Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D432V | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
| D432N | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
| D432H | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
| D432G | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
| N470D | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
| P585S | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Candidate |
Extended spectrum of quinolone resistance, even to a potential latter third-generation agent, as a result of a minimum of two GrlA and two GyrA alterations in quinolone-resistant Staphylococcus aureus.
Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.
Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.