Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(C)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(C) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 124 | CLINDAMYCIN, ERYTHROMYCIN +15 | Staphylococcus aureus +62 | Germany, Denmark|United States|Ethiopia|England|Singapore|Asia|Belgium|Kenya|New Zealand, Texas, Denmark, Turkey, Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, Switzerland, Global, Ireland, Tunisia, Northwest USA, Spain, Serbia, Brazil, United Kingdom, China, Nsukka agricultural zone, Nigeria, Sanandaj, Italy, Germany|Egypt|Brazil|Chile|Vietnam|Russia|Belarus|Thailand, The Gambia, Alberta, Nepal, Russia, Taiwan, Iran, La Rioja region, Northern Spain|Spain, Sri Lanka|United Kingdom|Australia, Poland, Egypt, Northern Province|Kigali District, Kuwait, Pakistan, GA, USA, Portugal, Pacific region|Hawaii, Europe, Asia|Europe|Americas|China|Taiwan, South Africa, Hawai'i|Hawaiʻi Island, Poland|Ukraine, Eastern Tanzania, Benin, North America|South America|Europe|Asia|Africa, Lusaka|Ndola, La Rioja, Spain, Tanzania, Malaysia, Japan, Algeria, Southeast Nigeria|Nigeria, United States|Europe|Russia|Canada|Australia|global, East Africa | 1980, 1986, 1987, 1988, 1997, 1998, 2003, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DQ088624.1 | AAY88963.1 |
| ErmC | Card DatabaseReslit | 223 | macrolides, lincosamides +9 | Staphylococcus epidermidis +99 | France, Seattle, Wash.|Montevideo, Uruguay|DeKalb County, Ga., Europe|North America|Asia, United States, Australia, Germany|Austria, Spain, Iran, Brazil, Arctic sea ice, Turkey, Malaysia, China, UK|Germany|Australia|Europe|Asia|Africa, Germany, United States|Afghanistan, Poland, Nigeria, Belgium, Russia|Siberian Russia, Victoria, Australia|Australia, Kuwait, Republic of Suriname, Taiwan, Greece, Europe, Egypt, Canada, Italy, Michigan, USA, Guangdong Province, China, International Space Station, Delta State, Nigeria, Lithuania, East London|West London, Norway, Hainan, China, Maputo, Mozambique, Mexico City, India, Canada|United Kingdom|United States, Spain|Italy, Russia, Korea, Portugal, Pakistan, Europe|Spain, United Arab Emirates, Sweden, Sardinia, Italy|Italy, South Africa, Australia|New Zealand, Japan, Western Uganda, Northern Xinjiang, China, Slovakia|Hungary, Manhiça District, Southern Mozambique, Northern Algeria|cattle, Novosibirsk, Russia, Europe|Netherlands, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Zambia, Nepal|Kathmandu, Nepal, Bulgaria, Anhui, China, South-eastern Poland, Eastern Switzerland, Kenya, Mexico, Bangladesh, Edo, Nigeria, Saudi Arabia, Northern Pacific Ocean|Norway Sea|Europe, Algeria, Colombia, USA, Paraguay, USA|Japan|Taiwan|NASA's-JPL SAF, Nsukka, Nigeria, Edo State, Nigeria, Alexandria, Egypt, Israel|Germany|Kuwait|Syria, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy, South Korea, Portugal|various regions, Singapore, Europe|Africa|North America|South America|Asia|Oceania, Northwestern Transylvania, Romania, Xizang, Peruvian Amazon, Romania, Beira, Mozambique|Mozambique, Europe|USA, New Zealand, Xinjiang, China, urban jail|Cook County Health|Chicago, Illinois, USA|Chicago, Illinois, Northeast China, northwest China|China | 1985, 1988, 1999, 2000, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | M12730.1 | AAA98296.1 |
| ermC-cat | Reslit | 1 | erythromycin | Chlorobium tepidum | - | 2001 | - | - |
| erm C | Reslit | 3 | erythromycin, macrolides | Staphylococcus aureus +4 | Algeria, Europe|South America, Guangdong Province | 2018, 2021 | - | - |
| erm (C) | Reslit | 1 | macrolides, lincosamides +1 | - | Europe|Asia|Belgium|Netherlands|Thailand | 2018 | - | - |
| ermC-15 | Reslit | 1 | erythromycin | Listeria monocytogenes | China|Canada|Switzerland|USA|Italy | 2021 | PRJNA688596 | - |
| erm(C) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Staphylococcus aureus, Plasmid pE5, Staphylococcus hominis, Staphylococcus haemolyticus, Staphylococcus hyicus, Bacillus subtilis, Staphylococcus epidermidis, Staphylococcus chromogenes, Staphylococcus simulans | - | 1980 | V01278, M19652, M17990, Y09001, Y09002, Y09003, M13761, M12730, U82607, AF019140 | - |
Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.
The study identified and characterized various AMR genes, including ermA, ermC, msrA, linA/linA′, vga, vgb, and vat, which confer resistance to macrolides, lincosamides, and streptogramins in staphylococci.
Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
The study identifies the presence of known rRNA methylase genes (ermB, ermC, and ermF) in erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp., which confer resistance to erythromycin.
Biochemical and molecular characterization of erthromycin-resistant avian Staphylococcus spp. isolated from chickens.
The study identified the presence of ermC and ermA genes in avian Staphylococcus spp., with ermC being plasmid-borne and ermA predominantly chromosomally located. Both genes confer resistance to erythromycin.
Transfer of Erythromycin Resistance from Poultry to Human Clinical Strains of Staphylococcus aureus.
The study demonstrates the transfer of erythromycin resistance genes ermA and ermC from poultry to human clinical strains of Staphylococcus aureus, highlighting the potential for cross-species transmission of antibiotic resistance.
Chromosomal gene inactivation in the green sulfur bacterium Chlorobium tepidum by natural transformation.
The study describes the successful inactivation of the nifD gene in Chlorobium tepidum using natural transformation and homologous recombination, utilizing antibiotic resistance markers including aacC1, aadA, and ermC-cat.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.
The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.
Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci.
The study identifies and characterizes the genes ermA, ermC, and msrA responsible for inducible and constitutive clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci using PCR and disk diffusion testing.
Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987.
The study identified the presence of acquired macrolide resistance genes erm(B), erm(C), erm(F), and mef(A) in Neisseria gonorrhoeae and Neisseria meningitidis isolates from 1940 to 1987. These genes were found in isolates dating back to 1955 and 1963, demonstrating the long-standing presence of these resistance mechanisms.
Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.
Antibiotic susceptibility of bacteria isolated from pasteurized milk and characterization of macrolide-lincosamide-streptogramin resistance genes.
The study identified the ermC gene in 2 out of 25 Micrococcaceae strains resistant to erythromycin and/or spiramycin, indicating its role in macrolide-lincosamide-streptogramin resistance.
Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.
The study identifies ermA, ermC, and msrA as genes responsible for clindamycin resistance in erythromycin-resistant Staphylococcus aureus isolates, with distinct phenotypes observed in disk diffusion testing.
Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas.
The study identified erm(B), erm(C), and erm(A) genes as mediators of inducible clindamycin resistance in pediatric community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains. The prevalence of inducible resistance decreased from 1999 to 2002.
Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.
Regulation of the erm(C) gene in Staphylococci from reservoir with different usage of macrolides.
The study shows that deletions in the regulatory region of the erm(C) gene lead to constitutive expression, resulting in resistance to various macrolides. The prevalence of constitutive erm(C) genes correlates with the usage of tylosin in different reservoirs.
Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins.
The study identified several AMR genes including erm(A), erm(C), erm(B), vat(D), vgb(A), and vga(A) that confer resistance to streptogramins. Mutations in the rplV gene, encoding ribosomal protein L22, also contributed to resistance against streptogramin B.
Characterization of a Strain of Community-Associated Methicillin-Resistant Staphylococcus aureus Widely Disseminated in the United States
The study characterizes a community-associated methicillin-resistant Staphylococcus aureus strain (USA300-0114) that exhibits resistance to multiple antibiotics, including penicillin, oxacillin, erythromycin, tetracycline, and fluoroquinolones. Key resistance genes identified include blaZ, msrA, mecA, tet(K), and ermC, along with the Panton-Valentine leucocidin toxin genes lukF-PV and lukS-PV.
Characterization of a novel type of MLSB resistance plasmid from Staphylococcus saprophyticus carrying a constitutively expressed erm(C) gene.
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus.
Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp.
The study identified the presence of ermA and ermC genes in Staphylococcus isolates, which are responsible for inducible clindamycin resistance. The accuracy of the D-test for detecting this resistance was evaluated, highlighting the importance of proper disk separation distances.
Modes and modulations of antibiotic resistance gene expression.
The paper discusses the regulation of antibiotic resistance genes, focusing on glycopeptide resistance in enterococci, efflux pumps in Gram-negative and Gram-positive bacteria, and the role of two-component systems in modulating resistance gene expression.
Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe.
The study identifies methicillin-resistant Staphylococcus aureus ST398 carrying resistance genes mecA, ermA, ermC, tetM, and aph2"-aac6', indicating resistance to penicillin, erythromycin, clindamycin, oxytetracycline, and gentamicin respectively.
Use of a DNA microarray for simultaneous detection of antibiotic resistance genes among staphylococcal clinical isolates.
The study developed a DNA microarray for the simultaneous detection of antibiotic resistance genes in staphylococcal clinical isolates, identifying genes such as mecA, blaZ, aac(6')-Ie-aph(2''), ermA, ermC, and msrA, which confer resistance to methicillin, penicillin, gentamicin, erythromycin, clindamycin, and macrolides/streptogramin B.
Differences in potential for selection of clindamycin-resistant mutants between inducible erm(A) and erm(C) Staphylococcus aureus genes.
The study shows that erm(C) isolates have a higher mutation frequency to clindamycin resistance compared to erm(A) isolates, indicating a greater potential for selection of clindamycin-resistant mutants.
Induction of erm(C) expression by noninducing antibiotics.
The study demonstrates that ketolides can induce the expression of the inducible erm(C) gene in Escherichia coli, leading to increased dimethylation of A2058 in 23S rRNA, which confers resistance to macrolides.
Erythromycin-induced ribosome stalling and RNase J1-mediated mRNA processing in Bacillus subtilis.
The study identifies the ermC gene as a key player in erythromycin resistance in Bacillus subtilis, showing that ribosome stalling induced by erythromycin leads to mRNA processing mediated by RNase J1.
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage.
The study identifies multiple AMR genes and mutations in a multidrug-resistant Staphylococcus aureus strain, including mecA, aadD, bleO, ermC, tet, and a chromosomal mutation in gyrA, contributing to resistance against beta-lactams, aminoglycosides, macrolides, tetracyclines, and fluoroquinolones.
Identification and characterization of antibiotic resistance genes in Lactobacillus reuteri and Lactobacillus plantarum.
Pathogen profiling: rapid molecular characterization of Staphylococcus aureus by PCR/electrospray ionization-mass spectrometry and correlation with phenotype.
The study describes a rapid and high-throughput method for molecular characterization of Staphylococcus aureus using PCR coupled with electrospray ionization-mass spectrometry (ESI-MS). The method successfully identified genes associated with antibiotic resistance, including mecA, ermA, ermC, and mupA, which confer resistance to methicillin, erythromycin, and mupirocin.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among clinical staphylococcal isolates in a Turkish university hospital.
