fecA

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iron transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fecA

AMR Rules

Browse AMR rules for fecA

Validation StatusCandidate

Overview

Mechanism: plasmid-encoded ferric citrate transport system
Validation Method: experimental validation
Drug Classes: cefiderocol
Organisms: Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa
Geographic Location: Italy
Papers: 3
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A190T	-	-	Escherichia coli	cefiderocol	Reslit	Candidate
T339A	-	-	Pseudomonas aeruginosa	cefiderocol	Reslit	Candidate
H363R	-	-	Pseudomonas aeruginosa	cefiderocol	Reslit	Candidate

Papers3

Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae.

PMID 39714320 · 2025

The study identifies the plasmid-borne fec gene cluster as a novel mechanism of cefiderocol resistance in KPC-producing Klebsiella pneumoniae, demonstrating that the ferric citrate transport system reduces susceptibility to cefiderocol.

Gene Information

Gene Name: fecA
Allele: fecA
Encodes: iron transporter
Source Database: Reslit
Mechanism: plasmid-encoded ferric citrate transport system
Confers Resistance To: cefiderocol
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Italy
Validation Method: experimental validation
Sequence Accession: CP168103|PQ130559|PQ085644

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

A190T

Escherichia coli

cefiderocol

Reslit

Candidate

T339A

Pseudomonas aeruginosa

cefiderocol

Reslit

Candidate

H363R

Pseudomonas aeruginosa

cefiderocol

Reslit

Candidate

fecA

Mutations

Gene Information

Browse AMR Genes

fecA

Mutations

Gene Information