glpR

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transcriptional repressor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to glpR

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: loss of function reduces antibiotic susceptibility
Validation Method: MIC assays, growth curve analysis, epithelial cell and Drosophila melanogaster colonization models
Drug Classes: tobramycin, fosfomycin
Organisms: Pseudomonas aeruginosa, Escherichia coli, Citrobacter freundii
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A86E	-	-	Escherichia coli, Citrobacter freundii	fosfomycin	Reslit	Candidate

Papers2

Activation of the Pseudomonas aeruginosa glycerol regulon reduces antibiotic susceptibility and modulates virulence phenotypes.

PMID 40980926 · 2025

Loss of the glpR gene reduces tobramycin susceptibility in the CF-adapted isolate FRD1, and this effect is mediated through the activation of the glycerol regulon, which influences antibiotic resistance and virulence traits.

Gene Information

Gene Name: glpR
Allele: glpR
Encodes: transcriptional repressor
Source Database: Reslit
Mechanism: loss of function reduces antibiotic susceptibility
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: MIC assays, growth curve analysis, epithelial cell and Drosophila melanogaster colonization models

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

A86E

Escherichia coli, Citrobacter freundii

fosfomycin

Reslit

Candidate

glpR

Mutations

Gene Information

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glpR

Mutations

Gene Information