The study identified the prevalence of erm(A), erm(C), msr(A), and msr(B) genes in erythromycin-resistant staphylococcal isolates, highlighting geographical variations in resistance mechanisms.
Massively parallel pathogen identification using high-density microarrays.
The study demonstrates the use of a high-density microarray for the identification of pathogens and the detection of antibiotic resistance genes, including blaZ, ermC, mph, and tetK, in clinical samples.
Phenotypic and genotypic study of macrolide, lincosamide and streptogramin B (MLSB) resistance in clinical isolates of Staphylococcus aureus in Tehran, Iran.
The study identified ermA and ermC genes as the primary determinants of MLSB resistance in erythromycin-resistant Staphylococcus aureus isolates in Tehran, Iran. The combination of ermA and ermC was the most prevalent resistance mechanism.
Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates.
The study identified the distribution of erm genes (ermA, ermB, and ermC) among staphylococci isolates and found that constitutive MLS B resistance was the most prevalent phenotype, with ermA being the most common gene in S. aureus and ermC in CNS isolates.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Characterization of a cryptic plasmid pSM429 and its application for heterologous expression in psychrophilic Pseudoalteromonas.
The study characterizes the cryptic plasmid pSM429 from Pseudoalteromonas sp. BSi20429 and develops a shuttle vector pWD for heterologous expression. The erythromycin resistance gene ermC was successfully expressed in Pseudoalteromonas sp. SM20429, demonstrating the utility of the system for cold-adapted protein production.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Genotypes, exotoxin gene content, and antimicrobial resistance of Staphylococcus aureus strains recovered from foods and food handlers.
The study identified various AMR genes in S. aureus strains from foods and food handlers, including blaZ, mupA, ermC, msrB, msrA, aacA, aphD, aadD, and tetK, which confer resistance to beta-lactams, mupirocin, erythromycin, clindamycin, aminoglycosides, and tetracycline.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
ermA, ermC , tetM and tetK are essential for erythromycin and tetracycline resistance among methicillin-resistant Staphylococcus aureus strains isolated from a tertiary hospital in Malaysia.
The study identified ermA, ermC, tetM, and tetK as essential genes for erythromycin and tetracycline resistance in MRSA strains from a Malaysian hospital.
Clinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China.
The study identified the presence of the ermC gene in three out of five Staphylococcus lugdunensis isolates, which conferred resistance to erythromycin, clindamycin, and penicillin. Additionally, the mecA gene was found in one isolate, indicating resistance to cefoxitin and penicillin.
DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.
The study identifies and characterizes novel SCCmec-SCCM1 composite islands in MRSA isolates, highlighting the presence of various AMR genes such as blaZ, erm(A), aadD, qacA, qacC, merA, merB, fosB, sdrM, aacA-aphD, far1 (fusB), Q6GD50 (fusC), and cat-pC194 (pMC524).
High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureus isolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage.
The study identified various AMR genes in nasal Staphylococcus aureus isolates from donkeys, including blaZ, erm(A), erm(C), tet(M), and fusC, which confer resistance to penicillin, erythromycin, tetracycline, and fusidic acid.
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
The study identifies key AMR genes and mutations in the EMRSA-15 pandemic clone, including blaZ, ermC, mecA, and mutations in grlA and gyrA that confer fluoroquinolone resistance.
Antimicrobial susceptibility and molecular subtypes of Staphylococcus aureus isolated from pig tonsils and cow's milk in China.
The study identified mecA, ermC, and ermB genes associated with methicillin and erythromycin resistance in Staphylococcus aureus isolates from pig tonsils and cow's milk in China.
Comparison of Multi-Drug Resistant Environmental Methicillin-Resistant Staphylococcus aureus Isolated from Recreational Beaches and High Touch Surfaces in Built Environments.
The study identified multiple antibiotic resistance genes in environmental MRSA isolates, including aadD, erm(A), erm(C), msr(A), tet(K), and tet(M), which confer resistance to kanamycin, erythromycin, clindamycin, and tetracycline. These genes were found in a high proportion of the isolates, indicating that environmental MRSA can serve as reservoirs for antibiotic resistance genes.
Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.
The study identifies novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398, which also harbor cadmium and copper resistance determinants.
Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.
Expression of the ermC gene leads to resistance against macrolide antibiotics by modifying the 23S rRNA, which affects translation and reduces bacterial fitness.
Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle.
The study found that erythromycin resistance in Staphylococcus spp. was primarily mediated by the erm(C) gene, which was detected in isolates from beef cattle. The use of macrolides in cattle led to an increase in erythromycin-resistant enterococci, mainly Enterococcus hirae.
Microarray-based genotyping and clinical outcomes of Staphylococcus aureus bloodstream infection: an exploratory study.
The study identified several genes associated with clinical outcomes in Staphylococcus aureus bloodstream infections, including mecA, bla, ermC, aadD, sed/sej/ser, and ssl11. These genes were found to be significantly associated with mortality, sepsis, and other clinical endpoints.
Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan.
The study identified several AMR genes in MRSA and MSSA isolates, including ermC, tetK, tetM, blaZ, msrA, and ermA, which confer resistance to clindamycin, tetracycline, penicillin, and erythromycin. These findings highlight the genetic basis of antimicrobial resistance in S. aureus isolates from military personnel in the US and Afghanistan.
Regulation of gene expression by macrolide-induced ribosomal frameshifting.
Telithromycin activates ermC expression through a novel mechanism involving ribosomal frameshifting within the ermCL regulatory ORF, bypassing the stop codon and enabling translation through the intergenic spacer.
Prevalence of antibiotic resistance in multi-drug resistant coagulase-negative staphylococci isolated from invasive infection in very low birth weight neonates in two Polish NICUs.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CNS) isolated from very low birth weight neonates, including mecA, ermC, msrA, aac(6')/aph(2''), and aph(3')-IIIa, which conferred resistance to methicillin, erythromycin, clindamycin, gentamicin, and amikacin.
Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia.
The study identified the prevalence of inducible clindamycin resistance in staphylococcal isolates, with erm(C) being the most prevalent gene among S. aureus isolates.
Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus.
The study identifies several AMR genes including ermC, dfhR, tetK, and qacC in the ST93 clone of S. aureus, which confer resistance to erythromycin, trimethoprim, tetracycline, and quaternary ammonium compounds/beta-lactams respectively. Mutations in the agr locus were found to affect virulence gene expression.
Diversity of antibiotic resistance genes and staphylococcal cassette chromosome mec elements in faecal isolates of coagulase-negative staphylococci from Nigeria.
The study identified several antibiotic resistance genes, including aac(6')-aph(2"), ermC, msrA, tetK, tetM, and mecA, in faecal isolates of coagulase-negative staphylococci from Nigeria. These genes were associated with resistance to gentamicin, erythromycin, and tetracycline, as well as methicillin resistance.
Characterization of methicillin-resistant coagulase-negative staphylococci in milk from cows with mastitis in Brazil.
The study identified methicillin-resistant coagulase-negative staphylococci (MRCoNS) in milk from cows with mastitis in Brazil, highlighting the presence of various antimicrobial resistance genes including mecA, tet(K), str, ant(4')-I, aac(6')-aph(2"), lnu(B), lsa(E), and a modified erm(C) gene with an 89-bp deletion.
A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals.
The study identified that companion animal isolates of MRSA were less likely to harbor the plasmid-encoded erm(C) gene, which confers erythromycin resistance, and when present, were more likely to have mutations leading to clindamycin resistance.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Rapid Diagnostic Approaches for Antimicrobial Resistance
The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.
Meticillin-resistant Staphylococcus aureus isolated from Iranian hospitals: virulence factors and antibiotic resistance properties.
The study identified several AMR genes in meticillin-resistant Staphylococcus aureus (MRSA) isolates from Iranian hospitals, including mecA, tetK, ermA, ermC, aacA-D, linA, msrA, vatA, vatC, and vatB. Additionally, the Panton-Valentine leukocidin (PVL) gene was found in 40.9% of the isolates.
Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
The study identifies multiple antimicrobial resistance genes in MRSA strains from Krasnoyarsk, Siberian Russia, including mecA, blaZ, ermA, ermC, cat, aacA-aphD, aadD, tet, spc, ble, qacA, cad, and mer, which confer resistance to various antibiotics such as methicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, gentamicin, kanamycin, tetracycline, spectinomycin, bleomycin, quaternary ammonium compounds, cadmium, and mercury.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive Staphylococcus aureus and coagulase-negative staphylococcal isolates from bovine mastitis.
The study identified various MLS resistance genes, including erm(C), mph(C), erm(B), ere(A), vga(A), lnu(A), and msr(A)/msr(B), in Staphylococcus aureus and coagulase-negative staphylococci isolates from bovine mastitis, highlighting a high prevalence of inducible MLS resistance.
Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.
The study identified erm(C), erm(B), erm(A), msr(A), and lnu(A) as the primary genes responsible for resistance to macrolides, lincosamides, and streptogramin B in Staphylococcus hominis isolates.
Molecular epidemiology of heteroresistant vancomycin-intermediate Staphylococcus aureus in Brazil.
The study identified ermA and ermC genes in 12 heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) isolates, which conferred resistance to clindamycin and erythromycin. The isolates exhibited diverse SCCmec types and genetic profiles, indicating limited epidemiological relationships.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Epidemiological and Inducible Resistance in Coagulase Negative Staphylococci.
The study identified erm(A), erm(B), erm(C), and erm(TR) genes in erythromycin-resistant Coagulase Negative Staphylococci (CNS) isolates, indicating inducible clindamycin resistance. The majority of the isolates exhibited unique genomic patterns, suggesting limited transmission of resistant strains.
A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy.
The study identifies multiple AMR genes in CC97 MRSA isolates from Italian dairy cattle and pigs, including erm(B), erm(C), vga(A), tet(K), tet(M), blaZ, and aacA-aphD, which confer resistance to various antibiotics such as erythromycin, clindamycin, tiamulin, tetracycline, penicillin, and aminoglycosides.
The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis.
The study identified the prevalence of genes responsible for MLSB resistance in erythromycin-resistant S. epidermidis, highlighting the frequent occurrence of ermC, mphC, msrA, and linA/A'.
Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil.
The study identified the presence of ermA and ermC genes in Staphylococcus spp. isolates, which are responsible for MLS B resistance, with ermC being more frequently detected than ermA. The D test was emphasized for detecting inducible resistance to clindamycin.
Distribution of Genes Encoding Resistance to Macrolides Among Staphylococci Isolated From the Nasal Cavity of Hospital Employees in Khorramabad, Iran.
The study identified the presence of ermA, ermB, ermC, and msrA genes in Staphylococcus isolates from hospital employees, highlighting the prevalence of macrolide resistance mechanisms in both S. aureus and coagulase-negative staphylococci.
Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.
The study identifies several macrolone compounds with potent antibacterial activity against key respiratory pathogens, including those with macrolide resistance mechanisms. These compounds demonstrate superiority over existing macrolide antibiotics in vitro and in vivo, with minimal induction of resistance genes.
Metagenome and Metatranscriptome Analyses Using Protein Family Profiles.
