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Browse Geneshflkc

hflkc

SPFH domain proteins

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to hflkc

Browse AMR rules for hflkc

Validation StatusCandidate

Overview

Mechanism: Contributes to aminoglycoside and oxidative stress tolerance
Validation Method: Phenotypic analysis using Biolog phenotypic arrays and MIC testing
Drug Classes: aminoglycosides
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

1

Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance.

PMID 37347165 · 2023

The study identifies that the HflKC SPFH protein complex contributes to aminoglycoside and oxidative stress resistance in E. coli.

Gene Information

Gene Name: hflkc
Allele: hflKC
Encodes: SPFH domain proteins
Source Database: Reslit
Mechanism: Contributes to aminoglycoside and oxidative stress tolerance
Confers Resistance To: aminoglycosides
Organisms Tested In: • Escherichia coli
Validation Method: Phenotypic analysis using Biolog phenotypic arrays and MIC testing

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research