fabG

3-oxoacyl-[acyl-carrier-protein] reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fabG

Browse AMR rules for fabG

Overview

Mechanism: single resistance variant
Drug Classes: triclosan, isoniazid
Organisms: Escherichia coli
Papers: 2
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y151V	-	single resistance variant, beta-ketoacyl-ACP reductase FabG	Escherichia coli	triclosan	Card DatabaseReference Gene Catalog	Candidate
-	C15T	-	-	isoniazid	Reslit	Candidate
-	C8T	-	-	isoniazid	Reslit	Candidate

Papers2

1

Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes.

PMID 27577999 · 2016

Escherichia coli fabG mutations conferring resistance to triclosan; CARD accession: CARD:3004049

Mutation Information

Protein Change: Y151V
Organisms: Escherichia coli
Confers Resistance To: triclosan
Effect on Function: single resistance variant
Source Database: Card Database

2

Transmission of multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular epidemiological study.

PMID 35089253 · 2022

Mutation Information

fabG: c.C15T fabG: c.C8T

Nucleotide Change: C15T, C8T
Confers Resistance To: isoniazid
Validation Method: sequencing of drug resistance-associated genes
Source Database: Reslit