The study demonstrates the utility of HMM-GRASPx for profiling antimicrobial resistance (AMR) gene families in metagenomic data sets, highlighting the distinct resistome profiles across different body sites and the importance of AMR gene abundance in understanding bacterial communities.
Characterization of Staphylococcus aureus isolates from raw milk sources in Victoria, Australia.
Only one isolate was resistant to penicillin, carrying the blaZ gene, while no resistance to other antibiotics was found.
Nasal carriage of resistant Staphylococcus aureus in a medical student community.
The study identified the presence of mecA, ermA, and ermC genes in Staphylococcus aureus isolates from medical students, indicating resistance to oxacillin, cephoxitin, erythromycin, and clindamycin.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals.
The study identified the ermC gene, which confers resistance to macrolides, lincosamides, and streptogramin B, and SAAV_1916, a multidrug ABC transporter, which is associated with resistance in the highly virulent MRSA1679a strain.
Variety of Antimicrobial Resistances and Virulence Factors in Staphylococcus aureus Isolates from Meat Products Legally and Illegally Introduced to Germany.
The study identified multiple antimicrobial resistance genes and mutations in Staphylococcus aureus isolates from meat products, including resistance to β-lactams, macrolides, aminoglycosides, tetracyclines, and others.
A Low Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B Resistance Phenotype among Methicillin-Susceptible Staphylococcus aureus Isolated from Malaysian Patients and Healthy Individuals.
The study found a low prevalence of inducible MLSB (iMLSB) and MS resistance phenotypes among methicillin-susceptible Staphylococcus aureus (MSSA) isolates in Malaysia. The ermC gene was detected in all iMLSB isolates, while the msrA gene was found in the MS isolate.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA USA300 (ST8-spa t008) in an academic hospital of Paramaribo, Republic of Suriname.
The study identified several AMR genes, including ermC, dfrG, and qacC, which confer resistance to erythromycin, trimethoprim, and quaternary ammonium compounds, respectively, in MRSA USA300 isolates from Suriname.
mecA-related structure in methicillin-resistant coagulase-negative staphylococci from street food in Taiwan.
The study identified mecA and mecA Ss genes in methicillin-resistant coagulase-negative staphylococci (MRCoNS) from street food in Taiwan, along with several other resistance genes such as ermA, ermC, tet(M), tet(K), tet(O), and aac(6')-Ie-aph(2'')-Ia, which confer resistance to oxacillin, erythromycin, tetracycline, and gentamicin.
Replication properties of pIM13, a naturally occurring plasmid found in Bacillus subtilis, and of its close relative pE5, a plasmid native to Staphylococcus aureus.
Replication properties of pIM13, a naturally occurring plasmid found in Bacillus subtilis, and of its close relative pE5, a plasmid native to Staphylococcus aureus.
Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control.
The study identified the presence of macrolide resistance genes msr, erm(C), and erm(T) in Staphylococcus aureus isolates following mass drug administration with azithromycin, contributing to increased prevalence of macrolide-resistant strains.
Resistance gene transfer: induction of transducing phage by sub-inhibitory concentrations of antimicrobials is not correlated to induction of lytic phage.
Sub-inhibitory concentrations of antimicrobials induce transducing phage particles capable of transferring the ermC erythromycin resistance gene between MRSA isolates.
Emergence of a Staphylococcus aureus Clone Resistant to Mupirocin and Fusidic Acid Carrying Exotoxin Genes and Causing Mainly Skin Infections.
The study identifies a Staphylococcus aureus clone resistant to mupirocin and fusidic acid, carrying exotoxin genes such as mupA, fusB, ermC, ermA, lukS/lukF-PV, eta, etb, and fnbA, which contribute to its pathogenicity and resistance mechanisms.
Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia.
The study identified the presence of CA-MRSA ST93-IV and LA-MRSA ST398-V in Australian pigs, farm workers, and the environment. It also reported the first linezolid-resistant MRSA isolate in Australia. Resistance mechanisms included genes such as blaZ, ermC, fexA, tetK, tetL, vgaA, lnuB, aadD, aadE, and cfr.
Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Four resistance genes (aac(6')-Ii, ermC, qacA, tetQ) were significantly more abundant in ICU patients than in healthy subjects, while catA and tetW were more abundant in healthy subjects.
Molecular characterization of vancomycin-resistant Staphylococcus aureus strains isolated from clinical samples: A three year study in Tehran, Iran.
The study identified vancomycin-resistant Staphylococcus aureus (VRSA) strains carrying the vanA gene, along with multiple resistance genes such as mecA, ermA, ermB, ermC, msrA, msrB, tetM, ant(4')-Ia, aac(6')-Ie/aph(2'')-Ia, and aph(3')-IIIa. These strains exhibited high-level resistance to vancomycin and other antibiotics.
Nasal and pharyngeal carriage of methicillin-resistant Staphylococcus sciuri among hospitalised patients and healthcare workers in a Serbian university hospital.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
Dissemination of macrolides, fusidic acid and mupirocin resistance among Staphylococcus aureus clinical isolates.
The study characterizes mupA and mupB genes involved in mupirocin resistance in methicillin-resistant Staphylococcus aureus.
Biofilm-Forming Clinical Staphylococcus Isolates Harbor Horizontal Transfer and Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes, including aac6-aph2a, ermC, tetK, and vanB, along with horizontal transfer genes such as pre pSK41, nes pSK41, traE, traG, traK, traL, traM, and pre pT181, in biofilm-forming Staphylococcus isolates.
Detection of Antibiotic Resistance and Resistance Genes in Enterococci Isolated from Sucuk, a Traditional Turkish Dry-Fermented Sausage.
The study identified several AMR genes including ermB, ermC, gyrA, tetM, tetL, and vanA in Enterococcus isolates from Sucuk, highlighting the potential for these bacteria to serve as reservoirs of antibiotic resistance genes.
Polymerase chain reaction detection of genes responsible for multiple antibiotic resistance Staphylococcus aureus isolated from food of animal origin in Egypt.
The study identified several antibiotic resistance genes in multiple drug-resistant Staphylococcus aureus isolates from food of animal origin in Egypt, including blaZ, tetK, ermB, msrA, ermC, and aac(6')-aph(2").
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds.
The study identified several AMR genes and mutations in non-aureus staphylococci from Canadian dairy herds, including blaZ, mecA, fexA, norA, sav1866, dha, mphC, msrA, tet38, tetK, tetL, tetM, folP, and mprF. Mutations in mprF and rpoC were associated with daptomycin resistance, while mutations in cls were not linked to resistance.
Characterization of resistance to selected antibiotics and Panton-Valentine leukocidin-positive Staphylococcus aureus in a healthy student population at a Malaysian University.
The study identified blaZ, msrA, and ermC genes as responsible for penicillin and erythromycin resistance in Staphylococcus aureus isolates from healthy students in Malaysia.
The human clone ST22 SCCmec IV methicillin-resistant Staphylococcus aureus isolated from swine herds and wild primates in Nepal: is man the common source?
The study identified AMR genes erm(C), aacC-aphD, and blaZ in MRSA isolates from swine and primates, along with a chromosomal mutation gyrA Ser84Leu associated with ciprofloxacin resistance.
Clonal Lineage Diversity, Antibiotic Resistance, and Virulence Determinants Among Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolated from Nurses at a Teaching Hospital in Ilam, Iran: Successful Nares Decolonization by Mupirocin.
The study identified several AMR genes in S. aureus isolates from nurses, including ermC, msrA, tetK, aac(6')-Ie/aph(2')-Ia, aph(3')-IIIa, and ant(4')-Ia, which conferred resistance to erythromycin, clindamycin, tetracycline, and gentamicin.
New Gene Responsible for Resistance of Clinical Corynebacteria to Macrolide, Lincosamide and Streptogramin B.
The study identifies the erm(X) and erm(C) genes as responsible for MLSB resistance in Corynebacterium spp., with erm(X) being the primary gene detected and erm(C) being reported for the first time in this context.
Emerging of antimicrobial resistance in staphylococci isolated from clinical and food samples in Algeria.
The study identified several AMR genes in staphylococci from clinical and food samples in Algeria, including blaZ, mecA, tetM, tetK, aacA-aphD, and ermC. These genes conferred resistance to penicillin, methicillin, tetracycline, gentamicin, and erythromycin.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
Detection of methicillin-resistant Staphylococcus aureus (MRSA) in clinical samples of patients with external ocular infection.
Three S. aureus isolates were resistant to cefoxitin and considered MRSA, with the mecA gene identified. The ermC and pvl genes were detected in one MRSA isolate from a diabetic patient.
Death Associated to Methicillin Resistant Staphylococcus aureus ST8 Infection in Two Dolphins Maintained Under Human Care, Italy.
The study reports the isolation of Methicillin-resistant Staphylococcus aureus (MRSA) from two dolphins, identifying the presence of the methicillin-resistance gene mecA, penicillase genes blaZ, blaI, and blaR, as well as genes for macrolide resistance (ermC) and aminoglycoside resistance (aadD).
Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains.
The study identified erythromycin resistance genes erm(B) and erm(C) and tetracycline resistance genes tet(K) and tet(M) in Lactobacillus fermentum strains. None of the strains were able to transfer these resistance genes to other bacteria via conjugation.
Investigation of the Dominant Microbiota in Ready-to-Eat Grasshoppers and Mealworms and Quantification of Carbapenem Resistance Genes by qPCR.
The study quantified the presence of carbapenem resistance genes (bla OXA-48, bla NDM-1, and bla VIM) in ready-to-eat mealworms and grasshoppers from various countries, revealing varying frequencies of these genes in different samples.
Vascular access infection by Staphylococcus aureus from removed dialysis accesses.
The study identified erythromycin resistance genes erm(A), erm(B), erm(C), and msr(A) in Staphylococcus aureus isolates, highlighting their role in resistance mechanisms.
Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator.
Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator.
Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis.
Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis.
Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China.
The study identified several AMR genes and mutations in MRSA isolates from Guangdong, China, including aac(6')-aph(2"), ermA, ermB, ermC, lnuA, dfrG, rpoB, fexA, and mutations in gyrA, gyrB, grlA, and grlB associated with resistance to various antibiotics.
Genetic Diversity Analysis of Methicillin-resistant Staphylococcus aureus Strains Isolated from Intensive Care Unit in Iran.
The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Clonally Diverse Methicillin and Multidrug Resistant Coagulase Negative Staphylococci Are Ubiquitous and Pose Transfer Ability Between Pets and Their Owners.
The study identifies various AMR genes such as erm(A), erm(C), mupA, vga(A), and lnu(A) in methicillin-resistant coagulase-negative staphylococci (MRCoNS) from humans and pets, highlighting the prevalence of multidrug resistance and potential for interspecies transmission.
Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species From Ready-to-Eat Seafood.
The study identified various antimicrobial resistance genes including ermA, ermB, ermC, mphC, vanA, vanB, tetA, and tetM in Enterococcus species isolated from ready-to-eat seafood, indicating the presence of multidrug-resistant strains.
Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia.
The study identified a dominant PVL-positive ST5-MRSA-IVc clone in Sri Lanka, which was also found in the UK and Australia. The clone exhibited resistance to methicillin, erythromycin, tetracycline, gentamicin, and streptothricin.
Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems.
