Browse AMR Genes

Explore antimicrobial resistance genes from the literature

hemL

glutamate-1-semialdehyde aminotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to hemL

Browse AMR rules for hemL

Overview

Drug Classes: nitrofurantoin
Organisms: Salmonella enterica, Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T297P	-	-	Salmonella enterica, Escherichia coli	nitrofurantoin	Reslit	Candidate

Papers1

1

Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin.

PMID 31986134 · 2020

Mutation in the coding region of hemL leads to increased antibiotic uptake, causing heightened susceptibility to nitrofurantoin.

Mutation Information

Protein Change: T297P
Organisms: Salmonella enterica, Escherichia coli
Confers Resistance To: nitrofurantoin
Validation Method: mutant construction and MIC measurements
Source Database: Reslit