fur

Fur regulatory protein

Overview

Drug Classes: metronidazole
Organisms: Helicobacter pylori
Papers: 3
Mutations: 17

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R3I	-	-	-	metronidazole	Reslit	Candidate
R3S	-	-	-	metronidazole	Reslit	Candidate
R3N	-	-	-	metronidazole	Reslit	Candidate
R3K	-	-	-	metronidazole	Reslit	Candidate
E8K	-	-	-	metronidazole	Reslit	Candidate
G40D	-	-	-	metronidazole	Reslit	Candidate
T41P	-	-	-	metronidazole	Reslit	Candidate
T41I	-	-	-	metronidazole	Reslit	Candidate
T41K	-	-	-	metronidazole	Reslit	Candidate
T41M	-	-	-	metronidazole	Reslit	Candidate
T41Q	-	-	-	metronidazole	Reslit	Candidate
E95G	-	-	-	metronidazole	Reslit	Candidate
K57T	-	-	-	metronidazole	Reslit	Candidate
H99R	-	-	-	metronidazole	Reslit	Candidate
C78Y	-	-	-	metronidazole	Reslit	Candidate
P114S	-	-	-	metronidazole	Reslit	Candidate
N118K	-	-	Helicobacter pylori	metronidazole	Reslit	Candidate

Papers3

Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reduction.

PMID 21464913 · 2011

Mutations in the fur gene affect metronidazole resistance in H. pylori.

Mutation Information

fur: p.R3I fur: p.R3S fur: p.R3N fur: p.R3K fur: p.E8K fur: p.G40D fur: p.T41P fur: p.T41I fur: p.T41K fur: p.T41M fur: p.T41Q fur: p.E95G fur: p.K57T fur: p.H99R fur: p.C78Y fur: p.P114S

Protein Change: R3I, R3S, R3N, R3K, E8K, G40D, T41P, T41I, T41K, T41M, T41Q, E95G, K57T, H99R, C78Y, P114S
Confers Resistance To: metronidazole
Validation Method: Transformation of H. pylori strain M1.5 with the furR3I allele and assessment of metronidazole resistance.; Transformation of H. pylori strain M1.5 with the furR3S allele and assessment of metronidazole resistance.; Transformation of H. pylori strain M1.5 with the furR3N allele and assessment of metronidazole resistance.; Transformation of H. pylori strain M1.5 with the furR3K allele and assessment of metronidazole resistance.; Transformation of H. pylori strain M1.5 with the furE8K allele and assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furG40D allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furT41P allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furT41I allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furT41K allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furT41M allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furT41Q allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furE95G allele followed by assessment of metronidazole resistance.; PCR-based mutagenesis and transformation of H. pylori strain M1.5 with the furK57T allele followed by assessment of metronidazole resistance.; PCR and transformation with assessment of metronidazole resistance
Source Database: Reslit

Analysis of antibiotic susceptibility and genomic characteristics of Helicobacter pylori by whole-genome resequencing in Northern China.

PMID 39661273 · 2025

Mutation Information

fur: p.N118K

Protein Change: N118K
Organisms: Helicobacter pylori
Confers Resistance To: metronidazole
Validation Method: whole-genome resequencing
Source Database: Reslit

Antibiotic Resistance, Susceptibility Testing and Stewardship in Helicobacter pylori Infection.

PMID 37511471 · 2023

novel mutations in metronidazole-resistant strains

Mutation Information

fur: p.N118K

Protein Change: N118K
Organisms: Helicobacter pylori
Confers Resistance To: metronidazole
Validation Method: reported in cited literature
Source Database: Reslit

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R3I	-	-	-	metronidazole	Reslit	Candidate
R3S	-	-	-	metronidazole	Reslit	Candidate
R3N	-	-	-	metronidazole	Reslit	Candidate
R3K	-	-	-	metronidazole	Reslit	Candidate
E8K	-	-	-	metronidazole	Reslit	Candidate
G40D	-	-	-	metronidazole	Reslit	Candidate
T41P	-	-	-	metronidazole	Reslit	Candidate
T41I	-	-	-	metronidazole	Reslit	Candidate
T41K	-	-	-	metronidazole	Reslit	Candidate
T41M	-	-	-	metronidazole	Reslit	Candidate
T41Q	-	-	-	metronidazole	Reslit	Candidate
E95G	-	-	-	metronidazole	Reslit	Candidate
K57T	-	-	-	metronidazole	Reslit	Candidate
H99R	-	-	-	metronidazole	Reslit	Candidate
C78Y	-	-	-	metronidazole	Reslit	Candidate
P114S	-	-	-	metronidazole	Reslit	Candidate
N118K	-	-	Helicobacter pylori	metronidazole	Reslit	Candidate

fur

Mutations

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fur

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