The study identified several antibiotic resistance genes in soil microbiota from conventional and organic farming systems, including genes conferring resistance to beta-lactams, aminoglycosides, tetracyclines, and rifampicin. The primary resistance mechanisms were attributed to efflux pumps, particularly RND and ABC transporters.
Differences in distribution of MLS antibiotics resistance genes in clinical isolates of staphylococci belonging to species: S. epidermidis, S. hominis, S. haemolyticus, S. simulans and S. warneri.
The study identifies and characterizes MLS B resistance genes, including erm(A), erm(C), lnu(A), msr(A), msr(B), and mph(C), in various coagulase-negative staphylococci species, highlighting their distribution and association with resistance mechanisms.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring inducible macrolide-lincosamide-streptogramin B resistance and comparison with similar plasmids expressing constitutive resistance.
The study identified the ermC gene on plasmid pT48, which confers inducible resistance to macrolides, lincosamides, and streptogramin B in Staphylococcus aureus. The gene shows homology with other resistance plasmids but has distinct features in its leader region.
The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring inducible macrolide-lincosamide-streptogramin B resistance and comparison with similar plasmids expressing constitutive resistance.
The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring inducible macrolide-lincosamide-streptogramin B resistance and comparison with similar plasmids expressing constitutive resistance.
Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990-2017.
The study characterizes the antimicrobial resistance profiles of Staphylococcus aureus clinical isolates in Malaysia, highlighting the presence of mecA gene conferring beta-lactam resistance and erm gene contributing to MLSB resistance.
Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity.
The study identifies several AMR genes and mutations associated with hospital adaptation and pathogenicity in Staphylococcus haemolyticus, highlighting the importance of mecA, aacA-aphD, blaZ, ermC, mphC, qacA, qacB, folP, folB, and sraP in clinical isolates.
Molecular characteristics and virulence gene profiles of Staphylococcus aureus isolates in Hainan, China.
The study identified ermC, tetK, and tetM as the primary genes responsible for erythromycin and tetracycline resistance in Staphylococcus aureus isolates from Hainan, China.
International travel as source of a hospital outbreak with an unusual meticillin-resistant Staphylococcus aureus clonal complex 398, Denmark, 2016.
The study identifies the PVL-positive human variant of MRSA CC398 as the cause of an outbreak in a Danish maternity unit, highlighting the role of international travelers in introducing such strains into healthcare settings.
Evolution of Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated from Healthy Turkeys in Egypt: First Report of Linezolid Resistance.
This study identified the first report of linezolid resistance in coagulase-negative staphylococci (CoNS) isolated from healthy turkeys in Egypt. The study found that 79.5% of the isolates were resistant to linezolid, and the resistance was associated with the presence of the cfr, optrA, and valS genes. The study also found high levels of resistance to other antibiotics, including erythromycin, chloramphenicol, oxacillin, daptomycin, and tigecycline.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in México City in an eight-years survey.
The study identifies various AMR genes and mutations in multidrug-resistant Staphylococcus epidermidis strains isolated from a children's hospital in Mexico City, highlighting the presence of genes such as blaZ, mecA, and others, as well as mutations in gyrA and rpoB contributing to resistance.
MRSA Strains in Nepalese Rhesus Macaques (Macaca mulatta) and Their Environment.
The study identified several AMR genes in MRSA isolates from Rhesus macaques, environmental samples, and human patients in Nepal, including aacA-aadD, dfrA, erm(C), aacA-aphD, aphA3, sat, and blaZ.
Methicillin-Resistant Staphylococcus aureus Strains in Swiss Pigs and Their Relation to Isolates from Farmers and Veterinarians.
The study identifies several AMR genes in MRSA strains from Swiss pigs, including aac(6')-aph(2"), dfrG, erm(A), erm(C), spc, str, tet(K), tet(M), and vga(E). These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, erythromycin, clindamycin, lincomycin, streptogramin B, streptomycin, tetracycline, streptogramin A, pleuromutilin, and lincomycin.
Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.
The study identified several antibiotic and biocide resistance genes in Staphylococcus species associated with bovine mastitis in Rwanda, including blaZ, tet(K), erm(C), vga(A), sal(A), lnu(A), msr(A), dfrA, dfrD, dfrG, smr, qacAB, cadD, copB, and arsA. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, clindamycin, trimethoprim, and biocides like quaternary ammonium compounds.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Patients Admitted to Kuwait Hospitals in 2016-2017.
The study identified LA-MRSA isolates belonging to CC96, CC97, and CC398, with CC97 being the dominant clone. Resistance genes such as erm(A), erm(C), msr(A), aacA-aphD, fusC, tet(K), cat, and dfrS1 were detected, indicating multidrug resistance.
Assessment of inducible clindamycin resistance and Hyper Variable Region (HVR) of mecA gene in clinical staphylococci.
The study identified erm(C) gene-mediated inducible clindamycin resistance in 7% of staphylococcal isolates, with 4% in S. aureus and 11% in coagulase-negative Staphylococci. It also found that 50% of MRSA isolates harbored the mecA gene, and 42% exhibited hypervariable region (HVR) of mecA. Vancomycin-resistant S. aureus (VRSA) was observed in 7% of isolates.
Molecular characterization of methicillin-resistant Staphylococcus aureus clinical strains from the endotracheal tubes of patients with nosocomial pneumonia.
The study identified various AMR genes and mutations in MRSA strains from endotracheal tubes, including ermC, ermA, msrA, aac(6')-aph(2"), tetK, and fusB, along with quinolone resistance mutations in gyrA, gyrB, grlA, and grlB.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Virulence Factors and Phylogeny of Staphylococcus aureus Associated With Bovine Mastitis in Russia Based on Genome Sequences.
The study identified antibiotic resistance genes blaZ, ermC, aac(3), aph(2), and norA in Staphylococcus aureus isolates associated with bovine mastitis in Russia. These genes conferred resistance to penicillin, erythromycin, and gentamicin.
Two genes involved in clindamycin resistance of Bacillus licheniformis and Bacillus paralicheniformis identified by comparative genomic analysis.
The study identified ermC and speG as genes contributing to clindamycin resistance in Bacillus licheniformis and Bacillus paralicheniformis. ermC confers cross-resistance to clindamycin and erythromycin, while speG confers resistance to clindamycin.
Value of multiplex PCR for detection of antimicrobial resistance in samples retrieved from patients with orthopaedic infections.
The study evaluated the performance of multiplex PCR (mPCR) for detecting antimicrobial resistance genes in clinical samples from patients with orthopaedic infections. It identified several resistance genes, including mecA, mecC, aac(6')/aph(2''), ermA, ermC, rpoB, vanA, vanB, ctx-M, blaNDM, blaOXA-23, blaOXA-24, blaOXA-48, blaOXA-58, blaIMP, blaKPC, gyrA83, gyrA87, and aacA4, which confer resistance to various antibiotics such as oxacillin, aminoglycosides, macrolides/lincosamides, rifampin, vancomycin, third-generation cephalosporins, carbapenems, and fluoroquinolones.
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque.
The study identified multiple AMR genes in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates from dental plaque, including mecA, dfrA, dfrG, aacA-aphD, aadD, aphA3, ermC, msrA, tetK, norA, qacA, and qacC. These genes confer resistance to various antibiotics such as oxacillin, penicillin G, trimethoprim, gentamicin, erythromycin, tetracycline, and quaternary ammonium compounds.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Genetic Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Human Bloodstream Infections: Detection of MLS(B) Resistance.
The study identified multiple AMR genes in MRSA isolates from bloodstream infections, including blaZ, ermA, ermC, msrA/B, mphC, aac(6')-Ie-aph(2'')-Ia, and ant(4')-Ia, which conferred resistance to various antibiotics such as beta-lactams, macrolides, lincosamides, streptogramin B, and aminoglycosides.
Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.
The study identified high prevalence of multidrug-resistant ST239 isolates with strong biofilm-producing ability. Key AMR genes included mupA, fusC, erm(A), erm(C), ant(4')-Ia, aac(6')-Ie/aph(2''), aph(3')-IIIa, tetM, and tetK.
Accumulation of antibiotic-resistant genes in anaerobic biofilm reactor fed with household chemical products.
The study identified the accumulation of ermC genes in anaerobic biofilm reactors fed with household chemical products, suggesting that these compounds exhibit antimicrobial activity similar to erythromycin.
Staphylococci in poultry intestines: a comparison between farmed and household chickens.
The study identified several AMR genes in staphylococci from poultry intestines, including ermC, mecA, tetK, tetM, and aacA-aphD, which confer resistance to erythromycin, clindamycin, tetracycline, and gentamicin. Multidrug resistance was prevalent among the isolates.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
The study identified various AMR genes and mutations associated with daptomycin resistance in MRSA strains, including genes such as aac(6')-Ib, blaZ, mecA, ermC, fexB, tetM, tet38, dfrC, fosD, and vgaA, as well as mutations in mprF, rpoB, grlA, grlB, and gyrA.
Farming Practices Influence Antibiotic Resistance and Biogenic Amine Capacity of Staphylococci from Bulk Tank Ewe's Milk.
The study identified tetracycline resistance gene tetM, erythromycin resistance genes ermB and ermC, and ciprofloxacin resistance gene grlA in staphylococci from bulk tank ewe's milk. These genes were experimentally validated through PCR and phenotypic assays.
Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance.
The study demonstrates that outer membrane (OM) disruption can overcome intrinsic, acquired, and spontaneous antibiotic resistance in Gram-negative bacteria. Specifically, OM disruption by SPR741 effectively counteracts resistance mediated by macrolide resistance elements (mphA, ermC, mphB, ereA), rifampicin resistance elements (arr, rph-Lm, rpoB), and other resistance mechanisms.
Staphylococcus aureus and Methicillin Resistant S. aureus in Nepalese Primates: Resistance to Antimicrobials, Virulence, and Genetic Lineages.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from Nepalese primates, including erm(C), aacA-aphD, blaZ, msr(A), and mph(C). These genes conferred resistance to multiple antibiotics such as erythromycin, clindamycin, gentamicin, penicillin, and others.
Antibiotic resistance and typing of the methicillin-resistant Staphylococcus aureus clones in Kuwait hospitals, 2016-2017.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including mupA, aacA-aphD, erm(A), erm(C), tet(K), tet(M), fusC, fusB, and faR1, which conferred resistance to mupirocin, gentamicin, erythromycin, tetracycline, and fusidic acid.
Genotyping of methicillin resistant Staphylococcus aureus from the United Arab Emirates.
The study identified various methicillin-resistant Staphylococcus aureus (MRSA) strains in the United Arab Emirates, including novel variants with resistance genes such as fusC, ermC, aacA-aphD, mupR, and cfr. These genes confer resistance to fusidic acid, erythromycin/clindamycin, gentamicin, mupirocin, and chloramphenicol/florfenicol/linezolid/tigecycline, respectively.
Antimicrobial Resistance of Coagulase-Positive Staphylococcus Isolates Recovered in a Veterinary University Hospital.
The study identified various antimicrobial resistance genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates, including blaZ, erm(B), erm(C), aph(3'), ant(6), aad(6), SAT-4, cat(pc221), dfr(G), tet(K), and tet(M). These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, trimethoprim, and tetracycline.
