Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump protein
Overview
Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance.
The efflux pump gene hefA plays an important role in multidrug resistance of H. pylori, as evidenced by increased MICs of several antibiotics in MDR strains and reduced susceptibility in the hefA knockout mutant.
Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori.
The study identifies the efflux pump gene hefA as playing a crucial role in multidrug resistance in Helicobacter pylori, with efflux pump inhibitors like CCCP and pantoprazole showing effectiveness in restoring antibiotic susceptibility.
Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics.
The study found that biofilm-forming cells of Helicobacter pylori exhibited increased resistance to antibiotics, which was associated with enhanced expression of the efflux pump genes hp1165 and hefA.
Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice.
The paper discusses the mechanisms of antibiotic resistance in Helicobacter pylori, focusing on genes and mutations associated with resistance to amoxicillin, clarithromycin, furazolidone, levofloxacin, and metronidazole. Key findings include the identification of specific mutations in 23S rRNA, gyrA, gyrB, PBP1A, porD, oorD, RdxA, and other genes that contribute to resistance against these antibiotics.
Population structure of Helicobacter pylori and antibiotic resistance-associated variants in a high-risk area of gastric cancer.
The study identified novel resistance variants in H. pylori strains from a high-risk area of gastric cancer, including mutations in the hefA gene associated with metronidazole and tetracycline resistance.
High Prevalence of hefA Efflux Pump Overexpression in Isolates of Helicobacter pylori Resistant to Clarithromycin.
The study identifies hefA efflux pump overexpression as a significant mechanism of clarithromycin resistance in Helicobacter pylori isolates from southern Chile, independent of 23S rRNA mutations.
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