ermE

erythromycin resistance methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ermE

Browse AMR rules for ermE

Overview

Drug Classes: erythromycin
Papers: 1
Mutations: 7

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P20T	-	-	-	erythromycin	Reslit	Candidate
G40D	-	-	-	erythromycin	Reslit	Candidate
R36P	-	-	-	erythromycin	Reslit	Candidate
R36E	-	-	-	erythromycin	Reslit	Candidate
R47S	-	-	-	erythromycin	Reslit	Candidate
N42A	-	-	-	erythromycin	Reslit	Candidate
F43A	-	-	-	erythromycin	Reslit	Candidate

Papers1

1

Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.

PMID 39516040 · 2025

Mutation Information

ermE: p.P20T ermE: p.G40D ermE: p.R36P ermE: p.R36E ermE: p.R47S ermE: p.N42A ermE: p.F43A

Protein Change: P20T, G40D, R36P, R36E, R47S, N42A, F43A
Confers Resistance To: erythromycin
Validation Method: random mutagenesis and phenotypic assays; site-directed mutagenesis and phenotypic assays
Source Database: Reslit