Characterization of highly virulent community-associated methicillin-resistant Staphylococcus aureus ST9-SCCmec XII causing bloodstream infection in China.
The study identified a highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ST9-SCCmec XII isolate, ZY462471, which exhibited resistance to multiple antibiotics including erythromycin, clindamycin, oxacillin, tetracycline, ciprofloxacin, levofloxacin, and gentamicin. The isolate was found to harbor the mecA, blaZ, and ermC genes, contributing to its resistance profile.
Evidence for the Dissemination to Humans of Methicillin-Resistant Staphylococcus aureus ST398 through the Pork Production Chain: A Study in a Portuguese Slaughterhouse.
The study identified multiple antimicrobial resistance genes in MRSA ST398 isolates from a Portuguese slaughterhouse, highlighting the dissemination of these resistant strains through the pork production chain and their potential to colonize humans.
Comparative genomics of Staphylococcus epidermidis from prosthetic-joint infections and nares highlights genetic traits associated with antimicrobial resistance, not virulence.
The study identifies several AMR genes and mutations associated with resistance to beta-lactams, aminoglycosides, fluoroquinolones, and antiseptics in Staphylococcus epidermidis isolates from prosthetic-joint infections.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition.
The study identifies key residues in ErmC and ErmE that are essential for their function in methylating A2058 of 23S rRNA, thereby conferring resistance to macrolides, lincosamides, and streptogramin B. Functional analyses reveal that specific amino acid residues, such as Tyr-104, Arg-134 in ErmC, and Tyr-134, Lys-164, and Arg-171 in ErmE, are critical for substrate recognition and methylation activity.
Comparative characterisation of human and ovine non-aureus staphylococci isolated in Sardinia (Italy) for antimicrobial susceptibility profiles and resistance genes.
The study identified various AMR genes in non-aureus staphylococci from ovine and human sources, including blaZ, tetK, msrA, ermC, smr, and qacA/B, which confer resistance to penicillin, tetracycline, erythromycin, and antiseptics.
Methicillin-Resistant Staphylococcus epidermidis Lineages in the Nasal and Skin Microbiota of Patients Planned for Arthroplasty Surgery.
The study identified methicillin-resistant Staphylococcus epidermidis (MRSE) lineages, including multidrug-resistant (MDRSE) strains, in the nasal and skin microbiota of patients before hospital admission for arthroplasty surgery. Key AMR genes identified include qacA (chlorhexidine tolerance), aac(6')-aph(2'') (aminoglycoside resistance), and ermC (macrolide-lincosamide resistance).
Occurrence of Antibiotic Resistance Genes in Hermetia illucens Larvae Fed Coffee Silverskin Enriched with Schizochytrium limacinum or Isochrysis galbana Microalgae.
The study identified several tetracycline resistance genes (tet(M), tet(S), tet(K)), erythromycin resistance genes (erm(B), erm(C)), a methicillin resistance gene (mecA), and an aminoglycoside resistance gene (aac(6')-Ib) in Hermetia illucens larvae and frass. The presence of these genes suggests potential safety concerns regarding the reuse of frass in agriculture.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Staphylococcus aureus in Intensive Pig Production in South Africa: Antibiotic Resistance, Virulence Determinants, and Clonality.
The study identified several AMR genes in S. aureus isolates from intensive pig production in South Africa, including ermC, blaZ, tetK, aac(6')-aph(2"), and mecA, which confer resistance to erythromycin, penicillin, tetracycline, gentamicin, and methicillin respectively.
Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
The study identified various AMR genes and mutations in S. aureus isolates from SSTIs in ambulatory patients in Portugal, including blaZ, mecA, erm(A), erm(C), msr(A), mph(C), aadD, aacA-aphD, aph(3')-IIIa, and fusC, along with mutations in grlA, gyrA, and fusA associated with fluoroquinolone and fusidic acid resistance.
Genetic mechanisms and correlated risk factors of antimicrobial-resistant ESKAPEE pathogens isolated in a tertiary hospital in Malaysia.
The study identified several AMR genes and mutations in ESKAPEE pathogens, including vanA, vanB, blaTEM, blaSHV, blaCTX-M, blaOXA, blaVEB, blaVIM, blaNDM, aac(6')-Ib, aadB, ermC, qnrS1, and gyrA mutations, highlighting the prevalence of multidrug resistance in these isolates.
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus.
The paper discusses the mechanisms of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), focusing on genes such as blaZ, mecA, and dltA, which are involved in beta-lactam and glycopeptide resistance. It highlights the importance of understanding these resistance mechanisms to develop new therapeutic strategies.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
The study identified multiple beta-lactamase genes, including blaTEM-105, blaOXA-1, blaKPC-2, blaCTX-M-15, blaCMY-111, blaOXA-10, blaCTX-M-1, blaHYDRO, and blaBLP, along with qnrS1, aadC, and ermC, which confer resistance to beta-lactam, quinolone, aminoglycoside, and macrolide/lincosamide/streptogramin B antibiotics. These genes were found in various bacterial species and were validated through functional screening.
Characterization of methicillin-resistant Staphylococcus pseudintermedius isolates from Australian animals: discovery of novel sequence types
The study identified several AMR genes in MRSP isolates, including blaZ, mecA, cat-pC221, ermB, ermC, tetM, dfrG, aac6-aph2, ant6-Ia, aph3-III, and aadD, which confer resistance to various antibiotics such as oxacillin, penicillin, chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim, and gentamicin.
Antimicrobial Resistance Genes in Bacteria Isolated From Japanese Honey, and Their Potential for Conferring Macrolide and Lincosamide Resistance in the American Foulbrood Pathogen Paenibacillus larvae.
The study identified the ermC gene on the plasmid pJ18TS1mac and the lsaB and oleC genes on an integrative conjugative element (ICE) in honey-derived bacteria, which conferred resistance to tylosin and lincomycin in Paenibacillus larvae. Additionally, the ermL and ermB genes on plasmid pJ45TS6 were found to contribute to macrolide resistance.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.
The study identifies multiple AMR genes and mutations in ST9 S. aureus, including mecA, blaZ, lnu(B), lsa(E), erm(C), fexA, tet(L), dfrG, vwb, and the MDR ST9 element, highlighting their role in multidrug resistance and host adaptation.
Antimicrobial Resistance Profiles of Coagulase-Negative Staphylococci in Community-Based Healthy Individuals in Germany.
The study identified several AMR genes in commensal CoNS from healthy individuals in Germany, including mecA, tetK/L, tetM, ermA, ermC, ermB, fusB, fusC, aac(6')/aph(2"), cat194, fexB, and spc. These genes were associated with resistance to methicillin, tetracycline, erythromycin, fusidic acid, gentamicin, chloramphenicol, florfenicol, and spectinomycin.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Association of Macrolide Resistance Genotypes and Synergistic Antibiotic Combinations for Combating Macrolide-Resistant MRSA Recovered from Hospitalized Patients.
The study identified the presence of ermA, ermC, and msrA genes in macrolide-resistant MRSA isolates, which contribute to resistance against macrolide antibiotics. The presence of these genes was associated with synergistic effects when combined with other antibiotics like linezolid, ceftriaxone, and gentamicin.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Prevalence and Characteristics of Staphylococcus aureus Isolated From Retail Raw Milk in Northern Xinjiang, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail raw milk in northern Xinjiang, China, including blaZ, mecA, ermA, ermB, ermC, aacA-aphD, tetK, tetM, vanA, rpoB, linA, optrA, and cfr, which confer resistance to penicillin, methicillin, oxacillin, erythromycin, gentamicin, tetracycline, vancomycin, rifampin, clindamycin, linezolid, chloramphenicol, and florfenicol.
Environmental Surveillance and Characterization of Antibiotic Resistant Staphylococcus aureus at Coastal Beaches and Rivers on the Island of Hawai'i.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from coastal beaches and rivers on the island of Hawai'i, highlighting the presence of multidrug-resistant strains.
Antimicrobial Resistance of Enterococcus sp. Isolated from Sheep and Goat Cheeses.
The study identified the presence of vanA, ermB, ermA, ermC, and msrC genes in Enterococcus isolates from sheep and goat cheeses, contributing to resistance against vancomycin and erythromycin.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk Samples of Dairy Cows in Manhiça District, Southern Mozambique.
The study identified several AMR genes in S. aureus isolates from raw milk samples, including blaZ for penicillin resistance, tetK for tetracycline resistance, mecA for methicillin resistance, ermC for erythromycin and clindamycin resistance, and dfrG for co-trimoxazole resistance.
Co-Carriage of Metal and Antibiotic Resistance Genes in Sewage Associated Staphylococci.
The study identified the co-carriage of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in sewage-associated staphylococci, particularly highlighting the presence of blaZ, cadD, cadX, erm(C), and Vga(A)LC in various isolates.
Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies.
The study identified tet K, tet M, erm B, and erm C as the primary genes responsible for tetracycline and erythromycin resistance in meat-associated bacteria, highlighting the impact of livestock management strategies on the spread of antibiotic resistance.
Molecular Characterization of Staphylococcus aureus Isolated from Human and Food Samples in Northern Algeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from human and food samples in northern Algeria, including blaZ, ermB, ermC, aphA3, sat, tetK, and tetM.
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections.
The study identified several antimicrobial resistance genes in Listeria monocytogenes isolates, including beta-lactam resistance genes blaTEM-101 and blaTEM-105, macrolide resistance gene ermC-15, aminoglycoside resistance genes aadA10_2, aadA6_1, and aadA6_2, quinolone resistance gene oqxB_1, and sulfonamide resistance gene sul4_1.
Antimicrobial susceptibility, multilocus sequence typing, and virulence of listeria isolated from a slaughterhouse in Jiangsu, China.
The study identified tetracycline resistance genes tetA and tetM, erythromycin resistance genes ermA, ermB, and ermC, and the aminoglycoside resistance gene aac(6')-Ib in Listeria isolates from a slaughterhouse in Jiangsu, China.
Carvacrol Essential Oil: A Natural Antibiotic against Zoonotic Multidrug-Resistant Staphylococcus Species Isolated from Diseased Livestock and Humans.
The study identified the presence of mecA, vanC1, and ermC resistance genes in multidrug-resistant Staphylococcus isolates from livestock and human samples, highlighting the effectiveness of carvacrol essential oil in reducing resistance gene expression.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine-review.
The review highlights the presence of antibiotic-resistant bacteria and resistance genes in the environments of animal farms in Poland and Ukraine, emphasizing the spread of multidrug-resistant strains such as MRSA and Salmonella. Key resistance genes identified include blaTEM, blaPSE, floR, tetA, tetB, tetC, tetG, cat1, dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3, ermB, tetL, tetW, tetM, blaZ, mecA, qnrS1, qnrS3, qnrB10, qnrB19, blaCTX-M-25, and blaOXA-21.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistant Staphylococcus aureus (MRSA) isolated from pets and pet owners in Malaysia.
The study identified multiple AMR genes including mecA, tetK, tetL, ermA, ermB, ermC, msrA, scn, chp, sak, sea, and sep in S. aureus isolates from pets and pet owners in Malaysia, indicating the presence of multidrug-resistant and methicillin-resistant strains.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Epidemiological study on Listeria monocytogenes in Egyptian dairy cattle farms' insights into genetic diversity of multi-antibiotic-resistant strains by ERIC-PCR.
