hadA

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enoyl-CoA hydratase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to hadA

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: variant-based GWAS
Drug Classes: isoniazid, streptomycin
Organisms: Mycobacterium tuberculosis
Geographic Location: Portugal
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
C61S	-	-	Mycobacterium tuberculosis	isoniazid	Reslit	Candidate

Papers2

Genome-wide association study and PhyC analysis reveal lineage-specific and convergent evolution of drug resistance in Mycobacterium tuberculosis

PMID 30922221 · 2023

The study identifies several genes and mutations associated with drug resistance in Mycobacterium tuberculosis, highlighting lineage-specific and convergent evolution of resistance mechanisms.

Gene Information

Gene Name: hadA
Allele: hadA
Encodes: enoyl-CoA hydratase
Source Database: Reslit
Confers Resistance To: isoniazidstreptomycin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Portugal
Validation Method: variant-based GWAS

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hadA

Mutations

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hadA

Mutations

Gene Information