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fepR

transcriptional regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fepR

Browse AMR rules for fepR

Validation StatusCandidate

Overview

Mechanism: overexpression of the MATE efflux pump FepA
Validation Method: genomic analysis and in silico prediction
Drug Classes: ciprofloxacin
Organisms: Listeria monocytogenes
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
108fs	-	reduced DNA binding	Listeria monocytogenes	ciprofloxacin	Reslit	Candidate
A64G	-	-	Listeria monocytogenes	ciprofloxacin	Reslit	Candidate

Papers2

1

FepR as a Central Genetic Target in the Adaptation to Quaternary Ammonium Compounds and Cross-Resistance to Ciprofloxacin in Listeria monocytogenes.

PMID 35663878 · 2022

Gene Information

Gene Name: fepR
Allele: fepR
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: overexpression of the MATE efflux pump FepA
Confers Resistance To: ciprofloxacin
Organisms Tested In: • Listeria monocytogenes
Validation Method: genomic analysis and in silico prediction

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