ermbl

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regulatory element for ermB

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Validation StatusCandidate

Overview

Mechanism: expression of ermB
Validation Method: chromosomal integration and MIC testing
Drug Classes: erythromycin, clindamycin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Epitranscriptional m6A modification of rRNA negatively impacts translation and host colonization in Staphylococcus aureus.

PMID 38252661 · 2024

The study identifies ermB as a gene that confers resistance to macrolides, lincosamides, and streptogramin B (MLS) antibiotics through the m6A2058 modification of rRNA, which impairs translation and host colonization in Staphylococcus aureus.

Gene Information

Gene Name: ermbl
Allele: ermBL
Encodes: regulatory element for ermB
Source Database: Reslit
Mechanism: expression of ermB
Confers Resistance To: erythromycinclindamycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: chromosomal integration and MIC testing
Sequence Accession: GSE168265

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ermbl

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ermbl

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