), which confer resistance to erythromycin, virginiamycin, and tetracycline, respectively.
Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistant Staphylococcus aureus (MRSA) isolated from pets and pet owners in Malaysia.
The study identified multiple AMR genes including mecA, tetK, tetL, ermA, ermB, ermC, msrA, scn, chp, sak, sea, and sep in S. aureus isolates from pets and pet owners in Malaysia, indicating the presence of multidrug-resistant and methicillin-resistant strains.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Multiple-locus variable-number tandem repeat analysis for genotyping of erythromycin-resistant group B streptococci in Iran.
The study identified ermTR, ermB, and tetM as the primary resistance genes in erythromycin-resistant group B streptococci (GBS) isolates from Iran, with ermTR and ermB being strongly associated with the constitutive MLSB phenotype.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Molecular Epidemiology of Multidrug-Resistant Pneumococci among Ghanaian Children under Five Years Post PCV13 Using MLST.
The study identified the ermB, mefA, tetM, and pbp2b genes as the genetic basis for erythromycin, tetracycline, and penicillin resistance in multidrug-resistant pneumococci isolated from Ghanaian children.
Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance.
The study identified 1295 open reading frames recognized as antimicrobial resistance protein-coding genes in porcine gut microbiomes, highlighting tetracycline, aminoglycoside, and MLS resistance as predominant. Key ARGs like tet(W/N/W), APH(3')-IIIa, and ErmB were found to be highly prevalent and associated with resistance to specific antibiotics.
Population structure of ocular Streptococcus pneumoniae is highly diverse and formed by lineages that escape current vaccines.
The study identifies macrolide resistance genes mefA, msrD, ermB, and tetracycline resistance gene tetM in ocular Streptococcus pneumoniae isolates, highlighting the prevalence of resistance to macrolides and tetracycline in this population.
Assessment of Long-Term Macrolide Exposure on the Oropharyngeal Microbiome and Macrolide Resistance in Healthy Adults and Consequences for Onward Transmission of Resistance.
The study found that long-term exposure to azithromycin and erythromycin increased macrolide resistance in oropharyngeal streptococci, with erm(B) and mef genes being significantly upregulated. No evidence of onward transmission of resistance to close contacts was observed.
Comparing Long-Read Assemblers to Explore the Potential of a Sustainable Low-Cost, Low-Infrastructure Approach to Sequence Antimicrobial Resistant Bacteria With Oxford Nanopore Sequencing.
The study identifies the presence of the bla KPC gene in Klebsiella pneumoniae isolates using long-read sequencing, highlighting its role in carbapenem resistance.
Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage
The study demonstrates that generalized transduction by bacteriophages can rapidly transfer antimicrobial resistance genes between Staphylococcus aureus strains, leading to the formation of double-resistant progeny. The resistance genes erm(B) and tet(K) were identified as responsible for erythromycin and tetracycline resistance, respectively.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017.
The study identifies ermB, tetM, and aac6-aph2 as key AMR genes in C. difficile RT 017, highlighting their role in the global spread of multidrug-resistant strains.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Antimicrobial Resistance, Biofilm Formation, and Virulence Genes in Enterococcus Species from Small Backyard Chicken Flocks.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus species isolated from backyard chickens, including ermB, ermA, tetM, tetL, vanA, cat, and pbp5. These genes were associated with resistance to erythromycin, tetracycline, vancomycin, chloramphenicol, and ampicillin.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Identification and genetic characterization of two conjugative plasmids that confer azithromycin resistance in Salmonella.
The study identifies two conjugative plasmids and a non-transferable virulence plasmid that encode azithromycin resistance in Salmonella. The resistance is conferred by the erm(B) gene and the IS 26-mph(A)-mrx-mphR- IS 6100 genetic structure.
Beyond CC398: Characterisation of Other Tetracycline and Methicillin-Resistant Staphylococcus aureus Genetic Lineages Circulating in Spanish Hospitals.
The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
Molecular Characteristic, Antibiotic Resistance, and Detection of Highly Immunoreactive Proteins of Group B Streptococcus Strains Isolated From Urinary Tract Infections in Polish Adults.
The study identified ermB and mefA/E genes as contributors to macrolide resistance in Group B Streptococcus (GBS) strains isolated from urinary tract infections in Polish adults. The ermB gene was present in all cMLS B phenotype strains, while mefA/E was found in three M phenotype strains.
A shotgun metagenomics approach to detect and characterize unauthorized genetically modified microorganisms in microbial fermentation products.
The study identifies and characterizes various AMR genes, including cat, aadD, ble, ermB, and bla, in genetically modified microbes (GMMs) using shotgun metagenomics. These genes were detected through metagenomics sequencing and qPCR, confirming their presence in the GMM strains.
Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.
The study identified a decrease in the abundance of various antibiotic resistance genes (ARGs) during thermophilic composting of human excreta, including genes conferring resistance to aminoglycosides, macrolides, sulfonamides, and tetracyclines.
Mechanism of action, resistance, synergism, and clinical implications of azithromycin.
The paper discusses various mechanisms of macrolide resistance, including mutations in 23S rRNA, ribosomal proteins L4 and L22, and the presence of genes such as ermB, mphA, mef(E), and efflux pumps like lpeAB and CmeABC. These mechanisms contribute to high-level macrolide resistance in several bacterial species.
Genetic Characterization of a Conjugative Plasmid That Encodes Azithromycin Resistance in Enterobacteriaceae.
The study identifies a conjugative plasmid carrying three macrolide resistance genes: erm(B), a novel erm(42) gene, and mph(A), which confer resistance to azithromycin in Enterobacteriaceae.
The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils.
Strain WUSS351 is multidrug-resistant and possesses several antimicrobial systems, including the ABC transporter system sstFEG and Bce system genes bceBA and bceSR, which confer bacitracin resistance. Additionally, the macrolide-lincosamide-streptogramin B resistance gene erm(B) and the tetracycline resistance gene tet(O) were identified.
Prevalence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter Isolated from Broilers and Broiler Meat Raised without Antibiotics.
The study identified several antimicrobial resistance genes in Campylobacter isolates, including gyrA, tet(O), blaOXA-61, blaOXA-184, and aph(3')-IIIa, which confer resistance to fluoroquinolones, tetracycline, beta-lactamases, and aminoglycosides, respectively.
Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile.
The study identified several AMR genes and mutations in C. difficile isolates from dogs, including erm(B), cfr(C), tet(M), and pCD-METRO, which confer resistance to erythromycin, clindamycin, tetracycline, and metronidazole, respectively.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
Antimicrobial resistance-Do we share more than companionship with our dogs?
The study identified various antimicrobial resistance genes (ARGs) in fecal samples from dogs and their owners, highlighting the presence of tetracycline, MLS, aminoglycoside, and sulfonamide resistance genes. Dogs exhibited a higher diversity of aminoglycoside resistance genes compared to owners.
Characteristics of Streptococcus agalactiae Colonizing Nonpregnant Adults Support the Opportunistic Nature of Invasive Infections.
The study identified ermA, ermB, and mefE genes associated with macrolide resistance in Streptococcus agalactiae isolates from nonpregnant adults, along with tetM for tetracycline resistance and aph(3')-IIIa and ant(6)-Ia for streptomycin resistance.
Increase of Macrolide-Resistance in Streptococcus pneumoniae Strains After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Lima, Peru.
The study found a significant increase in macrolide resistance in Streptococcus pneumoniae strains after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Lima, Peru. The primary resistance mechanisms identified were the erm(B) gene and the mef(A/E) gene.
Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome.
The study identified novel integron gene cassettes and variants of Tn 916 conjugative transposons in the human oral metagenome using an inverse PCR-based approach. It also discovered the presence of tetracycline resistance gene tet(M) and erythromycin resistance gene erm(B) associated with these mobile genetic elements.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Clinical and Genomic Investigation of an International Ceftriaxone- and Azithromycin-Resistant Shigella sonnei Cluster among Men Who Have Sex with Men, Montréal, Canada 2017-2019.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time.
The study identified several antimicrobial resistance genes, including ermB, CTX-M-1, OXA-1, and qnrS, which were associated with resistance to various antibiotics in dogs. These genes were detected in fecal samples and linked to phenotypic resistance.
16-membered ring macrolides and erythromycin induce ermB expression by different mechanisms.
16-membered ring macrolides specifically induce ermB expression through a mechanism distinct from erythromycin, involving the translation of the N-terminus of ermBL and the RNA sequence of the C-terminus of ermBL.
Multiplex real-time PCR using SYBR Green: Unspecific intercalating dye to detect antimicrobial resistance genes of Streptococcus pneumoniae in cerebrospinal fluid.
The study developed a SYBR Green-based multiplex qPCR assay to detect antimicrobial resistance genes in Streptococcus pneumoniae, including pbp2b, ermB, and mef, which are associated with resistance to penicillin, erythromycin, and clindamycin.
Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects.
The study identified several antibiotic and metal(loid) resistance genes in gut microbiota from chronic kidney disease (CKD) subjects, including genes encoding beta-lactamases, quinolone resistance proteins, macrolide phosphotransferases, and efflux pumps. Additionally, genes conferring resistance to arsenicals and heavy metals were detected.
Antibiotic resistance and virulence genes in Enterococcus species isolated from raw and processed seafood.
The study identified tetracycline resistance gene tet M, erythromycin resistance gene erm B, aminoglycoside resistance gene aac(6')-aph(2'')-la, and virulence genes agg 2 and gel E in Enterococcus species isolated from seafood.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genetic background of Cambodian pneumococcal carriage isolates following pneumococcal conjugate vaccine 13.
The study identified multiple antimicrobial resistance (AMR) genes in Cambodian pneumococcal carriage isolates, including ermB, mefA, cat, tet(M), tet(O), folA, and folP, which confer resistance to erythromycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole. These genes were validated through predictive resistance profiling using the CDC-AMR pipeline.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Calves as Main Reservoir of Antibiotic Resistance Genes in Dairy Farms.
The study identifies calves as the main reservoir of antibiotic resistance genes (ARGs) in dairy farms, highlighting the presence of bla TEM, erm B, sul 2, and tet A, which confer resistance to penicillins, MLS, sulfonamides, and tetracyclines, respectively.
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Investigation of Antimicrobial Susceptibilities and Resistance Genes of Campylobacter Isolates from Patients in Edirne, Turkey.
Multiple Mechanisms Confer Resistance to Azithromycin in Shigella in Bangladesh: a Comprehensive Whole Genome-Based Approach.
The study identifies mph(A), erm(B), and msr(E) as key genes contributing to azithromycin resistance in Shigella isolates from Bangladesh, highlighting the role of plasmid-borne resistance gene clusters in the dissemination of resistance.
Virulence Profiling, Multidrug Resistance and Molecular Mechanisms of Campylobacter Strains from Chicken Carcasses in Tunisia.
The study identified multiple AMR genes and mutations in Campylobacter strains from chicken carcasses in Tunisia, highlighting the presence of multidrug-resistant strains with high resistance rates to various antibiotics.
Antimicrobial Susceptibility Profiles and Molecular Characterisation of Staphylococcus aureus from Pigs and Workers at Farms and Abattoirs in Zambia.
The study identified tetracycline resistance genes (tetM, tetK, tetL) and erythromycin resistance genes (ermB, ermC) in Staphylococcus aureus isolates from pigs and workers in Zambia. These genes were detected through PCR and are associated with resistance to tetracycline and erythromycin, highlighting the need for continued surveillance of antimicrobial resistance in this region.
A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella.
The study identifies that the plasmid pKSR100 confers a broader range of antimicrobial resistance compared to pAPR100, contributing to its greater epidemiological success. pKSR100 carries more AMR genes, including those for macrolides, sulfonamides, trimethoprim, beta-lactams, aminoglycosides, and tetracyclines, while pAPR100 has fewer AMR genes, primarily for macrolides, beta-lactams, and tetracyclines.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Characterization of Streptococcus pneumoniae Macrolide Resistance and Its Mechanism in Northeast China over a 20-Year Period.
The study identified the presence of ermB, mefA, and tetM genes in erythromycin-resistant Streptococcus pneumoniae strains in northeast China, highlighting the high prevalence of macrolide resistance mediated by these genes.
Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial.
Single-dose azithromycin increased pneumococcal resistance to erythromycin, clindamycin, and oxacillin in the short term, but resistance levels returned to baseline after 6 months.
Genomic Insights of First ermB-Positive ST338-SCCmecV(T)/CC59 Taiwan Clone of Community-Associated Methicillin-Resistant Staphylococcus aureus in Poland.
The study reports the first Polish isolate of a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain carrying the ermB gene, which confers constitutive resistance to macrolides, lincosamides, and streptogramin B antibiotics (cMLS-B).
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Genetic diversity and antimicrobial resistance of invasive, noninvasive and colonizing group B Streptococcus isolates in southern Brazil.
