Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosome splitting factor
Overview
Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.
The study identifies hflX as a significant mediator of macrolide-lincosamide resistance in Mycobacterium abscessus and Mycobacterium smegmatis, demonstrating that its deletion leads to hypersensitivity to these antibiotics.
The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition.
The WblC/WhiB7 transcription factor controls intrinsic resistance to translation-targeting antibiotics by altering ribosome composition in Streptomyces coelicolor.
Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessus.
The study identifies several genes regulated by WhiB7 that contribute to antibiotic resistance in Mycobacterium abscessus, including erm41, hflX, MAB_2780c, MAB_4532c, MAB_1409c, and MAB_3543c.
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