The study identified multiple antibiotic resistance genes in Listeria monocytogenes strains from Egyptian dairy cattle farms, including bla CTX-M, bla DHA-1, qnrS, qnrA, qnrB, parC, ermB, msrA, dfrD, tetM, and int-Tn, which confer resistance to various antibiotics such as beta-lactams, quinolones, macrolides, and tetracyclines.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Beyond CC398: Characterisation of Other Tetracycline and Methicillin-Resistant Staphylococcus aureus Genetic Lineages Circulating in Spanish Hospitals.
The study characterizes various tetracycline and methicillin-resistant Staphylococcus aureus genetic lineages circulating in Spanish hospitals, identifying multiple AMR genes including blaZ, tetK, tetL, tetM, ermC, ermB, ant(4')-Ia, aac(6')-Ie-aph(2'')-Ia, mupA, and fusB.
Comparative Genomic Analysis of a Panton-Valentine Leukocidin-Positive ST22 Community-Acquired Methicillin-Resistant Staphylococcus aureus from Pakistan.
The study identifies the presence of the aminoglycoside resistance gene aac(6')-Ie-aph(2'')-Ia, the plasmid-associated gene erm(C) conferring resistance to macrolides, lincosamides, and streptogramins, and the methicillin resistance gene mecA in the PVL-positive ST22 CA-MRSA strain Lr2 from Pakistan.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
Comparative Phenotypic and Genomic Features of Staphylococci from Sonication Fluid of Orthopedic Implant-Associated Infections with Poor Outcome.
The study identified various AMR genes in Staphylococcus isolates from orthopedic implant-associated infections, including mecA, blaZ, aminoglycoside modifying enzymes, and erythromycin resistance genes, highlighting the prevalence of multidrug resistance among these isolates.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Antimicrobial Susceptibility Profiles and Molecular Characterisation of Staphylococcus aureus from Pigs and Workers at Farms and Abattoirs in Zambia.
The study identified tetracycline resistance genes (tetM, tetK, tetL) and erythromycin resistance genes (ermB, ermC) in Staphylococcus aureus isolates from pigs and workers in Zambia. These genes were detected through PCR and are associated with resistance to tetracycline and erythromycin, highlighting the need for continued surveillance of antimicrobial resistance in this region.
Antibiotic resistance genes of public health importance in livestock and humans in an informal urban community in Nepal.
The study identified several antibiotic resistance genes, including bla SHV-1, QnrS, ermC, tetA, tetB, aacC2, and aadA1, in various sources such as humans, animals, and water in an urban informal settlement in Nepal.
Comparison between Some Phenotypic and Genotypic Methods for Assessment of Antimicrobial Resistance Trend of Bovine Mastitis Staphylococcus aureus Isolates from Bulgaria.
The study identified blaZ, mecA, ermC, and tetK genes in Staphylococcus aureus isolates from bovine mastitis cases in Bulgaria, highlighting resistance to penicillin, methicillin, erythromycin, and tetracycline.
Molecular characterization of multi-drug-resistant Staphylococcus aureus in mastitis bovine milk from a dairy farm in Anhui, China.
The study identified multidrug-resistant Staphylococcus aureus in bovine milk samples, highlighting the presence of resistance genes blaZ, ermC, rpoB, and ant(4')-la, which confer resistance to penicillin, macrolides, rifampicin, and spectinomycin, respectively.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.
The study identifies several AMR genes, including ant(6)-Ia, aph(3')-III, blaZ, mecA, ermC, and tetK, which contribute to resistance against aminoglycosides, beta-lactams, macrolides, and tetracyclines in VISA DAP-R CA-MRSA. Additionally, a mutation in mprF (Thr345Ala) is linked to daptomycin and glycopeptide resistance.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Antimicrobial Resistance and Virulence Genes in Staphylococci Isolated from Aviary Capercaillies and Free-living Birds in South-eastern Poland.
The study identified several AMR genes in Staphylococcus isolates from birds, including mecA, blaZ, msrA/B, ermC, mphC, tetK, tetM, cfr, norA, aac(6')-aph(2"), sea, and tst. These genes conferred resistance to various antibiotics such as methicillin, beta-lactams, macrolides, tetracyclines, chloramphenicol, florfenicol, fluoroquinolones, and aminoglycosides.
Outbreak investigation including molecular characterization of community associated methicillin-resistant Staphylococcus aureus in a primary and secondary school in Eastern Switzerland.
The study identified a cluster of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in a school in Eastern Switzerland, characterized by ST5 sequence type and efflux-mediated macrolide resistance. The outbreak was linked to a local school, and decolonization efforts successfully reduced the incidence of CA-MRSA cases.
Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant.
The study identified multiple antimicrobial resistance genes, including fexA, ermC, cfr, aac(6')-aph(2''), dfrG, tetK, blaZ, mecA, norA, tetM, and ermA, in Staphylococcus and Mammaliicoccus species isolated from a swine manure treatment plant, indicating widespread resistance to various antibiotics.
Comparative Genomic Analysis of a Multidrug-Resistant Staphylococcus hominis ShoR14 Clinical Isolate from Terengganu, Malaysia, Led to the Discovery of Novel Mobile Genetic Elements.
The study identified multiple AMR genes in the multidrug-resistant S. hominis ShoR14 isolate, including tetK, norA, aac(6')-aph(2"), aadD, blaZ, mecA, mupA, fusC, ermC, sul4, dfrC, and catA7, which contribute to resistance against various antibiotics.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
The study identified S. aureus isolates carrying genes conferring resistance to penicillin-G, trimethoprim, tetracycline, erythromycin, gentamicin, and other antibiotics. Key resistance genes included blaZ, tetK, tetM, dfrG, ermA, ermC, aacA-aphD, aad9, and mecA.
Genotypic and Phenotypic Characterization of Erythromycin-Resistant Staphylococcus aureus Isolated from Bovine Mastitis and Humans in Close Contact.
The study identified the presence of ermA, ermB, and ermC genes in erythromycin-resistant Staphylococcus aureus isolates from bovine mastitis and humans in close contact, highlighting the genetic similarity and potential zoonotic transmission of these resistance genes.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Temporal Stability of AMR Erm(C) Gene in the Human Skin Virome
The study identifies the erm(C) gene as a prevalent antimicrobial resistance gene in the human skin virome, showing its stability and abundance across multiple anatomical locations and time points.
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins.
The study identified various AMR genes associated with resistance to macrolides, lincosamides, and streptogramins in Enterococci, including ermB, ermA, ermC, ereA, lnuA, mphC, mefA, and mefE. These genes were found to be highly prevalent and contribute to the resistance mechanisms observed in the isolates.
Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates.
The study identified several AMR genes associated with erythromycin and clindamycin resistance in Staphylococcus aureus, including ermC, ermA, ermB, msrA, msrB, lnuA, and mphC. These genes were detected through PCR and phenotypic analysis.
Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Hospitalized Newborn Infants.
The study identified multiple AMR genes and mutations in five MDR-MRSA isolates from newborn infants, including blaZ, mecA, ermC, norA, sdrM, lmrS, and mutations in gyrA and parC contributing to fluoroquinolone resistance, as well as fusA mutations causing fusidic acid resistance.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.
The study evaluated the effectiveness of a combined probiotic-phage sanitation system (PCHSφ) in reducing microbial contamination and antimicrobial resistance (AMR) in hospital environments. PCHSφ significantly reduced staphylococcal contamination and AMR gene prevalence compared to conventional chemical disinfection and PCHS alone.
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Antibiotic resistance in potential probiotic lactic acid bacteria of fermented foods and human origin from Nigeria.
The study identified various antibiotic resistance genes including aac(6')-Ii, ermB, ermC, tetM, vanE, and parC in lactic acid bacteria from Nigerian fermented foods and human sources.
Emergence of community-associated methicillin-resistant Staphylococcus aureus ΨUSA300 among Japanese people with HIV, resulted from stepwise mutations in 2010s.
The study identified the emergence of the ΨUSA300 clone among Japanese people with HIV, which acquired lineage-specific nonsynonymous mutations leading to resistance against fluoroquinolones, erythromycin, and clindamycin. Key resistance mechanisms included the gyrA 84L and grlA 80Y mutations, as well as the presence of msrA, ermC, and aacA-aphD genes.
Antibiotic Susceptibility Profiling of Human Pathogenic Staphylococcus aureus Strains Using Whole Genome Sequencing and Genome-Scale Annotation Approaches.
The study identified several AMR genes in multidrug-resistant S. aureus strains, including blaZ, mecA, mecC, norA, norC, MgrA, tet(45), APH(3′)-IIIa, ermC, AAC(6′)-APH(2″), and fusC. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, lincosamides, streptogramin B, and fusidic acid.
Methicillin-Resistant Staphylococcus aureus Strains Isolated from Burned Patients in a Tunisian Hospital: Molecular Typing, Virulence Genes, and Antimicrobial Resistance.
The study identified several AMR genes in MRSA isolates from burned patients, including blaZ, erm(C), msr(A), and tet(M), which confer resistance to penicillin, erythromycin, and tetracycline.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk and Humans in Eastern Tanzania: Genetic Diversity and Inter-Host Transmission.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk and humans in eastern Tanzania, including blaZ, dfrG, erm(C), tet(K), and str, which confer resistance to penicillin, trimethoprim, macrolides, tetracycline, and streptomycin, respectively.
Prevalence and antibiotic resistance of Staphylococcus aureus associated with a college-aged cohort: life-style factors that contribute to nasal carriage.
The study identified several AMR genes in S. aureus isolates, including blaZ, mecA, tetM, dfrS1, ermA, ermC, msrA, and norA, which conferred resistance to penicillin, cefoxitin, tetracycline, trimethoprim, azithromycin, and ciprofloxacin.
Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.
The study identified several AMR genes including blaZ, mecA, tetK, tetM, ermC, and ermB in Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. These genes conferred resistance to penicillin, methicillin, tetracycline, and erythromycin.
The Prevalence of the Virulence Genes of Staphylococcus aureus in Sickle Cell Disease Patients at KSUMC, Riyadh, Saudi Arabia.
The study identified the presence of several virulence genes and antibiotic resistance genes in clinical Staphylococcus aureus and MRSA isolates from SCD patients, including blaZ, mecA, tetK, and ermC.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Baseline azithromycin resistance in the gut microbiota of preterm born infants.
The study identifies the presence of macrolide resistance genes in the gut microbiota of preterm infants, with erm(C) and msr(A) being the most common. These genes were found in various bacterial genera, including Staphylococcus and Enterococcus.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Molecular basis and evolutionary cost of a novel macrolides/lincosamides resistance phenotype in Staphylococcus haemolyticus.
This study identified a novel constitutive MLS resistance phenotype in Staphylococcus haemolyticus due to a deletion in the leader peptide of the ermC gene, leading to continuous expression of the methyltransferase and resistance to erythromycin and clindamycin.
An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004-2020).
The study identifies erm(C), erm(A), erm(T), msr(A), and mph(C) as key genes contributing to erythromycin resistance in methicillin-susceptible Staphylococcus aureus (MSSA) isolates in Spain, with a notable increase in erm(T) prevalence post-2013.
