Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
erythromycin resistance methylase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ermAM | Reslit | 3 | erythromycin, macrolides +2 | Streptococcus faecalis +2 | - | 1987, 1996, 1998 | AF066796|AF066797 | - |
| ErmAM | Reslit | 1 | macrolides | Streptococcus +2 | - | 2025 | 5IGH|5IGU|3FPP|6XCQ|1YUB | - |
Constitutive expression of erythromycin resistance mediated by the ermAM determinant of plasmid pAMβ1 results from deletion of 5′ leader peptide sequences.
The study identifies the ermAM determinant of plasmid pAMβ1 as a gene responsible for erythromycin resistance through DNA methylation of 23S rRNA. It also reveals that the constitutive expression of this gene results from the deletion of 5' leader peptide sequences.
Computational investigation of natural compounds as inhibitors against macrolide-resistant protein using virtual screening, molecular docking and MD simulations.
The study identifies natural compounds that show high binding affinity against enzymes involved in macrolide resistance, including ErmAM, EreC, mphA, mphB, and the tripartite macrolide-specific efflux pump. These compounds demonstrate potential as inhibitors of macrolide resistance mechanisms.
Novel mechanism of macrolide resistance in Streptococcus pneumoniae.
The study identifies ermAM as a gene responsible for high-level macrolide-lincosamide-streptogramin B resistance in Streptococcus pneumoniae. A novel low-level macrolide resistance mechanism was also discovered, which does not involve known resistance genes like ermA, ermC, ermAM, ereA, ereB, or msrA.
Detection of Tn917-like sequences within a Tn916-like conjugative transposon (Tn3872) in erythromycin-resistant isolates of Streptococcus pneumoniae.
The study identifies the presence of Tn917-like sequences within a Tn916-like conjugative transposon (Tn3872) in erythromycin-resistant isolates of Streptococcus pneumoniae, highlighting the role of the ermAM gene in conferring erythromycin resistance.
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