hipa7

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toxin

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to hipa7

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: confers high-level survival to multiple antibiotic classes
Validation Method: experimental validation through survival assays
Drug Classes: ciprofloxacin, ampicillin, kanamycin, mitomycin c
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Antibiotic-persistent bacterial cells exhibiting low-level ROS are eradicated by ROS-independent membrane disruption.

PMID 40586599 · 2025

The study identifies hipA7 and metG2 mutations as conferring high-level survival to multiple antibiotic classes in E. coli, highlighting their role in persistence and the effectiveness of aminoglycoside-polymyxin combinations in eradicating persister cells.

Gene Information

Gene Name: hipa7
Allele: hipA7
Encodes: toxin
Source Database: Reslit
Mechanism: confers high-level survival to multiple antibiotic classes
Confers Resistance To: ciprofloxacinampicillinkanamycinmitomycin c
Organisms Tested In: • Escherichia coli
Validation Method: experimental validation through survival assays

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hipa7

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hipa7

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