Multidrug Resistance in Enterococci Isolated from Cheese and Capable of Producing Benzalkonium Chloride-Resistant Biofilms.
The study identified vancomycin resistance genes (vanA), erythromycin resistance genes (ermC), beta-lactam resistance gene (pbp5), aminoglycoside resistance gene (aac(6')-Ie-aph(2'')-Ia), and penicillin resistance gene (blaZ) in Enterococcus isolates from cheese. These isolates also showed multidrug resistance and biofilm formation capabilities.
Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.
The study identified multiple AMR genes in methicillin-resistant staphylococci and mammaliicocci from bulk tank milk, highlighting their role as potential reservoirs of antimicrobial resistance genes.
Comparative De Novo and Pan-Genome Analysis of MDR Nosocomial Bacteria Isolated from Hospitals in Jeddah, Saudi Arabia.
The study identified multiple antibiotic resistance genes in multidrug-resistant (MDR) nosocomial bacteria isolated from hospitals in Jeddah, Saudi Arabia. These included beta-lactamase genes such as SHV, OXA, CTX-M, TEM-1, NDM-1, VIM-1, and ere(A), as well as macrolide/lincosamide/streptogramin B resistance genes like ermA, ermB, ermC, msrA, and quaternary ammonium compound resistance genes such as qacA, qacB, and qacC.
A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA).
The review highlights the role of PBP2a, encoded by the mecA gene, in conferring resistance to β-lactam antibiotics in MRSA. It also discusses the importance of β-lactamase enzymes, such as those encoded by blaZ, in degrading β-lactam antibiotics.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Antimicrobial Resistance Profiles of Staphylococcus Isolated from Cows with Subclinical Mastitis: Do Strains from the Environment and from Humans Contribute to the Dissemination of Resistance among Bacteria on Dairy Farms in Colombia?
The study identified several AMR genes in Staphylococcus isolates from dairy farms in Colombia, including blaZ, aacA-aphD, mecA, tetK, and ermC, which confer resistance to β-lactams, aminoglycosides, methicillin, tetracyclines, and macrolides, respectively.
Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.
The study identified several antimicrobial resistance genes in staphylococci isolated from the skin microbiota of healthy goats and sheep, including mecA, blaZ, tetL, tetK, ermB, ermC, lnu, and grlA. These genes confer resistance to various antibiotics such as methicillin, penicillin, tetracycline, macrolides, lincosamides, and fluoroquinolones.
Macrolide-Lincosamide Resistance and Virulence Genes in Staphylococcus aureus Isolated from Clinical Specimens in Ardabil, Iran.
The study identified high frequencies of erythromycin and clindamycin resistance in Staphylococcus aureus isolates from Ardabil, Iran, with ermC being the most prevalent erythromycin resistance gene.
Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.
The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.
Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K(3).
The study identified several macrolide resistance genes, including erm(A), erm(B), erm(C), msr(A), and mph(C), in Staphylococcus aureus isolates. These genes were associated with resistance to erythromycin and azithromycin.
Comparative genomic analysis of antibiotic resistance and virulence genes in Staphylococcus aureus isolates from patients and retail meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Genomic epidemiology of the primary methicillin-resistant Staphylococcus aureus clones causing invasive infections in Paraguayan children.
The study identified several AMR genes in MRSA isolates causing invasive infections in Paraguayan children, including mecA, blaZ, ermC, aac(6')-aph(2"), tet(38), cat(pC221), fos-B-Saur, and rphC, which confer resistance to various antibiotics such as methicillin, penicillin, erythromycin, clindamycin, gentamicin, tetracycline, chloramphenicol, and rifampin.
Antibiotic prescribing patterns and carriage of antibiotic-resistant Escherichia coli and Enterococcus species in healthy individuals from selected communities in Lusaka and Ndola districts, Zambia.
The study identified several AMR genes in E. coli and Enterococcus species, including bla CTX-M, sul2, qnrA, and various erm genes, highlighting the prevalence of multidrug resistance in commensal bacteria from healthy individuals in Zambia.
Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of Tigheibacillus jepli gen. nov., sp. nov.
The study identifies Tigheibacillus jepli as a novel spore-forming species with intrinsic resistance to third- and fourth-generation cephalosporins, lacking known β-lactamases, suggesting resistance via variant penicillin-binding proteins. It also reports three vancomycin resistance-related ARG in T. jepli.
Antimicrobial resistance markers distribution in Staphylococcus aureus from Nsukka, Nigeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from Nsukka, Nigeria, including MecA, VanA, VanB, ErmB, and ErmC, which confer resistance to methicillin, vancomycin, and macrolides.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Molecular detection of multidrug and methicillin resistance in Staphylococcus aureus isolated from wild pigeons (Columba livia) in South Africa.
The study identified multiple antibiotic resistance genes, including mecA, tetM, aac(6')-aph(2"), ermC, and blaZ, in Staphylococcus aureus isolates from wild pigeons in South Africa, highlighting the presence of multidrug-resistant and methicillin-resistant S. aureus in the environment.
Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
The study identified several macrolide resistance genes, including mph(A), mph(B), mef(B), erm(B), mef(C)-mph(G), erm(C), erm(42), ere(A), and msr(E)-mph(E), associated with azithromycin resistance in E. coli and Salmonella from food-producing animals and meat in Europe. The study also highlighted the importance of the mph(A) operon structure and its regulatory region in determining azithromycin resistance.
Characterization of resistance and virulence factors in livestock-associated methicillin-resistant Staphylococcus aureus.
The study identified several AMR genes including mecA, mecC, tetM, ermA, ermC, vanA, and vanC in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, and vancomycin. Additionally, virulence factors like PVL, tsst-1, icaA, and icaB were prevalent in the isolates.
Genetic Complexity of CC5 Staphylococcus aureus Isolates Associated with Sternal Bursitis in Chickens: Antimicrobial Resistance, Virulence, Plasmids, and Biofilm Formation.
The study identified multiple antimicrobial resistance genes in S. aureus isolates from sternal bursitis in chickens, including aph(3')-IIIa, tetK, tet38, ermC, parC, and fosB, which confer resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, and fosfomycin.
Phenotypic and genotypic characterization of commensal staphylococci isolated from young volunteers in Alexandria, Egypt.
The study identified the presence of macrolide resistance genes ermB, ermC, and msrA in Staphylococcus aureus and other staphylococci (SOSA) isolates, with ermB showing the highest prevalence. These genes confer resistance to erythromycin and azithromycin.
Mobile genetic element-driven genomic changes in a community-associated methicillin-resistant Staphylococcus aureus clone during its transmission in a regional community outbreak in Japan.
The study identified the blaZ gene as a determinant of penicillin resistance in the TDC clone of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) during a regional outbreak in Japan.
ST913-IVa-t991 Methicillin-Resistant Staphylococcus aureus among Pediatric Patients, Israel.
The study identified two AMR genes, ermC and cat, associated with erythromycin, clindamycin, and chloramphenicol resistance in t991 MRSA isolates from Israel. These findings highlight the genetic diversity and resistance mechanisms of this emerging MRSA lineage.
Ribosomal RNA methylation in Staphylococcus aureus and Escherichia coli: effect of the "MLS" (erythromycin resistance) methylase.
The study identifies and characterizes the MLS methylase genes ermB and ermC, which confer resistance to macrolides, lincosamides, and streptogramin B by methylating specific adenosine residues in the 23S rRNA of Staphylococcus aureus and Escherichia coli.
Genomic characterization of methicillin-resistant Staphylococcus aureus isolated from patients attending regional referral hospitals in Tanzania.
The study identifies the presence of various AMR genes in MRSA isolates from Tanzanian regional hospitals, including blaZ, erm(C), aac(6')-aph(2''), and tet(K). These genes contribute to resistance against beta-lactams, macrolides, aminoglycosides, and tetracyclines, highlighting the complexity of resistance profiles in MRSA.
Antimicrobial Susceptibility and Genomic Profiles of Multidrug-Resistant Staphylococcus aureus from Nasopharynx of Asymptomatic Children in Dhaka, Bangladesh.
The study identified multidrug-resistant Staphylococcus aureus isolates, including MRSA-ST80, carrying various AMR genes such as mecA, blaI, blaZ, ermC, aph-S-tph, dha1, norA, tet38, mepA, lmrS, and fosB. Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Methicillin-resistant Staphylococcus aureus outbreak in a Dutch equine referral clinic.
The study identified multiple AMR genes including aac(6')-Ie/aph(2'')-Ia, tetM, dfrK, ermC, and dfrC in MRSA isolates from horses, staff, and the environment. Additionally, mutations in folP, gyrA, and rpoB were found to confer resistance to sulfonamides, fluoroquinolones, and rifampicin respectively.
Inducible clindamycin-resistant and biofilm formation in the Staphylococcus aureus isolated from healthcare worker's anterior nasal carriage.
The study identified the presence of ermC, ermA, ermB, and ereA genes in Staphylococcus aureus isolates from healthcare workers, contributing to macrolide-lincosamide-streptogramin B resistance and clindamycin resistance.
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.
The Intestinal Resistome of Preterm Infants Exhibited a Rich Diversity of ARGs
The study identified a rich diversity of antibiotic resistance genes (ARGs) in the intestinal microbiota of preterm infants, with beta-lactam, MLS, and tetracycline resistance being the most prevalent. Key ARGs included ermC, ermB, mecA, TEM-4, ANT(4')-Ib, isaA, vgaC, and oqxB, which were associated with various bacterial species and drug classes.
Prevalence of pathogens and antimicrobial resistance of isolated Staphylococcus spp. in bovine mastitis milk in South Korea, 2018-2022.
The study identified several antimicrobial resistance genes in Staphylococcus spp. isolated from bovine mastitis milk, including mecA, blaZ, tetK, ermC, lnuA, and lnuB. These genes were associated with resistance to penicillins, tetracyclines, erythromycin, and lincomycin.
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.
The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles.
The QIAstat-Dx BCID GN and GPF kits showed high accuracy in detecting AMR genes such as blaZ, mecA, ermC, aac(6')-lb, ctx-m, ampC, shv, tem, tetM, and aac(6')/aph(2") in various bacteria, correlating well with phenotypic resistance results.
Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Methicillin-Resistant S. aureus Carrying the PVL and Toxic Shock Syndrome Toxin in Healthy Dogs in Algeria.
The study identified methicillin-resistant S. aureus (MRSA) in healthy dogs in Algeria, with isolates carrying the mecA gene and other resistance genes such as blaZ, ant(6)-Ia, aph(3')-III, erm(C), and tet(K). Some isolates also harbored the PVL and tst genes encoding virulence factors.
Deciphering the genomic character of the multidrug-resistant Staphylococcus aureus from Dhaka, Bangladesh.
The study identified multiple AMR genes in multidrug-resistant S. aureus isolates from Bangladesh, including mecA, blaZ, ermC, mepA, norA, norC, sdrM, and lmrS, which confer resistance to various antibiotics.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021-2024.
The study identified several AMR genes associated with macrolide, lincosamide, and tetracycline resistance in Streptococcus agalactiae isolates from Bulgaria. These include ermB, ermA/TR, ermC, mefA, mefE, msrD, lnuB, lsaC, lsaE, tetM, and tetO. High resistance rates to macrolides (60.3%) and tetracyclines (89.1%) were observed.
