grcC1

polyprenyl diphosphate synthetase

Validation StatusCandidate

Overview

Mechanism: reduces cell wall permeability
Validation Method: overexpression, CRISPRi, CRISPR/Cpf1-assisted gene editing
Drug Classes: linezolid, clarithromycin, vancomycin, clofazimine, rifampicin, cefoxitin, levofloxacin, moxifloxacin, linezolid|clarithromycin|vancomycin|clofazimine|rifampicin|cefoxitin|levofloxacin|moxifloxacin
Organisms: Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium smegmatis
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A132V	-	reduced cell wall permeability	Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium smegmatis	linezolid\|clarithromycin\|vancomycin\|clofazimine\|rifampicin\|cefoxitin\|levofloxacin\|moxifloxacin	Reslit	Candidate

Papers1

GrcC1 mediates low-level resistance to multiple drugs in M. marinum, M. abscessus, and M. smegmatis.

The study identifies a novel mutation (A132V) in the grcC1 gene that confers low-level resistance to multiple drugs in Mycobacterium species.

Gene Name: grcC1
Allele: grcC1
Encodes: polyprenyl diphosphate synthetase
Source Database: Reslit
Mechanism: reduces cell wall permeability
Confers Resistance To: linezolidclarithromycinvancomycinclofaziminerifampicincefoxitinlevofloxacinmoxifloxacin
Organisms Tested In: • Mycobacterium marinum
• Mycobacterium abscessus
• Mycobacterium smegmatis
Validation Method: overexpression, CRISPRi, CRISPR/Cpf1-assisted gene editing

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Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A132V	-	reduced cell wall permeability	Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium smegmatis	linezolid\|clarithromycin\|vancomycin\|clofazimine\|rifampicin\|cefoxitin\|levofloxacin\|moxifloxacin	Reslit	Candidate