The study identified the presence of macrolide resistance genes mef A/E, erm B, and erm A/TR in Group B Streptococcus (GBS) isolates, with serotype V being strongly associated with erythromycin resistance. The most common genotypes were Ia/MT12 and V/MT18, showing high resistance to macrolides.
Antimicrobial Resistance in Chicken Waste: Characterization of AMR Genes and Mutations
The study identifies the presence of multiple antibiotic resistance genes (ARGs) in chicken waste, highlighting the risk of environmental contamination and the spread of multidrug-resistant bacteria.
Tetracycline, Macrolide and Lincosamide Resistance in Streptococcus canis Strains from Companion Animals and Its Genetic Determinants.
The study identified tetracycline resistance genes tet(O), tet(M), and tet(T), and MLS resistance genes erm(B) and erm(TR) in Streptococcus canis strains from companion animals.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Molecular Typing Reveals Environmental Dispersion of Antibiotic-Resistant Enterococci under Anthropogenic Pressure.
The study identified multiple antibiotic resistance genes in Enterococcus isolates from various aquatic environments, highlighting the role of anthropogenic pressure in the spread of antibiotic-resistant enterococci.
Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion.
The paper discusses the mechanisms of resistance in carbapenem-resistant Gram-negative bacteria, highlighting the role of various beta-lactamases such as blaOXA-51, blaOXA-23, blaOXA-24, blaOXA-48, blaKPC, blaNDM, blaVIM, and blaIMP, as well as aminoglycoside modifying enzymes like aac(6')-Ib and aadA, and quinolone resistance genes such as qnrS1.
Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae.
The paper discusses the development and evaluation of new antimicrobial agents against Neisseria gonorrhoeae, highlighting the importance of monitoring resistance mechanisms such as mutations in GyrA and ParC that confer resistance to fluoroquinolones.
Phage-Plasmids Spread Antibiotic Resistance Genes through Infection and Lysogenic Conversion.
Phage-plasmids (P-Ps) carry a variety of antibiotic resistance genes (ARGs), including beta-lactamases, aminoglycoside-modifying enzymes, and carbapenemases. These genes are often located in integrons and are associated with transposable elements. P-Ps can be induced by mitomycin C and can transfer resistance genes through lysogenic conversion.
Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli.
The study identifies erm(B), mph(A), mph(B), and mef(C) as acquired macrolide resistance genes in porcine clinical E. coli, demonstrating their association with increased macrolide MICs and the potential of peptidomimetics to potentiate macrolide activity.
Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea.
The study identified erythromycin and clindamycin resistance mediated by ermB and ermA genes in invasive group B Streptococcus (GBS) isolates from Korean adults. Levofloxacin resistance was observed in ST10 and ST654 serotype Ib strains.
Characterization and Transferability of erm and tet Antibiotic Resistance Genes in Lactobacillus spp. Isolated from Traditional Fermented Milk.
The study identifies the presence of erm(B) and tet(M) antibiotic resistance genes in Lactobacillus spp. isolated from traditional fermented milk, highlighting their potential to transfer resistance to pathogenic bacteria.
Longitudinal Analysis of Antimicrobial Resistance among Enterococcus Species Isolated from Australian Beef Cattle Faeces at Feedlot Entry and Exit.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Antimicrobial susceptibility to polymyxin B and other comparators against Gram-negative bacteria isolated from bloodstream infections in China: Results from CARVIS-NET program.
The study found that 94.1% of the 1939 Gram-negative isolates were susceptible to polymyxin B, and the sensitivity of the strains to polymyxin B was highly correlated with their sensitivity to colistin.
Comparative Analysis of the Molecular Characteristics of Group B Streptococcus Isolates Collected from Pregnant Korean Women Using Whole-genome Sequencing.
The study identified ermB, ermA, tetM, and tetO as genes conferring resistance to erythromycin and tetracycline in Group B Streptococcus isolates from pregnant Korean women.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Persistence of transferable oxazolidinone resistance genes in enterococcal isolates from a swine farm in China.
The study identified the persistence of transferable oxazolidinone resistance genes, particularly optrA, poxtA, and cfr(D), in enterococcal isolates from a swine farm in China. These genes were found to confer resistance to linezolid, tedizolid, chloramphenicol, and florfenicol.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
First Genome-Based Characterisation and Staphylococcal Enterotoxin Production Ability of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains Isolated from Ready-to-Eat Foods in Algiers (Algeria).
The study identified several AMR genes and mutations in S. aureus strains isolated from ready-to-eat foods in Algeria, including blaZ, ermB, lmrS, tet(L), tet(38), aph(3')-IIIa, ant(6)-I, mecA, and a gyrA mutation (S84L) conferring resistance to various antibiotics.
Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC) Escherichia coli Clinical Isolate Co-Producing Two Carbapenemases and a 16S rRNA Methylase.
The study describes an extensively drug-resistant (XDR) E. coli ST361 isolate co-carrying bla KPC-3, bla NDM-5, and various other resistance genes on multiple plasmids, showing resistance to nearly all antibiotics except tigecycline, colistin, and fosfomycin.
Genomic Insights into the Mobilome and Resistome of Sentinel Microorganisms Originating from Farms of Two Different Swine Production Systems.
The study identified erm(B) as a common AMR gene across multiple bacterial taxa, contributing to resistance against macrolides, lincomycins, and streptogramin B. The resistome was found to be taxon-dependent, with significant differences in AMR gene abundance between intensive and organic-extensive swine farms.
Web-based prediction of antimicrobial resistance in enterococcal clinical isolates by whole-genome sequencing.
The study evaluated the accuracy of whole-genome sequencing (WGS) for predicting antimicrobial resistance in enterococcal clinical isolates. It identified several AMR genes and mutations, including aac(6')-aph(2"), erm(B), erm(T), tet(L), tet(M), vanA, vanB, vanD, optrA, poxtA, and mutations in gyrA and parC, which were validated through genomic sequencing and phenotypic AST.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance: mechanisms and implications
The review discusses various molecular mechanisms of antibiotic resistance, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and efflux pumps, highlighting their roles in conferring resistance to multiple antibiotics.
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
The study identified 17 antibiotic resistance genes in Staphylococcus pseudintermedius isolates from healthy dogs, including blaZ, mecA, ermB, tetM, aac(6')-aph(2''), ant(6)-Ia, aph(3')-IIIa, spw, str, and dfrG. It also found mutations in gyrA and parC genes associated with fluoroquinolone resistance, and mutations in rpoB and clpP linked to vancomycin resistance.
Relationships between Virulence Genes and Antibiotic Resistance Phenotypes/Genotypes in Campylobacter spp. Isolated from Layer Hens and Eggs in the North of Tunisia: Statistical and Computational Insights.
The study identified several AMR genes and mutations in Campylobacter isolates from layer hens and eggs in Tunisia, including tet(O), cmeB, erm(B), blaOXA-61, and mutations in gyrA and 23S rRNA. These genes and mutations were associated with resistance to tetracycline, fluoroquinolones, macrolides, and beta-lactams.
Comparative virulence and antimicrobial resistance distribution of Streptococcus suis isolates obtained from the United States.
The study identified several antimicrobial resistance (AMR) genes in Streptococcus suis isolates from the United States, including ble, tetO, ermB, lsaE, lnuB, ant(9)-Ia, and ant(6)-Ia, which confer resistance to glycopeptides, tetracyclines, macrolide-lincosamide-streptogramin B, pleuromutilins, and aminoglycosides respectively.
Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution.
The study characterizes the ermB and tetK genes as conferring resistance to erythromycin and tetracycline, respectively, in Staphylococcus aureus strains NE327 and NE201KT7. These genes were experimentally validated in the study.
A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.
The study reports the emergence of XDR Shigella sonnei strains with cef R azi R and col R phenotypes associated with waterborne outbreaks in China, highlighting the role of plasmid-mediated AMR genes such as bla CTX-M-14, mphA, mcr-1, and others in the spread of multidrug resistance.
Detection of Methicillin-Resistant Staphylococcus aureus in Clinical and Subclinical Mastitis in Ruminants and Studying the Effect of Novel Green Synthetized Nanoparticles as One of the Alternative Treatments.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in mastitic milk samples from ruminants and characterized resistance genes including mecA, blaZ, ermB, tetM, and tetK. Green synthesized titanium dioxide nanoparticles (TiO2 NPs) showed potent antibacterial activity against MRSA.
Association of CRISPR-Cas System with the Antibiotic Resistance and Virulence Genes in Nosocomial Isolates of Enterococcus.
The study found that the CRISPR-Cas system is associated with reduced antibiotic resistance and virulence in Enterococcus isolates. Specific resistance genes such as ermB, aadE, ant(6), aac(6')-aph(2"), tetM, and vanA were identified in the isolates.
Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics.
The study identifies the presence of the integrative and conjugative element ICE Sag37 in type Ib ST12 GBS isolates, which carries multiple antibiotic resistance genes such as erm(B), tet(O), aadE, aphA, ant-6, lsa(E), and lun(B), contributing to high resistance rates to erythromycin and clindamycin. Additionally, the virulence gene pezT was found in these isolates.
Isolation, Identification, and Genetic Characterization of Antibiotic Resistance of Salmonella Species Isolated from Chicken Farms.
The study identified several AMR genes in Salmonella isolates from chicken farms in Egypt, including blaTEM, blaSHV, ermB, ereA, and mphA, which conferred resistance to ampicillin, erythromycin, and lincomycin.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
ggMOB: Elucidation of genomic conjugative features and associated cargo genes across bacterial genera using genus-genus mobilization networks.
The study identifies various conjugative features and associated cargo genes, highlighting the significant role of conjugation in the spread of antimicrobial resistance (AMR) across bacterial genera. Key AMR genes such as Tn916, CTn341, SXT, ICEEc2, ICEclc, Tn1549, and Tn4555 were found to be prevalent in conjugative genomes, demonstrating their involvement in the dissemination of resistance traits.
Dissemination and characteristics of high-level erythromycin-resistant Enterococcus faecalis from bulk tank milk of dairy companies in Korea.
The study identified several AMR genes, including ermB, tetM, tetL, optrA, aac(6')-Ie-aph(2'')-la, ant(6')-Ia, and Int-Tn, in high-level erythromycin-resistant Enterococcus faecalis isolates from bulk tank milk in Korea.
Microbiological Biodiversity of Regional Cow, Goat and Ewe Milk Cheeses Produced in Poland and Antibiotic Resistance of Lactic Acid Bacteria Isolated from Them.
The study identified tetracycline, erythromycin, and chloramphenicol resistance genes in lactic acid bacteria isolated from regional cheeses in Poland.
Hydrothermal pre-treatment followed by anaerobic digestion for the removal of tylosin and antibiotic resistance agents from poultry litter.
The study characterizes the removal of tylosin and antibiotic resistance genes (ARGs) from poultry litter using hydrothermal pre-treatment followed by anaerobic digestion. It identifies the reduction of ermB, intI1, sul1, and tetA genes, indicating effective mitigation of antibiotic resistance.
Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women.
The study identified several antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, including ermB, mefA/E, ermTR, tetM, tetO, and aphA3, which confer resistance to macrolides, tetracyclines, and aminoglycosides.
Genotypic and Phenotypic Characterization of Erythromycin-Resistant Staphylococcus aureus Isolated from Bovine Mastitis and Humans in Close Contact.
The study identified the presence of ermA, ermB, and ermC genes in erythromycin-resistant Staphylococcus aureus isolates from bovine mastitis and humans in close contact, highlighting the genetic similarity and potential zoonotic transmission of these resistance genes.
Antibiotic Susceptibility, Resistance Gene Determinants and Corresponding Genomic Regions in Lactobacillus amylovorus Isolates Derived from Wild Boars and Domestic Pigs.
The study identified tetracycline resistance gene tetW, erythromycin resistance gene ermB, and streptomycin resistance gene aadE in Lactobacillus amylovorus isolates from domestic pigs, while only one wild boar isolate carried aadE. The findings highlight differences in resistance gene prevalence between wild and domestic pigs.
Molecular Epidemiology of Group B Streptococcus Isolates from Pregnant Women with Premature Rupture of Membranes in Fuzhou, China.
The study identified several AMR genes in GBS isolates from pregnant women with PROM in Fuzhou, China, including mreA, ermB, mefA, mefE, ermA, ermTR, tetM, and tetK, which are associated with resistance to erythromycin and tetracycline.
Molecular epidemiology of Clostridioides difficile in companion animals: Genetic overlap with human strains and public health concerns.
The study identified antimicrobial resistance genes and mutations in Clostridioides difficile isolates from companion animals, including ermB for clindamycin resistance, pCD-METRO plasmid for metronidazole resistance, and gyrA and rpoB mutations for moxifloxacin and rifampicin resistance, respectively.
Antimicrobial Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella Isolates in Taiwan, 2017 to 2018.
The study identifies mph(A), erm(42), erm(B), and ramAp as the primary mechanisms of azithromycin resistance in non-typhoidal Salmonella isolates from Taiwan.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China.