The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.
The study identified several AMR genes in Staphylococcus hominis, including erm(C), tetK, acc(6')-Ie aph(2''), aph(3')-IIIa, ant(4')-Ia, msr(B), mph(C), lnu(A), and vga, which confer resistance to various antibiotics such as macrolides, lincosamides, streptogramins, tetracyclines, and aminoglycosides. The majority of the strains exhibited multidrug resistance.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Synergistic Antibacterial and Antibiofilm Effects of Clindamycin and Zinc Oxide Nanoparticles Against Pathogenic Oral Bacillus Species.
The study identifies the ermC gene as a clindamycin resistance determinant in oral Bacillus species and demonstrates the synergistic antibacterial and antibiofilm effects of clindamycin and zinc oxide nanoparticles.
Study on molecular characteristics of Staphylococcus from yak milk-Xizang.
The study identified several AMR genes in Staphylococcus isolates from yak milk, including blaZ, mecA, gyrA, glrB, gyrB, lnuA, tetK, aacA-aphD, vga, and ermC, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and aminoglycosides.
Detection of Antibiotic-Resistance Genes in Drinking Water: A Study at a University in the Peruvian Amazon.
The study detected the presence of antibiotic-resistance genes (ermC, amp, QEP, marA, and qEmarA) in all water samples analyzed, highlighting the widespread dissemination of resistance factors in drinking water.
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Phenotypic and Genotypic Bacterial Virulence and Resistance Profiles in Hidradenitis Suppurativa.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) strains carrying the mecA gene, as well as erythromycin resistance mediated by the ermC gene. Additionally, the study highlighted the presence of biofilm-forming bacteria, which may contribute to chronicity and antibiotic tolerance in hidradenitis suppurativa.
Identification of Novel Staphylococcus aureus Core and Accessory Virulence Patterns in Chronic Rhinosinusitis.
The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.
AmrProfiler: A Comprehensive Tool for Antimicrobial Resistance Gene Detection and Analysis
AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.
Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant Staphylococcus aureus: potential for cross-species transmission of ST59-MRSA.
The study identified several antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from bovine mastitis, including erm(B), erm(C), tet(L), tet(K), mecA, fexA, aac(6')-aph(2''), ant(4')-Ia, ant(6)-Ia, and aph(2'')-Ia. These genes were associated with resistance to various antibiotics such as erythromycin, tetracycline, penicillin, oxacillin, cefoxitin, florfenicol, and gentamicin.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Multidrug-Resistant Staphylococcus aureus in Diabetic Foot Infections (DFI) from Beira, Mozambique: Prevalence and Virulence Profile.
The study identified high levels of multidrug resistance in Staphylococcus aureus isolates from diabetic foot infections in Beira, Mozambique, with resistance genes blaZ, mecA, vancA, vancB, ermB, ermC, dfrA, and dfrG being prevalent.
The impact of green spaces, urban settings, seasonal changes, and pollutants on dissemination of antimicrobial genes in air.
The study identified several antimicrobial resistance genes (ARGs) in airborne samples, including blaTEM, mecA, aac(6')-Ib, ermB, ermC, tetM, tetW, sul1, and sul3. It found that the relative abundance of these ARGs varied with vegetation coverage, seasons, and environmental factors. High vegetation areas showed slightly lower ARG abundance compared to urban heat islands and low/no vegetation areas. The study highlights the potential of planting non-allergenic vegetation to reduce airborne ARG dissemination.
TRENDS IN MULTIPLE ANTIBIOTIC RESISTANCE AMONG PREDOMINANT HOSPITAL ISOLATES: ANNUAL VARIATIONS AND PEAK SEASONAL PATTERNS
The study identified mecA, vanA, and tetM as key resistance genes in Staphylococcus aureus isolates with high multiple antibiotic resistance indices, indicating the presence of methicillin-resistant and vancomycin-resistant strains.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Genomic and phenotypic characterization of methicillin-resistant Staphylococcus aureus ST965: an emerging hospital-adapted clone with enhanced invasiveness.
The study identifies multiple AMR genes in ST965-MRSA, including blaI-blaR-blaZ, erm(B), erm(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, mepA, mepR, cadD, cadC, and the plasmid pYF965, which contribute to multidrug resistance and hospital adaptation.
Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance.
The study presents a framework to predict no-effect concentrations for antibiotic resistance selection in the environment by integrating minimum inhibitory concentration (MIC) data with resistance-related fitness costs. It identifies various AMR genes and their resistance profiles through competition experiments.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
Prevalence, toxin virulence genes and investigating the effect of mutations in the tetracycline gene (tetK) on the response of methicillin-resistant Staphylococcus aureus to antibiotics: a study in sickle cell disease patients in Riyadh, Saudi Arabia.
The study identified the tetracycline resistance gene tetK in MRSA isolates from SCD patients in Riyadh, Saudi Arabia, and detected several mutations in the tetK gene that correlate with altered antibiotic susceptibility.
Pristinamycin-antibiotic combinations against methicillin-resistant Staphylococcus aureus recovered from skin infections.
The study identifies the presence of ermA, ermC, msrA, and mecA genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates, contributing to resistance against macrolides, lincosamides, streptogramin B, and beta-lactams. It also evaluates the effectiveness of pristinamycin combinations with other antibiotics against these resistant isolates.
Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand.
The study identified several AMR genes in Staphylococcus aureus ST1 isolates from New Zealand, including blaZ, tet(38), mecA, mecR1, qacA, qacB, ermC, fusC, mupA, and others. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, methicillin, quaternary ammonium compounds, erythromycin, fusidic acid, mupirocin, and fluoroquinolones. The study also highlighted the presence of a novel prophage, φSabovST1, in bovine ST1 isolates, which encoded bovine-adapted leukocidins.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis.
The study identifies key resistance mechanisms in Neisseria gonorrhoeae, including the widespread presence of efflux pump genes (norM, farB, mtrC, mtrA) and specific resistance genes such as bla TEM, tet(C), and erm(C). It highlights the increasing prevalence of antimicrobial resistance and the need for global surveillance and targeted interventions.
Bovine mastitis and antimicrobial resistance in Pakistan's dairy sector: current status and future prospects.
The paper highlights the high prevalence of bovine mastitis in Pakistan, particularly caused by Staphylococcus aureus, and discusses the growing concern of antimicrobial resistance (AMR) due to the frequent and often inappropriate use of antibiotics in mastitis management.
Genomic diversity and antimicrobial resistance of Staphylococcus aureus in Saudi Arabia: a nationwide study using whole-genome sequencing.
The study identified multiple AMR genes in S. aureus isolates from Saudi Arabia, highlighting the genetic diversity and resistance patterns associated with mass gatherings. Key genes include mecA, mecR1, aacA-aphD, knt, tet(K), ermC, msrA, fcl_1, natA, macB, and dppB, which confer resistance to various antibiotics.
Prevalence and antimicrobial resistance characterization of multidrug-resistant Staphylococcus epidermidis isolated from raw milk of dairy cattle and ewes.
The study identified the presence of multidrug-resistant Staphylococcus epidermidis in raw milk samples from dairy cattle and ewes, with high prevalence of resistance genes mecA, tetK, and ermC.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities.
The study identifies the ermC gene encoded on a plasmid as a key factor in the amplification and spread of MRSA in an urban jail and its connected communities, with strong associations to clindamycin and erythromycin resistance.
Antimicrobial Resistance in Staphylococcus aureus at the Human-Animal-Environment Interface in East Africa: A Systematic Review and Meta-Analysis
The study identified key resistance genes including mecA, blaZ, tet(K), and erm(C) in Staphylococcus aureus isolates from East Africa, highlighting the prevalence of methicillin-resistant and multidrug-resistant strains.
High colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.
The study identified multiple AMR genes in MRSA isolates from critically ill patients during the COVID-19 pandemic, including erm(C), msr(A), mph(C), smr, aph(3')-III3a, and various virulence genes such as sasG, ebpS, scn, egc_cluster, fnbpB, cna, and pvl.
Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities.
The study identifies the ermC gene on a plasmid as a key factor in the spread of methicillin-resistant Staphylococcus aureus (MRSA) in an urban jail and its connected communities, showing its association with increased resistance to clindamycin and erythromycin.
Distribution of Staphylococcus aureus drug resistance genes, biofilm formation and cell wall characteristics in dairy cattle from dairy farms in Northeast China.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from dairy cattle in Northeast China, including tetM, aph(3')-III, ermC, aac(6')/aph(2'), grlB, gyrB, blaZ, and mecA, which confer resistance to tetracycline, aminoglycosides, erythromycin, fluoroquinolones, and beta-lactams.
Molecular Epidemiology, Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-Susceptible Staphylococcus Aureus Infection in Neonates.
The study identifies key antimicrobial resistance genes in methicillin-susceptible Staphylococcus aureus (MSSA) isolates, including blaZ, erm(C), and tet(K), which confer resistance to penicillin, macrolides, and tetracycline respectively. These findings highlight the complexity of antimicrobial resistance in MSSA and the need for continued surveillance and tailored antimicrobial stewardship.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
Emergence of Multidrug-Resistant and Biofilm-Producing Staphylococcus aureus from Raw Poultry in Algeria: Implications for Public Health.
The study identified several AMR genes in S. aureus isolates from raw poultry in Algeria, including blaZ, mecA, tet(M), tet(K), tet(S), erm(B), and erm(C). These genes were associated with resistance to penicillin, methicillin, tetracycline, and erythromycin.
Conformational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance.
Conformational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance.
Posttranscriptional modification of mRNA conformation: mechanism that regulates erythromycin-induced resistance., The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring inducible macrolide-lincosamide-streptogramin B resistance and comparison with similar plasmids expressing constitutive resistance., Replication properties of pIM13, a naturally occurring plasmid found in Bacillus subtilis, and of its close relative pE5, a plasmid native to Staphylococcus aureus., Molecular analysis of naturally occuring ermC-encoding plasmids in staphylococci isolated from animals with and without previous contact with macrolide/lincosamide antibiotics., Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis., Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator., Molecular properties of the erythromycin resistance plasmid pPV141 from Staphylococcus chromogenes., Molecular characterization of the erythromycin resistance plasmid pPV142 from Staphylococcus simulans.
Molecular properties of the erythromycin resistance plasmid pPV141 from Staphylococcus chromogenes.
Molecular properties of the erythromycin resistance plasmid pPV141 from Staphylococcus chromogenes.
Molecular analysis of naturally occuring ermC-encoding plasmids in staphylococci isolated from animals with and without previous contact with macrolide/lincosamide antibiotics.
Molecular analysis of naturally occuring ermC-encoding plasmids in staphylococci isolated from animals with and without previous contact with macrolide/lincosamide antibiotics.
Molecular analysis of naturally occuring ermC-encoding plasmids in staphylococci isolated from animals with and without previous contact with macrolide/lincosamide antibiotics.
Molecular analysis of naturally occuring ermC-encoding plasmids in staphylococci isolated from animals with and without previous contact with macrolide/lincosamide antibiotics.
Molecular characterization of the erythromycin resistance plasmid pPV142 from Staphylococcus simulans.
Molecular characterization of the erythromycin resistance plasmid pPV142 from Staphylococcus simulans.
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