gspD

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secretion system component

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to gspD

AMR Rules

Browse AMR rules for gspD

Validation StatusCandidate

Overview

Mechanism: upregulated expression enhances bacterial secretion systems
Validation Method: transcriptomic analysis and qRT-PCR
Drug Classes: levofloxacin, trimethoprim sulfamethoxazole
Organisms: Pseudomonas aeruginosa PAS81, Stenotrophomonas maltophilia
Geographic Location: China
Papers: 2
Databases: Reslit

Papers2

Pseudomonas aeruginosa heteroresistance to levofloxacin caused by upregulated expression of essential genes for DNA replication and repair.

PMID 36620018 · 2022

The study identifies that upregulated expression of genes involved in DNA replication and repair, such as recA, uvrD, xseB, ssb, mutM, and crc, contributes to levofloxacin heteroresistance in Pseudomonas aeruginosa strains PAS71 and PAS81. Additionally, the expression of genes related to bacterial secretion systems, such as gspD, vgrG1, hcpC, clpV1, and ppkA, is increased in PAS81 under LVX stress.

Gene Information

Gene Name: gspD
Allele: gspD
Encodes: secretion system component
Source Database: Reslit
Mechanism: upregulated expression enhances bacterial secretion systems
Confers Resistance To: levofloxacin
Organisms Tested In: • Pseudomonas aeruginosa PAS81
Validation Method: transcriptomic analysis and qRT-PCR
Sequence Accession: PRJNA781681|PRJNA891088|GSE217409|GSE189021

Genomic and machine learning approaches to predict antimicrobial resistance in Stenotrophomonas maltophilia.

PMID 40530807 · 2025

The study identifies key genetic markers associated with resistance to levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT) in Stenotrophomonas maltophilia, including mutations in parC, gyrA, and smeT, as well as the presence of sul1, sul2, Gsh2, and gspD genes.