The study identified multiple AMR genes in S. agalactiae isolates from dairy goats in China, including pbp2b, tetL, tetM, tetK, tetO, ermA, ermB, mefA, aphA3, aad6, lnu(B), gryA, and parC, which confer resistance to various antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, lincosamides, and quinolones.
Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.
The study identifies the presence of MLS resistance genes ermB, mefA/E, msrA/B, and msrC in lactic acid bacteria isolated from food samples, highlighting the prevalence of macrolide-lincosamide-streptogramin resistance in LAB.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
Increasing trend of antimicrobial resistance in Shigella associated with MSM transmission in Barcelona, 2020-21: outbreak of XRD Shigella sonnei and dissemination of ESBL-producing Shigella flexneri.
The study reports an increasing trend of antimicrobial resistance in Shigella spp. among MSM in Barcelona, primarily due to the spread of XDR ESBL-producing S. sonnei and MDR ESBL-producing S. flexneri. Key AMR genes identified include bla CTX-M-27, mph(A), erm(B), dfrA17, sul1, and aadA5, along with fluoroquinolone resistance mutations in gyrA (S83L) and parC (S80I).
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand.
The study identifies multiple AMR genes, including tetO, ermB, optrA, and ermA, in a multidrug-resistant S. suis strain causing an outbreak in Thailand.
Comparative Genome Analysis of Enterococcus cecorum Reveals Intercontinental Spread of a Lineage of Clinical Poultry Isolates.
The study identifies six genes associated with avian clinical isolates of Enterococcus cecorum, which can help distinguish them from nonclinical isolates.
Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania.
The study identified erm(B) and mef(A)-msr(D) as common genes conferring resistance to macrolides and clindamycin, while tet(M) was responsible for tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from HIV patients in Tanzania.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Antimicrobial Resistance and Virulence Genes of Streptococcus Agalactiae Isolated from Mastitis Milk Samples in China.
The study identified several AMR genes in multidrug-resistant Streptococcus agalactiae isolates from bovine mastitis milk samples in China, including ermB, ermA, lnuA, tetM, tetK, tetS, and tetO. These genes conferred resistance to macrolides, lincosamides, and tetracyclines.
Antimicrobial Resistance in Salmonella from Food-Producing Animals and Carcases
The report highlights the presence of carbapenemase-producing E. coli isolates carrying bla OXA-48, bla OXA-181, and bla NDM-5 genes in pigs, bovines, and meat, indicating the need for continued monitoring and follow-up.
Antimicrobial Resistance in Salmonella from Food-Producing Animals and Carcases
The report highlights the presence of carbapenemase-producing E. coli isolates carrying bla OXA-48, bla OXA-181, and bla NDM-5 genes in pigs, bovines, and meat, indicating the need for continued monitoring and follow-up.
Dissemination of Tn916-Related Integrative and Conjugative Elements in Streptococcus pneumoniae Occurs by Transformation and Homologous Recombination in Nasopharyngeal Biofilms.
The study identifies tetM and ermB as genes conferring tetracycline and erythromycin resistance, respectively, in Streptococcus pneumoniae. These genes are part of Tn2009 and Tn2010, which are disseminated through transformation and homologous recombination in nasopharyngeal biofilms.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Intra-host variation of genetic lineages or AMR genotypes of CoPS
The study identifies various AMR genes including blaZ, dfrA, dfrG, ermB, catA, aac6′-aph2″, tet(M), dfrK, and ant4′ in Staphylococcus aureus and Staphylococcus pseudintermedius isolates. Additionally, a mutation in grlA (S80F) was found to confer fluoroquinolone resistance.
Multidrug-resistant Aeromonas bacteria prevalence in Nile tilapia broodstock.
The study identified multidrug-resistant Aeromonas hydrophila strains in Nile tilapia broodstock, with resistance genes sul1, tetA, qnrs, and ermB detected in the isolates.
Genomic Analysis of Vancomycin-Resistant Staphylococcus aureus Isolates from the 3rd Case Identified in the United States Reveals Chromosomal Integration of the vanA Locus.
The study identifies the chromosomal integration of the vanA locus in vancomycin-resistant Staphylococcus aureus (VRSA) isolates, highlighting the role of plasmid pWC79 in multidrug resistance and the genetic mechanisms behind the emergence of VRSA.
Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades.
The study identifies pELF1-like plasmids in Enterococcus faecium that carry multiple antimicrobial resistance genes, including vancomycin resistance determinants, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and oxazolidinone resistance genes. These plasmids are associated with multidrug-resistant clades and demonstrate high stability and self-transmissibility.
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins.
The study identified various AMR genes associated with resistance to macrolides, lincosamides, and streptogramins in Enterococci, including ermB, ermA, ermC, ereA, lnuA, mphC, mefA, and mefE. These genes were found to be highly prevalent and contribute to the resistance mechanisms observed in the isolates.
Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates.
The study identified several AMR genes associated with erythromycin and clindamycin resistance in Staphylococcus aureus, including ermC, ermA, ermB, msrA, msrB, lnuA, and mphC. These genes were detected through PCR and phenotypic analysis.
Evolution of Antibiotic Resistance in Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Multi-Profile Hospital over 5 Years (2017-2021).
The study identified various beta-lactamase genes including blaCTX-M, blaTEM, blaOXA, blaKPC, blaNDM, and blaVIM, as well as qnr, aac(6')-Ib, aadA, ermB, mefA, tetA, and oqxAB, which contribute to resistance against multiple antibiotics in E. coli and K. pneumoniae isolates from a hospital over five years.
Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.
The study identified tetracycline resistance gene tet(O), macrolide-lincosamide-streptogramin resistance gene erm(B), and aminoglycoside resistance genes ant(6)-Ia and aph(3')-III in two Streptococcus suis serotype 1 strains.
A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022.
The study identified various antimicrobial resistance genes in probiotic bacteria, highlighting the presence of mobile genetic elements and the potential for horizontal gene transfer.
Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.
The study evaluated the effectiveness of a combined probiotic-phage sanitation system (PCHSφ) in reducing microbial contamination and antimicrobial resistance (AMR) in hospital environments. PCHSφ significantly reduced staphylococcal contamination and AMR gene prevalence compared to conventional chemical disinfection and PCHS alone.
Emergence of Erythromycin-Resistant Invasive Group A Streptococcus, West Virginia, USA, 2020-2021.
The study identified the emergence of erythromycin-resistant invasive group A Streptococcus (iGAS) in West Virginia, with a high prevalence of resistance mediated by the ermT, ermA, ermB, and mefA genes. The majority of isolates were resistant to erythromycin and clindamycin, with emm92 and emm11 being the most common emm types.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Epidemiological and genomic analyses of human isolates of Streptococcus suis between 2005 and 2021 in Shenzhen, China.
The study identified multiple antimicrobial resistance genes in human isolates of Streptococcus suis, including ant(6)-Ia, tet(O), and erm(B), which confer resistance to streptomycin, tetracycline, and erythromycin/clindamycin respectively.
Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China.
The study identified 24 antibiotic resistance genes (ARGs) in 96 Streptococcus suis isolates, including erm(B), tet(O), ant(6)-Ia, and optrA, which confer resistance to multiple antibiotic classes such as macrolides, tetracyclines, aminoglycosides, and linezolid. These genes were found in isolates from both swine and humans in China.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis.
The study identified various antimicrobial resistance genes (ARGs) in the oral microbiota, including mefA, msrD, ermB, ermF, cfxA, blaCSP(1), tetM, tetQ, and pgpB, which confer resistance to antibiotics such as erythromycin, azithromycin, penicillin, ampicillin, tetracycline, and colistin. These genes were found in multiple bacterial species and were associated with different resistotypes in healthy, caries, and periodontitis groups.
Microbiological Epidemiology of Invasive Infections Due to Non-Beta-Hemolytic Streptococci, France, 2021.
The study characterizes AMR genes and mutations in non-beta-hemolytic streptococci, highlighting high resistance rates to beta-lactams, MLS, and tetracyclines, with specific resistance mechanisms involving erm(A), erm(B), lnu(C), lsa(A), meff, and tet(M).
Antibiotic resistance in potential probiotic lactic acid bacteria of fermented foods and human origin from Nigeria.
The study identified various antibiotic resistance genes including aac(6')-Ii, ermB, ermC, tetM, vanE, and parC in lactic acid bacteria from Nigerian fermented foods and human sources.
Concordance between Genotypic and Phenotypic Drug-Resistant Profiles of Shigella Isolates from Taiyuan City, Shanxi Province, China, 2005 to 2016.
The study identified various AMR genes and mutations in Shigella isolates from Taiyuan City, including beta-lactamases (blaTEM-1, blaOXA-1, blaCTX-M-14, blaCTX-M-55), quinolone resistance genes (qnrS1), aminoglycoside resistance genes (aac(3)-IId), tetracycline resistance genes (tetA, tetB), macrolide resistance genes (mphA, ermB), and chloramphenicol resistance gene (catI). Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Erythromycin resistance of clinical Campylobacter jejuni and Campylobacter coli in Shanghai, China.
The study identified erm(B) and A2075G mutation in 23S rRNA as the main mechanisms of erythromycin resistance in Campylobacter isolates from Shanghai, China.
Molecular epidemiology and characterization of antimicrobial-resistant Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China.
The study identified several antimicrobial resistance genes in Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China, including mphC, ermB, floR, aadD, sul1, and gyrA, which confer resistance to erythromycin, florfenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Wastewater treatment plants, an "escape gate" for ESCAPE pathogens.
The study identifies several AMR genes and mutations in various pathogens found in wastewater treatment plants, highlighting the role of these facilities as reservoirs for antibiotic-resistant bacteria and genes.
Whole-Genome Sequencing Revealed the Fusion Plasmids Capable of Transmission and Acquisition of Both Antimicrobial Resistance and Hypervirulence Determinants in Multidrug-Resistant Klebsiella pneumoniae Isolates.
The study identified multiple antimicrobial resistance genes and hypervirulence determinants in multidrug-resistant Klebsiella pneumoniae isolates, highlighting the role of fusion plasmids in the transmission of these traits.
A Genomic Snapshot of Antibiotic-ResistantEnterococcus faecalis within Public Hospital Environments in South Africa.
The study identified tet(M) and erm(B) as the most common antibiotic-resistant genes in Enterococcus faecalis isolates from South African hospitals, along with other resistance genes such as dfrG, catA, and optrA.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
The Genetic Diversity and Antimicrobial Resistance of Pyogenic Pathogens Isolated from Porcine Lymph Nodes.
The study identified tetracycline resistance genes tetM and tetO, and erythromycin resistance gene ermB in Streptococcus dysgalactiae isolates from porcine lymph nodes.
Analysis of Antibiotic-Resistant and Virulence Genes of Enterococcus Detected in Calf Colostrum-One Health Perspective.
The study identified multiple antibiotic-resistant genes in Enterococcus isolates from bovine colostrum, including tet(K), tet(L), tet(M), erm(B), and ant(6)-Ia, which confer resistance to tetracycline, erythromycin, and streptomycin. High rates of multidrug resistance were observed.
Bacterial Communities Associated with Houseflies (Musca domestica L.) Inhabiting Hospices in South Africa.
The study identified antibiotic resistance genes ermB, tetA, blaSHV, and blaTEM in houseflies from hospices in South Africa, indicating potential health risks due to the presence of resistant bacteria.
Evaluation of Enterotoxins and Antimicrobial Resistance in Microorganisms Isolated from Raw Sheep Milk and Cheese: Ensuring the Microbiological Safety of These Products in Southern Brazil.
The study identified several antimicrobial resistance genes, including tetM, ermB, strA, tetL, sul1, sul2, and AAC(6)', in Staphylococcus spp. isolated from raw sheep milk and cheese in southern Brazil. These genes conferred resistance to various antibiotics, highlighting the prevalence of antimicrobial resistance in these microorganisms.
Characterization of microbial community and antibiotic resistome in intra urban water, Wenzhou China.
The study identified several antimicrobial resistance genes (ARGs) in urban water samples from Wenzhou, China, including intI1, tetA, ermA, ermB, qnrB, sul1, sul2, blaSHV, and blaCTX-M. These genes were found to be associated with different bacterial species and were linked to resistance against various antibiotics such as tetracyclines, erythromycin, fluoroquinolones, sulfonamides, and beta-lactams.
Occurrence of antimicrobial-resistant Staphylococcus aureus in a Brazilian veterinary hospital environment.
The study identified several AMR genes in Staphylococcus aureus isolates from a Brazilian veterinary hospital, including blaZ, mecA, norA, norC, tetM, tet38, ermA, and ermB, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and erythromycin.
The gut microbiome and resistome of conventionally vs. pasture-raised pigs.
The study found that conventionally raised pigs had a significantly higher abundance of antimicrobial resistance genes (ARGs) compared to pasture-raised pigs, particularly for aminoglycosides, beta-lactams, macrolides-lincosamides-streptogramin B, and tetracyclines. Several ARGs, including aph(3')-IIIa, erm(B), erm(X), tet(Q), tet(36), tet(W/N/W), blaOXA-193, and cfxA2, were identified as being more prevalent in the gut microbiome of conventionally raised pigs.
