furA

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transcriptional regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to furA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: upstream truncation leading to reduced katG expression
Validation Method: complementation of the M. tuberculosis Δ(furA-katG) strain with katG and different portions of the truncated region
Drug Classes: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A14V	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Candidate

Papers2

An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations.

PMID 25092698 · 2014

An upstream truncation of the furA-katG operon in a Mycobacterium tuberculosis clinical isolate leads to high-level isoniazid resistance by reducing katG expression.

Gene Information

Gene Name: furA
Allele: furA
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: upstream truncation leading to reduced katG expression
Confers Resistance To: isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: complementation of the M. tuberculosis Δ(furA-katG) strain with katG and different portions of the truncated region

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

A14V

single resistance variant

Mycobacterium tuberculosis

isoniazid

Card Database

Candidate

furA

Mutations

Gene Information

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furA

Mutations

Gene Information