Browse AMR Genes

Explore antimicrobial resistance genes from the literature

gshF

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to gshF

Browse AMR rules for gshF

Overview

Mechanism: single resistance variant
Drug Classes: daptomycin
Organisms: Enterococcus faecalis
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E554K	-	single resistance variant, bifunctional glutamate--cysteine ligase/glutathione synthetase GshF	Enterococcus faecalis	daptomycin	Card DatabaseReference Gene Catalog	Candidate

Papers1

1

Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.

PMID 23959318 · 2013

Enterococcus faecalis gshF with mutation conferring daptomycin resistance; CARD accession: CARD:3003805

Mutation Information

Protein Change: E554K
Organisms: Enterococcus faecalis
Confers Resistance To: daptomycin
Effect on Function: single resistance variant
Source Database: Card Database