Clostridium ramosum Bacteremia in an Immunocompetent Patient with SARS-CoV-2 Infection: A Case Report.
The study identifies two antimicrobial resistance genes, tetM and ermB, in the Clostridium ramosum strain WD-I2, explaining resistance to tetracycline and macrolides.
Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.
The study identified several AMR genes including blaZ, mecA, tetK, tetM, ermC, and ermB in Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. These genes conferred resistance to penicillin, methicillin, tetracycline, and erythromycin.
Genome characteristics of the optrA-positive Clostridium perfringens strain QHY-2 carrying a novel plasmid type.
The study identifies the optrA gene, which confers resistance to oxazolidinones and phenicols, along with other resistance genes such as fexA, erm(A), erm(B), erm(Q), aac(6')-aph(2''), and lnu(P) in the optrA-positive Clostridium perfringens strain QHY-2. These genes are located on a novel plasmid type, highlighting the potential for horizontal transmission of antibiotic resistance among C. perfringens strains.
Role of a typical swine liquid manure treatment plant in reducing elements of antibiotic resistance.
The study identified and characterized several antibiotic resistance genes (ARGs) in swine wastewater treatment plants, including blaTEM, ermB, qnrB, sul1, and tetA, which were found to be present in the raw wastewater and showed significant reductions after anaerobic digestion.
Molecular characteristics and phylogenetic analysis of Clostridium perfringens from different regions in China, from 2013 to 2021.
The study identified various AMR genes in Clostridium perfringens isolates from China, including mprF, tetA(P), tetB(P), ErmQ, LnuP, AAC(6′)-Ie-APH(2″)-Ia, ANT(6)-Ib, tet44, and ErmB, which confer resistance to antibiotics such as penicillin, tetracycline, clindamycin, and aminoglycosides.
Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.
The study identified the presence of antimicrobial resistance genes tet(O) and erm(B) in all seven Streptococcus suis serotype 4 strains, which confer resistance to tetracycline, erythromycin, azithromycin, and clindamycin.
Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.
The study identified the presence of antimicrobial resistance genes tet(O) and erm(B) in all seven Streptococcus suis serotype 4 strains, which confer resistance to tetracycline, erythromycin, azithromycin, and clindamycin.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Genomic Features of Antimicrobial Resistance in Staphylococcus pseudintermedius Isolated from Dogs with Pyoderma in Argentina and the United States: A Comparative Study.
The study identified various antimicrobial resistance genes and mutations in Staphylococcus pseudintermedius isolates from dogs in Argentina and the United States, highlighting differences in resistance profiles between the two regions.
An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice.
The study found that calorie restriction increased the abundance of tetracycline resistance genes (tet W-01) and decreased the abundance of MLSB resistance genes (erm B) in mouse feces. It also identified that sul 2 was associated with sulfonamide resistance.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Baseline azithromycin resistance in the gut microbiota of preterm born infants.
The study identifies the presence of macrolide resistance genes in the gut microbiota of preterm infants, with erm(C) and msr(A) being the most common. These genes were found in various bacterial genera, including Staphylococcus and Enterococcus.
Genetic characterization of MDR genomic elements carrying two aac(6')-aph(2") genes in feline-derived clinical Enterococcus faecalis isolate.
The study identified a multidrug-resistant E. faecalis isolate (ESC1) carrying a novel composite transposon with two aac(6')-aph(2") genes, along with several other resistance genes on plasmids, contributing to resistance against multiple antibiotics.
Resistance and Biofilm Production Profile of Potential Isolated from Kpètè-Kpètè Used to Produce Traditional Fermented Beer.
The study identified the ermB gene in staphylococci, which confers resistance to erythromycin. Additionally, various Enterobacteriaceae and staphylococci species exhibited multidrug resistance and biofilm production capabilities.
Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections.
The review discusses the application of CRISPR-Cas systems in diagnosing and treating ESKAPE infections, highlighting their potential in detecting and targeting drug-resistant pathogens.
Antimicrobial resistance and molecular typing of Staphylococcus aureus isolates from raw milk in Hunan Province.
The study identified multiple antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk in Hunan Province, including femB, ermB, aacA-aphD, tetM, flor, and mecA, which conferred resistance to various antibiotics such as penicillin, erythromycin, gentamicin, doxycycline, florfenicol, and others.
Serotype distribution, antimicrobial susceptibility and molecular epidemiology of invasive Streptococcus pneumoniae in the nine-year period in Serbia.
The study identified macrolide resistance genes ermB and mefA in invasive Streptococcus pneumoniae isolates, highlighting high levels of macrolide resistance and the presence of multidrug-resistant and extensively drug-resistant strains.
Regulation Transcriptional of Antibiotic Resistance Genes (ARGs) in Bacteria Isolated from WWTP.
The study identifies several antibiotic resistance genes (ARGs) in bacteria isolated from wastewater treatment plants, including sul, qnr, cat1, aadA1, sat-1, tetA, ermB, and act, which confer resistance to sulfonamides, quinolones, chloramphenicol, streptomycin/spectinomycin, kanamycin, tetracycline, macrolides, and beta-lactams, respectively.
Genetic characteristics, antimicrobial susceptibility, and virulence genes distribution of Campylobacter isolated from local dual-purpose chickens in central China.
The study identified the gyrA T86I mutation and tet(O) as the most prevalent resistance mechanisms in Campylobacter isolates from local dual-purpose chickens in central China, with high resistance rates to ciprofloxacin and tetracycline.
Molecular characterization of invasive Streptococcus pneumoniae clinical isolates from a tertiary children's hospital in eastern China.
The study identified multiple AMR genes in invasive S. pneumoniae isolates, including erm(B), mef(A), msr(D), tet(M), cat-TC, and blaTEM-116, which conferred resistance to erythromycin, tetracycline, chloramphenicol, and beta-lactam antibiotics. All isolates exhibited multidrug resistance.
Secondary Infection Surveillance with Metagenomic Next-Generation Sequencing in COVID-19 Patients: A Cross-Sectional Study.
The study identified several AMR genes, including blaKPC, blaSHV, blaCTX-M, blaTEM, blaOXA-23, blaOXA-51, blaNDM, mecA, and ErmB, which confer resistance to various antibiotics in clinically relevant pathogens.
Whole genome sequence-based characterization of virulence and antimicrobial resistance gene profiles of Staphylococcus aureus isolated from food poisoning incidents in eastern China.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from food poisoning incidents in Eastern China, including blaZ, aadD1, mecA, ermB, and tetM, which confer resistance to penicillin, gentamicin, methicillin, erythromycin, and tetracycline, respectively.
Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.
The study identified multiple AMR genes in methicillin-resistant staphylococci and mammaliicocci from bulk tank milk, highlighting their role as potential reservoirs of antimicrobial resistance genes.
Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp.
The study identified ermB, mefE, and tetM as the primary genes responsible for macrolide, tetracycline, and quinolone resistance in Gemella sp. Additionally, specific mutations in gyrA were linked to levofloxacin resistance.
Comparative De Novo and Pan-Genome Analysis of MDR Nosocomial Bacteria Isolated from Hospitals in Jeddah, Saudi Arabia.
The study identified multiple antibiotic resistance genes in multidrug-resistant (MDR) nosocomial bacteria isolated from hospitals in Jeddah, Saudi Arabia. These included beta-lactamase genes such as SHV, OXA, CTX-M, TEM-1, NDM-1, VIM-1, and ere(A), as well as macrolide/lincosamide/streptogramin B resistance genes like ermA, ermB, ermC, msrA, and quaternary ammonium compound resistance genes such as qacA, qacB, and qacC.
Clostridioides difficile from Fecally Contaminated Environmental Sources: Resistance and Genetic Relatedness from a Molecular Epidemiological Perspective.
The study identified multiple AMR genes in C. difficile isolates from environmental sources, including gyrA, gyrB, blaCDD-1, blaCDD-2, tet(M), tet(40), aph(3')-IIIa, ant(6)-la, sat-4, and ermB, which confer resistance to fluoroquinolones, beta-lactams, tetracyclines, aminoglycosides, and MLS B antibiotics.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Synergistic effects of polymyxin and vancomycin combinations on carbapenem- and polymyxin-resistant Klebsiella pneumoniae and their molecular characteristics.
Development of a portable on-site applicable metagenomic data generation workflow for enhanced pathogen and antimicrobial resistance surveillance.
The study characterizes several antimicrobial resistance genes, including tet(W), tet(Q), mdf(A), erm(B), lsa(A), and aac(6')-Iaa, through the use of a spiked-in mock community and long-read sequencing.
Distribution and association of antimicrobial resistance and virulence characteristics in Enterococcus spp. isolates from captive Asian elephants in China.
The study identified tet(M), erm(B), and cfr as the most prevalent antimicrobial resistance genes in Enterococcus spp. isolates from captive Asian elephants, highlighting their role in resistance to tetracycline, erythromycin, and chloramphenicol, respectively.
Decoding the genetic structure of conjugative plasmids in international clones of Klebsiella pneumoniae: A deep dive into blaKPC, blaNDM, blaOXA-48, and blaGES genes.
The study characterizes the genetic structure of plasmids harboring major carbapenemase genes (blaKPC, blaNDM, blaOXA-48, and blaGES) in Klebsiella pneumoniae, identifying the most prevalent allele types and their co-occurrence with other resistance genes.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Distribution of Antibiotic Resistance in a Mixed-Use Watershed and the Impact of Wastewater Treatment Plants on Antibiotic Resistance in Surface Water.
The study identified several antibiotic resistance genes (ARGs) in surface water and wastewater, including ermB, qnrS, blaKPC, blaSHV, blaCTX-M, and tetB, highlighting the presence of multidrug-resistant bacteria and the role of wastewater treatment plants in spreading antibiotic resistance.
Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.
The study identified several antimicrobial resistance genes in staphylococci isolated from the skin microbiota of healthy goats and sheep, including mecA, blaZ, tetL, tetK, ermB, ermC, lnu, and grlA. These genes confer resistance to various antibiotics such as methicillin, penicillin, tetracycline, macrolides, lincosamides, and fluoroquinolones.
Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome.
The study found that seasonal azithromycin use in pediatric protracted bacterial bronchitis did not promote antimicrobial resistance but modulated the nasopharyngeal microbiome. High levels of azithromycin resistance were observed in S. pneumoniae and H. influenzae, but no significant increase in resistance was linked to azithromycin use. Genomic sequencing identified resistance genes such as erm(B), tet(M), msr(D), and mef(A) in S. pneumoniae isolates.
Macrolide-Lincosamide Resistance and Virulence Genes in Staphylococcus aureus Isolated from Clinical Specimens in Ardabil, Iran.
The study identified high frequencies of erythromycin and clindamycin resistance in Staphylococcus aureus isolates from Ardabil, Iran, with ermC being the most prevalent erythromycin resistance gene.
Dynamics of antimicrobial resistance and virulence of staphylococcal species isolated from foods traded in the Cape Coast metropolitan and Elmina municipality of Ghana.
The study identified multiple antimicrobial resistance genes in staphylococcal isolates from food samples, including genes conferring resistance to tetracycline, gentamicin, methicillin, erythromycin, and vancomycin. High prevalence of multidrug resistance was observed, highlighting the potential health risks associated with food-borne staphylococci.
Genotypic characterization, antimicrobial susceptibility and virulence determinants of Campylobacter jejuni and Campylobacter coli isolated from pastured poultry farms.
The study identified the tetO gene associated with tetracycline resistance and the ermB gene associated with erythromycin resistance in Campylobacter jejuni and Campylobacter coli isolates from pastured poultry farms. Additionally, a Thr86Ile mutation in the gyrA gene was found to confer resistance to quinolones in both species.
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue.
The study reports the successful mutasynthesis of pristinamycin I derivatives by targeting the phenylglycine residue, highlighting the role of pglA and snaE1 in pristinamycin biosynthesis.
A novel invasive Streptococcus pyogenes variant sublineage derived through recombinational replacement of the emm12 genomic region.
The study identifies a novel sublineage of Streptococcus pyogenes (emm82/ST36) that emerged through recombinational replacement of the emm12 genomic region, exhibiting diverse resistance mechanisms including macrolide and tetracycline resistance.
Clostridium neonatale antimicrobial susceptibility, genetic resistance determinants, and genotyping: a multicentre spatiotemporal retrospective analysis.
The study identified several AMR genes in Clostridium neonatale, including erm(B), tet(O), tet(32), tet(M), bla TEM-116, bla CBP-1-like, and aph(3')-IIa, which confer resistance to clindamycin, tetracycline, cefotaxime, and gentamicin. These genes are associated with mobile genetic elements.
Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention.
