ftsX

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ABC transporter subunit

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ftsX

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: mutation
Validation Method: transformation assays
Drug Classes: ceftriaxone, penicillin
Organisms: Neisseria gonorrhoeae, L. monocytogenes
Geographic Location: China
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G243R	-	-	L. monocytogenes	penicillin	Reslit	Candidate

Papers2

Novel Genes Related to Ceftriaxone Resistance Found among Ceftriaxone-Resistant Neisseria gonorrhoeae Strains Selected In Vitro.

PMID 26787702 · 2016

The study identified mutations in the penA and ftsX genes that contribute to ceftriaxone resistance in Neisseria gonorrhoeae. The A501V mutation in penA and the T31P mutation in ftsX were shown to increase the MIC of ceftriaxone.

Gene Information

Gene Name: ftsX
Allele: ftsX
Encodes: ABC transporter subunit
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: ceftriaxone
Organisms Tested In: • Neisseria gonorrhoeae
Geographic Location: China
Validation Method: transformation assays
Sequence Accession: ERP001822

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ftsX

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ftsX

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