Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component sensor histidine kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| M1I | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| T136I | - | increased GraSR function | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| R232K | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| F38G | - | The F38G mutation reduces the ability of GraS to sense and respond to cationic antimicrobial peptides, leading to decreased resistance to polymyxin B. | Staphylococcus aureus | polymyxin b | Reslit | Candidate |
| T224I | - | - | - | teicoplanin | Reslit | Candidate |
| T24K | - | - | - | teicoplanin | Reslit | Candidate |
| T224K | - | - | - | teicoplanin | Reslit | Candidate |
| L26F | - | - | - | teicoplanin | Reslit | Candidate |
| I59L | - | - | - | teicoplanin | Reslit | Candidate |
| S52N | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.
A point mutation in the two-component sensor gene graS (T136I) was identified as a major contributor to intermediate vancomycin resistance in clinical Staphylococcus aureus.
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