Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosome-splitting factor
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| hflXr | Reslit | 1 | lincomycin, erythromycin | Listeria monocytogenes | - | 2018 | PRJEB25942 | - |
| HflXr | Reslit | 1 | erythromycin, lincomycin | Listeria monocytogenes | - | 2021 | - | - |
| hflxr | Reslit | 1 | macrolides, lincosamides +2 | Listeria monocytogenes | - | 2022 | EMD-15161|EMD-15204|EMD-15175|EMD-15864|EMD-15670|8A57|8A63|8A5I | - |
HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance.
The study identifies hflXr (also called lmo0762) as an antibiotic resistance gene in Listeria monocytogenes, which confers protection against lincomycin and erythromycin by mediating ribosome splitting and recycling.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
HflXr confers resistance to macrolides, lincosamides, pleuromutilins, and streptogramins in Listeria monocytogenes through an allosteric ribosome protection mechanism.
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