The study found that twice-daily rifaximin prophylaxis significantly increased antibiotic resistance gene (ARG) abundance in the gut microbiome, while other treatment groups showed no significant changes. Several ARGs, including blaTEM-1, mdtM, sul2, aph(6)-Id, aph(3")-Ib, erm(B), mph(A), qepA4, qnrB19, qnrS1, and arr, were identified in E. coli isolates from the TrEAT TD cohort.
Deciphering the Role of WWTPs in Cold Environments as Hotspots for the Dissemination of Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in cold environments, highlighting their role as hotspots for the dissemination of ARGs. Key genes included aadA, aadB, ampC, blaSHV, blaTEM, dfrA1, ermB, fosA, qnrS, and tetA(A).
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
High Incidence of Multiple-Drug-Resistant Pheromone-Responsive Plasmids and Transmissions of VanA-Type Vancomycin-Resistant Enterococcus faecalis between Livestock and Humans in Taiwan.
The study identifies vanA, ermB, and bcrABDR genes in VanA-type vancomycin-resistant Enterococcus faecalis isolates from Taiwan, highlighting the role of pheromone-responsive conjugative plasmids in transmitting multiple-drug resistance between livestock and humans.
Rapid Detection of Antimicrobial Resistance Genes in Critically Ill Children Using a Custom TaqMan Array Card.
The study validated a custom AMR-TAC for detecting AMR genes in critically ill children, revealing the presence of various AMR genes such as ermB, mecA, mecC, bla CTX-M-1, bla CTX-M-9, vanA, and vanB in respiratory and fecal samples.
Multiplex Real-Time PCR for the Detection of Tetracycline, Ciprofloxacin, and Erythromycin Resistance Determinants from Human and Foodborne Campylobacter jejuni and Campylobacter coli.
The study developed a multiplex real-time PCR assay to detect tetracycline, ciprofloxacin, and erythromycin resistance determinants in Campylobacter jejuni and Campylobacter coli. The assay successfully detected tet(O), erm(B), GyrA_T86I/V, and A2075G mutations.
Molecular characterisation and antimicrobial resistance of Streptococcus agalactiae isolates from dairy farms in China.
The study identified tetracycline resistance genes tet(M), tet(O), and erythromycin resistance gene erm(B) in Streptococcus agalactiae isolates from dairy farms in China.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides.
The study found that Neolamarckia cadamba leaves extract (NCLE) reduced the abundance of antibiotic resistance genes (ARGs) in cecal contents of lipopolysaccharide (LPS)-induced broilers by maintaining microbial balance.
Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K(3).
The study identified several macrolide resistance genes, including erm(A), erm(B), erm(C), msr(A), and mph(C), in Staphylococcus aureus isolates. These genes were associated with resistance to erythromycin and azithromycin.
Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022.
The study identified the prevalence of antimicrobial resistance genes in Streptococcus suis isolates from Spain, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E). High resistance levels were observed for clindamycin, chlortetracycline, and sulfadimethoxine.
Pathogenic Potential and Antibiotic Susceptibility: A Comprehensive Study of Enterococci from Different Ecological Settings.
The study identified several antibiotic resistance genes in Enterococcus isolates, including ermB (macrolide resistance), vanA (glycopeptide resistance), aphA3 (aminoglycoside resistance), aac6′-aph2″ (aminoglycoside resistance), and cat pIP501 (chloramphenicol resistance).
Epitranscriptional m6A modification of rRNA negatively impacts translation and host colonization in Staphylococcus aureus.
The study identifies ermB as a gene that confers resistance to macrolides, lincosamides, and streptogramin B (MLS) antibiotics through the m6A2058 modification of rRNA, which impairs translation and host colonization in Staphylococcus aureus.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Prevalence, antibiotic resistance, and genomic characterisation of Campylobacter spp. in retail chicken in Hanoi, Vietnam.
The study identified multiple AMR genes and mutations in Campylobacter isolates from retail chicken in Hanoi, Vietnam, including aminoglycoside resistance genes (aadE, aadA9, aph(2'')-If, aac(6')-Ie/aph(2'')-Ia), erythromycin resistance gene ermB, tetracycline resistance gene tet(O), beta-lactam resistance gene blaOXA-193, and a quinolone resistance mutation (T86I) in gyrA.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
Development and validation of multiplex real-time PCR for simultaneous detection of six bacterial pathogens causing lower respiratory tract infections and antimicrobial resistance genes.
The study developed and validated multiplex real-time PCR assays for the simultaneous detection of six bacterial pathogens and 14 antimicrobial resistance (AMR) genes directly from respiratory samples. The assays demonstrated high sensitivity and specificity for detecting pathogens and AMR genes, with particular emphasis on beta-lactamases, macrolide resistance, and methicillin resistance.
Prevalence and antimicrobial resistance of Enterococcus spp. isolated from animal feed in Japan.
The study identified ermB as a resistance gene in Enterococcus faecium isolates from animal feed, contributing to erythromycin resistance.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Serotype, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in all age groups living in Southwest China during 2018-2022.
The study identified several AMR genes in Streptococcus pneumoniae isolates from Southwest China, including msrD, mefA, ermB, tetM, and catTC, which confer resistance to erythromycin, tetracycline, and chloramphenicol. High levels of resistance to erythromycin (96.96%) and tetracycline (79.85%) were observed, along with significant multidrug resistance.
Macrolide and lincosamide resistance of Streptococcus agalactiae in pregnant women in Poland.
The study identifies the ermB, mefA, ermA, lnuB, lsaE, and tetM genes as key contributors to macrolide and lincosamide resistance in Streptococcus agalactiae isolates from pregnant women in Poland.
Antimicrobial Resistance in Salmonella spp. from Food-Producing Animals and Human Cases in the EU
The study identifies several AMR genes, including bla CTX-M-1, bla CTX-M-14b, bla SHV-12, tet(X3), and tet(X4), in Salmonella isolates from food-producing animals and human cases in the EU. These genes confer resistance to various antibiotics, highlighting the spread of multidrug-resistant Salmonella strains.
Clinical, microbiological, and molecular characterization of pediatric invasive infections by Streptococcus pyogenes in Spain in a context of global outbreak.
The study identified tetracycline resistance mediated by tetM, erythromycin and clindamycin resistance mediated by ermB, ermT, and mefA in Streptococcus pyogenes isolates from pediatric invasive infections in Spain.
Multidrug-resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage.
The study identified multidrug-resistant Enterococcus faecium strains carrying resistance genes such as aac(6')-Ii, erm(B), erm(T), tet(L), tet(M), and msr(C), as well as mutations in gyrA and parC contributing to ciprofloxacin resistance.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Antibiotic prescribing patterns and carriage of antibiotic-resistant Escherichia coli and Enterococcus species in healthy individuals from selected communities in Lusaka and Ndola districts, Zambia.
The study identified several AMR genes in E. coli and Enterococcus species, including bla CTX-M, sul2, qnrA, and various erm genes, highlighting the prevalence of multidrug resistance in commensal bacteria from healthy individuals in Zambia.
Antimicrobial resistance and virulence profiling of Staphylococcus pseudintermedius isolated from cats, Bangladesh.
The study identified methicillin-resistant S. pseudintermedius (MRSP) with the mecA gene, erythromycin resistance genes ermA and ermB, and tetracycline resistance genes tetK and tetL in cats in Bangladesh.
Antimicrobial resistance markers distribution in Staphylococcus aureus from Nsukka, Nigeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from Nsukka, Nigeria, including MecA, VanA, VanB, ErmB, and ErmC, which confer resistance to methicillin, vancomycin, and macrolides.
Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements.
The study identified various AMR genes and mutations in Klebsiella pneumoniae ST147 isolates, including bla NDM-5, bla NDM-1, bla OXA-181, bla OXA-232, bla OXA-48, aadA1, aph(3')-VI, bla CTX-M-15, bla TEM-1B/C, bla OXA-9, truncated catA1, qnrS1, sul1, dfrA5, mph(A), erm(B), aac(6')-Ib, aac(6')-Ib3, sul2, aph(3')-Ia, rmtB, fosA, oqxAB, bla SHV-11/67, arr-3, and catB3.
Detection of Macrolide-Resistant Streptococcus pneumoniae Genes and Its Clinical Outcomes in a Tertiary Teaching Hospital in Malaysia.
The study identified the presence of the mef(A) and erm(B) genes in erythromycin-resistant Streptococcus pneumoniae isolates, with mef(A) being the most prevalent. These genes contribute to macrolide resistance, as evidenced by elevated MIC values.
Streptococcus suis serotype 4: a population with the potential pathogenicity in humans and pigs.
The study identified multiple antibiotic resistance genes in Streptococcus suis serotype 4, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, oxazolidinones, and chloramphenicol. Prophages were identified as the primary vehicle for the dissemination of these resistance genes.
Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia.
The study identified several AMR genes including erm(B), erm(A), lsa(C), mef(A), tet(M), tet(O), aac(6')-aph(2''), ant(6)-Ia, aph(3')-III, and aadE in GBS isolates from Saudi Arabia, highlighting the prevalence of resistance to macrolides, lincosamides, tetracycline, and aminoglycosides.
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia.
The study identifies AMR genes such as ermB, tetM, aac(6')-Ib, sat4A, ant6-Ia, and aph3-III in Clostridioides difficile strains, particularly in RT014/020. Mutations in gyrA and gyrB contribute to fluoroquinolone resistance. AMR is uncommon, with limited evidence of clonal transmission.
Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains from Domestic Geese in Poland.
The study identifies the presence of resistance genes erm47 and ermB in Erysipelothrix rhusiopathiae strains from domestic geese in Poland, along with other resistance genes such as tetM, lnuB, lsaE, ant(6)-Ia, and spw. It also highlights the role of integrative and conjugative elements (ICEs) and prophage DNA in the spread of these resistance genes.
Design and Validation of Primer Sets for the Detection and Quantification of Antibiotic Resistance Genes in Environmental Samples by Quantitative PCR.
The study presents eleven novel primer sets for the detection and quantification of antibiotic resistance genes (ARGs) in environmental samples using qPCR. These primers target genes such as aadA, aadB, ampC, blaTEM, blaSHV, dfrA1, ermB, fosA, mecA, qnrS, and tetA(A), which are responsible for resistance to various antibiotics including aminoglycosides, beta-lactams, trimethoprim, macrolides, fosfomycin, quinolones, and tetracyclines.
Complete genome sequence of the linezolid-resistant clinical Enterococcus faecalis N23-3408 linked to a livestock lineage in Switzerland.
The linezolid-resistant E. faecalis N23-3408 harbors the optrA gene on a plasmid, along with other resistance genes including cat, erm(B), fexA, tet(L), and tet(M).
Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
The study identified several macrolide resistance genes, including mph(A), mph(B), mef(B), erm(B), mef(C)-mph(G), erm(C), erm(42), ere(A), and msr(E)-mph(E), associated with azithromycin resistance in E. coli and Salmonella from food-producing animals and meat in Europe. The study also highlighted the importance of the mph(A) operon structure and its regulatory region in determining azithromycin resistance.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
The Genetic Landscape of Antimicrobial Resistance Genes in Enterococcus cecorum Broiler Isolates.
The study identified several antimicrobial resistance genes (ARGs) in Enterococcus cecorum isolates, including ant(6)-la, ermB, lsaE, tet(M), tet(L), and vanA, which are associated with resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, and glycopeptides. Additionally, point mutations in GyrA, GyrB, ParC, and PBP2x were found to contribute to resistance against enrofloxacin and β-lactam antibiotics.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Suppression PCR-Based Selective Enrichment Sequencing for Pathogen and Antimicrobial Resistance Detection on Cell-Free DNA in Sepsis-A Targeted, Blood Culture-Independent Approach for Rapid Pathogen and Resistance Diagnostics in Septic Patients.
The study presents a novel method called SUPSETS for detecting pathogens and antimicrobial resistance genes (AMRs) in sepsis using cell-free DNA. It identifies tetracycline resistance (tetB), vancomycin resistance (vanA), and macrolide resistance (ermB) in clinical samples.
Detection of the antibiotic resistance genes content of intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients from European countries.
The study identified and compared the prevalence of antibiotic resistance genes in intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients in European countries, highlighting differences in gene carriage between gut microbiota and clinical strains.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
The study identifies several AMR genes and mutations in Enterococcus isolates, including vanB for vancomycin resistance, lsaA, lsaE, lnuB for lincosamide resistance, tetM and tetL for tetracycline resistance, aac6'-Ii, aac6'-aph2'', aph3'-III, and ant6-Ia for aminoglycoside resistance, msrC, ermB, and ermT for macrolide resistance, and mutations in gyrA, parC, pbp5, and 23S rRNA for fluoroquinolone, penicillin, and linezolid resistance.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Phenotypic and genotypic characterization of commensal staphylococci isolated from young volunteers in Alexandria, Egypt.
The study identified the presence of macrolide resistance genes ermB, ermC, and msrA in Staphylococcus aureus and other staphylococci (SOSA) isolates, with ermB showing the highest prevalence. These genes confer resistance to erythromycin and azithromycin.
