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fadD9

Acyl-CoA synthetase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fadD9

Browse AMR rules for fadD9

Overview

Drug Classes: dapsone
Organisms: Mycobacterium leprae
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G267S	-	-	Mycobacterium leprae	dapsone	Reslit	Candidate
D520N	-	-	Mycobacterium leprae	dapsone	Reslit	Candidate

Papers1

1

Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.

PMID 40391941 · 2025

Previously reported as a dapsone resistance mutation

Mutation Information

fadD9: p.G267S fadD9: p.D520N

Protein Change: G267S, D520N
Organisms: Mycobacterium leprae
Confers Resistance To: dapsone
Validation Method: DNA sequencing
Source Database: Reslit