hemA

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glutamyl-tRNA reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to hemA

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: metabolic bottleneck in heme biosynthesis
Validation Method: agar dilution assay
Drug Classes: gentamicin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L276Q	-	-	Escherichia coli	gentamicin	Reslit	Candidate

Papers1

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks.

PMID 39748127 · 2025

Metabolic mutations in E. coli lead to pathway-specific bottlenecks that reduce antibiotic susceptibility, particularly affecting purine nucleotide biosynthesis for carbenicillin and respiratory chain pathways for gentamicin.

Gene Information

Gene Name: hemA
Allele: hemA
Encodes: glutamyl-tRNA reductase
Source Database: Reslit
Mechanism: metabolic bottleneck in heme biosynthesis
Confers Resistance To: gentamicin
Organisms Tested In: • Escherichia coli
Validation Method: agar dilution assay

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hemA

Mutations

Gene Information

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hemA

Mutations

Gene Information