Machine learning-based classification reveals distinct clusters of non-coding genomic allelic variations associated with Erm-mediated antibiotic resistance.
The study identifies how specific alleles in the upstream regions of the ermB gene influence the formation of RNA hairpin structures, thereby modulating ermB expression and affecting MLS resistance. Experimental validation confirmed the predictive model linking allele combinations to resistance phenotypes.
Genome analysis of multidrug resistant Enterococcus faecium and Enterococcus faecalis circulating among hospitalized patients in uMgungundlovu District, KwaZulu-Natal, South Africa.
The study identified multiple AMR genes including VanC-1, VanG, Vex2, Vex3, emeA, Isa, ermB, TetM, fosB, ParC, ParE, gyrA, gyrB, MATE, MFS, and pmrA in multidrug-resistant Enterococcus faecium and Enterococcus faecalis. These genes conferred resistance to various antibiotics such as vancomycin, tetracycline, erythromycin, clindamycin, ciprofloxacin, and moxifloxacin.
Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.
The study identified novel methicillin-resistant Staphylococcus pseudintermedius (MRSP) lineages, including ST726 and ST551, and characterized antimicrobial resistance genes such as mecA, blaZ, tetK, and mupA. It also noted a high prevalence of multidrug resistance (MDR) among MRSP isolates.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Macrolones target bacterial ribosomes and DNA gyrase, and can evade resistance mechanisms by inhibiting both targets. Mutations in gyrA and 23S rRNA are associated with resistance to fluoroquinolones and macrolides, respectively.
Characterization of group A streptococci causing invasive diseases in Sri Lanka.
The study identified erythromycin resistance mediated by erm(B) and mef(A) genes, and tetracycline resistance mediated by the tet(M) gene in group A streptococci isolates from Sri Lanka.
Ribosomal RNA methylation in Staphylococcus aureus and Escherichia coli: effect of the "MLS" (erythromycin resistance) methylase.
The study identifies and characterizes the MLS methylase genes ermB and ermC, which confer resistance to macrolides, lincosamides, and streptogramin B by methylating specific adenosine residues in the 23S rRNA of Staphylococcus aureus and Escherichia coli.
Effect of Stepwise Exposure to High-Level Erythromycin on Anaerobic Digestion.
The study identifies ermB and mefA as dominant erythromycin resistance genes in anaerobic digestion systems, with ermB conferring resistance via target alteration and mefA via efflux pumps.
Population genomics uncovers global distribution, antimicrobial resistance, and virulence genes of the opportunistic pathogen Klebsiella aerogenes.
The study characterizes various antimicrobial resistance genes in Klebsiella aerogenes, including beta-lactamases, carbapenemases, and colistin resistance genes, highlighting the diversity and global distribution of these resistance mechanisms.
The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli.
The study identified multiple antibiotic resistance genes in a multidrug-resistant Escherichia coli strain, including blaTEM, ermA, ermB, aadA1, qnrS, qepA, oqxA, tetA, tetB, and tetC, which conferred resistance to various antibiotics such as beta-lactams, macrolides, aminoglycosides, quinolones, and tetracyclines. The combination of matrine and berberine hydrochloride showed synergistic antibacterial effects against this strain.
Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae.
The study identifies mefE and ermB as key genes responsible for macrolide resistance in Streptococcus pneumoniae, highlighting their role in the acquisition of resistance through transformation and recombination events in Tn916-related elements.
A first study of meat-borne enterococci from butcher shops: prevalence, virulence characteristics, antibiotic resistance and clonal relationship.
The study identified tetracycline resistance gene tet(L), aminoglycoside resistance gene aac(6')-Ie-aph(2")-la, and macrolide/lincosamide/streptogramin B resistance gene ermB in Enterococcus isolates from meat samples.
Characterization of azithromycin-resistant Shigella flexneri serotype 2a isolates using whole genome sequencing in Ontario from 2016 to 2018.
The study identified the presence of mph(A) and erm(B) genes on plasmids in azithromycin-resistant Shigella flexneri serotype 2a isolates, contributing to resistance against azithromycin.
Inducible clindamycin-resistant and biofilm formation in the Staphylococcus aureus isolated from healthcare worker's anterior nasal carriage.
The study identified the presence of ermC, ermA, ermB, and ereA genes in Staphylococcus aureus isolates from healthcare workers, contributing to macrolide-lincosamide-streptogramin B resistance and clindamycin resistance.
A nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.
The study presents a nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, which allows for the controlled expression of genes in various streptococci and enterococci. The system includes the nisRK regulatory system and the PnisA promoter, enabling inducible gene expression. The system was validated through cloning, transformation, and expression of the emm6.1::ha1 fusion gene, demonstrating successful integration and expression in multiple bacterial species.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.
The study identified high frequencies of tetracycline and macrolide resistance genes, specifically tetO and ermB, in European Streptococcus suis isolates.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Group B Streptococcus Infections in Non-Pregnant Adults, Italy, 2015-2019.
The study identified the erm(B) gene as a major contributor to macrolide resistance, tet(M) and tet(O) genes as primary determinants of tetracycline resistance, and noted a significant increase in resistance to erythromycin and clindamycin among Group B Streptococcus isolates in Italy.
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
The role of TiO(2) and gC(3)N(4) bimetallic catalysts in boosting antibiotic resistance gene removal through photocatalyst assisted peroxone process.
The study identifies the effectiveness of photocatalyst-assisted peroxone process in removing antibiotic resistance genes such as blaTEM, ermB, qnrS, and tetM.
A single amplified genome catalog reveals the dynamics of mobilome and resistome in the human microbiome.
The study identifies numerous AMR genes in oral and fecal SAGs, highlighting the presence of resistance mechanisms such as efflux pumps, quinolone resistance proteins, dihydrofolate reductases, erythromycin ribosome methyltransferases, and aminoglycoside phosphotransferases.
Trends in shigellosis notifications in England, January 2016 to March 2023.
The study identifies bla CTX-M-27 and bla CTX-M-15 as key contributors to third-generation cephalosporin resistance in Shigella species, with distinct associations with sexual transmission and travel. Azithromycin resistance is linked to ermB and mphA, while ciprofloxacin resistance is associated with mutations in gyrA, parC, and qnr genes.
The Intestinal Resistome of Preterm Infants Exhibited a Rich Diversity of ARGs
The study identified a rich diversity of antibiotic resistance genes (ARGs) in the intestinal microbiota of preterm infants, with beta-lactam, MLS, and tetracycline resistance being the most prevalent. Key ARGs included ermC, ermB, mecA, TEM-4, ANT(4')-Ib, isaA, vgaC, and oqxB, which were associated with various bacterial species and drug classes.
First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.
The study identified multiple carbapenem resistance genes, including bla KPC-2, bla PDC-36/12, and bla POM-1, in multidrug-resistant Gram-negative bacteria isolated from a pediatric hospital in the Gaza Strip. These genes were found in various bacterial species such as Escherichia coli and Klebsiella pneumoniae.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
An antimicrobial resistance gene situationer in the backyard swine industry of a Philippine City.
The study identified the presence of antimicrobial resistance genes (ARGs) in swine feces from backyard farms in Davao City, Philippines, including bla TEM, ermB, qnrS, and tetM, which are associated with resistance to beta-lactams, macrolides, fluoroquinolones, and tetracyclines, respectively.
Genomic evaluation of the probiotic and pathogenic features of Enterococcus faecalis from human breast milk and comparison with the isolates from animal milk and clinical specimens.
The study identified antibiotic resistance genes lsaA, tetM, and ermB in Enterococcus faecalis isolates from human breast milk, with fewer resistance genes compared to clinical isolates. Mutations in gyrA and parC were observed in clinical isolates, contributing to quinolone resistance.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
Limited Evidence of Spillover of Antimicrobial-Resistant Klebsiella pneumoniae from Animal/Environmental Reservoirs to Humans in Vellore, India.
The study found that clinical and hospital sewage isolates of Klebsiella pneumoniae had a higher number of AMR genes compared to livestock isolates, suggesting that AMR is more prevalent in human-associated settings. Several beta-lactamase genes, including blaCTX-M, blaNDM, blaKPC, and blaOXA-48, were detected in clinical isolates, contributing to resistance against carbapenems and other antibiotics. Other AMR genes such as qnrS1, aac(6')-Ib, aadA, ermB, mefA, tet(A), mph(A), cat, cfr, vanA, mcr-1, fosA, sul1, and dfrA1 were also identified, highlighting the diversity of resistance mechanisms in K. pneumoniae.
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
The study identifies a clonal expansion of multidrug-resistant Shigella sonnei (genotype 3.6.1.1.2) with resistance to multiple antibiotics, including ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, and azithromycin.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance.
Probiotics from health supplements were found to harbor ARGs conferring resistance to tetracycline, macrolide, aminoglycoside, and glycopeptide antibiotics. Specifically, aadA and erm(B)-1 were detected in transconjugants after co-incubation with streptomycin-adapted probiotics.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021-2024.
The study identified several AMR genes associated with macrolide, lincosamide, and tetracycline resistance in Streptococcus agalactiae isolates from Bulgaria. These include ermB, ermA/TR, ermC, mefA, mefE, msrD, lnuB, lsaC, lsaE, tetM, and tetO. High resistance rates to macrolides (60.3%) and tetracyclines (89.1%) were observed.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
Characterization of integrative and conjugative elements carrying erm(B) and tet(O) resistance determinants in streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: CompArative GEne cluster analysis toolbox with ICEfinder.
The study identified and characterized integrative and conjugative elements (ICEs) carrying the erm(B) and tet(O) resistance genes in Streptococcus uberis isolates from bovine milk in Japan. These genes confer resistance to macrolides, lincosamides, streptogramin B, and tetracyclines.
Antibiotic susceptibility testing and molecular characterization based on whole-genome sequencing of Streptococcus pneumoniae isolates from pediatric infections at the National Regional Medical Center of Southwest China during the COVID-19 pandemic.
The study identified several AMR genes in Streptococcus pneumoniae isolates, including tet(M), erm(B), msr(D), and mef(A), which confer resistance to tetracycline, erythromycin, and macrolides. These findings highlight the genetic basis of antibiotic resistance in pneumococcal isolates during the post-pandemic period in Southwest China.
Genomic insights into the probiotic potential and genes linked to gallic acid metabolism in Pediococcus pentosaceus MBBL6 isolated from healthy cow milk.
The study identified two antibiotic resistance genes, lnu(A) and erm(B), in Pediococcus pentosaceus MBBL6, which confer resistance to linezolid and macrolides, respectively.
Increasing rates of erm(B) and erm(N) in human Campylobacter coli and Campylobacter jejuni erythromycin-resistant isolates between 2018 and 2023 in France.
The study identifies an increase in erm(B) and erm(N) genes in erythromycin-resistant Campylobacter isolates in France between 2018 and 2023, with erm(N) predominantly found in a CRISPR-Cas9 operon and erm(B) in multidrug resistance genomic islands.
Prediction of antimicrobial susceptibility of pneumococci based on whole-genome sequencing data: a direct comparison of two genomic tools to conventional antimicrobial susceptibility testing.
The study evaluated the performance of two genomic tools, Pathogenwatch and AREScloud, for predicting antimicrobial susceptibility of pneumococci. It identified the presence of the ermB gene associated with erythromycin resistance and the tetM gene linked to tetracycline resistance.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
The presence of antibiotic-resistant bacteria at four Norwegian wastewater treatment plants: seasonal and wastewater-source effects.
The study identified the presence of resistance genes ermB, tetA, and tetM in wastewater treatment plants in Norway, highlighting their persistence in effluent and the need for advanced treatment processes to mitigate their environmental spread.
Antimicrobial activity of adipose-derived mesenchymal stromal cell secretome against methicillin-resistant Staphylococcus aureus.
The study identifies mecA, ermA, and ermB genes as contributors to resistance in MRSA isolates against AD-MSC secretome.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Genetic analysis reveals the genetic diversity and zoonotic potential of Streptococcus dysgalactiae isolates from sheep.
The study identified tet(M), tet(O), and erm(B) as the primary AMR genes in S. dysgalactiae isolates from sheep, contributing to resistance against doxycycline and erythromycin.
Clostridioides difficile recovered from hospital patients, livestock and dogs in Nigeria share near-identical genome sequences.
The study identified several AMR genes and mutations in C. difficile isolates from Nigeria, including erm(B) for clindamycin resistance, tet(M) for tetracycline resistance, cfr(B) for linezolid resistance, and erm(A) for MLSB resistance. Additionally, gyrA-Thr82Ile mutation was found to confer fluoroquinolone resistance.
Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region.
The study identified a high prevalence of aminoglycoside and tetracycline resistance genes, including aph(3')-IIIa, ermB, mcr-1, qnrB19, and tetQ, in hospitalized patients from a high animal husbandry region. Unique resistance genes and mutations, such as dfrF and gyrB, were noted at discharge.
