ftsZ

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cell division protein FtsZ

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ftsZ

AMR Rules

Browse AMR rules for ftsZ

Validation StatusCandidate

Overview

Validation Method: reduction of ftsZ mRNA levels and sensitization to oxacillin
Drug Classes: oxacillin, cefixime
Organisms: Staphylococcus aureus, Staphylococcus pseudintermedius, Neisseria gonorrhoeae
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A318V	-	-	Neisseria gonorrhoeae	cefixime	Reslit	Candidate

Papers2

Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro.

PMID 26560174 · 2015

Antisense PNAs targeting mecA and ftsZ in MRSA and MRSP reduced mRNA levels and sensitized the bacteria to oxacillin, demonstrating potential for reversing β-lactam resistance.

Gene Information

Gene Name: ftsZ
Allele: ftsZ
Encodes: cell division protein FtsZ
Source Database: Reslit
Confers Resistance To: oxacillin
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus pseudintermedius
Validation Method: reduction of ftsZ mRNA levels and sensitization to oxacillin

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ftsZ

Mutations

Gene Information

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ftsZ

Mutations

Gene Information