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hfq

RNA chaperone

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to hfq

Browse AMR rules for hfq

Overview

Mechanism: disrupted proton motive force along with lower metabolic activity and reduced intracellular ATP
Drug Classes: cefepime
Organisms: Acinetobacter baumannii
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
F39A	-	disrupted proton motive force along with lower metabolic activity and reduced intracellular ATP	Acinetobacter baumannii	cefepime	Reslit	Candidate

Papers1

1

Hfq balances energetic efficiency and antibiotic persistence in Acinetobacter baumannii.

PMID 40787984 · 2025

Mutations in hfq affect antibiotic persistence.

Mutation Information

Protein Change: F39A
Organisms: Acinetobacter baumannii
Confers Resistance To: cefepime
Effect on Function: disrupted proton motive force along with lower metabolic activity and reduced intracellular ATP
Validation Method: Chromosomal introduction and persistence assays
Source Database: Reslit