Colonization of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci and its associated factors in cancer patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.
The study found a significant prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) colonization among cancer patients, highlighting the need for improved antibiotic stewardship and early detection strategies.
Abundance of clinically relevant antimicrobial resistance genes in the golden jackal (Canis aureus) gut.
The study identified a high prevalence of clinically relevant antimicrobial resistance genes in golden jackals, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla SHV), quinolone resistance (qnrS), and class 1 integrons (Int1).
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of Streptococcus suis Serotype 3.
The study identified the presence of the tet(W) and erm(B) genes in the S. suis strain YA, which confer resistance to tetracyclines and macrolide-lincosamide-streptogramin antibiotics, respectively.
Characteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes of Staphylococcus aureus isolates from caprine mastitis in China.
The study identified several AMR genes in S. aureus isolates from caprine mastitis in China, including blaZ, mecA, tetK, tetM, ermB, lnu(B), aacA-aphD, and gyrA, which confer resistance to various antibiotics such as penicillin, oxacillin, tetracycline, erythromycin, lincomycin, gentamicin, amikacin, and fluoroquinolones.
Fecal carriage and molecular characterization of carbapenem-resistant Enterobacteriaceae from hospitalized children in a tertiary hospital of Shandong, China.
The study identified bla NDM-1, bla NDM-5, and bla OXA-1 as the most prevalent carbapenemase genes in CRE isolates from hospitalized children in Shandong, China. Additional resistance genes such as bla CTX-M-55, bla CTX-M-15, sul 1, tet A, and mcr-1.26 were also characterized.
Novel insights into carbohydrate utilisation, antimicrobial resistance, and sporulation potential in Roseburia intestinalis isolates across diverse geographical locations.
The study identified tetracycline resistance genes tet(O) and tet(40), and the erythromycin resistance gene ermB in Roseburia intestinalis isolates.
Predomination of hypervirulent ST283 and genetic diversity of levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae in Thailand.
The study identified multiple AMR genes and mutations associated with tetracycline, erythromycin, clindamycin, and levofloxacin resistance in multidrug-resistant, hypervirulent Streptococcus agalactiae isolates in Thailand, highlighting the predominance of hypervirulent ST283 and the emergence of MDR-GBS.
Genomic islands and molecular mechanisms relating to drug-resistance in Clostridioides (Clostridium) difficile PCR ribotype 176.
The study identifies several AMR genes and mutations in C. difficile PCR ribotype 176, including a novel 23S rRNA methyltransferase mrmA associated with high-level erythromycin resistance. It also characterizes mutations in gyrA, rpoB, pbp1, and pbp3 contributing to resistance against fluoroquinolones, rifampicin, and carbapenems, along with the aac(6')-Ie-aph(2'')-Ia gene and ermB gene for aminoglycoside and macrolide resistance, respectively.
Effect of Sub-Inhibitory Concentrations of Quaternary Ammonium Compounds and Heavy Metals on Antibiotic Resistance and Expression of Virulence Factors Among Staphylococcus spp. from Dairy Products.
Sub-inhibitory concentrations of benzalkonium chloride and cadmium chloride induce the overexpression of antibiotic resistance genes such as bla Z, erm B, mec A, tet K, and tet M in Staphylococcus isolates from dairy products, leading to increased antibiotic resistance.
Impact of the Technical Snow Production Process on Bacterial Community Composition, Antibacterial Resistance Genes, and Antibiotic Input-A Dual Effect of the Inevitable.
The study identified several antibiotic resistance genes (ARGs) in water and snow samples from ski resorts, including blaTEM, blaCTX-M, mecA, ereA, ermB, strA, tetK, and sulIII. These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and sulfonamides. The presence of these ARGs highlights the potential environmental impact of technical snow production on antimicrobial resistance.
High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.
The study identified the vanA gene as the primary determinant of vancomycin resistance in all 29 VREfm isolates. Additional resistance genes such as aac(6')-Ii, ant(6')-Ia, erm(B), msr(C), tet(L), tet(M), aph(3')-III, aph(2'')-Ia, and inu(B) were also characterized, contributing to resistance against a variety of antibiotics.
Salad Vegetables as a Reservoir of Antimicrobial-Resistant Enterococcus: Exploring Diversity, Resistome, Virulence, and Plasmid Dynamics.
The study identified vancomycin resistance genes (vanC, vanXY-C2) in a vancomycin-susceptible E. faecalis isolate, along with optrA, tetM, ermB, lsa(A), msr(C), and ant(6)-Ia genes in Enterococcus isolates, highlighting the presence of multidrug-resistant strains in salad vegetables.
Monitoring Antibiotic Resistance in Wastewater: Findings from Three Treatment Plants in Sicily, Italy.
The study identified the presence and abundance of various antibiotic resistance genes (ARGs) in wastewater samples from three treatment plants in Sicily, Italy. Key findings include the consistent detection of bla SHV, bla OXA, bla NDM, bla VIM, bla TEM, bla CTX-M, erm(A), and erm(B) across all samples, with particular emphasis on their roles in conferring resistance to beta-lactams and macrolides.
First WGS Characterization of Streptococcus suis Isolated From a Case of Human Meningitis in Southern Italy.
The study identified the presence of tetracycline resistance gene tet(W) and macrolide-lincosamide-streptogramin resistance gene erm(B) in a Streptococcus suis strain isolated from a human case of meningitis in Italy. Additionally, a mutation in the pbp1a gene was found to be responsible for penicillin resistance.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Changing patterns and biological features of community-acquired Clostridioides difficile infection in Southwest China: 7 years of surveillance data.
The study identified ermA and tetM as genes conferring resistance to erythromycin and tetracycline, respectively, in C. difficile strains. These findings were supported by antibiotic resistance testing.
Changing patterns and biological features of community-acquired Clostridioides difficile infection in Southwest China: 7 years of surveillance data.
The study identified ermA and tetM as genes conferring resistance to erythromycin and tetracycline, respectively, in C. difficile strains. These findings were supported by antibiotic resistance testing.
Prevalence and antimicrobial resistance profile of Listeria spp. isolated from raw fish.
The study identified blaTEM, ampC, and ereB as the most prevalent antimicrobial resistance genes in L. monocytogenes isolates from raw fish, with high resistance rates to multiple antibiotics.
Phenotypic and genotypic characteristics of macrolide, lacosamide, and streptogramin resistance in clinically resistant Streptococci and their correlation with reduced biocide susceptibility.
The study identifies ermB, ereA, msrA, mefA, and mefE as key genes associated with MLS resistance in Streptococci, highlighting the role of efflux mechanisms and ribosomal methylation in conferring resistance to macrolides, lincosamides, and streptogramins.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Population structure, antibiotic resistance and molecular characteristics of Streptococcus pneumoniae causing invasive disease in Hubei, China.
The study identified high prevalence of ermB and tetM genes in Streptococcus pneumoniae isolates, which are associated with macrolide and tetracycline resistance, respectively. ST271 strains showed higher resistance rates to several antibiotics compared to non-ST271 strains.
Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant Staphylococcus aureus: potential for cross-species transmission of ST59-MRSA.
The study identified several antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from bovine mastitis, including erm(B), erm(C), tet(L), tet(K), mecA, fexA, aac(6')-aph(2''), ant(4')-Ia, ant(6)-Ia, and aph(2'')-Ia. These genes were associated with resistance to various antibiotics such as erythromycin, tetracycline, penicillin, oxacillin, cefoxitin, florfenicol, and gentamicin.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
The study identified multidrug-resistant Escherichia coli isolates from Nigeria, highlighting the presence of virulence genes and mobile genetic elements, along with specific mutations in gyrA and parC that confer resistance to fluoroquinolones.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Genomic characterization of vancomycin-resistant enterococci in Norwegian poultry.
The study identified vanA and narAB genes on pVEF-like plasmids in vancomycin-resistant Enterococcus faecium and E. hirae isolates from Norwegian poultry, along with additional resistance genes such as ermB, tetM, and aac(6')-Ii.
Rabbit carcasses as important vectors of multidrug-resistant Enterococcus faecalis, but not E. faecium: prevalence and molecular characterization from a study in Poland.
The study identified multiple AMR genes in Enterococcus faecalis isolates from rabbit carcasses, including aac(6')-Ie-aph(2")-Ia, ant(6)-Ia, aph(3')-IIIa, ermB, tetM, and tetL, which were consistent with the observed phenotypic resistance patterns.
Multidrug-Resistant Staphylococcus aureus in Diabetic Foot Infections (DFI) from Beira, Mozambique: Prevalence and Virulence Profile.
The study identified high levels of multidrug resistance in Staphylococcus aureus isolates from diabetic foot infections in Beira, Mozambique, with resistance genes blaZ, mecA, vancA, vancB, ermB, ermC, dfrA, and dfrG being prevalent.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
The impact of green spaces, urban settings, seasonal changes, and pollutants on dissemination of antimicrobial genes in air.
The study identified several antimicrobial resistance genes (ARGs) in airborne samples, including blaTEM, mecA, aac(6')-Ib, ermB, ermC, tetM, tetW, sul1, and sul3. It found that the relative abundance of these ARGs varied with vegetation coverage, seasons, and environmental factors. High vegetation areas showed slightly lower ARG abundance compared to urban heat islands and low/no vegetation areas. The study highlights the potential of planting non-allergenic vegetation to reduce airborne ARG dissemination.
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.
Genomic surveillance of invasive Streptococcus pneumoniae strains in south Tunisia during 2012-2022.
The study identified the resistance genes erm B and tet M as the most prevalent in invasive Streptococcus pneumoniae isolates in south Tunisia, conferring resistance to erythromycin and tetracycline, respectively.
Genomic analysis and pneumococcal population dynamics across PCV implementation in South Korea, 1997-2023.
The study identified the presence of ermB and tetM genes in Streptococcus pneumoniae isolates, which confer resistance to azithromycin, erythromycin, and tetracycline. These genes were found in isolates from both invasive and non-invasive pneumococcal diseases.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
TRENDS IN MULTIPLE ANTIBIOTIC RESISTANCE AMONG PREDOMINANT HOSPITAL ISOLATES: ANNUAL VARIATIONS AND PEAK SEASONAL PATTERNS
The study identified mecA, vanA, and tetM as key resistance genes in Staphylococcus aureus isolates with high multiple antibiotic resistance indices, indicating the presence of methicillin-resistant and vancomycin-resistant strains.
Characteristics of Staphylococcus saprophyticus Isolated from Humans and Animals.
The study identified several AMR genes in Staphylococcus saprophyticus strains isolated from humans and animals, including blaZ, mecA, ermA, ermB, tetM, fusB, and mupA, which confer resistance to various antibiotics such as beta-lactams, macrolides, tetracyclines, fusidic acid, and mupirocin.
Genomic and phenotypic characterization of methicillin-resistant Staphylococcus aureus ST965: an emerging hospital-adapted clone with enhanced invasiveness.
The study identifies multiple AMR genes in ST965-MRSA, including blaI-blaR-blaZ, erm(B), erm(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, mepA, mepR, cadD, cadC, and the plasmid pYF965, which contribute to multidrug resistance and hospital adaptation.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Whole-genome sequencing and bioinformatic tools powered by machine learning to identify antibiotic-resistant genes and virulence factors in Escherichia coli from sepsis.
The study identified several known and novel antibiotic-resistant genes in E. coli isolates from sepsis patients using whole-genome sequencing and machine learning. Key findings include the presence of blaCTX-M, blaSHV, blaTEM, aac(6')-Ib, aadA, qnrS1, ermB, mexAB-OprM, acrAB-TolC, and oqxAB genes, which confer resistance to various antibiotics.
Epidemiology and genetic characteristics of Clostridioides difficile isolates in Northwest China.
The study identified 13 resistance genes, including cdeA, ermB, 23S rRNA, vanXYG, tetM, and tetB(P), along with mutations in gyrA, gyrB, and rpoB, conferring resistance to fluoroquinolones, macrolides, lincosamides, glycopeptides, tetracyclines, and rifamycins in Clostridioides difficile isolates from Northwest China.
Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae.
The study identifies two lytic bacteriophages, vB_KpnP_XY3 and vB_KpnP_XY4, effective against multidrug-resistant Klebsiella pneumoniae. These phages demonstrate broad temperature and pH tolerance, chloroform resistance, and potent lytic activity against MDR K. pneumoniae strains, significantly reducing bacterial load and inflammation in a murine pneumonia model.
Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.
The study identifies tetracycline resistance genes (tet(Q), tet(A)), macrolide resistance genes (mef(A), erm(B), erm(F)), and lincosamide resistance gene (lnu(C)) in the natural microbiota of dogs and cats, highlighting their potential as vectors for antimicrobial resistance.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
Genomic and Antimicrobial Resistance Analysis of an ST25 Streptococcus suis Strain Isolated from a Human in Zhejiang Province, China.
The study identified the tetracycline resistance gene tet(O) and the macrolide resistance gene erm(B) in an ST25 Streptococcus suis strain isolated from a human in Zhejiang Province, China.
Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population.
The study identified tetracycline resistance genes tet(O) and tet(40), as well as the MLS B resistance gene erm(B) in S. suis serotype 14 strains, highlighting their significant antimicrobial resistance profiles.
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model.
The study identifies multiple ESBL-producing E. coli isolates and characterizes their resistance genes, highlighting the transfer of bla CTX-M-1 plasmids among isolates in a chicken cecal fermentation model.
Factors affecting CRISPR-Cas defense against antibiotic resistance plasmids harboured by Enterococcus faecalis laboratory model strains and clinical isolates.
The study demonstrates that the presence of multiple plasmids in a donor strain can significantly increase the conjugative transfer of antibiotic resistance plasmids, particularly when the recipient lacks a functional CRISPR-Cas system. Specifically, pTEF2 and pCF10 were shown to enhance the transfer of pTEF1, a plasmid encoding erythromycin resistance, in Enterococcus faecalis.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Molecular epidemiology and antibiotic resistance of group B Streptococcus in pregnant women and neonates from Haikou, China: implications for vaccine development and antimicrobial stewardship.
The study identified high rates of tetracycline (89.1%) and clindamycin (55.1%) resistance in GBS strains from Haikou, China. Key resistance genes included mreA, ermB, tetM, catQ, cat(pC194), ant(6)-Ia, aph(3')-III, and aac(6')-aph(2'').
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance and Virulence in Campylobacter spp. Isolated from Turkeys: Uncovering a Neglected Reservoir in the One Health Context.
The study identified several antimicrobial resistance genes, including tetO, gyrA (Thr-86-Ile mutation), ermB, Ery23S (A2075G mutation), and cmeB, in Campylobacter jejuni and C. coli isolates from turkeys, highlighting the presence of multidrug resistance and virulence factors.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Genomic identification and characterization of Streptococcus oralis group that causes intraamniotic infection.
The study identified the presence of ermB and tet(M) genes in Streptococcus oralis strain RAOG5826, which confer resistance to clindamycin, erythromycin, and tetracycline. Additionally, mutations in penicillin-binding proteins were found to contribute to reduced susceptibility to penicillin and ampicillin.
Phenotypic and genomic analysis of the emerging poultry pathogen Enterococcus cecorum in UK isolates.
The study identifies multiple AMR genes and mutations in UK E. cecorum isolates, including tet(L), tet(M), ant(6)-la, ermB, NarA/NarB, and lnuC, as well as mutations in pbp2x and gyrA that confer resistance to various antibiotics.
Integrative genomic characterization of five Pediococcus acidilactici strains reveals differing probiotic safety profiles.
The study identified plasmid-borne AMR genes such as tet(M) and erm(B) in some Pediococcus acidilactici strains, highlighting the need for careful safety assessments of probiotics.
In-depth characterization of virulence traits, pathogenicity, antibiogram, and antibiotic resistance genes of MDR Vibrio parahaemolyticus retrieved from shrimp.
The study identified multiple antibiotic resistance genes in MDR Vibrio parahaemolyticus strains isolated from shrimp, including bla TEM, bla OXA, tet A, aad A, erm B, and sul 1, which confer resistance to various antibiotics.
Increase of macrolide resistance among Streptococcus pyogenes pharyngitis driven by a mef(A)-msr(D)/emm2-ST55 lineage in Portugal (2014-2019).
The study identifies the emergence of a mef(A)-msr(D) positive emm2-ST55 lineage as a major driver of increased macrolide resistance in Streptococcus pyogenes pharyngitis in Portugal between 2014 and 2019. It also characterizes various macrolide resistance genes including erm(A), erm(B), erm(T), tet(O), and tet(M) associated with different genetic lineages.
Phenotypic and genotypic characterization of ST103 serotype Ia Streptococcus agalactiae isolated from bovine mastitis in China.
The study identified tetracycline resistance genes tetO and tetM, as well as the macrolide resistance gene ermB in ST103 serotype Ia Streptococcus agalactiae isolates from bovine mastitis in China.
Molecular epidemiology and antimicrobial susceptibility of group A Streptococcus isolated from children in Greece during 2023.
The study identified emm1, emm12, and emm89 as the most prevalent emm types among GAS isolates. Resistance to erythromycin, tetracycline, and clindamycin was observed, with specific resistance mechanisms involving ermA, ermB, and mefA genes.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
High-resolution genomic and molecular characterization of vancomycin-resistant enterococci from hospitalized patients in a tertiary care center in Riyadh, Saudi Arabia.
The study identified vanA, tet(M), erm(B), aac(6')-Ii, and aad(6) as key vancomycin-resistant genes in E. faecium, along with liaR and liaS mutations linked to daptomycin resistance.
Multidrug-resistant Klebsiella pneumoniae and Klebsiella oxytoca isolated from backyard broiler chickens and their contacts with antimicrobial resistance genes of Klebsiella pneumoniae.
The study identified multiple antimicrobial resistance genes in Klebsiella pneumoniae and Klebsiella oxytoca isolates from backyard broiler chickens and human contacts, including ermB, blaTEM, blaCTX-M1, sul1, tetA, gyrA, blaOXA-48, and mcr-1, indicating widespread multidrug resistance.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
An integrated phenotypic and genomic approach to characterize MBL-producing Enterobacterales strains circulating in a Sicilian transplant center.
The study characterizes MBL-producing Enterobacterales strains, identifying NDM-1, NDM-5, and VIM-1 as the most prevalent metallo-beta-lactamases. It also identifies various aminoglycoside, quinolone, and sulfonamide resistance genes, highlighting the multidrug-resistant nature of these isolates.
City or Suburb, Resistance Flows: Wastewater-Borne ESKAPE and AMR Genes in Malaysian Hospitals.
The study identified several AMR genes, including ermB, VanA, BlaTEM, tetA, Sul1, and BlaNDM-1, in ESKAPE pathogens from hospital wastewater in Klang Valley and suburban areas of Malaysia. These genes were associated with resistance to various antibiotics, highlighting the significance of hospital wastewater as a reservoir for AMR genes.
Streptococcus suis avian expansion suggests shared antibiotic use drives host jumps.
The study identified multidrug-resistant S. suis lineages in birds, highlighting the role of shared antibiotic use in host jumps and the presence of resistance genes like ermB and tetO.
Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes.
The study identifies tetracycline and clindamycin resistance genes (tet and erm) in various Clostridia species from preterm infants, highlighting their role as reservoirs of antimicrobial resistance.
Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.
The study found that PID cases were associated with higher abundance of G. vaginalis and other CST IV organisms, while controls had higher levels of L. crispatus. No specific AMR genes were characterized in this paper.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
The prevalence and molecular epidemiology of Clostridioides difficile in hospital-based pediatric populations in China.
The study identified ermB as a major determinant of clindamycin resistance, gyrA T82I mutations as a key factor in moxifloxacin resistance, and tet(M) as a contributor to tetracycline resistance in C. difficile isolates from pediatric populations in China.
Characterization of Lactococcus isolated from diseased yellowtail in Japan using whole-genome sequencing.
The study identified the erm(B) gene as the primary cause of erythromycin resistance and multiple variants of the lsa(D) gene associated with lincomycin resistance in Lactococcus isolates from diseased yellowtail in Japan.
Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in paediatric patients in Japan (2020-2023).
The study identified high resistance rates to erythromycin, penicillin, cefotaxime, and meropenem among Streptococcus pneumoniae isolates from pediatric patients in Japan. Key resistance genes included ermB, mefE, and tetM.
Serotypes, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in Sichuan Province, China in 2023.
The study identified nine resistance genes in 105 Streptococcus pneumoniae strains, including erm(B), mef(A), msr(D), tet(M), and others. High resistance rates were observed to erythromycin, clindamycin, tetracycline, and trimethoprim/sulfamethoxazole, with a multidrug resistance rate of 85.71%.
Antimicrobial resistance and virulence gene profiles of Enterococcus faecalis and Enterococcus faecium isolated from subclinical bovine mastitis milk and cow dung.
The study identified vanA, tetM, ermB, vanB, and tetK as the main antimicrobial resistance genes in Enterococcus faecalis and Enterococcus faecium isolates from subclinical bovine mastitis milk and cow dung samples.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Co-selection of genetic antibiotic resistance in Streptococcus pneumoniae after repeated azithromycin mass drug administrations in Niger.
Repeated azithromycin mass drug administrations in Niger led to the co-selection of genetic resistance to macrolides, tetracyclines, and trimethoprim-sulfamethoxazole in Streptococcus pneumoniae, primarily mediated by mobile genetic elements.
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.
The study identifies multiple antibiotic resistance genes (ARGs) in urban sewage samples from India, highlighting the presence of genes such as blaTEM, catB, aac(6')-Ib, sul1, ermB, dfrA1, mphA, sul2, blaOXA, blaCTX-M, and qnrS, which confer resistance to various antibiotic classes.
Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.
Arsenic and microplastics significantly influenced the spread of antibiotic resistance genes (ARGs) during vermicomposting, with specific genes like bla ampC, bla LRA-1, bla FEZ-1, aph(3′)-II, ermB, vanY, mefA, catA, tetX4, bla IMP-11, aadK, ant(3′)-Ih-aac(6′)-Id, ermG, bla OXA-119, tetR, vatE, smeE, mexD, bla OXA-3, amrB, tetY, class A beta-lactamase, dfrA1, alanine adenosyltransferase JOHN-1, mdtB, mdtE, and erm-41 being enriched under various treatment conditions.
Genomic and Phenotypic Landscape of Antibiotic Resistance in Gut Lactic Acid Bacteria from Livestock Environments.
The study identified multiple antibiotic resistance genes in lactic acid bacteria (LAB) from livestock environments, including van(T), erm(B), cat(A), tet(W), lsa(D), arr, van(Y), and qac(G). These genes conferred resistance to various antibiotics, highlighting the potential for horizontal gene transfer and the importance of monitoring LAB for AMR.
Genomic insights into the expansion of meropenem-resistant GPSC1-CC320 Streptococcus pneumoniae serotype 19A isolates from children under 5 years of age with invasive infections, 2018-2024.
The study identifies the presence of tet(M), erm(B), mef(A), and msr(D) genes in meropenem-resistant Streptococcus pneumoniae serotype 19A isolates, which confer resistance to tetracycline, erythromycin, and azithromycin. These isolates also exhibit a unique combination of pbp alleles (pbp1a-13, pbp2b-11, pbp2x-16) that contributes to their resistance profile.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
Emergence of Multidrug-Resistant and Biofilm-Producing Staphylococcus aureus from Raw Poultry in Algeria: Implications for Public Health.
The study identified several AMR genes in S. aureus isolates from raw poultry in Algeria, including blaZ, mecA, tet(M), tet(K), tet(S), erm(B), and erm(C). These genes were associated with resistance to penicillin, methicillin, tetracycline, and erythromycin.
Molecular resistance mechanisms to newly approved antibiotics (2017-2025) in WHO priority pathogens.
The paper reviews molecular resistance mechanisms to newly approved antibiotics in WHO priority pathogens, identifying various beta-lactamases, efflux pumps, and target site modifications that confer resistance.
Wilson's disease-associated gut dysbiosis: novel insights into microbial functional alterations, virulence changes, and resistance markers.
The study identified several antibiotic resistance genes (ARGs) associated with Wilson's disease, including tetQ, ermB, cfxA6, Bbif_ileS_MUP, and Bado_rpoB_RIF, which were found to be differentially abundant in patients compared to healthy controls.
Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy.
The study identified several AMR genes and mutations in clindamycin-resistant S. agalactiae, including ermB, mreA, tetM, tetO, aph(3')-III, gyrA, and parC. Mutations in gyrA and parC were associated with levofloxacin resistance.
A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis.
A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis.
The closely related ermB-ermAM genes from Clostridium perfringens, Enterococcus faecalis (pAM beta 1), and Streptococcus agalactiae (pIP501) are flanked by variants of a directly repeated sequence.
Complete nucleotide sequence of plasmid pGB3631, a derivative of the Streptococcus agalactiae plasmid pIP501.
Complete nucleotide sequence of plasmid pGB3631, a derivative of the Streptococcus agalactiae plasmid pIP501.
Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence analysis of the orf eta-copS region.
In vitro selection of resistance to four beta-lactams and azithromycin in Streptococcus pneumoniae.
The study identified ermB and mefE genes as mechanisms of azithromycin resistance in Streptococcus pneumoniae, with ermB encoding a macrolide ribosome methyltransferase and mefE encoding an efflux pump.
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria.
The study identified multiple penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria, characterizing their resistance mechanisms through molecular techniques. Key findings include the identification of specific penicillin-binding protein genes (pbp1a, pbp2b, pbp2x) and resistance genes (ermB, mefE, tetM, cat) associated with resistance to penicillin, erythromycin, tetracycline, and chloramphenicol.
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